Category: 58551-69-2

Ji, Le-ting published the artcileClinical efficacy and mechanism of penehyclidine hydrochloride in reducing adverse reactions of carboprost tromethamine, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(22), 4139-4141, database is CAplus.

Objective: To observe the clin. efficacy and mechanism of penehyclidine hydrochloride in reducing adverse reactions of carboprost tromethamine. Methods: 60 cases of parturients who received carboprost tromethamine injection during cesarean uterine contraction were divided into group A, group B, and group C. Three minutes before intrauterine infusion of carprost tromethamine, group C received i.v. infusion of normal saline, group A received i.v. infusion of penehyclidine hydrochloride 0.5 mg, and group B received i.v. infusion of penehyclidine hydrochloride 1 mg. Result: The incidence of adverse reactions in group A and group B was lower than that in group C, and there was no difference in the incidence of adverse reactions between group A and group B. The levels of motilin and angiotensin in group A and group B were significantly lower than those in group C. Conclusion: Penehyclidine hydrochloride can reduce the clin. adverse reactions of carprost tromethamine. The gastrointestinal adverse reactions may be inhibited by reducing motilin while the cardiovascular adverse reactions may be inhibited by reducing angiotensin II.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Li published the artcileClinical effect of oxytocin combined with prostaglandins on prevention of postpartum hemorrhage of high-risk pregnancy puerpera with caesarean section, Synthetic Route of 58551-69-2, the publication is Xiandai Yaowu Yu Linchuang (2014), 29(6), 619-622, database is CAplus.

The aim of this paper is to investigate the clin. efficacy of oxytocin combined with prostaglandins in the prevention of postpartum hemorrhage of high-risk pregnancy puerpera with caesarean section. High-risk pregnancy puerpera(330 cases) with caesarean section in Affiliated Hospital of Yan’an University from Jan. 2012 to Dec. 2013 were randomly divided into 3 groups(110 cases in each group): carboprost tromethamine+oxytocin(CTO) group, carboprost methylate+oxytocin(CMO) group, and oxytocin group. And patients in the CTO group were i.m. given carboprost tromethamine 250 μg in the body of uterus following fetus expulsion, and then were iv oxytocin 10 U. The patients in the CMO group were sublingual administered with carboprost methylate 1 mg following fetus expulsion, and were iv oxytocin 10 U. The patients in the oxytocin group were iv oxytocin 10 U following fetus expulsion, and were i.m. given oxytocin 10 U in body of uterus. The quantity of bleeding was compared among the three groups during the operation, 2, and 2-4 h after operation. The postpartum hemorrhage, blood transfusion, and addnl. hemostatic measures after delivery were observed among the three groups. The side reaction was also observed among the three groups. During operation, 2, and 2-4 h after operation, the quantity of bleeding of maternal in the CTO group was less than that in the CMO group and oxytocin group, with the significant difference(P<0.05). During the operation, 2 h after operation, the quantity of bleeding of maternal in the CMO group was significantly less than that in the oxytocin group(P<0.05). While 2-4 h after the operation, there was no significant difference. The postpartum hemorrhage, blood transfusion rate, and addnl. intervention measures to stop bleeding in the CTO and CMO groups were significantly lower than those in the oxytocin group(P<0.05). The side effects of the three groups were 9.09%, 8.18%, and 6.36%, resp., and there was no significant difference. CTO is effective in preventing postpartum hemorrhage of high-risk pregnancy. CMO could reach a certain preventive effect, but the application of oxytocin simply showed poor efficacy.

Xiandai Yaowu Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Synthetic Route of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Peng, Hui published the artcileTherapeutic effect of hemabate on preventing and treating bleeding in cesarean section or post-operation of high-risk parturient women, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Yixue Linchuang Yanjiu (2009), 26(7), 1335-1336, database is CAplus.

The aim of this paper is to investigate therapeutic effect of hemabate on preventing and treating bleeding in cesarean section or post-operation of high-risk parturient women, and its safety. 60 High-risk parturient women were divided into two groups: hemabate group (A group with 30 cases)and oxytocin+methyl carboprost suppository group (B group with 30 cases). The bleeding amount was recorded during operation and 24h post- operation. Bleeding incidence rate in group B was significantly higher than that in group A (16.7 vs 6.67%). The bleeding amounts during operation and 24h post-operation were 441.57±252.03 mL and 651.26±308.24 mL in B group, while those in group A were 317.31±162.47 mL and 512.26±251.54 mL, resp., with significant difference between the two groups (P<0.05). Hemabate can effectively reduce bleeding amount in cesarean section or post-operation of high-risk parturient women and has advantages of safety, high performance, quickness and convenience.

Yixue Linchuang Yanjiu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Lili published the artcileEfficacy of Electroacupuncture Combined with Tropisetron in Treating Carboprost Tromethamine-Induced Nausea and Vomiting during Cesarean Section under Lumbar Anesthesia., Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Complementary medicine research (2021), 28(6), 516-522, database is MEDLINE.

OBJECTIVE: We evaluated the efficacy of electroacupuncture combined with tropisetron in treating carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. METHODS: A total of 264 patients aged 22-40 years were enrolled, who received carboprost tromethamine and suffered nausea and vomiting during cesarean section under lumbar anesthesia. The patients were divided randomly into the control group, electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group. RESULTS: Compared to the control group, the nausea and vomiting scores decreased at T3 in both the electroacupuncture and electroacupuncture + tropisetron groups, and decreased at T4 in the electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group; the motilin, gastrin, and 5-hydroxytryptamine (5-HT) levels decreased at T5 in the other 3 groups. Compared to the electroacupuncture + tropisetron group, the nausea and vomiting scores increased at T3 in the control and tropisetron groups, and increased at T4 in the other 3 groups; the motilin, gastrin, and 5-HT levels increased at T5. CONCLUSIONS: Our study suggested that electroacupuncture combined with tropisetron could effectively relieve carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. The effect was better than its single application, and the reduced 5-HT, motilin, and gastrin levels might be involved in the underlying mechanism.

Complementary medicine research published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H22N2O4, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qiu, Qian published the artcileEffect of ergometrine combined with carboprost tromethamine on preventing postpartum hemorrhage in patients with scar uterus after cesarean section and its effect on GSH-Px SOD MDA and postpartum lactation, Category: alcohols-buliding-blocks, the publication is Hebei Yixue (2021), 27(11), 1901-1907, database is CAplus.

Objective: To investigate the effect of the combination of Ergometrine and Carboprost Tromethamine Injection in preventing postpartum hemorrhage in patients with scarred uterus re-cesarean section and its influence on glutathione peroxidase (GSH-px), superoxide dismutase (SOD), malondialdehyde (MDA) and postpartum lactation. Methods: A total of 92 patients with scarred uterus re-cesarean section in our hospital from Feb. 2018 to Apr. 2020 were selected as the research objects. They were divided into observation group and control group by simple randomization method, with 46 cases in each group. The control group was treated with Carboprost Tromethamine Injection to prevent postpartum hemorrhage, and the observation group was treated with Ergometrine combined with Carboprost Tromethamine Injection to prevent postpartum hemorrhage. The efficacy, postpartum hemorrhage, recovery, lactation, and adverse reactions, coagulation function indexes [activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), D-dimer (DD)], serum GSH-px, SOD, MDA levels before and 24 h after the operation of the two groups were compared. Results: After treatment, the total effective rate of the observation group was 93.48% higher than that of the control group 76.09% (P<0.05). The bleeding volume and rate of postpartum hemorrhage at 2 h and 24 h in the observation group were lower than those in the control group, the duration of lochia and hospital stay were shorter than those in the control group, and the uterine fundus declined faster than the control group (P<0.05). The levels of APTT, PT, FIB, DD, and serum MDA in the two groups aT24 h after surgery were lower than those before the operation, and the observation group was lower than the control group, and the serum GSH-px and SOD levels were higher than those before operation, and the observation group was higher than the control group (P<0.05). The lactation initiation time of the observation group was shorter than that of the control group, and the lactation volume scores of the 1 and 2 d postpartum were higher than those of the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combined application of Ergometrine and Carboprost Tromethamine Injection to prevent postpartum hemorrhage in patients with scarred uterus re-cesarean section can significantly improve the preventive effect, reduce postpartum hemorrhage, and promote the recovery of patients, improve coagulation function and lactation, reduce serum GSH-px, SOD, MDA levels, reduce oxidative stress, and have good safety.

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ling, Zhang published the artcileEffect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Pakistan Journal of Pharmaceutical Sciences (2018), 31(5), 2257-2262, database is CAplus.

Carboprost tromethamine is a synthetic prostaglandin derivative, which can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery. In this study, we explored the effect of carboprost tromethamine on the prevention of postpartum hemorrhage after cesarean section and the effect on coagulation function and hemodynamics. At the same time, the effects of oxytocin and carboprost tromethamine were studied in different groups. The results showed that the amount of 2h bleeding (256.7 ± 65.21) mL and the amount of 24h hemorrhage (308.3 ± 78.3) after the operation were significantly decreased, and the difference was statistically significant (P<0.05). After the operation, the levels of APTT, TT and Fib in the two groups were significantly lower than those before the operation. The levels of SBP (119.4 ± 8.24) mmHg and DBP (79.6 ± 6.21) mmHg in the exptl. group were significantly higher than those of the control group. In summary, carboprost tromethamine has a significant effect on the prevention of postpartum hemorrhage in cesarean section, and has a significant effect on improving the state of hypercoagulable blood and maintaining the stable hemodynamic state, which has clin. a value.

Pakistan Journal of Pharmaceutical Sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ling, Zhang published the artcileEffect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section., Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Pakistan journal of pharmaceutical sciences (2018), 31(5(Special)), 2257-2262, database is MEDLINE.

Carboprost tromethamine is a synthetic prostaglandin derivative, which can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery. In this study, we explored the effect of carboprost tromethamine on the prevention of postpartum hemorrhage after cesarean section and the effect on coagulation function and hemodynamics. At the same time, the effects of oxytocin and carboprost tromethamine were studied in different groups. The results showed that the amount of 2h bleeding (256.7±65.21) mL and the amount of 24h hemorrhage (308.3±78.3) after the operation were significantly decreased, and the difference was statistically significant (P<0.05). After the operation, the levels of APTT, TT and Fib in the two groups were significantly lower than those before the operation. The levels of SBP (119.4±8.24) mmHg and DBP (79.6±6.21) mmHg in the experimental group were significantly higher than those of the control group. In summary, carboprost tromethamine has a significant effect on the prevention of postpartum hemorrhage in cesarean section, and has a significant effect on improving the state of hypercoagulable blood and maintaining the stable hemodynamic state, which has clinical a value.

Pakistan journal of pharmaceutical sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Shu-hui published the artcileEffect observation of prevention on postpartum bleeding in cesarean section by carboprost tromethamine injection combined with calcium gluconate, Product Details of C25H47NO8, the publication is Yixue Zongshu (2014), 20(14), 2664-2665, database is CAplus.

The preventive effect on postpartum bleeding in Cesarean section by carboprost tromethamine injection combined with calcium gluconate was investigated. A total of 192 maternal patients cases with the risk factors of postpartum hemorrhage and a clear indication of Cesarean section from Jan.2010 to Jan.2013 in Traditional Chinese Medicine Hospital of Beijing Shunyi District were randomly divided into oxytocin group and combination therapy group with 96 cases in each: the oxytocin group was given oxytocin 10-20 U and carboprost 10 mg, on the basic of which, the other group was added carboprost tromethamine injection 25 μg. The amount of bleeding within 24 h and adverse reactions were observed in the two groups. The postoperative hemorrhage during operation and within 24 h after operation of the combination therapy group were significantly less than oxytocin group [(216.9±54.4) mL vs (360.6±52.8) mL, (128.0±29.1) mL vs (221.9±42.7) mL, P<0.05]. And adverse reactions in the combination therapy group were significantly less than the oxytocin group [10.4% (10/96) vs 31.3% (30/96), P<0.05]. Carboprost tromethamine injection combined with calcium gluconate could effectively prevent intraoperative postpartum hemorrhage of Cesarean section, reduce adverse reaction, thus was worth of promotion in clin.

Yixue Zongshu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C18H28N2O7, Product Details of C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Li-ping published the artcileHemabate combined with sodium potassium magnesium calcium and glucose injection in high-risk cesarean section, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Shequ Yixue Zazhi (2012), 10(24), 33-34, database is CAplus.

Objective: To discuss the application of Hemabate combined with Na-K-Mg-Ca-glucose injection to high-risk cesarean section. Methods: 80 women with indication of high-risk cesarean section were divided into a Hemabate combined with Na-K-Mg-Ca-glucose injection group (group A) and a Hemabate combined with Ringer’s lactate injection group (group B). The blood pressure, HR, PaO₂, hemorrhage, Hemabate dose, and side effect ratio were monitored. Results: Hemabate dose of Group A was 250 μg 32 cases, 500 μg 6 cases, and 750 μg 2 cases, and that of Group B was 250 μg 22 cases, 500 μg 12 cases, and 750 μg 6 cases with statistical significance (P < 0.05). Group B had high hemorrhage than Group A 2 h postoperatively and 24 h postoperatively with statistical significance (all P < 0.05). Group A had postoperative hemorrhage > 500 mL 8 cases (20%), uterine filling and surgery 3 cases (7.5%) and nausea and vomiting 17 cases (42.5%). Group B had postoperative hemorrhage 500 mL 17 cases (42.5%), uterine filling and surgery 6 cases (15), and nausea and vomiting 32 cases (80%) with statistical significance (all P < 0.05). Conclusion: The Hemabate combined with perioperative i.v. infusion of Na-K-Mg-Ca-glucose injection for high-risk cesarean section could reduce hemorrhage, Hemabate dose, and nausea and vomiting.

Shequ Yixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Gao-feng published the artcileOxycodone inhibits adverse reactions of carboprost tromethamine and influence of inflammatory cytokines during cesarean section, COA of Formula: C25H47NO8, the publication is Guangdong Yixue (2017), 38(20), 3197-3199, 3203, database is CAplus.

Objective: The paper observed the effect of oxycodone on the adverse reactions of carprost tromethamine during cesarean section and its effect on inflammatory cytokines. Methods: Fifty parturients undergoing cesarean section with elective spinal anesthesia, aged 25-35 years old, ASA grade I or II, were divided into oxycodone group (group A) and control group (B) by random number table method group). Group A was given oxycodone 0.07 mg/kg after carboprost tromethamine was given to the parturients, and group B was given symptomatic treatment after carboprost tromethamine adverse reactions occurred in the parturients. The two groups of parturients applied the same formula for postoperative analgesia, and both groups were diluted with normal saline. The paper observed the adverse reactions after the administration of carprost tromethamine and observed the changes in heart rate (HR), mean arterial pressure (MAP), and pulse oxygen saturation (SpO₂) at 2, 5, and 10 min, and observed the changes before and after the administration of oxycodone. Maternal peripheral blood interleukin-2 (IL-2) and VAS scores at relevant time points after surgery were performed at 6, 12, 24, and 48 h after surgery. Results: Comparing group A and group B, the adverse reactions of carboprost tromethamine were significantly reduced, the level of IL-2 in peripheral venous blood was significantly increased at 6, 12, 24, and 48 h after surgery (P < 0.05), VAS score Significantly reduced (P < 0.05). Compared with group B, there were no statistically significant differences in MAP, HR, and SpO₂ at 2 and 10 min after carboprost tromethamine (P > 0.05); but 5 min after carprost tromethamine was administered when compared with group B, MAP and HR were significantly reduced, the difference was statistically significant (P < 0.05), and the SpO₂ difference was not statistically significant (P > 0.05). Conclusion: Oxycodone 0.07 mg/kg applied in cesarean section could significantly reduce the adverse reactions of carprost tromethamine, provide good postoperative analgesia, and increase the secretion of IL-2 after cesarean section. The vital signs of women who were given proper oxycodone during cesarean section were more stable.

Guangdong Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts