Category: 57-55-6

Using COSMO-RS to Predict Hansen Solubility Parameters was written by Wojeicchowski, Jose Pedro;Ferreira, Ana M.;Okura, Tifany;Pinheiro Rolemberg, Marlus;Mafra, Marcos R.;Coutinho, Joao A. P.. And the article was included in Industrial & Engineering Chemistry Research in 2022.COA of Formula: C3H8O2 This article mentions the following:

Hansen solubility parameters (HSP) provide essential information on the nature of solvents, being a useful tool in their selection for product and process design. In this work, linear models were developed to estimate HSP based on the use of COSMO-RS (conductor-like screening model for realistic solvents) descriptors. Hansen solubility parameters for 195 compounds were obtained from the literature and classified into two categories: training set (133 compounds) and testing set (62 compounds). Then a factorial regression was carried out to predict dispersion, hydrogen-bonding interaction, and polar contribution of HSP (δ_D, δ_H, and δ_P, resp.) based on σ-moments and energy COSMO-RS descriptors. The description of the dispersion contribution was the least successful due to the low variability of the exptl. data, despite the database containing compounds of a widely different chem. nature. The models obtained proved to be more than simple math. equations since a phys. meaning is achieved when COSMO-RS descriptors are used. The models developed were then applied to the test database. An excellent performance was observed, with δ_H showing the highest R² (0.90), and the MAE obtained were 0.98, 1.74, and 1.44 MPa^1/2 for δ_D, δ_H, and δ_P, resp., which are lower than those found in previous works. Finally, HSP data for caffeine, nicotine, paracetamol, and D-camphor were estimated The results were close to the literature data and those predictive by the HSPiP software. Moreover, it was shown that δ_P and δ_H drive the mols.’ polarity, impacting their log K_ow (a quant. measure of polarity). This work shows that COSMO-RS descriptors are a tool to predict HSP through linear models, opening new doors in the screening, design, and selection of solvents to be used in chem. processes. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6COA of Formula: C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology was written by Mills, Carolyn E.;Waltmann, Curt;Archer, Andre G.;Kennedy, Nolan W.;Abrahamson, Charlotte H.;Jackson, Alexander D.;Roth, Eric W.;Shirman, Sasha;Jewett, Michael C.;Mangan, Niall M.;Olvera de la Cruz, Monica;Tullman-Ercek, Danielle. And the article was included in Nature Communications in 2022.Safety of 1,2-Propanediol This article mentions the following:

Abstract: Engineering subcellular organization in microbes shows great promise in addressing bottlenecks in metabolic engineering efforts; however, rules guiding selection of an organization strategy or platform are lacking. Here, we study compartment morphol. as a factor in mediating encapsulated pathway performance. Using the 1,2-propanediol utilization microcompartment (Pdu MCP) system from Salmonella enterica serovar Typhimurium LT2, we find that we can shift the morphol. of this protein nanoreactor from polyhedral to tubular by removing vertex protein PduN. Anal. of the metabolic function between these Pdu microtubes (MTs) shows that they provide a diffusional barrier capable of shielding the cytosol from a toxic pathway intermediate, similar to native MCPs. However, kinetic modeling suggests that the different surface area to volume ratios of MCP and MT structures alters encapsulated pathway performance. Finally, we report a microscopy-based assay that permits rapid assessment of Pdu MT formation to enable future engineering efforts on these structures. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volumetric and Ultrasonic Studies on Interactions of Hexylene and Propylene Glycols in Aqueous Solutions of Glutaraldehyde at Different Temperatures was written by Kaur, Parminder;Chakraborty, Nabaparna;Kumar, Harsh;Singla, Meenu;Juglan, Kailash Chandra. And the article was included in Journal of Solution Chemistry in 2022.HPLC of Formula: 57-55-6 This article mentions the following:

To determine the various interactions between glutaraldehyde and glycols (hexylene and propylene), various thermodn. and acoustic properties have been analyzed by using the d. (ρ) and ultrasonic velocity (c) of liquid mixtures of (hexylene or propylene + aqueous glutaraldehyde solutions), resp., in the concentration ranges from (0.01 to 0.04) mol·kg^-1 at the temperatures of 293.15, 298.15, 303.15, 308.15 K. Thermodn. parameters including the apparent molar volume (V_Φ) and partial molar volume (V⁰Φ) have been calculated from the d. values. These parameters show that the (solute-solvent) interaction for propylene glycol is weaker as compared to hexylene glycol. Acoustic parameters including the apparent molar isentropic compressibility (K_Φ,s) and partial molar isentropic compression (K⁰Φ,s) have been determined by using ultrasonic velocity values. Pair and triplet interaction coefficients have also been determined by using partial molar volume of transfer and partial molar isentropic compression of transfer. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6HPLC of Formula: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formulation and evaluation of nasal insert for nose-to-brain drug delivery of rivastigmine tartrate was written by Shaghlil, Lena;Alshishani, Anas;Sa’aleek, Asmaa Abu;Abdalkader, Hamdy;Al-ebini, Yousef. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:

Nose-to-Brain drug delivery can bypass blood-brain-barrier though the olfactory region using different devices and dosage forms. This work aimed to fabricate and characterize a novel dosage form, nasal inserts, containing rivastigmine tartrate. Four formulas were fabricated using gelatin/HPMC matrix in a different ratios and grades. The fabricated nasal inserts were characterized in terms of phys. appearance, surface pH, diameter and length, mech. properties, and mucoadhesive behavior. The content uniformity, release profile, Ex-vivo permeation of rivastigmine tartrate were also investigated. The release profiles for all nasal inserts were fitted to kinetics model. Phys. and chem. stability of the dosage form were evaluated. F2 appears to have the best sustained release profile, where F1 appears to have the best immediate release profile. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 1,2-Propanediol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Valorization of tomato pomace: extraction of value-added components by deep eutectic solvents and their application in the formulation of cosmetic emulsions was written by Vasyliev, Georgii;Lyudmyla, Khrokalo;Hladun, Kateryna;Skiba, Margarita;Vorobyova, Viktoria. And the article was included in Biomass Conversion and Biorefinery in 2022.Formula: C3H8O2 This article mentions the following:

Deep eutectic solvents (DESs) have been explored as an alternative to hazardous solvents to extract phenolic compounds The aim of this work was estimate the performance of choline chloride-based DESs regarding the extraction of phenolic compounds of tomato pomace and determination of their antioxidant activity. Green choline chloride-based DESs coupled with ultrasound-assisted extraction were performed to extract The solvents were choline chloride:1,2-propanediol (1:2 v/w):water (10% weight/weight) and choline chloride:lactic acid (1:2 v/w):water (10% weight/weight). The phytochem. constituents of tomato pomace extracts were verified with a combination of high-performance liquid chromatog. coupled to diode-array detection and tandem mass spectrometry (HPLC-DAD-MS). The total antioxidant activity of the extracts was assessed using phosphomolybdenum (PM) method. The redox behavior of tomato pomace extracts was evaluated by means of cyclic voltammetry. The DES-based tomato pomace extracts were used as the antioxidant agent to develop a natural cosmetic formulation (colloidal solutions). The -potential, colloidal stability, and the antioxidant, antimicrobial, and antifungal activity were studied. The antioxidant activity of the cosmetic emulsions has been studied by means of cyclic voltammetry. The tomato pomace extracts contain significant quantity of phenolic acids and flavanols (26-37% of the total compounds). Chlorogenic acid was detected as the main phenolic compound in tomato pomace extracts (ranging from 37.23 to 52.33μg/g). The total antioxidant power of the extracts varies in the range at 408 to 511.18μg/g extract Choline chloride-based DESs have low values of oxidation potentials. Zeta-potential of obtained colloidal solutions (cosmetic formulation) varies from – 0.0102 to – 0.0594 mV indicating the moderate stability of obtained cosmetic emulsions. The following ranking of antioxidants was obtained: cosmetic emulsions with extract obtained by choline chloride:lactic acid deep eutectic solvent > cosmetic emulsions with extract obtained by choline chloride:1,2-propanediol deep eutectic solvent. Antibacterial and antifungal activity of the cosmetic emulsions with DES extracts relative to Gram-pos. (Bacillus subtilis), Gram-neg. (Escherichia coli), and Candida albicans wound pathogens were studied. Thus the DESs could serve as solvents to produce a phenolic-rich tomato extract could be readily applicable to cosmetic formulations. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Formula: C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Efficient and simple method for the quantification of alkyl polyglycosides by hydrolysis and photometric determination of reducing sugars was written by Buttler, Judith R.;Bechtold, Thomas;Pham, Tung. And the article was included in Arabian Journal of Chemistry in 2022.Quality Control of 1,2-Propanediol This article mentions the following:

Alkyl polyglycosides (APG) are important biodegradable surfactants for many applications. The lack of a chromophoric group and the mixture of stereoisomers and oligomers make the quantification by merely chromatic separation difficult. A simple and efficient quantification assay was developed based on the acid hydrolysis of alkyl polyglycoside and subsequent quantification of the hydrolytically cleaved glucose using the neocuproine assay. Complete hydrolysis of alkyl polyglycoside is achieved with 16 wt% sulfuric acid at 100 °C after 30 min and the separation of fatty alc. and clouding of the reaction mixture is prevented by adding 1,2-propylene-glycol. Hydrolytically cleaved sugars reduce the Cu(II)-neocuproine complex, leading to a color shift which permits the spectrophotometric quantification at 452 nm. A linear correlation between the absorbance of reduced Cu(II)-neocuproine complex and glucose or alkyl polyglycoside concentration is observed up to an analyte concentration of 25 mg/L. Statistical anal. according to one-tailled T-test (S′ 95%), has shown that the lower detection limit for alkyl polyglycosides is 2.97 mg/L and the limit of quantification 8.24 mg/L, resp. Apart from the simple execution, the assay is reliable and can be utilized both as scientific technique to quantify APG as well as for process and quality control in the industry. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Quality Control of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thermal decomposition of propylene oxide with different activation energy and Reynolds number in a multicomponent tubular reactor containing a cooling jacket was written by Memon, Abid A.;Memon, M. Asif;Bhatti, Kaleemullah;khan, Ilyas;Alshammari, Nawa;Al-Johani, Amnah S.;Hamadneh, Nawaf N.;Andualem, Mulugeta. And the article was included in Scientific Reports in 2022.Reference of 57-55-6 This article mentions the following:

In this article, we are focusing on heat and mass transfer through a Multicomponent tubular reactor containing a cooling jacket by thermal decomposition of propylene oxide in water. The chem. reaction is an irreversible, 1st order reaction and an exothermic reaction that yields propylene glycol with enthalpy = -84,666 J/mol. The constant rate of the reaction is followed by the Arrhenius equation in which the activation energy is taken on a trial basis in the range from 75,000 to 80,000 J/mol with a fixed frequency factor. For the fluid to flow, the Reynolds number is kept in the range from 100 to 1000. The three partial differential equations of mass, momentum, and energy are coupled to study heat and mass transfer in a tubular reactor by using the chem. interface in COMSOL Multiphysics 5.4. The initial concentration of propylene oxide is tested in the range from 2 to 3% and the thermal conductivity of the mixture is tested in the range 0.599-0.799. It was found that the amount deactivated of the compound decreases with an increase in Reynolds number Propylene oxide is decomposed at about 99.8% at Re = 100 at lower activation energy and gives the total maximum enthalpy change in the tubular reactor. Observing the relationship between Sherwood numbers to Nusselt numbers, it was deducted that the convective heat transfer is opposite to convective mass transfer for high Reynolds numbers In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Reference of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Potential of supercritical fluid myrtle extracts as an active ingredient and co-preservative for cosmetic and topical pharmaceutical applications was written by Pereira, Paula;Mauricio, Elisabete Muchagato;Duarte, Maria Paula;Lima, Katelene;Fernandes, Ana S.;Bernardo-Gil, Gabriela;Cebola, Maria-Joao. And the article was included in Sustainable Chemistry and Pharmacy in 2022.Related Products of 57-55-6 This article mentions the following:

This study investigated the applications of a myrtle extract obtained by supercritical fluid extraction (SFE), a technique considered environmentally friendly, as a possible antimicrobial ingredient in cosmetic and pharmaceutical formulations. The supercritical fluid extract was obtained at 230 bar and 45 °C, for 2 h, with a flow of CO₂ of 0.3 kg h^-1. A cosolvent (ethanol) was also used, with a flow 0.09 kg h^-1. The extracts thus obtained were tested against seven Gram-pos. bacteria and one yeast using the well diffusion and the broth dilution techniques. The results showed that the myrtle extract exhibits good antibacterial activity against all the bacteria strains studied and is superior to most of those obtained by conventional extraction methods. Antifungal activity was also present but at a lesser extent. Cell viability studies were carried out by exposing HaCat cells to a range of extract concentrations, from 0.1 μg/mL up to 60 μg/mL for 24 h, using the MTT assay. The Salmonella mutagenicity assay was applied to evaluate the mutagenicity and antimutagenicity of the extract The results obtained suggest that the myrtle extract obtained using a green solvent, supercritical CO₂, is safe and could reduce the genotoxic damage induced by reactive oxygen species (ROSs). In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts