Category: 52160-51-7

Aiura, Masato; Kanaoka, Yuichi published the artcile< Oxidation of pyrroles with benzoyl peroxide>, HPLC of Formula: 52160-51-7, the main research area is pyrrole oxidation benzoyl peroxide.

The pyrroles I (R = Me, PhCH2, Ph, p-MeOC6H4; R1 = R2 = H) were treated with (BzO)2 to give I (R1 = BzO, R2 = H, R1 = R2 = BzO). I (R = Me, Ph; R1 = CH2OHCHPhOH, CPh2OH; R2 = H) were cleaved with (BzO)2 to give I (R1 = BzO, R2 = H; R1 = R2 = BzO).

Heterocycles published new progress about Oxidation. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, HPLC of Formula: 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Takale, Balaram S.; Feng, Xiujuan; Lu, Ye; Bao, Ming; Jin, Tienan; Minato, Taketoshi; Yamamoto, Yoshinori published the artcile< Unsupported Nanoporous Gold Catalyst for Chemoselective Hydrogenation Reactions under Low Pressure: Effect of Residual Silver on the Reaction>, COA of Formula: C6H9NO, the main research area is carbonyl gold silver nanoporous chemoselective hydrogenation catalyst; alc preparation; alkyne gold silver nanoporous chemoselective hydrogenation catalyst; alkene stereoselective preparation.

For the first time, H-H dissociation on an unsupported nanoporous gold (AuNPore) surface is reported for chemoselective hydrogenation of CC, C=C, C=N, and C=O bonds under mild conditions (8 atm H2 pressure, 90 °C). Silver doping in AuNPore, which was inevitable for its preparation through a process of dealloying of Au-Ag alloy, exhibited a remarkable difference in catalytic activity between two catalysts, Au>99Ag1NPore and Au90Ag10NPore.The former was more active and the latter less active in H2 hydrogenation, while the reverse tendency was observed for O2 oxidation This marked contrast between H2 reduction and O2 oxidation is discussed. Further, Au>99Ag1NPore showed a high chemoselectivity toward reduction of terminal alkynes in the presence of internal alkynes which was not achieved using supported gold nanoparticle catalysts and other previously known methods. Reductive amination, which has great significance in synthesis of amines due to its atom-economical nature, was also realized using Au>99Ag1NPore, and the Au>99Ag1NPore/H2 system showed a preference for the reduction of aldehydes in the presence of imines. In addition to this high chemoselectivity, easy recovery and high reusability of AuNPore make it a promising heterogeneous catalyst for hydrogenation reactions.

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, COA of Formula: C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cordell, Geoffrey A. published the artcile< 2-Halopyrroles. Synthesis and chemistry>, SDS of cas: 52160-51-7, the main research area is halopyrrole; pyrrole halogenation; benzylbromopyrrole; bromopyrrole benzyl; chloropyrrole benzyl; stability halopyrrole; electrophilic substitution halopyrrole; formylation halopyrrole; diazo coupling halopyrrole.

Following the confirmation that both 2-chloropyrrole (I) and 2-bromopyrrole (II) were unstable species, a number of 1-alkyl and C-alkyl 2-halopyrroles were synthesized to investigate the range of instability. The 1-alkyl 2-halopyrroles synthesized were 2-chloro-1-methylpyrrole (III), 2-bromo-1-methylpyrrole, 1-benzyl-2-chloropyrrole, and 1-benzyl-2-bromopyrrole. The C-alkyl-2-halopyrroles synthesized were 5-chloro-2-methylpyrrole (IV), 2-tert-butyl-5-chloropyrrole, 5-chloro-2,3,4-trimethylpyrrole (V), and 5-bromo-2,3,4-trimethylpyrrole. Also synthesized were the 1-methyl derivatives of IV and V. Electrophilic substitution of I and II under the conditions for formylation and diazo coupling was examined In the case of the latter reaction no crystalline compounds could be isolated, but diazo coupling of III gave rise to exclusive α-substitution. Formylation of I gave the α-substituted derivative but II gave a product arising from the displacement of bromine, 5-chloropyrrole-2-carboxaldehyde, in addition to 5-bromopyrrole-2-carboxaldehyde.

Journal of Organic Chemistry published new progress about Coupling reaction. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, SDS of cas: 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bheeter, Linus P.; Henrion, Mickael; Brelot, Lydia; Darcel, Christophe; Chetcuti, Michael J.; Sortais, Jean-Baptiste; Ritleng, Vincent published the artcile< Hydrosilylation of aldehydes and ketones catalyzed by an N-heterocyclic carbene-nickel hydride complex under mild conditions>, Safety of (1-Methyl-1H-pyrrol-2-yl)methanol, the main research area is nitrogen heterocyclic carbene nickel hydride preparation mol crystal structure; aldehyde hydrosilylation nitrogen heterocyclic carbene nickel hydride complex catalyst; ketone hydrosilylation nitrogen heterocyclic carbene nickel hydride complex catalyst; alc preparation.

Half-sandwich N-heterocyclic carbene (NHC)-nickel complexes of the general formula [Ni(NHC)ClCp1] (Cp1 = Cp, Cp*) efficiently catalyze the hydrosilylation of aldehydes and ketones at room temperature in the presence of a catalytic amount of sodium triethylborohydride and thus join the fairly exclusive club of well-defined nickel(II) catalyst precursors for the hydrosilylation of carbonyl functionalities. Of notable interest is the isolation of an intermediate nickel hydride complex that proved to be the real catalyst precursor.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Safety of (1-Methyl-1H-pyrrol-2-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Jianxia; Darcel, Christophe; Sortais, Jean-Baptiste published the artcile< A convenient nickel-catalysed hydrosilylation of carbonyl derivatives>, Formula: C6H9NO, the main research area is aldehyde hydrosilylation reduction polymethylhydrosiloxane nickel; primary alc preparation; ketone hydrosilylation reduction polymethylhydrosiloxane nickel; secondary alc preparation; nickel hydrosilylation reduction catalyst; polymethylhydrosiloxane reducing agent.

Hydrosilylation of aldehydes and ketones catalyzed by nickel acetate and tricyclohexylphosphine as the catalytic system was demonstrated using polymethylhydrosiloxane as a cheap reducing reagent.

Catalysis Science & Technology published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Formula: C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Janczewski, Lukasz; Walczak, Malgorzata; Fraczyk, Justyna; Kaminski, Zbigniew J.; Kolesinska, Beata published the artcile< Microwave-assisted Cannizzaro reaction-Optimisation of reaction conditions>, Quality Control of 52160-51-7, the main research area is aldehyde microwave irradiation Cannizzaro reaction; carboxylic acid alc preparation.

The microwave-assisted Cannizzaro reaction was studied in order to develop fully reproducible synthetic protocols for transformation of aldehydes to carboxylic acid and alcs. Optimized were the following process parameters: power, temperature, and time. Aromatic, heteroaromatic and aliphatic aldehydes were used in the studies. It was found that furfural, thiophene-2-carbaldehyde, pyridinecarboxaldehyde and aromatic aldehydes react under mild conditions, while 1-methyl-pyrrole-2-carboxaldehyde derivatives and aliphatic aldehydes require more drastic reaction conditions and a longer exposure time to microwave radiation.

Synthetic Communications published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Quality Control of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. R.; Legg, R. F. published the artcile< Antimitotic activity of dehydroretronecine, a pyrrolizidine alkaloid metabolite, and some analogous compounds, in a rat liver parenchymal cell line>, Reference of 52160-51-7, the main research area is pyrrolizidine alkaloid metabolite antimitosis; pyrrolic alc antimitosis liver.

The actions of 13 pyrrolic alcs. with similar chem. properties were tested on cultured liver cells. Dehydroretronecine (I) [23107-12-2] and dehydrosupinidine (II) [27628-47-3] were putative metabolites of hepatotoxic pyrrolizidine alkaloids and the remainder were synthetic. All were either mono- or bifunctional alkylating agents. Groups of cells were exposed to the compounds, and later stimulated to divide by changing the medium, then fixed, stained, and the proportions of cells in mitosis counted and compared with those in similarly treated control cells. Eleven compounds partially or completely inhibited cell division at 10-4 M. Bifunctional compounds, including I and 2,3-bis(hydroxymethyl)-1-methylpyrrole [53365-77-8], had the highest antimitotic activity coupled with the lowest cytotoxicity. The least chem. reactive compound, 3-(hydroxymethyl)-1-methylpyrrole [68384-83-8], was neither antimitotic nor cytotoxic, whereas the monofunctional alkylating agents with highest reactivity, such as 3-(hydroxymethyl)-1,2-dimethylpyrrole [68384-74-7] were the most toxic to the cells. The mitotic block occurred at a postsynthetic stage of the cell cycle, and affected cells could grow to a giant size.

Chemico-Biological Interactions published new progress about Alkylating agents. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Reference of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tressl, Roland; Wondrak, Georg T.; Krueger, Ralph-Peter; Rewicki, Dieter published the artcile< New Melanoidin-like Maillard Polymers from 2-Deoxypentoses>, Application In Synthesis of 52160-51-7, the main research area is melanoidin Maillard polymer deoxypentose oligomerization antioxidant.

In the 2-deoxy-D-ribose/methyl 4-aminobutyrate Maillard system a trapped N-substituted 2-(hydroxymethyl)pyrrole is one of the major products. However, nontrapped representatives of this type of compound were hitherto not found in other Maillard model systems, indicating their extraordinary reactivity. Model experiments with 2-deoxy-D-ribose/methylamine enabled the detection of N-methyl-2-(hydroxymethyl)pyrrole and some derived linear oligomers as minor components. Consequently, N-methyl-2-(hydroxymethyl)pyrrole was synthesized and its oligomerization was studied under very mild acidic conditions. The deformylated dimeric bis(N-methyl-2-pyrrolyl)methane and trimeric N-methyl-2,5-bis(N-methyl-2-pyrrolylmethyl)pyrrole were characterized by GC/MS and NMR. Higher regular oligomers up to 6 N-methyl-2-pyrrolylmethyl units as well as corresponding dehydro-oligomers up to 12 units were identified by MALDI-TOF-MS. A complementary experiment starting with N-methyl-2-hydroxy[13C]methylpyrrole confirmed the structure and the oligomerization pathway. The possible significance of this type of model oligomer for the melanoidin formation in Maillard reactions is discussed. The antioxidative activity of the isolated dimer and trimer was tested in Fe(III)-thiocyanate and DPPH assays.

Journal of Agricultural and Food Chemistry published new progress about Antioxidants. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application In Synthesis of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Jianxia; Elangovan, Saravanakumar; Valyaev, Dmitry A.; Brousses, Remy; Cesar, Vincent; Sortais, Jean-Baptiste; Darcel, Christophe; Lugan, Noel; Lavigne, Guy published the artcile< Hydrosilylation of Aldehydes and Ketones Catalyzed by Half-Sandwich Manganese(I) N-Heterocyclic Carbene Complexes>, Formula: C6H9NO, the main research area is aldehyde ketone hydrosilylation manganese heterocyclic carbene complex catalyst.

Easily available manganese(I) N-heterocyclic carbene (NHC) complexes, Cp(CO)2Mn(NHC), obtained in one step from industrially produced cymantrene, were evaluated as pre-catalysts in the hydrosilylation of carbonyl compounds under UV irradiation Complexes with NHC ligands incorporating at least one mesityl group led to the most active and selective catalytic systems. A variety of aldehydes (13 examples) and ketones (11 examples) were efficiently reduced under mild conditions [Cp(CO)2Mn(IMes) (1 mol%), Ph2SiH2 (1.5 equiv), hν (350 nm), toluene, 25°, 1-24 h] with good functional group tolerance.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Formula: C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tressl, Roland; Wondrak, Georg T.; Krueger, Ralph-Peter; Rewicki, Dieter published the artcile< New Melanoidin-like Maillard Polymers from 2-Deoxypentoses>, Application In Synthesis of 52160-51-7, the main research area is melanoidin Maillard polymer deoxypentose oligomerization antioxidant.

In the 2-deoxy-D-ribose/methyl 4-aminobutyrate Maillard system a trapped N-substituted 2-(hydroxymethyl)pyrrole is one of the major products. However, nontrapped representatives of this type of compound were hitherto not found in other Maillard model systems, indicating their extraordinary reactivity. Model experiments with 2-deoxy-D-ribose/methylamine enabled the detection of N-methyl-2-(hydroxymethyl)pyrrole and some derived linear oligomers as minor components. Consequently, N-methyl-2-(hydroxymethyl)pyrrole was synthesized and its oligomerization was studied under very mild acidic conditions. The deformylated dimeric bis(N-methyl-2-pyrrolyl)methane and trimeric N-methyl-2,5-bis(N-methyl-2-pyrrolylmethyl)pyrrole were characterized by GC/MS and NMR. Higher regular oligomers up to 6 N-methyl-2-pyrrolylmethyl units as well as corresponding dehydro-oligomers up to 12 units were identified by MALDI-TOF-MS. A complementary experiment starting with N-methyl-2-hydroxy[13C]methylpyrrole confirmed the structure and the oligomerization pathway. The possible significance of this type of model oligomer for the melanoidin formation in Maillard reactions is discussed. The antioxidative activity of the isolated dimer and trimer was tested in Fe(III)-thiocyanate and DPPH assays.

Journal of Agricultural and Food Chemistry published new progress about Antioxidants. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application In Synthesis of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts