Cibanal, Irene Laura et al. published their research in European Journal of Plant Pathology in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 499-75-2

Propolis extract combined with oregano essential oil applied to lima bean seeds against Sclerotinia sclerotiorum was written by Cibanal, Irene Laura;Fernandez, Leticia Andrea;Rodriguez, Silvana Andrea;Pellegrini, Cecilia Noemi;Gallez, Liliana Maria. And the article was included in European Journal of Plant Pathology in 2022.Recommanded Product: 499-75-2 This article mentions the following:

In this study, propolis extract (EPE) and oregano essential oil (OEO), both natural products with different bioactive compounds, were evaluated in vitro and in vivo against Sclerotinia sclerotiorum. This phytopathogen is important worldwide as it can contaminate seeds and infect seedlings of many species. Antifungal susceptibility assays on culture media revealed that EPE and OEO were highly active against this phytopathogen, both individually and combined. EPE showed a fungistatic dose-dependent effect, acting mainly through diffusion, while OEO completely prevented mycelial growth at very low concentrations, with a combination of vapor and diffusion activity. Interestingly, OEO was more effective than EPE, as their min. inhibitory concentrations were 0.39渭l/mL and 5渭l/mL, resp. Combinations of EPE and OEO showed, depending on the doses, additive or synergistic antifungal effects. In the in vivo trial, dilutions of EPE and OEO made in sterile distilled water (SDW) were tested through a pathosystem with lima bean seeds and S. sclerotiorum. Seeds soaked in formulations with 40% EPE + 12% OEO + 48% SDW, and 20% EPE + 6% OEO + 74% SDW reduced disease incidence of 40% and 60% resp., significantly decreased severity, with a min. phytotoxic effect. This study strengthens previous work showing the antifungal action of EPE and OEO against S. sclerotiorum, and, as a main goal, highlights their potential for the development of biofungicides to protect lima bean seeds. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Recommanded Product: 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 499-75-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novato, Tatiane Pinheiro et al. published their research in Veterinary Parasitology in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C10H14O

Acaricidal activity of carvacrol and thymol on acaricide-resistant Rhipicephalus microplus (Acari: Ixodidae) populations and combination with cypermethrin: Is there cross-resistance and synergism? was written by Novato, Tatiane Pinheiro;Milhomem, Marlise Neves;Marchesini, Paula Barroso Cruz;Coutinho, Ana Lucia;Silva, Isabela Santos;de Souza Perinotto, Wendell Marcelo;de Azevedo Prata, Marcia Cristina;Ferreira, Lorena Lopes;Lopes, Welber Daniel Zanetti;Costa-Junior, Livio Martins;de Oliveira Monteiro, Caio Marcio. And the article was included in Veterinary Parasitology in 2022.COA of Formula: C10H14O This article mentions the following:

This study evaluated the acaricidal activity of thymol and carvacrol on Rhipicephalus microplus populations with different resistance profiles and investigated the synergistic effect of combinations of these monoterpenes with cypermethrin. The adult immersion test (AIT) was used to characterize the susceptibility of tick populations (45 field populations) to synthetic acaricides: deltamethrin, amitraz and chlorfenvinphos. The larval packet test (LPT) was used to determine the LC50 values for thymol (25 tick populations) and carvacrol (20 tick populations). The susceptible strain Porto Alegre (POA) was used as a reference for calculating the resistance ratio (RR). Subsequently, larval immersion tests (LIT) were performed with combinations of cypermethrin with thymol or carvacrol to assess a synergistic effect. In the AIT, deltamethrin showed efficacy > 90% in one (2.2%) population tested (mean: 12.1 and 11.1 for populations 1-25 and 26-40, resp.), whereas amitraz and chlorfenvinphos showed efficacy > 90% for two (4.4%) populations (mean: 61.3 and 47.3 for populations 1-25 and 26-40, resp.) and eight (17.7%) populations (mean: 69.7 and 59.7 for populations 1-25 and 26-40, resp.). In the LPT, the LC50 values for thymol and carvacrol varied from 0.67 to 2.12 mg/mL and 0.55-3.21 mg/mL, with an average LC50 for populations of 1.49 and 1.75 mg/mL, resp. For thymol, no resistance was observed in any of the populations, values of RR50 > 1.5. There was no correlation between the LC50 values for thymol and the efficacy of the chem. acaricides tested. Regarding carvacrol, for only one tick population had the value of RR50 > 1.5, indicating an incipient resistance. No correlation was observed between the LC50 values for carvacrol and the efficacy of tested acaricides. The combination of thymol and carvacrol with cypermethrin showed a synergistic effect in the resistant population (Jaguar – thymol 4.19 and carvacrol 3.67), and no synergistic interaction were showed in the susceptible population. Answering the questions we conclude that: 1 – The comparison between the LC50 values for thymol and carvacrol in field populations and the susceptible strain POA suggests the absence of cross-resistance (ticks and terpenes), and the differences between the LC50 values for thymol and carvacrol in the different R. microplus populations are inherent to the characteristics of each population tested; 2 – the combination of thymol or carvacrol with cypermethrin showed a synergistic effect with different activity according to the population of ticks. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2COA of Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zhe et al. published their research in Journal of Thermal Analysis and Calorimetry in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C10H14O

New insights into the thermal degradation behavior of Hydroxypropyl-beta-cyclodextrin inclusion complexes containing carvacrol essential oil via thermogravimetric analysis was written by Li, Zhe;Jiang, Xiaoxia;Zhu, Lin;Chen, Fucai;Liu, Hongning;Ming, Liangshan. And the article was included in Journal of Thermal Analysis and Calorimetry in 2022.Formula: C10H14O This article mentions the following:

The physicochem. properties and thermodn. parameters of cyclodextrin inclusion complexes (ICs) containing essential oil were investigated by thermogravimetric anal. It is necessary to understand the ICs thermal decomposition behavior and kinetics to control and elucidate the inclusion complexation mechanisms. Carvacrol essential oil was encapsulated with hydroxypropyl-beta-cyclodextrin (HP-β CD) using the freeze-drying method. The IC was characterized by SEM, FT-IR, and phase solubility, which confirmed that there were mol. interactions between the carvacrol essential oil and HP-β CD. Moreover, thermal experiments were carried out by a thermogravimetric analyzer at different heating rates (10-40 °C min-1). In addition, three different models, i.e., FOW, KAS, and Starink, were used to calculate the kinetic energy. The FOW was a more proficient model for the calculation of activation energy (Ea). Further, the average values of Ea varied from conversion, and for carvacrol, HP-β CD, and carvacrol/HP-β CD IC, they were found to be 70.56, 162.15, and 152.57 kJ mol-1 based on the FOW model, resp. In general, carvacrol encapsulated into HP-β CD as an IC showed high thermal stability. The kinetic results could be useful in predicting the thermal performance of IC and in helping optimize exptl. procedures for the encapsulation of essential oils in cyclodextrins. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Menicucci, Felicia et al. published their research in International Biodeterioration & Biodegradation in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 499-75-2

Effects of trapped-into-solids volatile organic compounds on paper biodeteriogens was written by Menicucci, Felicia;Palagano, Eleonora;Michelozzi, Marco;Cencetti, Gabriele;Raio, Aida;Bacchi, Alessia;Mazzeo, Paolo P.;Cuzman, Oana A.;Sidoti, Alessandro;Guarino, Salvatore;Basile, Sara;Riccobono, Ornella;Peri, Ezio;Vizza, Francesco;Ienco, Andrea. And the article was included in International Biodeterioration & Biodegradation in 2022.HPLC of Formula: 499-75-2 This article mentions the following:

Paper items from historical archives and libraries are frequently colonized by biodeteriogens, the management of which is a major concern. Essential oil Volatile Organic Compounds (VOCs) of thymol, carvacrol and eugenol, with high levels of antimicrobial and insect repellent activity, were stabilized within crystalline networks of β-cyclodextrins and phenazine-based cocrystals, as a new tool for the control of paper-degrading agents. These formulations were obtained via solvent-free methodologies and resulted as easy handling powders, suitable for the treatment of paper items by indirect contact. Their antimicrobial activity was evaluated on the following species isolated from a book depository at Forte Belvedere (Florence, IT): Alternaria alternata, Aspergillus sp., Cladosporium sp., Trichoderma orientale, Metschnikowia sp., and Bacillus sp. Both formulates displayed a significant antimicrobial activity in vitro, with cocrystals showing higher efficacy than β-cyclodextrins. The formulates were also tested against the pest Lasioderma serricorne, towards which the cocrystals entrapping carvacrol and thymol exhibited repellent activity. Overall, the phenazine-carvacrol cocrystal was the best-performing formulate, also giving favorable outcomes in terms of antifungal activity in an on-paper in vitro experiment designed to reproduce on a small-scale the critical conditions of an infested archive. These promising results pave the way towards further experimentations of VOC-based solid formulates, to shed light on such products applicability for the preservation of paper items. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2HPLC of Formula: 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 499-75-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

do Carmo Sperandio, Natania et al. published their research in Revista Brasileira de Farmacognosia in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 5-Isopropyl-2-methylphenol

Effects on Pseudosuccinea columella Snails Exposed to Origanum vulgare and Thymus vulgaris Volatile Oils was written by do Carmo Sperandio, Natania;Vidal, Maria Larissa Bitencourt;da Silva, Ygor Henrique;Ito, Mitsue;Costa, Adilson Vidal;de Queiroz, Vagner Tebaldi;Ignacchiti, Mariana Drummond Costa;Boeloni, Jankerle Neves;Martins, Isabella Vilhena Freire. And the article was included in Revista Brasileira de Farmacognosia in 2022.Recommanded Product: 5-Isopropyl-2-methylphenol This article mentions the following:

Fasciolosis is an anthropozoonosis of clin. and economic importance that affects several mammals. The causative agent, Fasciola hepatica, has as an obligate intermediate host, the snail Pseudosuccinea columella; therefore, control actions against the mollusks are essential to control the disease. This study aims to evaluate the effect of volatile oils of Origanum vulgare L. and Thymus vulgaris L., both species members of Lamiaceae family, and their resp. major compounds, carvacrol and thymol, as an alternative in the control of the American ribbed fluke snail. The specimens were immersed in solutions with concentrations of 0.025% (mv-1), 0.05% (mv-1), and 0.1% (mv-1) and analyzed at 30 min, 2 h, 6 h, 12 h, and 24 h in relation to motility, adhesion in the plate, response to painful stimulus, and mortality. For ovigerous masses, the interruption or not of embryonic development was analyzed, with observations every 72 h up to 18 days. All compounds promoted the mortality of mollusks and the paralysis of the embryonic development. The test constituents promoted mortality after 30 min. Histol. analyses indicated the occurrence of necrosis, mainly in the digestive gland and in the albumen gland and disorganized connective tissue. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Recommanded Product: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yanan et al. published their research in Journal of Animal Science and Biotechnology in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 5-Isopropyl-2-methylphenol

Effects of different amino acid levels and a carvacrol-thymol blend on growth performance and intestinal health of weaned pigs was written by Wang, Yanan;Yang, Zhipeng;Zhou, Yuanfei;Tan, Jiajian;Sun, Haiqing;Sun, Defa;Mu, Yuyun;Peng, Jian;Wei, Hongkui. And the article was included in Journal of Animal Science and Biotechnology in 2022.Name: 5-Isopropyl-2-methylphenol This article mentions the following:

Over the past years, antibiotic growth promoter had been restricted in animal husbandry production in many countries because of antimicrobial resistance and foodborne antibiotic residues. However, the problems of poor intestinal health and low growth efficiency of piglets have not been solved completely in an antibiotic-free diet, and it is urgent to explore alternatives to antimicrobial growth promoters. Here, a total of 532 weaned pigs were assigned to one of 4 treatments, the low amino acid (AA) level diet (d 1 to d 14 is 1.35%, d 15 to d 42 is 1.25%) (Low AA), the low AA level diet supplementation with a carvacrol-thymol blend (50 mg carvacrol and 50 mg thymol/kg of diet) (CB) (Low AA+CB), the high AA level diet (d 1 to d 14 is 1.50%, d 15 to d 42 is 1.40%) (High AA), and the high AA level diet supplementation with a CB (High AA+CB), resp. Then we measured growth performance and intestinal health indicators of weaned pigs. Results showed that high AA level significantly reduced plasma urea nitrogen, plasma Interleukin-6 (IL-6) and fecal lipocalin-2 contents (P < 0.05), significantly increased the relative abundance of fecal Lactobacillus and Enterococcus, and had a trend to increase the fecal secretory IgA (sIgA) and mucin 2 (MUC 2) contents (P < 0.05) in piglets, thereby alleviating the diarrhea of piglets and reducing the feed conversion ratio (FCR) of piglets during d 1~14 after weaning. Dietary supplementation with CB significantly increased the activity of plasma antioxidant enzymes T-SOD and GSH-px (P < 0.05), while significantly reduced plasma malondialdehyde (MDA), plasma interleukin-1β (IL-1β), plasma endotoxin and D-lactic acid contents (P < 0.05). Meanwhile, CB significantly decreased fecal lipocalin-2 contents and the abundance of fecal Escherichia coli (P < 0.05). Thus, we hypothesis that dietary supplementation with CB significantly increased the average daily gain (ADG) of piglets (P < 0.05) during d 1∼14 after weaning through promoting intestinal health. These results suggest that high AA level and dietary supplementation with CB improved the growth performance of weaned pigs in an antibiotic-free diet by improving AA metabolism and intestinal antioxidant capacity. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Name: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Payandeh, Maryam et al. published their research in International Journal of Biological Macromolecules in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 5-Isopropyl-2-methylphenol

Chitosan nanocomposite incorporated Satureja kermanica essential oil and extract: Synthesis, characterization and antifungal assay was written by Payandeh, Maryam;Ahmadyousefi, Mehdi;Alizadeh, Hamidreza;Zahedifar, Mahboobeh. And the article was included in International Journal of Biological Macromolecules in 2022.Safety of 5-Isopropyl-2-methylphenol This article mentions the following:

The present study reports the design, synthesis, and characterization of nanoencapsulated Satureja kermanica essential oil/extract by chitosan biopolymer (SKEO-CSN)/(SKEX-CSN) for the antifungal efficacy against Fusarium oxysporum, Alternaria alternata, Botrytis cinerea, Sclerotinia sclerotiorum, Rhizoctonia solani, and Pythium aphanidermatum. The prepared SKEO-CSN and SKEX-CSN were characterized by Fourier transform IR (FTIR), SEM (SEM), transmission electron microscopy (TEM), thermogravimetric anal. (TGA), and X-ray diffraction anal. (XRD). GC-Mass anal. was done to identify Satureja kermanica essential oil chem. compounds (SKEO). Thirty-five different components were detected from GC-MS anal. Thymol (46.54 %), and Carvacrol (30.54 %) were demonstrated as major compounds Antifungal studies showed that the SKEO-CSN and SKEX-CSN formulation effectively inhibit fungal growth more than free SKEO and SKEX. According to the results, SKEO-CSN and SKEX-CSN provide a wide range of promising antifungal effects and can be applied as an efficient green strategy to protect plants from fungus infections. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Safety of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Erensoy, Gizem et al. published their research in Journal of Molecular Structure in 2023 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 5-Isopropyl-2-methylphenol

Synthesis, in vitro and in silico studies on novel 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles and their oxime derivatives as potent inhibitors of mPGES-1 was written by Erensoy, Gizem;Ding, Kai;Zhan, Chang-Guo;Ciftci, Gamze;Yelekci, Kemal;Duracik, Merve;Bingol Ozakpinar, Ozlem;Aydemir, Esra;Yilmaz, Zubeyde Nur;Sahin, Fikrettin;Kulabas, Necla;Tatar, Esra;Kucukguzel, Ilkay. And the article was included in Journal of Molecular Structure in 2023.Name: 5-Isopropyl-2-methylphenol This article mentions the following:

Human microsomal prostaglandin E synthase (mPGES)-1 is a glutathione-dependent membrane-bound enzyme which is involved in the terminal stage of prostaglandin E2 (PGE2) synthesis. It has been well reported as a key target for the discovery of new anti-inflammatory and anti-cancer drugs. Specific inhibitors of mPGES-1 are anticipated to selectively restrain the generation of PGE2 induced by the inflammatory stimuli, without obstructing of the regular biosynthesis of other homeostatic prostanoids. Therefore, the design of mPGES-1 inhibitors can represent a better choice to take control of PGE2 associated diseases, compared with conventional non-steroidal anti-inflammatory drugs and cyclooxygenase (COX) inhibitors, which are known for their serious side effects. Although there is an intensive effort for the identification of mPGES-1 inhibitors, none of the unveiled mols. so far have reached the clin. market. Therefore, the development of novel mPGES-1 inhibitors with proper drug-like properties is still an unmet medical need. As a continuation of the research for the identification of new chemotypes which might inhibit this enzyme, the design and synthesis of 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles I (R1 = CH3, C2H5; R2 = H, Br, Cl, OCH3, F; R3 = H, Cl) and their oxime derivatives IIas inhibitors of human mPGES-1 were reported. Twenty-four target compounds I and II were screened for their mPGES-1/COX-2 inhibitory activities as well as their cytotoxicity. Of these compounds, II (R1 = Me, R2 = Cl, R3 = H; R1 = Me, R2 = Br, R3 = H) showed potent mPGES-1 inhibition by IC50 values of 0.224±0.070 μM and 1.08±0.35 μM, resp. These two compounds have also been observed to inhibit angiogenesis in matrigel tube formation assay with no toxicity toward HUVEC cells. In silico studies were also held to understand inhibition mechanisms of the most active compounds using mol. docking, mol. dynamics calculations and ADMET predictions. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Name: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khalil, Mohamad et al. published their research in Current medicinal chemistry in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 5-Isopropyl-2-methylphenol

Beneficial Effects of Carvacrol on In Vitro Models of Metabolically-Associated Liver Steatosis and Endothelial Dysfunction: A Role for Fatty Acids in Interfering with Carvacrol Binding to Serum Albumin. was written by Khalil, Mohamad;Serale, Nadia;Diab, Farah;Baldini, Francesca;Portincasa, Piero;Lupidi, Giulio;Vergani, Laura. And the article was included in Current medicinal chemistry in 2022.Quality Control of 5-Isopropyl-2-methylphenol This article mentions the following:

BACKGROUND: Carvacrol, a plant phenolic monoterpene, is largely employed as food additive and phytochemical. OBJECTIVE: We aimed to assess the lipid lowering and protective effects of carvacrol in vitro using cellular models of hepatic steatosis and endothelial dysfunction. We also investigated if and how the binding of carvacrol to albumin, the physiological transporter for small compounds in the blood, might be altered by the presence of high levels of fatty acids (FAs). METHODS: Hepatic FaO cells treated with exogenous FAs mimic hepatosteatosis; endothelial HECV cells exposed to hydrogen peroxide are a model of endothelial dysfunction. In these models, we measured spectrophotometrically lipid accumulation and release, lipoperoxidation, free radical production, and nitric oxide release before and after treatment with carvacrol. The carvacrol binding to albumin in the presence or absence of high levels of FAs was assessed by absorption and emission spectroscopies. RESULTS: Carvacrol counteracted lipid accumulation and oxidative stress in hepatocytes and protected endothelial cells from oxidative stress and dysfunction. Moreover, high levels of FAs reduced the binding of carvacrol to albumin. CONCLUSION: The results suggest the good potential of carvacrol in ameliorating dysfunction of hepatic and endothelial cells in vitro. High levels of circulating FAs might compete with carvacrol for binding to albumin thus influencing its transport and bio-distribution. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Quality Control of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karimifar, Pourya et al. published their research in Food Bioscience in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C10H14O

Antibacterial, antioxidative and sensory properties of Ziziphora clinopodioides-Rosmarinus officinalis essential oil nanoencapsulated using sodium alginate in raw lamb burger patties was written by Karimifar, Pourya;Saei-Dehkordi, S. Siavash;Izadi, Zahra. And the article was included in Food Bioscience in 2022.Electric Literature of C10H14O This article mentions the following:

This study was aimed to encapsulate Ziziphora clinopodioides-Rosmarinus officinalis essential oil (Z-REO) using sodium alginate (NaAlg) and to evaluate its performance on antimicrobial and antioxidative activities and sensory attributes in lamb burger patties during cold storage for 12 days. GC-MS anal. of Z-REO indicated carvacrol (21.5%) and thymol (16.9%) were the major components. SEM images showed the formation of encapsulated particles. The presence of encapsulated Z-REO in NaAlg was proved based on the increase in band intensity of FTIR spectra. By increasing mass ratios of NaAlg:Z-REO from 1:1 to 2:1, and 4:1, encapsulation efficiency was increased. Average zeta-potential values (mV) of the mass ratios 4:1 and 2:1 were -48.67 and -44.83, indicating the stability of encapsulated particles. The average size of particles ranged from 159.14 nm to 256.14 nm. The results showed that the encapsulated nanoparticles could markedly decrease the growth of inoculated Escherichia coli O157:H7 and Staphylococcus aureus and delay the lipid oxidation of lamb patties compared to the control samples and in samples with free Z-REO. Furthermore, nanoparticles efficiently decreased discoloration and off-odor development in the patties. Therefore, NaAlg-Z-REO nanoparticles could efficiently reduce bacterial growth and oxidative or sensory deterioration of lamb patties during storage. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Electric Literature of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts