Category: 492-62-6

Sandilya, Avilasha A.; Natarajan, Upendra; Priya, M. Hamsa published the artcile< Molecular View into the Cyclodextrin Cavity: Structure and Hydration>, Related Products of 492-62-6, the main research area is cyclodextrin cavity hydration.

We find, through atomistic mol. dynamics simulation of native cyclodextrins (CDs) in water, that although the outer surface of a CD appears like a truncated cone, the inner cavity resembles a conical hourglass because of the inward protrusion of the glycosidic oxygens. Furthermore, the conformations of the constituent α-glucose mols. are found to differ significantly from a free monomeric α-glucose mol. This is the first computational study that maps the conformational change to the preferential hydrogen bond donating capacity of one of the secondary hydroxyl groups of CD, in consensus with an NMR experiment We have developed a simple and novel geometry-based technique to identify water mols. occupying the nonspherical CD cavity, and the computed water occupancies are in close agreement with the exptl. and d. functional theory studies. Our anal. reveals that a water mol. in CD cavity loses out about two hydrogen bonds and remains energetically frustrated but possesses higher orientational degree of freedom compared to bulk water. In the context of CD-drug complexation, these imply a nonclassical, i.e., enthalpically driven hydrophobic association of a drug in CD cavity.

ACS Omega published new progress about Binding energy. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Axelrod, Kevin; Samburova, Vera; Khlystov, Andrey Y. published the artcile< Relative abundance of saccharides, free amino acids, and other compounds in specific pollen species for source profiling of atmospheric aerosol>, Computed Properties of 492-62-6, the main research area is abundance saccharide free amino acid pollen species source profiling; atm aerosol; Amino acid; Anhydrosugar; Atmospheric aerosol; Bioaerosol; Pollen; Resin acid; Saccharide.

Though studies in bioaerosols are being conducted with increasing frequency over the past decade, the total breadth of knowledge on bioaerosols and their role in atm. processes is still minimal. In order to better characterize the chem. composition of fresh biol. aerosol for purposes of source apportionment and tracing in the atm., several plant pollen species were selected for detailed chem. analyses. For this purpose, different pollen species were purchased and collected around Reno, Nevada, USA, for further extraction and detailed chem. anal. These species included aspen, corn, pecan, ragweed, eastern cottonwood, paper mulberry, rabbitbrush, bitterbrush, lodgepole pine, and Jeffrey pine. Saccharides, free amino acids, and various other polar compounds (e.g., anhydrosugars and resin acids) were quant. analyzed using gas chromatog. and ultra-high performance liquid chromatog. coupled with mass spectrometry techniques (GC-MS and UPLC-MS), with the purpose to identify differences and nuances in chem. composition of specific pollen species. The saccharides β-D-fructose, α-D-glucose, and β-D-glucose were ubiquitously found across all pollen samples (10), and sucrose was found in five samples. D-galactose was also found in pine species. Total saccharides were 4.0 to 29% of total dry weight across all samples. Total free amino acids were 0.29% to 15% of total dry weight across all samples, with the most common amino acid being proline. Chem. profiles (including both saccharides and amino acids) of surface-deposited aerosol in the Lake Tahoe area correlated most closely with pine pollen than other analyzed pollen species, indicating that chem. profiles of pollen can be used to infer its contribution to local aerosols.

Science of the Total Environment published new progress about Adenostoma fasciculatum. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arruda, Henrique Silvano; Silva, Eric Keven; Pereira, Gustavo Araujo; Meireles, M. Angela A.; Pastore, Glaucia Maria published the artcile< Inulin thermal stability in prebiotic carbohydrate-enriched araticum whey beverage>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is araticum whey beverage inulin carbohydrate prebiotic thermal stability.

Inulin is a prebiotic carbohydrate widely used in the food industry due to its health-related claims and its ability to modify/improve the technol. properties of food products. However, industrial processes such as thermal treatments, can cause structure changes in prebiotic carbohydrates affecting their health benefits and technol. properties, but these aspects have received little attention. Therefore, this study aimed to evaluate the impact of thermal treatments (70-100°C/60 s) on inulin chem. stability in a dairy system, araticum flavoured whey beverage. Compared with untreated whey beverage, the thermally processed whey beverages did not exhibit any changes in pH (5.59), total soluble solids (24.63-25.19°Brix), glucose (16.11-17.97 mg/mL), fructose (17.75-19.49 mg/mL), sucrose (89.00-94.14 mg/mL) and lactose (61.59-67.19 mg/mL). The chromatog. anal. displayed no significant differences in content (GF2-GF4 ranged from 3.04 to 3.28 mg/mL) and profile of inulin (average DP = 10) between untreated and thermally processed beverages, showing that inulin had strong ability to resist thermal degradation in a dairy system. This study has provided consistent and clear results regarding inulin thermal stability, showing that inulin can be successfully added in thermally processed com. dairy beverages without prejudice to their prebiotic properties.

LWT–Food Science and Technology published new progress about Annona crassiflora. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Song, Jianxi; Wu, Ye; Ma, Xiaojing; Feng, Lijuan; Wang, Zhiguo; Jiang, Guiquan; Tong, Haibin published the artcile< Structural characterization and α-glycosidase inhibitory activity of a novel polysaccharide fraction from Aconitum coreanum>, Application of C6H12O6, the main research area is Aconitum polysaccharide ACPP1 structure glycosidase inhibitor; A. coreanum polysaccharides (ACPP); Characterization; α-Glycosidase.

α-Glycosidase is an essential target for the management of postprandial serum glucose in diabetic patients. Therefore, the interest has been growing in the screening of α-glycosidase inhibitor from natural resource. In the present study, the structure and α-glycosidase inhibitory activity of a polysaccharide (named as ACPP-1) from Aconitum coreanum were investigated. Based on the results from high performance gel permeation chromatog., GC-MS and 1D/2D NMR spectroscopy, ACPP-1 was a highly-linear polysaccharide with a mol. weight of 34.0 kD and containing over 90% of glucose. It was composed of (1→4)-α-D-Glcp and α-Araf. ACPP-1 exhibited a dose-dependent inhibitory effect against α-glycosidase activity in vitro and the IC50 value was ∼0.8 mg/mL. In oral starch tolerance test, treatment with ACPP-1 (800 mg/kg) significantly improved the starch tolerance in mice. Taken together, this study provided a potential intervention and management for postprandial hyperglycemia by the polysaccharide fraction from A. coreanum.

Carbohydrate Polymers published new progress about Aconitum coreanum. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gallegos, Felipe E.; Meneses, Lorena M.; Cuesta, Sebastian A.; Santos, Juan C.; Arias, Josefa; Carrillo, Pamela; Pilaquinga, Fernanda published the artcile< Computational Modeling of the Interaction of Silver Clusters with Carbohydrates>, Product Details of C6H12O6, the main research area is computational modeling interaction silver cluster carbohydrate.

Silver nanoparticles are recognized for their numerous phys., biol., and pharmaceutical applications. In the present study, the interaction of silver clusters with monosaccharide mols. is examined to identify which mol. works better as a reducing agent in the application of a green synthesis approach. Geometry optimization of clusters containing one, three, and five silver atoms is performed along with the optimization of α-D-glucose, α-D-ribose, D-erythrose, and glyceraldehyde using d. functional theory. Optimized geometries allow identifying the interaction formed in the silver cluster and monosaccharide complexes. An electron localization function anal. is performed to further analyze the interaction found and explain the reduction process in the formation of silver nanoparticles. The overall results indicate that glyceraldehyde presents the best characteristics to serve as the most efficient reducing agent.

ACS Omega published new progress about Complexation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiu, Lin; Xiao, Chao-Jiang; Shen, Yi; Xu, Wei; Liu, Xiao-Bo; Dong, Xiang; Jiang, Bei published the artcile< Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis>, Reference of 492-62-6, the main research area is hydroxypropionylated glucose derivative isolation Astragalus bhotanensis pharmacodynamics; Astragalus bhotanensis; Leguminosae; analgesic; antioxidant; cytotoxicity; hydroxypropionylated glucose derivatives.

Four previously undescribed hydroxypropionylated D-glucose derivatives, astrabhotins A-D, along with ten known compounds α-D-glucose, β-D-glucose, quebrachitol, 3-hydroxypropionic acid, oleic acid, isoliquiritigenin, liquiritigenin, odoratin, 7β-hydroxysitosterol and daucosterol, were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochem. properties. Astrabhotin A reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of was stronger than the standard drug aspirin. In addition, compounds and showed significant antioxidant activities with IC50 values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC50 values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, resp.

Natural Product Research published new progress about Analgesics. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vega-Rojas, Lineth Juliana; Luzardo-Ocampo, Ivan; Mosqueda, Juan; Palmerin-Carreno, Dulce Maria; Escobedo-Reyes, Antonio; Blanco-Labra, Alejandro; Escobar-Garcia, Konisgmar; Garcia-Gasca, Teresa published the artcile< Bioaccessibility and in vitro intestinal permeability of a recombinant lectin from Tepary bean (Phaseolus acutifolius) using the everted intestine assay>, SDS of cas: 492-62-6, the main research area is Phaseolus acutifolius lectin tepary bean intestinal permeability bioaccessibility; Tepary bean (Phaseolus acutifolius); apparent permeability; bioaccessibility; ex vivo everted intestine assay; in vitro and ex vivo gastrointestinal digestion; recombinant lectin.

Tepary bean (Phaseolus acutifolius) lectins exhibit differential in vitro and in vivo biol. effects, but their gastrointestinal interactions and digestion have not yet been assessed. This work aimed to evaluate the changes of a recombinant Tepary bean lectin (rTBL-1) through an in vitro and ex vivo gastrointestinal process. A polyclonal antibody was developed to selectively detect rTBL-1 by Western blot (WB) and immunohistochem. anal. Everted gut sac viability was confirmed until 60 min, where protein bioaccessibility, apparent permeability coefficient, and efflux ratio showed rTBL-1 partial digestion and absorption. Immunoblot assays suggested rTBL-1 internalization, since the lectin was detected in the digestible fraction. The immunohistochem. assay detected rTBL-1 presence at the apical side of the small intestine, potentially due to the interaction with the intestinal cell membrane. The in silico interactions between rTBL-1 and some saccharides or derivatives showed high binding affinity to sialic acid (-6.70 kcal/mol) and N-acetylglucosamine (-6.10 kcal/mol). The ultra-high-performance liquid chromatog.-electron spray ionization-quant. time-of-flight coupled to mass spectrometry (UHPLC-ESI-QTOF/MS) anal. showed rTBL-1 presence in the gastric content and the non-digestible fraction after intestinal simulation conditions. The results indicated that rTBL-1 partially resisted the digestive conditions and interacted with the intestinal membrane, whereas its digestion allowed the absorption or internalization of the protein or the derivative peptides. Further purification of digestion samples should be conducted to identify intact rTBL-1 protein and digested peptides to assess their physiol. effects.

International Journal of Molecular Sciences published new progress about Absorption. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Lin; Zhao, Xue; Wu, Ji’en; He, Yun; Yang, Hongshun published the artcile< Metabolic analysis of salicylic acid-induced chilling tolerance of banana using NMR>, Related Products of 492-62-6, the main research area is banana salicylic acid metabolic analysis; Cold injury; Energy status; Fruit; Metabolomics; Omics; Pathway; Principal component analysis; Salicylic acid.

Banana is highly susceptible to low temperature and salicylic acid (SA) can effectively improve the chilling tolerance. The metabolic changes of SA induced chilling responses of banana were studied. Bananas normally ripened under 15°C and dramatic metabolic difference compared with other groups was recorded. Accumulation of glucose (>1.5 folds) and consumption of unsaturated fatty acids (11.0-16.5%) were observed The glycolysis was induced to compensate the decreased energy charge. Low temperature (6°C) caused chilling damage and metabolites including glutamine, serine, and glucose were related to chilled bananas. Various physiol. changes such as sugar metabolism and consumption of reducing substances occurred to adapt the cold stress. SA released the cold injury and the disaccharides were increased by 18.1-21.4%. Further anal. revealed the synthesis of unsaturated fatty acids, amino acids such as proline, and enhanced energy charge. Thus, SA increased the chilling tolerance via a number of different metabolic mechanisms.

Food Research International published new progress about Banana. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hirai, Mitsuhiro; Ajito, Satoshi; Iwasa, Tatsuo; Wen, Durige; Igarashi, Noriyuki; Shimizu, Nobutaka published the artcile< Short-Distance Intermolecular Correlations of Mono- and Disaccharides in Condensed Solutions: Bulky Character of Trehalose>, Formula: C6H12O6, the main research area is cryptobiosis trehalose disaccharide monosaccharide condensed solution structure WAXS.

Organisms with tolerance to extreme environmental conditions (cryptobiosis) such as desiccation and freezing are known to accumulate stress proteins and/or sugars. Trehalose, a disaccharide, has received considerable attention in the context of cryptobiosis. It has already been shown to have the highest glass-transition temperature and different hydration properties from other mono- and disaccharides. In spite of the importance of understanding cryptobiosis by exptl. clarifying sugar-sugar interactions such as the clustering in concentrated sugar solutions, there is little direct exptl. evidence of sugar solution structures formed by intermol. interactions and/or correlation. Using a wide-angle X-ray scattering method with the real-space resolution from ∼3 to 120 Å, we clarified the characteristics of the structures of sugar solutions (glucose, fructose, mannose, sucrose, and trehalose), over a wide concentration range of 0.05-0.65 g/mL. At low concentrations, the second virial coefficients obtained indicated the repulsive intermol. interactions for all sugars and also the differences among them depending on the type of sugar. In spite of the presence of such repulsive force, a short-range intermol. correlation was found to appear at high concentrations for every sugar. The concentration dependence of the observed scattering data and p(r) functions clearly showed that trehalose prefers a more disordered arrangement in solution compared to other sugars, i.e., bulky arrangement. The present findings will afford a new insight into the mol. mechanism of the protective functions of the sugars relevant to cryptobiosis, particularly that of trehalose.

ACS Omega published new progress about Adaptation (cryptobiosis). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rubel Mozumder, N. H. M.; Lee, Yeong-Ran; Hwang, Kyeong Hwan; Lee, Min-Seuk; Kim, Eun-Hee; Hong, Young-Shick published the artcile< Characterization of tea leaf metabolites dependent on tea (Camellia sinensis) plant age through 1H NMR-based metabolomics>, Electric Literature of 492-62-6, the main research area is Camellia sinensis tea leaf metabolite.

Abstract: The chem. or metabolic compositions of tea (Camellia sinensis) varies according to numerous factors, such as geog. origin, cultivar, climate, plucking position, and horticultural practices. However, how the age of tea plants affects the metabolite compositions of tea leaves has not been reported yet. Therefore, we extended the metabolomic approach to the investigation of the age-related differences of tea leaf metabolites in the fresh leaves collected from tea plants aged 8 and 25 years. Multivariate statistical anal. with comprehensive metabolite profiles analyzed by 1H NMR spectroscopy showed the clear metabolic differentiation between the fresh tea leaves from different ages of the tea plants. Of the various tea leaf metabolites varied according to the age of the tea plants, theanine, glutamine, catechin, and gallocatechin were uniquely dependent on the age of tea plants, demonstrating a difference of theanine metabolism between young and old tea plants. These results suggest that leaves from 25-yr-old tea plants would still be worthy as a functional ingredient for the production in the food or cosmetic industry rather than quality-enhanced tea infusions for human consumption.

Applied Biological Chemistry published new progress about Camellia sinensis. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts