Category: 492-62-6

Ghlissi, Zohra; Kallel, Rim; Krichen, Fatma; Hakim, Ahmed; Zeghal, Khaled; Boudawara, Tahiya; Bougatef, Ali; Sahnoun, Zouheir published the artcile< Polysaccharide from Pimpinella anisum seeds: Structural characterization, anti-inflammatory and laser burn wound healing in mice>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is Staphylococcus Pimpinella laser burn wound healing seed polysaccharide antiinflammatory; Anti-inflammatory activity; Laser burn; Pimpinella anisum; Polysaccharide; Wound healing.

The polysaccharide preparation from Pimpinella anisum seeds (PAP) was isolated and characterized to evaluate its laser burn wound-healing and anti-inflammatory activities in mice. The structure characterization of PAP by Infra-red spectrometry (IR), NMR (NMR), Gas chromatogram-Mass spectrometer (GC-MS) and colorimetric methods revealed an optimum yield of 8.84%, a high quantity of carbohydrate (64.75%) and low levels of lipids, protein and sulfate. Galactose (33.47%), β-D-Glucose (26.71%) and a-D-Mannose (18.21%) were the major monosaccharides components presenting in PAP, and a smaller amounts of β-D-Galactose, D-Fructose, a-D-Glucose, a-L-Galactose and arabinose were detected. PAP showed noticeable antioxidant and antibacterial properties. The anti-inflammatory activity of PAP in the carrageenan-induced paw edema model in mice, demonstrated by reduced edema and cellular infiltration, and oxidative stress markers in muscle tissue. A beneficial wound healing effect was also revealed. The topical application of PAP based gel on laser burn lesions accelerates wound contraction, the re-epithelization and remodeling phases after seven days of treatment. The results demonstrated that PAP is a novel promising source of natural wound healing and anti-inflammatory drugs. The high content and varied PAP monosaccharides seem to be responsible for the observed biol. activities.

International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Jianfei; Huang, Jiaqi; Guo, Huanyu; Jiang, Shaoming; Zhang, Jing; Ning, Yuchen; Fang, Mudannan; Liu, Shijie published the artcile< Optimization of immobilization conditions for Lactobacillus penntosus cells>, Product Details of C6H12O6, the main research area is immobilization lactic acid fermentation Lactobacillus penntosus; Fermentation; Immobilization; Lactic acid; Lactobacillus pentosus.

Abstract: In this study, the immobilization technol. was used to improve the LA yield and shorten the fermentation time. The optimum conditions to immobilize Lactobacillus pentosus ATCC 8041 cell were determined by Taguchi design L16 (45). The immobilized L. pentosus ATCC 8041 cells prepared by 2% sodium alginate (SA) and 6% polyvinyl alc. (PVA) with the immobilization process by 0.10 M calcium chloride (CaCl2) and 2.5% boric acid (H3BO3) had the best performance of LA yield at the temperature of 35°C, which is significantly higher than that of L. pentosus ATCC 8041 free cells. These cells maintained the stable and efficient performance in 15 repeated batch fermentation, and they also have excellent mech. strength to keep from breakage caused by cell growth and agitation.

Bioprocess and Biosystems Engineering published new progress about Fermentation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dudka, Ilona; Thysell, Elin; Lundquist, Kristina; Antti, Henrik; Iglesias-Gato, Diego; Flores-Morales, Amilcar; Bergh, Anders; Wikstroem, Pernilla; Groebner, Gerhard published the artcile< Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status>, Category: alcohols-buliding-blocks, the main research area is proteome metabolome TMPRSS2 ERG phosphocholine hypoxanthine prostate cancer progression; 1H HRMAS NMR; Gleason score; Metabolomics; Prostate cancer; TMPRSS2-ERG.

Abstract: Background: Prostate cancer (PC) can display very heterogeneous phenotypes ranging from indolent asymptomatic to aggressive lethal forms. Understanding how these PC subtypes vary in their striving for energy and anabolic mols. is of fundamental importance for developing more effective therapies and diagnostics. Here, we carried out an extensive anal. of prostate tissue samples to reveal metabolic alterations during PC development and disease progression and furthermore between TMPRSS2-ERG rearrangement-pos. and -neg. PC subclasses. Methods: Comprehensive metabolomics anal. of prostate tissue samples was performed by non-destructive high-resolution magic angle spinning NMR (1H HR MAS NMR). Subsequently, samples underwent moderate extraction, leaving tissue morphol. intact for histopathol. characterization. Metabolites in tissue extracts were identified by 1H/31P NMR and liquid chromatog.-mass spectrometry (LC-MS). These metabolomics profiles were analyzed by chemometric tools and the outcome was further validated using proteomic data from a sep. sample cohort. Results: The obtained metabolite patterns significantly differed between PC and benign tissue and between samples with high and low Gleason score (GS). Five key metabolites (phosphocholine, glutamate, hypoxanthine, arginine and α-glucose) were identified, who were sufficient to differentiate between cancer and benign tissue and between high to low GS. In ERG-pos. PC, the anal. revealed several acylcarnitines among the increased metabolites together with decreased levels of proteins involved in β-oxidation; indicating decreased acyl-CoAs oxidation in ERG-pos. tumors. The ERG-pos. group also showed increased levels of metabolites and proteins involved in purine catabolism; a potential sign of increased DNA damage and oxidative stress. Conclusions: Our comprehensive metabolomic anal. strongly indicates that ERG-pos. PC and ERG-neg. PC should be considered as different subtypes of PC; a fact requiring different, sub-type specific treatment strategies for affected patients.

BMC Cancer published new progress about Acylcarnitines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Takeuchi, Hironori; Fujimori, Yusuke; Ueda, Yoshihiro; Shibayama, Hiromitsu; Nagaishi, Masaru; Yoshimura, Tomoyuki; Sasamori, Takahiro; Tokitoh, Norihiro; Furuta, Takumi; Kawabata, Takeo published the artcile< Solvent-Dependent Mechanism and Stereochemistry of Mitsunobu Glycosylation with Unprotected Pyranoses>, Application of C6H12O6, the main research area is unprotected pyranose stereoselective Mitsunobu glycosylation mechanism solvent effect.

An SN2 mechanism was proposed for highly stereoselective glycosylation of benzoic acid with unprotected α-D-glucose under Mitsunobu conditions in dioxane, while an SN1 mechanism was indicated for nonstereoselective glycosylation in DMF. The SN2-type stereoselective Mitsunobu glycosylation is generally applicable to various unprotected pyranoses as glycosyl donors in combination with a wide range of acidic glycosyl acceptors such as carboxylic acids, phenols, and imides, retaining its high stereoselectivity (33 examples). Glycosylation of a carboxylic acid with unprotected α-D-mannose proceeded also in an SN2 manner to directly afford a usually less accessible 1,2-cis-mannoside. One- or two-step total syntheses of five simple natural glycosides were performed using the glycosylation strategy presented here using unprotected α-D-glucose.

Organic Letters published new progress about Absolute configuration. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Klare, Juliane; Rurik, Marc; Rottmann, Eric; Bollen, Anke; Kohlbacher, Oliver; Fischer, Markus; Hackl, Thomas published the artcile< Determination of the Geographical Origin of Asparagus officinalis L. by 1H NMR Spectroscopy>, Computed Properties of 492-62-6, the main research area is Asparagus geog NMR spectroscopy; NMR; asparagus; food fraud; geographical origin; support vector machine.

Food authenticity concerning the geog. origin becomes increasingly important for consumers, food industries, and food authorities. In this study, nontargeted1H NMR metabolomics combined with machine learning methodologies was applied to successfully distinguish the geog. origin of 237 samples of white asparagus from Germany, Poland, The Netherlands, Spain, Greece, and Peru. Support vector classification of the geog. origin achieved an accuracy of 91.5% for the entire sample set and 87.8% after undersampling the majority class. Important regions of the spectra could be identified and assigned to potential chem. markers. A subset of samples was compared to isotope-ratio mass spectrometry (IRMS), an established method for the determination of origin of white asparagus in Germany. Here, SVM classification led to accuracies of 79.4% for NMR and 70.9% for IRMS. Finally, the classification of asparagus from different German regions was evaluated, and the influence of year and variety was analyzed.

Journal of Agricultural and Food Chemistry published new progress about Asparagus. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Emran, Mohammed Y.; Shenashen, Mohamed A.; El-Safty, Sherif A.; Reda, Abdullah; Selim, Mahmoud M. published the artcile< Microporous P-doped carbon spheres sensory electrode for voltammetry and amperometry adrenaline screening in human fluids>, Application of C6H12O6, the main research area is phosphorus carbon sphere sensory electrode voltammetry amperometry adrenaline human; Adrenaline; Biosensors; Electrochemical sensors/biosensors; Human serum; Nanoporous carbon; P-doped carbon spheres.

An electrochem. sensor-based phosphorus-doped microporous carbon spheroidal structures (P-MCSs) has been designed for selective adrenaline (ADR) signaling in human blood serum. The P-MCS electrode sensor is built with heterogeneous surface alignments including multiple porous sizes with open holes and meso-/macro-grooves, rough surface curvatures, and integral morphol. with interconnected and conjugated microspheres. In addition, the P atom-doped graphitic carbon forms highly active centers, increases charge mobility on the electrode surface, creates abundant active centers with facile functionalization, and induces binding to ADR mols. The designed P-MCS electrode exhibits ultrasensitive monitoring of ADR with a low detection limit of 0.002 μM and high sensitivity of 4330 μA μM-1 cm-2. In addition, two electrochem. techniques, namely, square wave voltammetry (SWV) and chronoamperometry (CA), were used; these techniques achieve high stability, fast response, and a wide linear range from 0.01 to 6 μM. The sensing assays based on P-MCSs provide evidence of the formation of active interfacial surface-to-ADR binding sites, high electron diffusion, and heavy target loads along with/without a plane of spheroids. Thus, P-MCSs can be used for the routine monitoring of ADR in human blood serum, providing a fast response, and requiring highly economical materials at extremely low concentrations Electrode surface modulation based on P-doped carbon spheres (P-MCS) exhibits high electrochem. activity with fast charge transport, multi-diffusible active centers, high loading of ADR, and facile mol./electron diffusion at its surface. The P-MCS sensitively and selectively detects the ADR in human fluids and can be used for clin. investigation of some neuronal diseases such as Alzheimer diseases.

Microchimica Acta published new progress about Adsorption. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Palivec, Vladimir; Michal, Pavel; Kapitan, Josef; Martinez-Seara, Hector; Bour, Petr published the artcile< Raman Optical Activity of Glucose and Sorbose in Extended Wavenumber Range>, Synthetic Route of 492-62-6, the main research area is Raman optical activity glucose sorbose extended wavenumber range; CH stretching; Raman optical activity; density functional theory; saccharide structure; spectral modeling.

Raman optical activity (ROA) is pursued as a promising method for structural analyses of sugars in aqueous solutions In the present study, exptl. Raman and ROA spectra of glucose and sorbose obtained in an extended range (50-4000 cm-1) are interpreted using mol. dynamics and d. functional theory, with the emphasis on CH stretching modes. A reasonable theor. basis for spectral interpretation was obtained already at the harmonic level. Anharmonic corrections led to minor shifts of band positions (up to 25 cm-1) below 2000 cm-1, while the CH stretching bands shifted more, by ∼180 cm-1, and better reproduced the experiment However, the anharmonicities could be included on a relatively low approximation level only, and they did not always improve the harmonic band shapes. The dependence on the structure and conformation shows that the CH stretching ROA spectral pattern is a sensitive marker useful in saccharide structure studies.

ChemPhysChem published new progress about Anharmonic molecular vibration (Anharmonic corrections). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Samaha, Hala; Chahine, Nathalie; Sobolev, Anatoly Petrovich; Menghini, Luigi; Makhlouf, Hassane published the artcile< 1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon>, HPLC of Formula: 492-62-6, the main research area is Crocus sativus antioxidant cultivation NMR metabolic profiling; Lebanon; NMR; geographical classification; metabolic profiling; microwave-assisted extraction; saffron.

Despite the beneficial health properties shown by Lebanese saffron, its qual. and quant. composition has never been investigated before. In the present study, NMR spectroscopy, together with antioxidant activity assays, were applied to evaluate the chem. composition of saffron samples of different geog. origins (Lebanon, Italy, Iran, and India) and to categorize the Lebanese saffron for the first time. The distinction between Lebanese saffron and that produced in other countries was attributed to its higher linolenic and linoleic fatty acids, glucose and picrocrocin contents. Moreover, spices produced in three different regions of the Lebanese territory have been clearly differentiated. Saffron cultivated in the Qaa region displayed a high glucose, fatty acids and polyphenols content, whereas Hermel saffron exhibited the largest rate of picrocrocin and glycosylated carotenoids. Finally, samples from Baalbeck showed lower rates for the majority of metabolites. Moreover, Lebanese saffron showed a high antioxidant activity in ABTS and DPPH assays. A low dose of saffron extract (10 μg/mL) inhibited the growth of human lung adenocarcinoma cells, probably due to the high polyphenolic content. This study highlights the quality and peculiarity of Lebanese saffron cultivated in Northern Beqaa district and allows for a good discrimination between spices produced in relatively close territory.

Molecules published new progress about Antioxidants. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Barros, A. B.; Moura, A. F.; Silva, D. A.; Oliveira, T. M.; Barreto, F. S.; Ribeiro, W. L. C.; Alves, A. P. N. N.; Araujo, A. J.; Moraes Filho, M. O.; Iles, B.; Medeiros, J. V. R.; Marinho-Filho, J. D. B. published the artcile< Evaluation of antitumor potential of cashew gum extracted from Anacardium occidentale Linn>, Computed Properties of 492-62-6, the main research area is anacardium colorectal carcinoma cashew gum antitumor melanoma model; Antitumor activity; Melanoma model; Polysaccharide.

This study aims to determine the antitumor potential of cashew gum in vitro and in vivo. The cashew gum structure is similar to already showed in literature. The cytotoxicity effect of CG was performed by MTT assay, and B16-F10 melanoma model was used to evaluate antitumor effect. The tumor inhibition was calculated based on tumor weight Hematol., histopathol., FTIR, oxidative stress and Western Blot anal. were performed to elucidate the mechanism of inhibition and toxic effects. As results, CG did not demonstrate cytotoxicity in vitro, however showed a significant tumor inhibition in vivo, with about 36.9 to 43% of reduction in tumor mass, with no toxicity to organs. Animals treated with CG did not show toxicity in normal tissues, FTIR spectrum and oxidative stress anal. of the tumor tissue indicated that CG cause tumor inhibition with the presence of apoptosis morphotype cells, without alterations in the levels of antioxidants components. In addition, it was observed that CG reduced the expression of γH2AX without changing the expression of caspase-3. With this, we can suggest that this polymer can assist in the anticancer activity and/or decrease the side effects of standard drugs used in treatment of cancer.

International Journal of Biological Macromolecules published new progress about Anacardium occidentale. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Haijing; Feng, Zhuolei; Han, Xue; Xing, Yue; Zhang, Xiaomei published the artcile< Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signaling pathway>, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is acylglycerolkinase glucose endothelialmesenchymal retinal microvascular endothelialcell LPAR1 TGFb Notch; acide lysophosphatidique; acylglycerol kinase; acylglycérol kinase; cellule endothéliale des microvaisseaux rétiniens; endothelial-mesenchymal transition; high glucose; hyperglycémie; lysophosphatidic acid; retinal microvascular endothelial cell; transition de l’endothélium au mésenchyme.

The endothelial-mesenchymal transition (EndMT) participates in the progression of diabetic retinopathy (DR), but cell-intrinsic factors modulating this process remain elusive. In this study, we explored the role of lysophosphatidic acid (LPA) – producing enzyme, acylglycerol kinase (AGK), in the EndMT of human retinal microvascular endothelial cells (HRECs) under high-glucose (HG) conditions. We found that AGK was significantly elevated in HG-treated cells. In addition, AGK knockdown reversed the HG-induced EndMT in HRECs, which was evidenced by the increased endothelial markers (CD31 and VE-cadherin) and decreased mesenchymal markers (FSP1 and β-SMA). Furthermore, downregulation of AGK inhibited the HG-induced activation of transforming growth factor β (TGF-β)/Notch pathways, whereas exogenous TGF-β1 (10 ng/mL) impeded the inhibitory effects of AGK knockdown on HG-induced EndMT in HRECs. Addnl., the silencing of AGK abolished the HG-induced upregulation of LPA and its receptor, LPA receptor 1 (LPAR1), and overexpression of LPAR1 further rescued the AGK knockdown-mediated inhibition of the EndMT process. In conclusion, we demonstrate that downregulation of AGK suppresses HG-induced EndMT in HRECs through regulating the LPAR1/TGF-β/Notch signaling pathway, indicating that AGK might be a potential therapeutic target for the treatment of DR.

Canadian Journal of Physiology and Pharmacology published new progress about Adhesion G protein-coupled receptor E2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts