Category: 492-62-6

Meng, Manli; Liu, Shuyue; Wang, Xinhua published the artcile< Pressure retarded osmosis coupled with activated sludge process for wastewater treatment: Performance and fouling behaviors>, Formula: C6H12O6, the main research area is membrane wastewater treatment osmosis biofoulant activated sludge pore; Forward osmosis; Membrane fouling; Pressure retarded osmosis; Support layer; Wastewater treatment.

A novel hybrid technol. integrating pressure retarded osmosis with activated sludge process (denoted as PRO-MBR) was proposed in this study for wastewater treatment. Here, performance and fouling behaviors of PRO-MBR were investigated. Excellent contaminants removal and power production were simultaneously achieved in the PRO-MBR. A significant drop of water flux in the PRO-MBR was mainly due to the severe fouling of the support layer in forward osmosis (FO) membrane including internal fouling and external fouling. Although the external fouling was identified to be the major type of fouling, the internal fouling dominated the overall decline of water flux. In addition, organic foulants and biofoulants were the dominant foulants for the external fouling while inorganic foulants were equal to organic foulants and biofoulants for the internal fouling. According to the variations of water flux in the PRO-MBR, the development of support layer fouling was divided into three stages.

Bioresource Technology published new progress about Biopolymers Role: BSU (Biological Study, Unclassified), BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iftikhar, Rabeeya; Ansari, Asma; Siddiqui, Nadir Naveed; Hussain, Fayaz; Aman, Afsheen published the artcile< Structural elucidation and cytotoxic analysis of a fructan based biopolymer produced extracellularly by Zymomonas mobilis KIBGE-IB14>, Synthetic Route of 492-62-6, the main research area is Zymomonas levan cytotoxicity fibroblast biomedical application; Chemical characterization; Cytotoxicity; Exopolysaccharide; Levan; NIH/3T3 Cell line.

Fructan based biopolymers have been extensively characterized and explored for their potential applications. Linear chained biopolymers, like levan-type fructan, have gained attention because they have exhibited unconventional stretchable and unbendable properties along with biodegradable and biocompatible nature. Current study deals with the chem. characterization and cytotoxic anal. of fructose based exopolysaccharide that was extracellularly produced by an indigenously isolated bacterial species (Zymomonas mobilis KIBGE-IB14). Maximum yield of exopolysaccharide (44.7 gL-1) was attained after 72 h of incubation at 30°C under shaking conditions (180 rpm) when the culture medium was supplemented with 150.0 gL-1 of sucrose as a sole carbon source. This exopolysaccharide displayed high water solubility index (96.0%) with low water holding capacity (17.0%) and an intrinsic viscosity of about 0.447 dL g-1. This biopolymer exhibited a characteristic linear homopolysaccharide structure of levan when characterized using Fourier Transform IR (FTIR), NMR (NMR) spectroscopy (1H, 13C, TOCSY and NOESY) while, Atomic Force Microscopy (AFM) revealed its pointed and thorny structure. The decomposition temperature of levan was approx. 245°C as revealed by Thermal Gravimetric Anal. (TGA). X-Ray Diffraction (XRD) results revealed its amorphous nature with crystalline phase. Cytotoxicity of different concentrations of levan was investigated against mouse fibroblast cell lines by measuring their cellular metabolic activity and it was noticed that a higher concentration of levan (2.0 mg ml-1) permitted the normal cell growth of NIH/3T3 cell lines. This non-cytotoxic and biocompatible nature suggests that this levan has the capability to be utilized in food and drug-based formulations as it exhibited biomedical potential.

Carbohydrate Research published new progress about Biocompatibility. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kotena, Zahrabatoul Mosapour; Fattahi, Alireza published the artcile< Computational insight into networking H-bonds in open and cyclic forms of glucose>, Reference of 492-62-6, the main research area is glucose open cyclic form hydrogen bond acidity stabilization energy.

We have studied the intramol. H-bonds existing in cyclic and open forms of glucose using B3LYP/6-311++G(d,p) level, AIM, and NBO methods. The theor. results indicated that based on acidity values, (ΔHacid), glucose in the open form is more acidic than cyclic form. The acidity values for open and cyclic glucose (332 and 338 kcal/mol) exhibit significantly lower values (i.e., stronger acid) than the reported acidity values for α-/ss-anomers of D-glucopyranose and simple alcs. Because their conjugate bases are more stabilized through trifurcated and bifurcated intramol. H-bonds. AIM anal. showed normal H-bonds in the conjugate bases of open glucose (O-Glc), bifurcated, and normal H-bonds in the conjugate base of cyclic glucose. In the conjugate base of glucose, the O-H···O bonds are categorized as mostly electrostatic and strong, whereas multiple interactions including C-H···O, C-H···H-C (dihydrogen bonding), C-H···C-H, and C=O···H are categorized as weak H-bonds. The NBO results confirm that the O-H···O intramol. H-bonds should be the strongest among all H-bonds existing within glucose.

Journal of Physical Organic Chemistry published new progress about Acidity. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ziemniak, Marcin; Pawledzio, Sylwia; Zawadzka-Kazmierczuk, Anna; Dominiak, Paulina M.; Trzybinski, Damian; Kozminski, Wiktor; Zielinski, Rafal; Fokt, Izabela; Priebe, Waldemar; Wozniak, Krzysztof; Pajak, Beata published the artcile< X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-D-glucose in solid state and solution>, Quality Control of 492-62-6, the main research area is deoxyglucose conformation electron density hydrogen bond supramol self assembly.

The structural studies on two bromo-substituted derivatives of 2-deoxy-D-glucose (2-DG), namely 2-deoxy-2-bromo-D-glucose (2-BG) and 2-deoxy-2-bromo-D-mannose (2-BM) are described. 2-DG itself is an inhibitor of hexokinase, the first enzyme in the glycolysis process, playing a vital role in both cancer cell metabolism and viral replication in host cells. Because of that, 2-DG derivatives are considered as potential anti-cancer and anti-viral drugs. An X-ray quantum crystallog. approach allowed us to obtain more accurate positions of hydrogen atoms by applying Hirshfeld atom refinement, providing a better description of hydrogen bonding even in the case of data from routine X-ray experiments Obtained structures showed that the introduction of bromine at the C2 position in the pyranose ring has a minor influence on its conformation but still, it has a noticeable effect on the crystal structure. Bromine imposes the formation of a layered supramol. landscape containing hydrogen bonds, which involves the bromine atom. Periodic DFT calculations of cohesive and interaction energies (at the B3LYP level of theory) have supported these findings and highlighted energetic changes upon bromine substitution. Based on mol. wavefunction from the refinement, we calculated the electrostatic potential, Laplacian, and ELI-D, and applied them to charge-d. studies, which confirmed the geometry of hydrogen bonding and involvement of the bromine atom with these intermol. interactions. NMR studies in the solution show that both compounds do not display significant differences in their anomeric equilibrium compared to 2-DG, and the pyranose ring puckering is similar in both aqueous and solid state.

RSC Advances published new progress about Bader electron density. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cho, Soon Ok; Lim, Joo Weon; Kim, Hyeyoung published the artcile< Oxidative stress induces apoptosis via calpain- and caspase-3-mediated cleavage of ATM in pancreatic acinar cells>, HPLC of Formula: 492-62-6, the main research area is calpain caspase ATM pancreatic acinar cell oxidative stress apoptosis; Ataxia telangiectasia mutated; calpain; caspase-3; glucose/glucose oxidase; pancreatic acinar cells.

Oxidative stress-induced DNA cleavage and apoptosis in pancreatic acinar cells has been implicated in the pathogenesis of acute pancreatitis. Thus, an efficient DNA repair process is key to prevention of apoptotic pancreatic acinar cell death. Ataxia telangiectasia mutated (ATM), a sensor of DNA breaks, functions by recruiting DNA repair proteins to initiate the DNA repair process. In the present study, we investigated whether H2O2 produced by the action of glucose oxidase on α-D-glucose (G/GO) induces apoptosis in pancreatic acinar AR42J cells through an alteration of the level of ATM. As a result, G/GO induced apoptosis by promoting a loss of cell viability, increase in Bax, decrease in Bcl-2, cleavage of poly (ADP-ribose) polymerase (PARP) and fragmentation of DNA. In addition, ATM cleavage along with elevated levels of calpain and caspase-3 activity was induced by G/GO. By using ATM siRNA, we demonstrated that reduction in ATM levels enhanced G/GO-induced apoptosis. Moreover, inhibition of calpain activity by calpeptin or calpastatin, or by inhibition of caspase-3 with z-DEVD, suppressed G/GO-induced apoptosis and ATM cleavage. Collectively, these findings suggest that proteolysis of ATM is the underlying mechanism of apoptosis of pancreatic acinar cells caused by exposure to oxidative stress.

Free Radical Research published new progress about Actins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maiti, Sudip; Li, Yingzi; Sasmal, Sheuli; Guin, Srimanta; Bhattacharya, Trisha; Lahiri, Goutam Kumar; Paton, Robert S.; Maiti, Debabrata published the artcile< Expanding chemical space by para-C-H arylation of arenes>, Application In Synthesis of 492-62-6, the main research area is biaryl scaffold preparation.

A robust catalytic system that displayed unique efficacy toward para-arylation of highly functionalized substrates such as drug entities, giving access to structurally diversified biaryl scaffolds, e.g., I was developed. This diversification process provided access to an expanded chem. space for further exploration in drug discovery. Further, the applicability of the transformation was realized through the synthesis of drug mols. bearing a biphenyl fragment. Computational and exptl. mechanistic studies further provided insight into the catalytic cycle operative in this versatile C-H arylation protocol.

Nature Communications published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hao; Zhou, Musen; Sebastian, Jessalyn; Wu, Jianzhong; Gu, Mengyang published the artcile< Efficient force field and energy emulation through partition of permutationally equivalent atoms>, HPLC of Formula: 492-62-6, the main research area is efficient force field energy emulation partition permutationally equivalent atom.

Gaussian process (GP) emulator has been used as a surrogate model for predicting force field and mol. potential, to overcome the computational bottleneck of ab initio mol. dynamics simulation. Integrating both at. force and energy in predictions was found to be more accurate than using energy alone, yet it requires O((NM)3) computational operations for computing the likelihood function and making predictions, where N is the number of atoms and M is the number of simulated configurations in the training sample due to the inversion of a large covariance matrix. The high computational cost limits its applications to the simulation of small mols. The computational challenge of using both gradient information and function values in GPs was recently noticed in machine learning communities, whereas conventional approximation methods may not work well. Here, we introduce a new approach, the atomized force field model, that integrates both force and energy in the emulator with many fewer computational operations. The drastic reduction in computation is achieved by utilizing the naturally sparse covariance structure that satisfies the constraints of the energy conservation and permutation symmetry of atoms. The efficient machine learning algorithm extends the limits of its applications on larger mols. under the same computational budget, with nearly no loss of predictive accuracy. Furthermore, our approach contains an uncertainty assessment of predictions of at. forces and energies, useful for developing a sequential design over the chem. input space. (c) 2022 American Institute of Physics.

Journal of Chemical Physics published new progress about Algorithm. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shan, Shan; Xiong, Yi; Guo, Jianguo; Liu, Mengyao; Gao, Xin; Fu, Xinjing; Zeng, Deyong; Song, Chen; Zhang, Yingchun; Cheng, Dayodu; Lu, Weihong published the artcile< Effect of an inulin-type fructan from Platycodon grandiflorum on the intestinal microbiota in rats exposed to PM2.5>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is Platycodon fructan gastroprotectant polysaccharide intestinal microbiota PM25 exposure; Intestinal microbiota; Inulin-type fructan; PM2.5; Platycodon grandiflorum.

In this study, an inulin-type fructan (PGPI-1-a) was isolated from the roots of Platycodon grandiflorum. PGPI-1-a was composed of (2 → 1)-linked β-D-fructofuranose (Fruf) and a terminal α-D-glucopyranose (Glcp) with a mol. weight of 12.1 kDa. PM2.5 exposure has brought a great threat to human health in recent years. Therefore, this study explored the effect of PGPI-1-a on the intestinal microbial community structure of rats exposed to PM2.5 using the animal model of PM2.5 inhalation exposure. The results showed that PGPI-1-a could regulate the intestinal microbiota by partly restoring the perturbed levels of Peptoniphilaceae_[G-2] and Lachnospiraceae_[G-2] caused by PM2.5 exposure. In addition, the relative abundance of Butyrivibrio, a butyric acid-producing genera, significantly increased after PGPI-1-a intervention. These results indicated that PGPI-1-a could improve the imbalance of intestinal microbiota due to PM2.5 exposure to a certain extent.

Carbohydrate Polymers published new progress about Actinobacteria. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Wei; Zhang, Yu-Ting; Wang, Chen; Guo, Wenshan; Ngo, Huu Hao; Chen, Xueming; Ni, Bing-Jie published the artcile< Responses of anaerobic hydrogen-producing granules to acute microplastics exposure during biological hydrogen production from wastewater>, Safety of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is AHPG microplastics wastewater biol hydrogen production; Anaerobic hydrogen-producing granule; Extracellular polymeric substance; Microplastics; Toxicity; Wastewater.

Anaerobic hydrogen-producing granule (AHPG) has been successfully applied in hydrogen production from wastewater. While various types of microplastics in large amounts are readily detected in both municipal and industrial wastewaters, however, to date the response of AHPG to multiple coexisting microplastics in wastewater is unknown yet. Herein, this study provided a first insight into the acute exposure-response relationship between multiple coexisting microplastics and the AHPG during biol. hydrogen production from wastewater. Fluorescence tagging found that many microplastics accumulated and covered on the surface of the whole granule. Morphol. and particle size of microplastics-bearing AHPG were characterized by microscopic observation, showing that the shock load of microplastics in the wastewater at the studied concentrations (40 and 80 mg/L) made the granule loose and even break down with the decreased particle size. The visualization of extracellular polymeric substances (EPS) structure revealed that microplastics decreased EPS production by 8.8-16.7%. Microbial community anal. demonstrated that the acute exposure of microplastics did not drive the change in the microbial community diversity and composition However, toxic leachates and upgraded oxidative stress induced by microplastics increased cell death up to 14.7% and decreased hydrogen production by 18.7%, when the AHPG exposed to 80 mg/L of microplastics. This work gained a new insight into the response of anaerobic microorganisms to coexisting microplastics in the real environment.

Water Research published new progress about Acidobacteria. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Silva, Lorena Mara A.; Filho, Elenilson G. Alves; Rodrigues, Tigressa Helena S.; Louredo, Francisca Jamila C.; Zocolo, Guilherme J.; Canuto, Kirley M.; Mikich, Sandra B.; Liebsch, Dieter; De Almeida, Adriana; De Brito, Edy S. published the artcile< Metabolomic Profiling of Phloem Sap from Different Pine Species and Implications on Black Capuchin>, Computed Properties of 492-62-6, the main research area is metabolomic phloem sap monosaccharide pine specie animal plant interaction; Capuchin monkey; Data fusion; NMR; Phloem sap; SPME–GC–MS.

In most com. pine farms in southern Brazil, black capuchin causes damage to wood and financial losses when it removes bark from some pine species to feed upon underlying vascular tissues. Therefore, this study aimed to evaluate the variability of the primary metabolites of phloem saps from 10 different species of pine by NMR spectroscopy, as well as the aroma compounds using SPME-GC-MS. Each technique provided a different set of metabolites that we can correlate to monkey predilection. The PCA showed monosaccharide (detected by NMR) and α-pinene (pine-like and resinous flavor descriptors) as attractive compounds for monkeys. On the other hand, the low content of monosaccharide and the high content of β-phellandrene (citrus odor descriptor) was observed in less attacked pine species (P. patula). The data fusion on primary metabolites and aroma compounds corroborated the individual analyses, complementing the comprehension of the monkey predilection. Thus, P. elliottii was an avoided tree even with high content of sugars possibly due to its high content of β-phellandrene (citrus odor). The results are useful for further behavioral studies to determine the role that each highlighted metabolite plays in chem. mediated animal-plant interactions.

Journal of Chemical Ecology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts