Category: 2216-51-5

Difluoroalkylation of Tertiary Amides and Lactams by an Iridium-Catalyzed Reductive Reformatsky Reaction was written by Biallas, Phillip;Yamazaki, Ken;Dixon, Darren J.. And the article was included in Organic Letters in 2022.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

An iridium catalyzed, reductive alkylation of abundant tertiary lactams and amides using 1-2 mol % of Vaska’s complex (IrCl(CO)(PPh₃)₂), tetramethyldisiloxane (TMDS) and difluoro-Reformatsky reagents (BrZnCF₂R) for the general synthesis of medicinally relevant α-difluoroalkylated tertiary amines, is described. A broad scope (42 examples), including N-aryl and N-heteroaryl substituted lactams, demonstrated an excellent functional group tolerance. Furthermore, late-stage drug functionalizations, a gram scale synthesis and common downstream transformations proved the potential synthetic relevance of this new methodol. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cationic DABCO-Based Catalyst for Site-Selective C-H Alkylation via Photoinduced Hydrogen-Atom Transfer was written by Matsumoto, Akira;Yamamoto, Masanori;Maruoka, Keiji. And the article was included in ACS Catalysis in 2022.Formula: C10H20O This article mentions the following:

A series of hydrogen-atom transfer (HAT) catalysts based on the readily available and tunable 1,4-diazabicyclo[2.2.2]octane (DABCO) structure was designed, and their photoinduced HAT catalysis ability was demonstrated. The combination of HAT catalyst with an acridinium-based organophotoredox catalyst enabled efficient and site-selective C-H alkylation of substrates ranging from unactivated hydrocarbons to complex mols. Notably, a HAT catalyst with addnl. substituents adjacent to a nitrogen atom further improved the site selectivity. Mechanistic studies suggested that the N-substituent of the catalyst played a crucial role, assisting in the generation of a dicationic aminium radical as an active species for the HAT process. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel highly efficient absolute optical resolution method by serial combination of two asymmetric reactions from acetylene monomers having racemic substituents was written by Tang, Yanan;Liu, Lijia;Suzuki, Junpei;Teraguchi, Masahiro;Kaneko, Takashi;Aoki, Toshiki. And the article was included in Chirality in 2022.Application of 2216-51-5 This article mentions the following:

For general optical resolution, an optical resolution agent is necessary, and the best agent should be selected for each racemic compound In this study, we will report that a novel optical resolution method by circularly polarized light (CPL) without any optical resolution agents has been developed by serially connecting two enantioselective reactions. These reactions we developed are the enantiomer-selective helix-sense-selective polymerization (ES-HSSP) and helix-sense-selective highly selective photocyclic aromatization (SCAT) by CPL (HS-SCAT). Since this significantly unique EPHS method (EPHS = ES-HSSP + HS-SCAT) does not need any optical resolution agents, any cocatalysts, and solvents for the selective decomposition reaction (HS-SCAT), this process is quite simple and convenient. Since this process does not include any decomposition of the target racemates themselves, both enantiomers could be obtained. The optical yields for isolated compounds that were enantiomerically separated by the EPHS method were very high, for example, 78%ee, 93%ee, and 85%ee for menthol, phenethyl alc., and 2-butanol, resp. In addition, their chem. yields were around 85% to 94%. Therefore, the EPHS method was found to show an excellent performance and can be applied to actual optical resolution for a wide range of racemic compounds This is the first absolute optical resolution by CPL showing high optical and chem. yields and expected to become a practical optical resolution method. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application of 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Natural-Product-Directed Catalytic Stereoselective Synthesis of Functionalized Fused Borane Cluster-Oxazoles for the Discovery of Bactericidal Agents was written by Varkhedkar, Rajesh;Yang, Fan;Dontha, Rakesh;Zhang, Jianglin;Liu, Jiyong;Spingler, Bernhard;van der Veen, Stijn;Duttwyler, Simon. And the article was included in ACS Central Science in 2022.Formula: C10H20O This article mentions the following:

The identification of an alternative chem. space to address the global challenge posed by emerging antimicrobial resistance is very much needed for the discovery of novel antimicrobial lead compounds B clusters are currently being explored in drug discovery due to their unique steric and electronic properties. However, the challenges associated with the synthesis and derivatization techniques of these compounds have limited their utility in the rapid construction of a library of mols. for screening against various biol. targets as an alternative mol. platform. Herein, the authors report a transition-metal-catalyzed regioselective direct B-H alkylation-annulation of the closo-dodecaborate anion with natural products such as menthol and camphor as the directing groups. This method allowed the rapid construction of a library of 1,2,3-trisubstituted clusters, which were evaluated in terms of their antibacterial activity against WHO priority pathogens. Several of the synthesized dodecaborate derivatives displayed medium- to high-level bactericidal activity against Gram-pos. and Gram-neg. bacteria. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective C-H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis was written by Maji, Kakoli;Thorve, Pradip Ramdas;Rai, Pramod;Maji, Biplab. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Formula: C10H20O This article mentions the following:

An enantioselective ortho-C(sp₂)-H functionalization of ketones/esters, e.g., I (R¹ = Me, Et, Ph, OMe; R² = H, 4-F, 3-MeO, 3,4-benzo, etc.) with 1,6-enynes II [Ar = Ph, X = NTs, O, C(COOMe)₂; Ar = 3-ClC₆H₄, 4-MeOC₆H₄, 3,5-Me₂C₆H₃, etc., X = NTs] is demonstrated via photoredox/cobalt dual catalysis. The method provides the corresponding arylmethylene-substituted carbo- and heterocycles III in high yields with functional group tolerance and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramol. cyclization, ortho-C-H bond insertion, and reductive elimination as the key mechanistic steps. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalyst-Dependent Stereospecific [3,3]-Sigmatropic Rearrangement of Sulfoxide-Ynamides: Divergent Synthesis of Chiral Medium-Sized N,S-Heterocycles was written by Zhu, Guang-Yu;Zhou, Ji-Jia;Liu, Li-Gao;Li, Xiao;Zhu, Xin-Qi;Lu, Xin;Zhou, Jin-Mei;Ye, Long-Wu. And the article was included in Angewandte Chemie, International Edition in 2022.SDS of cas: 2216-51-5 This article mentions the following:

Medium-sized N,S-heterocycles have received tremendous interest due to their biol. activities and potential medical applications. However, asym. synthesis of these compounds are extremely rare. Described herein is a catalyst-dependent [3,3]-sigmatropic rearrangement of sulfoxide-ynamides, enabling divergent and atom-economic synthesis of a series of valuable medium-sized N,S-heterocycles in moderate to good yields with broad substrate scope. Importantly, excellent enantioselectivities have been achieved via an unprecedented chirality-transfer. Moreover, theor. calculations are employed to elucidate the origins of the catalyst-dependent stereospecific [3,3]-rearrangement. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of phenanthrene on the essential oil composition and leaf metabolome in peppermint plants (Mentha piperita L.) was written by Li, Jian;Xu, Jie;Yang, Xinping;Ren, Lili;Wang, Yi;Ma, Di;Fan, Ping;Wang, Haifeng;Liu, Longxiang;Dong, Bin;Chen, Qingfeng;Wu, Tao. And the article was included in Industrial Crops and Products in 2022.HPLC of Formula: 2216-51-5 This article mentions the following:

Polycyclic aromatic hydrocarbons (PAHs) are an important type of persistent organic pollutant that endangers soil ecosystems and human health. Cultivating aromatic plants in PAH-contaminated soils is considered a safe and sustainable phytoremediation strategy to mitigate PAH soil pollution. However, the impact of PAHs on plant essential oils and the metabolic responses within aromatic plants remain unclear. In this study, we investigated the effects of the model PAH phenanthrene (Phe) on the chem. composition of essential oils in the ubiquitous aromatic plant peppermint (Mentha piperita L.) using gas chromatog.-mass spectrometry (GC-MS). A total of 56 essential oil components were identified in the plants, among which the ratios of 21 components were significantly altered by Phe exposure. However, the fundamental components of peppermint essential oils including menthol, menthone, menthofuran, and pulegone did not exhibit considerable changes in levels. Thus, Phe stress may have little effect on the primary characteristics of peppermint essential oils. We also evaluated the effects of Phe treatment on metabolome dynamics within peppermint leaves by detecting metabolites in leaves treated with Phe for 0, 1, 3, 5, and 7 days (d) using non-targeted metabolomics. Compared with their corresponding control groups, 26 key different metabolites in the Phe-treated groups were identified and annotated via enrichment anal. with the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Enriched metabolites were primarily involved in the oxidation of unsaturated fatty acids (UFAs), phenylpropanoid metabolism, amino acids, and the formation of vitamin C and caffeine. Phe treatment significantly promoted the oxidation of UFAs, phenylpropanoid metabolism, and histidine production in the first three days of Phe treatment. After 3 d, Phe gradually suppressed the oxidation of UFAs and -glutamic acid production, while promoting phenylpropanoid metabolism, in addition to the synthesis of vitamin C and caffeine. The dynamic changes in metabolic pathway functioning in Phe-treated peppermint leaves reveal adaptive defensive mechanisms to mitigate Phe stress. This study provides new insights into the responses of aromatic plants toward PAH stress, while also providing a reference for the application of aromatic plants in the phytoremediation of PAH-contaminated soils. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5HPLC of Formula: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

L-menthol-based eutectic solvents: Characterization and application in the removal of drugs from water was written by Bergua, Fernando;Castro, Miguel;Munoz-Embid, Jose;Lafuente, Carlos;Artal, Manuela. And the article was included in Journal of Molecular Liquids in 2022.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Increasing the sustainability of industrial processes implies the substitution of conventional solvents for others with less environmental impact. For its implementation, it is essential to know the value of the thermodn. and transport properties. In addition, having theories and correlations to predict their behavior under varied conditions is very interesting. In this work, we performed the thermophys. characterization of eutectic mixtures formed by L-menthol and medium chain fatty acids, deepening the study of the polymorphic behavior of L-menthol. In addition, we studied their ability both to dissolve drugs that are poorly soluble in water and to extract them from contaminated water. From the results, we can deduce that these mixtures may be suitable solvents in liquid-liquid extractions, although multistage processes can be necessary. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts