Category: 18621-18-6

In 1992,Nagao, Yoshimitsu; Abe, Takao; Shimizu, Hisashi; Kumagai, Toshio; Inoue, Yoshinori published 《Asymmetric synthesis of new non-natural 1β-methylcarbapenems bearing methylthio group at the C6 positionã€?Heterocycles published the findings.Recommanded Product: 18621-18-6 The information in the text is summarized as follows:

The asym. total synthesis of 1β-methylcarbapenems I (n = 1, 2) has been accomplished starting from optically active 4-substituted azetidin-2-one II and using the thiols III. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2002,Hayashi, Kazuhiko; Hiki, Shinsuke; Kumagai, Toshio; Nagao, Yoshimitsu published 《Synthesis of azetidine derivatives using 1-azabicyclo[1.1.0]butaneã€?Heterocycles published the findings.Quality Control of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

A THF solution of 1-azabicyclo[1.1.0]butane (2), obtained from 2,3-dibromopropylamine hydrobromide, was treated with HCl-EtOH, 48% HBr, ClCO2Et, Ts2O, HCO2H-2.7N HCl-MeOH, or Ac2O-3N HCl to give the corresponding 3-monosubstituted and 1,3-disubstituted azetidine derivatives (e.g. 77% 1-Carboethoxy-3-chloroazetidine). Similar treatment of 2 with AcSH afforded 1-acetyl-3-acetylthioazetidine, which was converted to 1-(1,3-thiazolidin-2-yl)azetidine-3-thiol hydrochloride. 2 And various bromides were heated to furnish 3-bromoazetidine derivatives (e.g. 45% 3-bromo-1-cyanomethylazetidine) and/or N,N-disubstituted 2,3-dibromopropylamines (e.g. 42% 2,3-dibromo-1-(N,N-dibenzylamino)propane). The reaction of 2 with benzoyl peroxide or N-bromosuccinimide gave each corresponding 1,3-disubstituted azetidine derivative (11% 1-benzoyl-3-benzoylperoxyazetidine or 3% 3-Bromo-1-(tetrahydrofuran-2-yl)azetidine). In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6Quality Control of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Quality Control of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2016,Barday, Manuel; Ho, Kelvin Y. T.; Halsall, Christopher T.; Aissa, Christophe published 《Regioselective Synthesis of 3-Hydroxy-4,5-alkyl-Substituted Pyridines Using 1,3-Enynes as Alkynes Surrogatesã€?Organic Letters published the findings.Related Products of 18621-18-6 The information in the text is summarized as follows:

The poor regioselectivity of the [4 + 2] cycloaddition of 3-azetidinones with internal alkynes bearing two alkyl substituents via nickel-catalyzed carbon-carbon activation is addressed using 1,3-enynes as substrates. The judicious choice of substitution on the enyne enables complementary access to each regioisomer of 3-hydroxy-4,5-alkyl-substituted pyridines, which are important building blocks in medicinal chem. endeavors. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Antitubercular Triazines: Optimization and Intrabacterial Metabolism》 was written by Wang, Xin; Inoyama, Daigo; Russo, Riccardo; Li, Shao-Gang; Jadhav, Ravindra; Stratton, Thomas P.; Mittal, Nisha; Bilotta, Joseph A.; Singleton, Eric; Kim, Thomas; Paget, Steve D.; Pottorf, Richard S.; Ahn, Yong-Mo; Davila-Pagan, Alejandro; Kandasamy, Srinivasan; Grady, Courtney; Hussain, Seema; Soteropoulos, Patricia; Zimmerman, Matthew D.; Ho, Hsin Pin; Park, Steven; Dartois, Veronique; Ekins, Sean; Connell, Nancy; Kumar, Pradeep; Freundlich, Joel S.. Synthetic Route of C3H8ClNOThis research focused ontriazine antitubercular agent intrabacterial drug metabolism pharmacokinetics; Bayesian models; Mycobacterium tuberculosis; intrabacterial drug metabolism; nitrofuran; triazine. The article conveys some information:

The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clin. relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F420H2 and one or more nitroreductases in addition to Ddn. An intrabacterial drug metabolism (IBDM) platform was leveraged to demonstrate the system kinetics, evidencing formation of NO. and a des-nitro metabolite. Structure-activity relationship studies focused on improving the solubility and mouse pharmacokinetic profile of JSF-2019 and culminated in JSF-2513, relying on the key introduction of a morpholine. Mechanistic studies with JSF-2019, JSF-2513, and other triazines stressed the significance of achieving potent in vitro efficacy via release of intrabacterial NO. along with inhibition of InhA and, more generally, the FAS-II pathway. This study highlights the importance of probing IBDM and its potential to clarify mechanism of action, which in this case is a combination of NO. release and InhA inhibition. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Synthetic Route of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Synthetic Route of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2016,Siebeneicher, Holger; Cleve, Arwed; Rehwinkel, Hartmut; Neuhaus, Roland; Heisler, Iring; Mueller, Thomas; Bauser, Marcus; Buchmann, Bernd published 《Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876》.ChemMedChem published the findings.Safety of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

Despite the long-known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only few endeavors have been undertaken to find a GLUT1-selective small-mol. inhibitor. Because other transporters of the GLUT1 family are involved in crucial processes, these transporters should not be addressed by such an inhibitor. A high-throughput screen against a library of ∼3 million compounds was performed to find a small mol. with this challenging potency and selectivity profile. The N-(1H-pyrazol-4-yl)quinoline-4-carboxamides were identified as an excellent starting point for further compound optimization. After extensive structure-activity relationship explorations, single-digit nanomolar inhibitors with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4 were obtained. The most promising compound, BAY-876 [N4-[1-(4-cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide], showed good metabolic stability in vitro and high oral bioavailability in vivo. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Safety of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Safety of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2015,Hodgson, David M.; Mortimer, Claire L.; McKenna, Jeffrey M. published 《Amine Protection/α-Activation with the tert-Butoxythiocarbonyl Group: Application to Azetidine Lithiation-Electrophilic Substitution》.Organic Letters published the findings.HPLC of Formula: 18621-18-6 The information in the text is summarized as follows:

Tert-Butoxythiocarbonyl (Botc), the long-neglected thiocarbonyl analog of Boc, facilitates (unlike its alkoxycarbonyl cousin) α-lithiation and electrophile incorporation on N-Botc-azetidine e. g.,. I. N,N,N’,N’-endo,endo-Tetramethyl-2,5-diaminonorbornane proved optimal as a chiral ligand, generating adducts with er up to 92:8. Facile deprotection, under conditions that left the corresponding N-Boc systems intact, was achieved using either TFA or via thermolysis in ethanol.Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Tetrahedron Letters included an article by Qiu, Zhenjiang; Zhu, Mingxiang; Zheng, Lu; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng. HPLC of Formula: 18621-18-6. The article was titled 《Regioselective α-benzylation of 3-iodoazetidines via Suzuki cross-coupling》. The information in the text is summarized as follows:

An efficient protocol for the synthesis of α-benzyl azetidines I [R = 4-F3COC6H4, 2-F-C6H4, naphthalen-2-yl, etc.; R1 = C(O)OCH2C6H5, C(O)OC(CH3)3] starting from benzylboronic acid pinacol ester derivatives II and 3-iodoazetidine III was developed. A wide range of α-benzyl azetidine derivatives I was obtained in moderate to good yields with high regioselectivity (>99%). In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Vicinal difunctionalization of carbon-carbon double bond for the platform synthesis of trifluoroalkyl amines》 was written by Beke, Ferenc; Meszaros, Adam; Toth, Agnes; Botlik, Bence Bela; Novak, Zoltan. Application In Synthesis of Azetidin-3-ol hydrochlorideThis research focused ontrifluoroalkyl amine preparation regioselective; amine trifluoroalkenyl iodonium salt three component diamination. The article conveys some information:

Herein, the controllable double nucleophilic functionalization of an activated alkene synthon I, originated from a trifluoropropenyliodonium salt with two distinct nucleophiles, enables the selective synthesis of trifluoromethylated ethylene amines and diamines RCH(CF3)CH2R1 (R = methyl(naphthalen-1-ylmethyl)aminyl, methyl(prop-2-yn-1-yl)aminyl, 3-azabicyclo[3.2.2]nonan-3-yl, etc.; R1 = {1-[(tert-butoxy)carbonyl]azetidin-3-yl}(2-phenylethyl)aminyl, 2-sulfanylidene-1,2-dihydropyridin-1-yl, etc.) on broad scale with high efficiency under mild reaction conditions. Considering the chem. nature of the reactants, this synthetic approach brings forth an efficient methodol. and provides versatile access to highly fluorinated amines. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Application In Synthesis of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Nature Chemistry included an article by Ruffoni, Alessandro; Julia, Fabio; Svejstrup, Thomas D.; McMillan, Alastair J.; Douglas, James J.; Leonori, Daniele. Electric Literature of C3H8ClNO. The article was titled 《Practical and regioselective amination of arenes using alkyl amines》. The information in the text is summarized as follows:

The formation of carbon-nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chems. to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chem. syntheses in academia and industry. In general, these mols. are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C-H bond (i.e., a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochems., peptides, chiral catalysts, polymers and organometallic complexes. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Electric Literature of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Electric Literature of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 18621-18-6In 2018 ,《Fine-tuned organic photoredox catalysts for fragmentation-alkynylation cascades of cyclic oxime ethers》 was published in Chemical Science. The article was written by Le Vaillant, Franck; Garreau, Marion; Nicolai, Stefano; Gryn’ova, Ganna; Corminboeuf, Clemence; Waser, Jerome. The article contains the following contents:

Fine-tuned organic photoredox catalysts were introduced for the metal-free alkynylation of alkylnitrile radicals generated via oxidative ring opening of cyclic alkylketone oxime ethers. The redox properties of the dyes were determined by both cyclic voltammetry and computation and covered an existing gap in the oxidation potential of photoredox organocatalysts. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts