Category: 1195-59-1

In 2019,Organic Letters included an article by Khan, Sardaraz; Li, Hongfang; Zhao, Can; Wu, Xue; Zhang, Yong Jian. Recommanded Product: 2,6-Pyridinedimethanol. The article was titled 《Asymmetric Allylic Etherification of Vinylethylene Carbonates with Diols via Pd/B Cooperative Catalysis: A Route to Chiral Hemi-Crown Ethers》. The information in the text is summarized as follows:

Pd-catalyzed regio- and enantioselective allylic etherification of vinylethylene carbonates (VECs) with diols has been developed. By using cooperative catalysts of the chiral palladium complex and triethylborane in mild conditions, the process gave monoetherified and bisetherified polyglycol derivatives with tetrasubstituted stereocenters in high yields with complete regioselectivities and high levels of enantio- and diastereoselectivities. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 2,6-Pyridinedimethanol

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The author of 《Exceptionally slow magnetic relaxation in a mononuclear hexacoordinate Ni(II) complexã€?were Titis, Jan; Chrenkova, Veronika; Rajnak, Cyril; Moncol, Jan; Valigura, Dusan; Boca, Roman. And the article was published in Dalton Transactions in 2019. Name: 2,6-Pyridinedimethanol The author mentioned the following in the article:

A hexacoordinate mononuclear [Ni(pydm)2](dnbz)2 complex shows field-induced slow magnetic relaxation with two or three relaxation channels that are strongly supported by an external magnetic field. At BDC = 0.8 T and T = 1.9 K, the low-frequency (LF) relaxation time is as slow as τ(LF) = 1.3 s with the mole fraction of x(LF) = 0.47. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Name: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Name: 2,6-Pyridinedimethanol

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Wan, Xueting; Jiang, Jian; Tu, Yanyan; Xu, Siyuan; Li, Jing; Lu, Huanjun; Li, Zhikai; Xiong, Lianhu; Li, Xiaohong; Zhao, Youliang; Tu, Yingfeng published an article in 2021. The article was titled 《A cascade strategy towards the direct synthesis of green polyesters with versatile functional groupsã€? and you may find the article in Polymer Chemistry.HPLC of Formula: 1195-59-1 The information in the text is summarized as follows:

The synthesis of polyesters with the desired functional groups without addnl. protection and deprotection steps remains a worthwhile challenge to polymer chemists. Herein, we put forward a solution for the direct preparation of green copolyesters with versatile functionalities via the cascade polycondensation-coupling ring-opening polymerization (PROP) using a biobased cyclic diester ethylene brassylate as the monomer and functional diols/polyether diols as initiators. The combination of two polymerization processes into one system enables the facile synthesis of biodegradable polyesters with versatile functionalities, including alkane, alkene, alkyne, aromatic, halide, ether, and amide functional groups, and poly(ether ester) multiblock copolymers, together with high functional group contents (50% molar ratio to brassylate) and relatively high mol. weights (up to 6 x 104 Da). The cascade strategy provides a feasible method for the synthesis of high functional group content polyesters with tailor-made properties, highly effective for post-modifications that are suitable for a variety of applications. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1195-59-1

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In 2018,Boca, Roman; Rajnak, Cyril; Moncol, Jan; Titis, Jan; Valigura, Dusan published 《Breaking the Magic Border of One Second for Slow Magnetic Relaxation of Cobalt-Based Single Ion Magnetsã€?Inorganic Chemistry published the findings.Safety of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

Instead of assembling complex clusters and/or expensive lanthanide-based systems as single ion magnets, we are focusing on mononuclear cobalt(II) systems among which the complex under study, [Co(pydca)(dmpy)]2·H2O (1), shows a field supported slow magnetic relaxation on the order of seconds at low temperature (pydca = pyridine-2,6-dicarboxylato, dmpy = 2,6-dimethanolpyridine). The low-frequency relaxation time is as slow as τ(LF) = 1.35(6) s at T = 1.9 K and BDC = 0.4 T. The properties of 1 are compared to the previously reported nickel and copper analogs which were the first examples of single ion magnets in the family of Ni(II) and Cu(II) complexes. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Safety of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Pyridinedimethanol

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《225Ac-H4py4pa for Targeted Alpha Therapy》 was written by Li, Lily; Rousseau, Julie; Jaraquemada-Pelaez, Maria de Guadalupe; Wang, Xiaozhu; Robertson, Andrew; Radchenko, Valery; Schaffer, Paul; Lin, Kuo-Shyan; Benard, Francois; Orvig, Chris. Product Details of 1195-59-1 And the article was included in Bioconjugate Chemistry in 2021. The article conveys some information:

Herein, we present the syntheses and characterization of a new undecadendate chelator, H4py4pa, and its bifunctional analog H4py4pa-phenyl-NCS, conjugated to the monoclonal antibody, Trastuzumab, which targets the HER2+ cancer. H4py4pa possesses excellent affinity for 225Ac (α, t1/2 = 9.92 d) for targeted alpha therapy (TAT), where quant. radiolabeling yield was achieved at ambient temperature, pH = 7, in 30 min at 10-6 M chelator concentration, leading to a complex highly stable in mouse serum for at least 9 d. To investigate the chelation of H4py4pa with large metal ions, lanthanum (La3+), which is the largest nonradioactive metal of the lanthanide series, was adopted as a surrogate for 225Ac to enable a series of nonradioactive chem. studies. In line with the 1H NMR spectrum, the DFT (d. functional theory)-calculated structure of the [La(py4pa)]- anion possessed a high degree of symmetry, and the La3+ ion was secured by two distinct pairs of picolinate arms. Furthermore, the [La(py4pa)]- complex also demonstrated a superb thermodn. stability (log K[La(py4pa)]- ~20.33, pLa = 21.0) compared to those of DOTA (log K[La(DOTA)]- ~24.25, pLa = 19.2) or H2macropa (log K[La(macropa)]- = 14.99, pLa ~8.5). Moreover, the functional versatility offered by the bifunctional py4pa precursor permits facile incorporation of various linkers for bioconjugation through direct nucleophilic substitution. In this work, a short phenyl-NCS linker was incorporated to tether H4py4pa to Trastuzumab. Radiolabeling studies, in vitro serum stability, and animal studies were performed in parallel with the DOTA-benzyl-Trastuzumab. Both displayed excellent in vivo stability and tumor specificity. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Product Details of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 1195-59-1

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Synthetic Route of C7H9NO2In 2019 ,《Functionally Versatile and Highly Stable Chelator for 111In and 177Lu: Proof-of-Principle Prostate-Specific Membrane Antigen Targeting》 appeared in Bioconjugate Chemistry. The author of the article were Li, Lily; Jaraquemada-Pelaez, Maria de Guadalupe; Kuo, Hsiou-Ting; Merkens, Helen; Choudhary, Neha; Gitschtaler, Katrin; Jermilova, Una; Colpo, Nadine; Uribe-Munoz, Carlos; Radchenko, Valery; Schaffer, Paul; Lin, Kuo-Shyan; Benard, Francois; Orvig, Chris. The article conveys some information:

Here, we present the synthesis and characterization of a new potentially nonadentate chelator, H4pypa and its bifunctional analog tBu4pypa-C7-NHS conjugated to PSMA (prostate-specific membrane antigen) – targeting peptidomimetic (Glu-urea-Lys). H4pypa is very functionally versatile and biol. stable. Compared to the conventional chelators (e.g. DOTA, DTPA), H4pypa has outstanding affinities for both 111In (EC, t1/2 ∼2.8 d) and 177Lu (β-,γ t1/2∼6.64 d). Its radiolabeled complexes were achieved at >98% radiochem. yield, RT within 10 min, at ligand concentration as low as 10-6 M, with excellent stability in human serum over at least 5-7 days (<1% transchelation). The thermodn. stabilities of the [M(pypa)]- complexes (M3+ = In3+, Lu3+, La3+) were dependent on the ionic radii, where the smaller In3+ has the highest pM value (30.5), followed by Lu3+ (22.6) and La3+ (19.9). All pM values are remarkably higher than those with DOTA, DTPA, H4octapa, H4octox and H4neunpa. Moreover, the facile and versatile bifunctionalization enabled by the p-OH group in the central pyridyl bridge of the pypa scaffold (compound 14) allows incorporation of a variety of linkers for bioconjugation through easy nucleophilic substitution. In this work, an alkyl linker was selected to couple H4pypa to a PSMA-targeting pharmacophore, proving that the bioconjugation sacrifices neither the tumor-targeting nor the chelation properties. The biodistribution profiles of 111In- and 177Lu-labeled tracers are different, but promising, with the 177Lu analog particularly outstanding. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Synthetic Route of C7H9NO2) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Synthetic Route of C7H9NO2

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Related Products of 1195-59-1In 2021 ,《Structural and Thermodynamics Studies on Polyaminophosphonate Ligands for Uranyl Decorporation》 appeared in Inorganic Chemistry. The author of the article were Ye, Gaoyang; Roques, Jerome; Solari, Pier-Lorenzo; Den Auwer, Christophe; Jeanson, Aurelie; Brandel, Jeremy; Charbonniere, Loic J.; Wu, Wangsuo; Simoni, Eric. The article conveys some information:

The development of actinide decorporation agents with high complexation affinity, high tissue specificity, and low biol. toxicity is of vital importance for the sustained and healthy development of nuclear energy. After accidental actinide intake, sequestration by chelation therapy to reduce acute damage is considered as the most effective method. Bis- and tetra-phosphonated pyridine ligands were designed, synthesized, and characterized for uranyl (UO22+) decorporation. Owing to the absorption of the ligand and the luminescence of the uranyl ion, UV-visible spectroscopy and time-resolved laser-induced fluorescence spectroscopy (TRLFS) were used to probe in situ complexation and structure variation of the complexes formed by the ligands with uranyl. D. functional theory (DFT) calculations and x-ray absorption fine structure (XAFS) spectroscopy on uranyl-ligand complexes revealed the coordination geometry around the uranyl center at pH 3 and 7.4. High affinity constants (log K ~17) toward the uranyl ion were determined by displacement titration A preliminary in vitro chelation study proves that bis-phosphonated pyridine ligands can remove uranium from calmodulin (CaM) at a low dose and in the short term, which supports further uranyl decorporation applications of these ligands.2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 1195-59-1

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In 2018,Soheili, Majid; Mohamadnia, Zahra; Karimi, Babak published 《Switching from Ethylene Trimerization to Ethylene Polymerization by Chromium Catalysts Bearing SNS Tridentate Ligands: Process Optimization Using Response Surface Methodology》.Catalysis Letters published the findings.HPLC of Formula: 1195-59-1 The information in the text is summarized as follows:

Two types of chromium catalysts bearing pyridine and amine based SNS ligands under the title of (pyridine-SNS-alkyl/CrCl3) and (amine-SNS-alkyl/CrCl3) were synthesized. Different thiolates such as octyl, pentyl, Bu, cyclohexyl and cyclopentyl thiolates were reacted with 2,6-pyridine-dimethylene-ditosylate (PMT)/THF solution at room temperature Then, the purified pyridine-based SNS ligands (1-5) were reacted with CrCl3 (THF)3 to obtain the pyridine-SNS-alkyl/CrCl3 catalysts (6-10) in 50-70% yields. MMAO-activated pyridine-SNS-alkyl/CrCl3 catalysts were capable of oligomerizing ethylene. Statistical exptl. design was conducted using the central composite design method and surface methodol. to study of the effect of important parameters such as ethylene pressure, Al/Cr ratio, catalyst concentration and the reaction temperature on 1-C6 productivity of catalyst (7). A quadratic polynomial equation was developed to predict the 1-C6 productivity. Ethylene oligomerization using the catalyst (7) was lead to a optimized reaction conditions, including the ethylene pressure of 19.5 bar, the temperature of 58.2 °C, the MMAO co-catalyst, Al/Cr = 841 and the catalyst concentration of 8.7 μmol. The catalytic properties for ethylene oligomerization are strongly affected by reaction temperature The exptl. results indicated the reasonable agreement with the predicted values. The transformation from ethylene trimerization to ethylene polymerization of catalyst system (7) was occurred by exchanging the reaction pressure. Influence of ligand structure with different substitutions on sulfur atom on productivity and selectivity was investigated. 1-C6 with the high selectivity and productivity 4318 (g 1-C6/g Cr h) was obtained for catalyst (7). In the second part, 1-C6 was obtained with high selectivity and productivity around 141 × 103 (g 1-C6/g Cr h) for amine-based catalyst. All amine-based catalysts (14-16) showed considerably higher catalytic activities compared to pyridine-based catalysts. According to the TGA anal. the thermal stability of pyridine-based catalysts was found to be higher than the amine-based catalysts. Graphical Abstract: Chromium complexes bearing pyridine and amine based SNS ligands have been synthesized and their catalytic performance in ethylene oligomerization has been investigated. A switching from ethylene trimerization to ethylene polymerization of the catalyst (7) was obtained utilizing exchanging of the ethylene pressure. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1195-59-1

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In 2019,New Journal of Chemistry included an article by Anamika; Agrahari, Anand K.; Manar, Krishna K.; Yadav, Chote Lal; Tiwari, Vinod K.; Drew, Michael G. B.; Singh, Nanhai. Electric Literature of C7H9NO2. The article was titled 《Highly efficient structurally characterized novel precatalysts: di- and mononuclear heteroleptic Cu(I) dixanthate/xanthate-phosphine complexes for azide-alkyne cycloadditions》. The information in the text is summarized as follows:

Novel heteroleptic dinuclear [Cu2(L)(PPh3)4] (L = 2,6-pyridinedimethyldixanthate L1 1, 1,4-benznedimethyldixanthate L2 2, 1,4-cyclohexanedixanthate L3 3) and mononuclear [Cu(L4)(PPh3)2] 4, (L4 = piperonylxanthate) and [Cu(L5)(dppf)] (5) (L5 = methylxanthate, dppf = 1,1′-bis(diphenylphosphino)ferrocene) complexes were synthesized and characterized by elemental (C, H, and N) anal., high resolution mass spectrometry, and IR, UV-visible, 1H, 13C{1H} and 31P{1H} NMR spectroscopy. Single crystal x-ray diffraction revealed S,S-bidentate coordination of the dixanthate group in dinuclear 1-3 while 4 and 5 are mononuclear. 1-5 Adopt tetrahedral coordination geometry about the Cu atom. These precatalysts having two and one Cu(I) centers in a single mol. were applied in Cu catalyzed azide-alkyne cycloaddition (CuAAC) reactions for the synthesis of a variety of glycoconjugate triazoles using the Click approach. Particularly, the dinuclear catalyst 1, formed on the pyridyl linker based dixanthate ligand, displayed outstanding and reusable catalytic activity for this reaction. Full optimization of the reaction conditions demonstrated a Click catalytic system with low catalyst loading under mild reaction conditions.2,6-Pyridinedimethanol(cas: 1195-59-1Electric Literature of C7H9NO2) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C7H9NO2

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Hosseinmardi, Soosan; Scheurer, Andreas; Heinemann, Frank W.; Kuepper, Karsten; Senft, Laura; Waldschmidt, Pablo; Ivanovic-Burmazovic, Ivana; Meyer, Karsten published an article in 2021. The article was titled 《Evaluation of Manganese Cubanoid Clusters for Water Oxidation Catalysis: From Well-Defined Molecular Coordination Complexes to Catalytically Active Amorphous Films》, and you may find the article in ChemSusChem.Application In Synthesis of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

With a view to developing multimetallic mol. catalysts that mimic the oxygen-evolving catalyst (OEC) in Nature′s photosystem II, the synthesis of various dicubanoid manganese clusters is described and their catalytic activity investigated for water oxidation in basic, aqueous solution Pyridinemethanol-based ligands are known to support polynuclear and cubanoid structures in manganese coordination chem. The chelators 2,6-pyridinedimethanol (H2L1) and 6-methyl-2-pyridinemethanol (HL2) were chosen to yield polynuclear manganese complexes; namely, the tetranuclear defective dicubanes [MnII2MnIII2(HL1)4(OAc)4(OMe)2] and [MnII2MnIII2(HL1)6(OAc)2] (OAc)2·2 H2O, as well as the octanuclear-dicubanoid [MnII6MnIII2(L2)4(O)2(OAc)10(HOMe/OH2)2]·3MeOH·MeCN. In freshly prepared solutions, polynuclear species were detected by electrospray ionization mass spectrometry, whereas X-band ESR studies in dilute, liquid solution suggested the presence of divalent mononuclear Mn species with g values of 2. However, the magnetochem. investigation of the complexes solutions by the Evans technique confirmed a haphazard combination of manganese coordination complexes, from mononuclear to polynuclear species. Subsequently, the newly synthesized and characterized manganese mol. complexes were employed as precursors to prepare electrode-deposited films in a buffer-free solution to evaluate and compare their stability and catalytic activity for water oxidation electrocatalysis. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 2,6-Pyridinedimethanol

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