Category: 1122-71-0

2-Hydroxymethylpyridines: 2-(hydroxymethyl)pyridine, 2-methyl-6-(hydroxymethyl)pyridine, and 2,6-bis(hydroxymethyl)pyridine) was written by Chumakov, Yu. I.;Stolyarov, Z. E.. And the article was included in Metody Polucheniya Khimicheskikh Reaktivov i Preparatov in 1963.HPLC of Formula: 1122-71-0 This article mentions the following:

2-(α-Acetoxymethyl)pyridines hydrolyzed with 10% NaOH at 100° 6 hrs. produced the corresponding title compounds (I), (II), and (III), resp. The reaction mixture was extracted with CH₂Cl₂ or CHCl₃ and the solvent removed by distillation The residue distilled in vacuo yielded 67-9% I, b₁₅ 108-9°, n²⁰_D 1.5430; picrate m. 157.5-58°. In the similar manner II gave 60% yield, b₅ 80-1°, n²⁰_D 1.5390. III, m. 114-14.5°, was obtained in 60% yield by recrystallization from C₆H₆. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0HPLC of Formula: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 1122-71-0

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Alcohol – Wikipedia,
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Synthesis, physical properties and application of a series of new polyoxometalate-based ionic liquids was written by Martinetto, Yohan;Basset, Salome;Pegot, Bruce;Roch-Marchal, Catherine;Camerel, Franck;Jeftic, Jelena;Cottyn-Boitte, Betty;Magnier, Emmanuel;Floquet, Sebastien. And the article was included in Molecules in 2021.Product Details of 1122-71-0 This article mentions the following:

This paper deals with the preparation and the characterization of four new ionic liquids resulting from the pairing of various polyoxotungstates or polyoxomolybdates with the cation trihexyltetradecylphosphonium. The phys. properties measured by different techniques evidence that the viscosity and the rheol. behaviors of such POM-based ionic liquids, POM-ILs, strongly depend on the nature of the POM, especially its charge. Playing on the nature of the POM, we can indeed obtain Newtonian liquids or some much more viscous materials exhibiting characteristics of resins or pseudo-plastics. In a second part of this study, the potentialities of using such materials both as solvent and catalyst for the oxidation of a series of alcs. are presented as proof of concept. This part highlights great differences in strength and selectivity as a function of the POM-IL used. Furthermore, a very simple way to recycle the catalyst is also presented. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Product Details of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 1122-71-0

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium-Catalyzed N-Alkylation for the Synthesis of 2-N-Pyridylmethyl Benzonitriles and an Exploration of Its Synthetic Utility was written by Chen, Mengmeng;Zhang, Min;Xie, Feng;Wang, Xiaoting;Jiang, Huanfeng. And the article was included in ChemCatChem in 2014.Reference of 1122-71-0 This article mentions the following:

The N-alkylation of 2-aminobenzonitriles with pyridyl methanols as the alkylating reagents has been demonstrated by using an easily available Ru₃(CO)₁₂/Binap/tBuOK [Binap=2,2′-bis(diphenylphosphino)-1,1′-binaphthyl] catalyst system. The synthetic protocol can be used to synthesize various 2-N-pyridylmethyl benzonitriles I (R¹ = H, 6-Me, 4-Cl; R² = H, 4-Me, 4,5-(OMe)₂, etc.) in moderate to good isolated yields. Through an exploration of its synthetic utility, a novel straightforward synthesis of biol. interesting 2,3-diaryl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ones is demonstrated, which provides an important basis for the discovery of new bioactive compounds In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Reference of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 1122-71-0

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Alcohol – Wikipedia,
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Total synthesis of (±)-monomorine was written by Le, Tri Q.;Oliver, Robert M. III;Arcari, Joel T.;Mitton-Fry, Mark J.. And the article was included in Tetrahedron Letters in 2012.HPLC of Formula: 1122-71-0 This article mentions the following:

An efficient, two-operation synthesis of the trail ant pheromone (±)-monomorine (I) is reported. The synthesis features an aqueous Claisen-Schmidt condensation followed by the stereocontrolled installation of the three resident stereocenters in a single operation. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0HPLC of Formula: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 1122-71-0

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Alcohol – Wikipedia,
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1-(Heteryloxy)silatranes was written by Iovel, I.;Golomba, L.;Popelis, J.;Grinberga, S.;Lukevics, E.. And the article was included in Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2000.Safety of 6-Methyl-2-pyridinemethanol This article mentions the following:

Novel heterocyclic 1-derivatives I of silatranes were obtained [R = Et, PhCH₂, 2-tetrahydrofurfuryl, 3-pyridinyl, and (6-methyl-2-pyridyl)methyl -]. The optimal synthetic method for these compounds is transesterification of tetraethoxysilane by an equimolar mixture of triethanolamine and a heterocyclic (or aromatic) hydroxyl-containing compound E.g., heating 0.01 mol each PhCH₂OH, N(CH₂CH₂OH)₃ and Si(OEt)₄ in 14 mL xylene containing 0.2 g KOH at (120-130°) gave 1-benzyloxysilatrane I (R = PhCH₂) in 75% yield. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Safety of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 6-Methyl-2-pyridinemethanol

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Alcohol – Wikipedia,
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Ketene and its derivatives. II. Reaction of methylpyridine 1-oxide and methylquinoline 1-oxide with ketene was written by Kato, Tetsuzo;Goto, Yoshinobu;Yamamoto, Yutaka. And the article was included in Yakugaku Zasshi in 1962.SDS of cas: 1122-71-0 This article mentions the following:

Reaction of CH₂:CO (produced from decomposition of Me₂CO by a ketene generator) and 4-picoline 1-oxide and fractionation of the product gave 5% 4-pyridinemethanol, b₁₅ 117-18°, 0.3% 4-methyl-3-pyridinol, m. 117-20°, and 4% 4-picoline. Similarly, 2,6-lutidine 1-oxide yielded 33% 6-methyl-2-pyridinemethanol (picrate m. 132-4°), 17% 3-hydroxy-2,6-lutidine, m. 205-7°, and 4% 2,6-lutidine; 4-nitro-2,6-lutidine 1-oxide yielded 8% 4-nitro-6-methyl-2-pyridinemethanol, m. 118-19°, 2% 4-hydroxy-6-methyl-2-pyridinemethanol (HCl salt m. 225-7°), and 3% 4-nitro-2,6-lutidine [picrate, m. 194° (decomposition)]; quinaldine 1-oxide yielded 16% 2-quinolinemethanol, b₄ 145-60° (picrate, m. 154-6°), and α,α’-bis(2-quinolinemethanol), m. 215° (decomposition); lepidine 1-oxide yielded 4% 3-hydroxylepidine (picrate m. 209-10°). 3-Picoline 1-oxide, 4-nitropyridine 1-oxide, and 4-nitro-2-picoline 1-oxide gave no reaction product with CH₂:CO. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 1122-71-0

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Presence of polarization bonds in some copper(II) complexes was written by Hall, D.;McKinnon, A. J.;Waters, J. M.;Waters, T. N.. And the article was included in Nature (London, United Kingdom) in 1964.SDS of cas: 1122-71-0 This article mentions the following:

The structures of bis(N-methyl-2-hydroxy-1-naphthaldiminato)copper(II) (I) and a second crystal modification of bis(salicylaldehydrato)copper(II) (II) were determined by space group requirements and 3-dimensional Fourier syntheses. The space group of I is P2₁/n with Z = 2, a 3.86, b 19.55, c 12.57, and β = 91.1°. II belongs to space group P2₁/c with Z = 2, a 11.75, b 4.00, c 12.42, and β = 90.3°. I and II are essentially sq. planar but the mols. pack so that there is an axial approach of 2.94 and 3.15 A., resp., to the hydroxy O of neighboring mols. and thus a deviation from overall mol. planarity. Within one mol. the 2 ligands are individually planar but mean planes through them are separated by 1.16 A. and 0.36 A. The distortions indicate that definite weak interactions exist; polarization bonding is suggested. The polarization bonds can involve different regions of the ligand, being to the O of the chelated ring in II and to a C of the benzene ring in the previously reported modification of II. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The reactions of pyridils and related compounds with alkali. II. The reactivities of several pyridils was written by Oda, Daihei. And the article was included in Nippon Kagaku Zasshi in 1961.Related Products of 1122-71-0 This article mentions the following:

Several diketones were prepared and their reactivities to alkali compared. 3-Pyridyl 3-picolyl ketone (10 g.) in 50 cc. dioxane oxidized with 8.4 g. SeO₂ 5 hrs. gave 6.6 g. 3,3′-pyridil (VII), m. 79-80°. 4-Pyridinecarboxaldehyde was treated with KCN to give 25% 4,4′-pyridoin, m. 165-7°, which was oxidized with HNO₃ to give 4,4′-pyridil (VIII), m. 179-70.5°. Similarly, 2-pyridinecarboxaldehyde N-oxide gave 2,2′-pyridoin N,N-dioxide, m. 152-3° (decomposition), which was oxidized to yield 2,2′-pyridil N,N’-dioxide (IX), decomposed at 240-5°. Oxidation of 2-pyridyl 3-picolyl ketone with SeO₂ yielded 2,3′-pyridil (X), m. 96-8°. 6,6′-Dimethyl-2,2′-pyridil (4.8 g.) treated with KOH as in the preceding part gave 2.8 g. 6-methylpicolinic acid, 0.08 g. 6-methyl-2-pyridylcarbinol, 0.4 g. 6,6′-dimethyl-2,2′-pyridoin, 0.15 g. NH₃, and 0.4 g. unidentified carbonyl compound VII gave di-βpyridylglycolic acid, which was oxidized to nicotinic acid (XI) and di-β-pyridyl ketone, m. 105-7°. VIII (2.1 g.) gave 0.95 g. isonicotinic acid, 0.06 g. γ-pyridylcarbinol, and 0.06 g. NH₃. X (2.1 g.) gave 0.8 g. XI, 0.05 g. NH₃, 0.03 g. III, and 0.27 g. IV. IX (4.9 g.) gave 3.2 g. di-α-pyridylcarbinol N-oxide, m. 148-9°, and 0.22 g. IV. The results indicated that low electron density on the 2- or 4-position was the cause of abnormal reaction. The idea was supported by the results on IX. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Related Products of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Helicates, boxes, and polymers from simple pyridine-alcohol ligands: the impact of the identity of the transition metal ion was written by Telfer, Shane G.;Parker, Nyree D.;Kuroda, Reiko;Harada, Takunori;Lefebvre, Julie;Leznoff, Daniel B.. And the article was included in Inorganic Chemistry in 2008.Category: alcohols-buliding-blocks This article mentions the following:

The coordination chem. of 6-methylpyridine-2-methanol (1) and enantiopure (R)-1-(6-methylpyridin-2-yl)ethanol (2) with a range of divalent 1st-row transition metal salts was studied in an effort to determine whether H-bonded helicates will form, as observed for Co(II) salts. H-bonded helicates, [Cu₂(1)₂(1-H)₂X₂] (X = Cl, Br), were only observed upon combining 1 with CuCl₂ and CuBr₂ in MeOH solution Other metal salts led to alternative products, viz. Cu(ClO₄)₂ in the presence of base gives [Cu₂(1)₂(1-H)₂](ClO₄)₂, ZnCl₂ and ZnBr₂ give the 1-dimensional helical coordination polymers [Zn(1-H)Cl]_∞ and [Zn(1-H)Br]_∞, a mixture of NiCl₂ and Ni(OAc)₂ produces the [Ni₄(1-H)₄Cl₂(OAc)₂(MeOH)₂] cubane, NiCl₂ leads to the [Ni₄(1-H)₄Cl₄(MeOH)₄] cubane, while MnCl₂ gives the known cubane [Mn₄(1-H)₆Cl₄]. The reaction of 2 with CuCl₂ produces the mononuclear complex Λ-[Cu(2)₂Cl]Cl, while reaction with CuBr₂ leads to a dimer, Λ,Λ-[Cu₂(2)₃(2-H)Br₂]Br, which is held together by a single H bond between the monomeric subunits. The solid-state CD spectra of these latter complexes were recorded and are very similar. The temperature-dependent magnetic behavior of [Cu₂(1)₂(1-H)₂X₂] (X = Cl, Br), [Cu₂(1)₂(1-H)₂](ClO₄)₂, [Cu₂(2)₃(2-H)Br₂]Br, and [Ni₄(1-H)₄Cl₂(OAc)₂(MeOH)₂] was studied. Weak antiferromagnetic coupling between the Cu(II) centers is mediated by the H bonds in the [Cu₂(1)₂(1-H)₂X₂] (X = Cl, Br) complexes. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Category: alcohols-buliding-blocks).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts