Category: 106-21-8

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis was written by Malwal, Satish R.;Chen, Lu;Hicks, Hunter;Qu, Fiona;Liu, Weidong;Shillo, Alli;Law, Wen Xuan;Zhang, Jianan;Chandnani, Neal;Han, Xu;Zheng, Yingying;Chen, Chun-Chi;Guo, Rey-Ting;Abdel Khalek, Ahmed;Seleem, Mohamed N.;Oldfield, Eric. And the article was included in Journal of Medicinal Chemistry in 2019.Application In Synthesis of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

We report that alkyl-substituted bisphosphonates have activity against Bacillus anthracis Sterne (0.40μg/mL), Mycobacterium smegmatis (1.4μg/mL), Bacillus subtilis (1.0μg/mL), and Staphylococcus aureus (13μg/mL). In many cases, there is no effect of serum binding, as well as low activity against a human embryonic kidney cell line. Targeting of isoprenoid biosynthesis is involved with 74 having IC₅₀ values of ∼100 nM against heptaprenyl diphosphate synthase and 200 nM against farnesyl diphosphate synthase. B. subtilis growth inhibition was rescued by addition of farnesyl diphosphate, menaquinone-4 (MK-4), or undecaprenyl phosphate (UP), and the combination of MK-4 and UP resulted in a 25× increase in ED₅₀, indicating targeting of both quinone and cell wall biosynthesis. Clostridioides difficile was inhibited by I, and since this organism does not synthesize quinones, cell wall biosynthesis is the likely target. We also solved 3 X-ray structures of inhibitors bound to octaprenyl diphosphate and(or) undecaprenyl diphosphate synthases. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Application In Synthesis of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Amine Organocatalysis of Remote, Chemoselective C(sp³)-H Hydroxylation was written by Hahn, Philip L.;Lowe, Jared M.;Xu, Yubo;Burns, Kevin L.;Hilinski, Michael K.. And the article was included in ACS Catalysis in 2022.Reference of 106-21-8 The following contents are mentioned in the article:

Authors introduce an organocatalytic approach for oxaziridinium-mediated C-H hydroxylation that employs secondary amines as catalysts. Authors also demonstrate the advantages of this operationally simple catalytic strategy for achieving high yielding and highly selective remote hydroxylation of compounds bearing oxidation-sensitive functional groups such as alcs., ethers, carbamates, and amides. By employing hexafluoroisopropanol as the solvent in the absence of water, a proposed hydrogen-bonding effect leads to, among other advantages, as high as ≥99:1 chemoselectivity for remote aliphatic hydroxylation of 2° alcs., an otherwise unsolved synthetic challenge normally complicated by substantial amounts of alc. oxidation Initial studies of the reaction mechanism indicate the formation of an oxaziridinium salt as the active oxidant and a C-H oxidation step that proceeds in a stereospecific manner via concerted insertion or hydrogen atom-transfer/radical rebound. Furthermore, preliminary results indicate that site selectivity can be affected by amine catalyst structure. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Reference of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 106-21-8

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Alcohol – Wikipedia,
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Non-classical temperature-dependent phase sequence: long-lived metastable piezoelectric helical columnar liquid crystalline polymorph was written by Nguyen, Manh Linh;Byun, Jaeduk;Shin, Tae Joo;Cho, Byoung-Ki. And the article was included in Journal of Materials Chemistry in 2021.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

The unusual polymorphic behavior of a liquid crystalline (LC) naphthalene derivative (1) based on 1,2,3-triazolyl linkages, is reported. Two individual polymorphs corresponding to metastable helical columnar (Col_hel) LC and thermodynamically stable monoclinic crystalline (Cry) phases can be obtained at room temperature by mild thermal treatments. According to the thermal, dynamic, and structural analyses of 1, the triazolyl H-bonded network along the columnar axis plays a key role in the formation of the polar helical columnar order and its longevity. As a consequence of the remarkable stability of the metastable Col_hel, a nonclassical phase sequence, i.e., Col_hel-liquid-cry-liquid upon heating, was observed, although it was also predicted theor. in monotropic LC polymorphism. Piezoelec. measurement of the poled Col_hel polymorph showed a noticeable increase in open-circuit voltage upon the application of force, which was >5 times greater than the measured voltage of the Cry polymorph. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Category: alcohols-buliding-blocks).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Visual detection of odorant geraniol enabled by integration of a human olfactory receptor into polydiacetylene/lipid nano-assembly was written by Kim, Taegon;Moon, Dongseok;Park, Jin Hyuk;Yang, Heehong;Cho, Seongyeon;Park, Tai Hyun;Ahn, Dong June. And the article was included in Nanoscale in 2019.Application In Synthesis of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

A new polydiacetylene lipid/human olfactory receptor nano-assembly was fabricated for the visual detection of an odorant for the first time. The assembly consisted of phospholipid-mixed polydiacetylenes (PDAs) and human olfactory receptors (hORs) in detergent micelles. To overcome the limitations of bioelectronic noses, hOR-embedded chromatic complexes (PDA/hORs) were developed, introducing PDAs that showed color and fluorescence transitions against various stimuli. The chromatic nanocomplexes reacted with target mols., showing a fluorescence intensity increase in a dose-dependent manner and target selectivity among various odorants. As a result, a color transition of the assembly from blue to purple occurred, allowing the visual detection of the odorant geraniol. Through CD (CD) spectroscopy and a tryptophan fluorescence quenching method, the structural and functional properties of the hORs embedded in the complexes were confirmed. Based on this first work, future array devices, integrating multiple nano-assemblies, can be substantiated and utilized in environmental assessment and anal. of food quality. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Application In Synthesis of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sulfamyl radicals direct photoredox-mediated Giese reactions at unactivated C(3)-H bonds was written by Kanegusuku, Anastasia L. G.;Castanheiro, Thomas;Ayer, Suraj K.;Roizen, Jennifer L.. And the article was included in Organic Letters in 2019.Name: 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

In the presence of the photoredox catalyst [Ir(dF(CF₃)ppy)₂(dtbbpy)]PF₆ and K₂CO₃ in MeCN under blue light irradiation and without oxygen, sulfamates such as I underwent chemoselective and regioselective Giese reactions with α,β-unsaturated carbonyl compounds via 1,6-H abstraction to yield functionalized esters such as II. The disclosed method relies on photoredox catalysts to drive the oxidation of alc.-anchored sulfamate esters to sulfamyl radicals; the sulfamyl radicals template otherwise rare 1,6-hydrogen-atom transfer (HAT) processes via seven-membered transition states to enable C(3)-H functionalization during Giese reactions. The transformation uses a catalytic oxidant rather than a stoichiometric oxidant or prefunctionalized reactant. Tertiary and secondary C(sp³) carbon atoms were alkylated with synthetically useful efficiencies. Reaction of a sulfamate with di-Et acetylenedicarboxylate followed by substitution with nucleophiles allowed the conversion of a product sulfamate into other readily manipulated derivatives This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Name: 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Microwave-Assisted Ultrafast RAFT Miniemulsion Polymerization of Biobased Terpenoid Acrylates was written by Castagnet, Thibault;Ballard, Nicholas;Billon, Laurent;Asua, Jose M.. And the article was included in Biomacromolecules in 2020.Formula: C10H22O The following contents are mentioned in the article:

There is a growing preference to move away from traditional petrochem.-based polymers toward biobased alternatives. Here, we report the microwave-assisted RAFT polymerization of several terpenoid acrylates (tetrahydrogeraniol, cyclademol, nopol, and citronellol). These biobased monomers give polymers with a broad range of glass transition temperatures and are excellent candidates to substitute oil-based (meth)acrylates in applications such as coatings and adhesives. First, the process was studied in miniemulsion, finding that all terpenoid acrylates showed a substantial increase in both polymerization rate and reaction control when microwave irradiation was applied. These observations were attributed to nonthermal microwave effects, namely, to changes in the kinetic coefficients under irradiation The reactions were also carried out in solution, where an amplified nonthermal microwave effect was observed The results indicate that nonthermal microwave effects allow RAFT polymerization of these terpenoid acrylates to proceed with both improved control and at higher polymerization rates compared to using conventional heating. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

High-throughput identification of volatile and semi-volatile organic compounds in archaeological samples by gas chromatography-mass spectrometry combined with advanced chemometrics methodology was written by Song, Jing-Jing;Wang, Xuan;Wang, Yang-Yang;Zhang, Yu-Ying;Yu, Yong-Jie. And the article was included in Microchemical Journal in 2020.HPLC of Formula: 106-21-8 The following contents are mentioned in the article:

Identification of compounds in food residues from archaeol. samples is important to determine their origin. However, high-throughput and accurate identification of compounds in archaeol. samples is challenging. In this work, we propose the use of gas chromatog.-mass spectrometry (GC-MS) combined with the recently developed chemometric tool autoGCMSDataAnal to identify compounds in archaeol. samples. Samples excavated from a tomb of the Xihan dynasty about 2000 BP were used to demonstrate the performance of our proposed methodol. Under the optimized GC-MS instrumental conditions, more than 300 total ion chromatogram peaks were automatically extracted for each sample. Coeluted components were automatically resolved and registered to construct resp. mass spectra, based on which compounds were accurately identified. Finally, more than 70 compounds were identified, among which more than 57% were confirmed by standards A comparison with the automated mass spectral deconvolution and identification system indicates that the combination of GC-MS with autoGCMSDataAnal is suitable for compound identification in archaeol. samples. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8HPLC of Formula: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogenation of Citral to Citronellal Catalyzed by Waste Fluid Catalytic Cracking Catalyst Supported Nickel was written by Huang, Yingying;Qiu, Shiming;Xu, Jianben;Lian, Huan. And the article was included in ACS Omega in 2021.Reference of 106-21-8 The following contents are mentioned in the article:

In this paper, a waste fluid catalytic cracking (FCC) catalyst is used as a carrier to prepare a supported non-noble metal nickel catalyst (Ni/wFCC), which is applied to the selective hydrogenation of citral to citronellal. X-ray powder diffraction, Fourier transform IR spectroscopy, and SEM were used to analyze the structural characteristics of the Ni-loaded sample. The catalyst after loading Ni still maintained a good zeolite structure, and the surface impurities were reduced. The effect of reaction conditions on the Ni/wFCC-catalyzed hydrogenation of citral to citronellal was investigated, and the optimal reaction conditions were obtained as follows: a Ni loading of 20 wt %, a catalyst amount of 5.6%, a hydrogenation temperature of 180°C, a hydrogenation time of 90 min, and a hydrogenation pressure of 3.0 MPa. Under these conditions, the conversion of citral and selectivity of citronellal were 98.5 and 86.6%, resp., indicating that the Ni/wFCC catalyst had strong catalytic activity and selectivity. This research provided new ideas for the recycling of waste FCC catalysts and industrial synthesis of citronellal. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Reference of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

High Pressure Vapor-Liquid Equilibrium Data for the Quaternary Carbon Dioxide + 1-Decanol + 3,7-Dimethyl-1-octanol + n-Dodecane System was written by Latsky, Carla;Schwarz, Cara E.. And the article was included in Journal of Chemical & Engineering Data in 2019.Application of 106-21-8 The following contents are mentioned in the article:

Vapor-liquid equilibrium (VLE) data were measured for the quaternary system containing CO₂, n-dodecane (nC₁₂), 1-decanol (C₁₀OH), and 3,7-dimethyl-1-octanol (37DM1O). The data were measured using a previously constructed static-analytic setup at temperatures between 308 and 348 K and pressures up to 19.2 MPa. The measured data indicated signs of a temperature inversion in the 1-decanol-rich mixtures The relative solubility anal. revealed that the components in the 1-decanol-rich mixtures could be separated with greater ease than the components in the n-dodecane-rich mixture The greater difficulty associated with separating components in the n-dodecane-rich mixture is likely linked to cosolvency effects which cause pinches in separation The data were modeled in Aspen Plus, using the RK-ASPEN model. The modeling results highlighted the need for fitted solute-solute interaction parameters. However, even with the inclusion of these parameters there still exists significant deviation between the exptl. and predicted data. The RK-ASPEN model can, therefore, only be used to approx. VLE data for the system. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Application of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Continuous flow synthesis of menthol via tandem cyclisation-hydrogenation of citronellal catalysed by scrap catalytic converters was written by Zuliani, Alessio;Cova, Camilla Maria;Manno, Roberta;Sebastian, Victor;Romero, Antonio A.;Luque, Rafael. And the article was included in Green Chemistry in 2020.Application In Synthesis of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

A continuous flow synthesis of menthol starting from citronellal catalyzed by scrap catalytic converters is reported. The reaction was conducted in a tandem system connecting in series two catalytic systems, with the first having Lewis acid properties (favoring the cyclization of citronellal to isopulegols) and the second having hydrogenation catalytic activity (catalyzing the hydrogenation of isopulegols to menthols). A Lewis acid catalyst was prepared by supporting iron oxide nanoparticles over a waste material, i.e. the ceramic core of scrap catalytic converters (SCATs) via a microwave assisted method. Most importantly, SCATs, containing a low residual noble metal content, could be directly employed in the second step as hydrogenation catalysts. The reaction was performed studying the influence on the yield and selectivity to (-)-menthol of various reaction parameters (T, p and flow rate). Under the best reaction conditions (at a flow rate of 0.1 mL min^-1 and at 373 K and 413 K for cyclization and hydrogenation steps resp.) a conversion of >99% of (+)-citronellal to (-)-menthol with 77% final yield was achieved. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Application In Synthesis of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts