Category: 100-55-0

《Bis(3-hydroxymethylpyridynium) hexafluorosilicate monohydrate as a new potential anticaries agent: Synthesis, crystal structure and pharmacological properties》 was written by Gelmboldt, Vladimir O.; Shyshkin, Ivan O.; Anisimov, Vladimir Yu.; Fonari, Marina S.; Kravtsov, Victor Ch.. Recommanded Product: 100-55-0 And the article was included in Journal of Fluorine Chemistry in 2020. The article conveys some information:

The hexafluorosilicate (LH)2SiF6·H2O (1, L = 3-hydroxymethylpyridine) was obtained by reaction of 45% hexafluorosilicic acid with a MeOH solution of L (H2SiF6:L = 3:1). The crystal structure 1 is stabilized by OH···O, NH···F, and OH···F H-bonds, and CH···F contacts. The symmetry of the SiF62- anion is close to D4h. The solubility of 1 in H2O was 1.63 mol % and the degree of hydrolysis of the salt in a 1 × 10-4 M aqueous solution was 91.6%. A PASS-anal. of the spectrum of biol. activity L highlighted a low probability of toxic effects. In addition to this study using 3-Pyridinemethanol, there are many other studies that have used 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Jud, Wolfgang; Salazar, Chase A.; Imbrogno, Joseph; Verghese, Jenson; Guinness, Steven M.; Desrosiers, Jean-Nicolas; Kappe, C. Oliver; Cantillo, David published an article in Organic Process Research & Development. The title of the article was 《Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow》.Recommanded Product: 3-Pyridinemethanol The author mentioned the following in the article:

An electrochem. method was developed for a mediated oxidation of primary alcs. to carboxylic acids. The method is compatible with a variety of alcs. bearing N-containing heterocycles in undivided batch and flow modes. The use of a heterogeneous NiOOH electron-proton transfer mediator avoids the need for homogeneous catalysts that contribute to more unit operations during downstream purging and increased process mass intensity. To demonstrate the applicability of this method for continuous processing, a single-pass flow electrochem. oxidation of nicotinyl alc. to nicotinic acid is demonstrated with a 77% isolated yield. The NiOOH-coated anodes show no reduction in catalysis efficiency over 12 h, and minimal Ni metal leaching (22.3μg per L) is observed The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 3-PyridinemethanolIn 2019 ,《Synthesis and antitumor activity of novel pyridinium fullerene derivatives》 appeared in International Journal of Nanomedicine. The author of the article were Yasuno, Takumi; Ohe, Tomoyuki; Ikeda, Hitomi; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko. The article conveys some information:

Nineteen pyridinium fullerene derivatives were newly designed and synthesized in this study. Their antiproliferative activities were evaluated using several cancer cell lines including drug-resistant cells. Furthermore, in-vivo antitumor activity of several derivatives was investigated in mouse xenograft model of human lung cancer. The derivatives inhibited the proliferation of cancer cell lines, including cisplatin resistant cells and doxorubicin-resistant cells. It was also shown that compounds I (10μM), II (10μM) and III (10μM) induced the intracellular oxidative stress. In addition, compound III (20 mg/kg) and cis-14 (15 mg/kg) significantly exhibited antitumor activity in mouse xenograft model of human lung cancer. These fullerene derivatives served as the lead compounds for a novel type of antitumor agents . The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Molecular capture using the precipitate of creaming-down by (-)-epigallocatechin-3-O-gallate》 were Tsutsumi, Hiroyuki; Sato, Ayano; Fujino, Satoru; Fujioka, Yusuke; Ishizu, Takashi. And the article was published in Chemical & Pharmaceutical Bulletin in 2019. Recommanded Product: 3-Pyridinemethanol The author mentioned the following in the article:

An aqueous solution of equimol. amounts of 2-chloropyrimidine and (-)-epigallocatechin 3-O-gallate (EGCg) afforded a colorless block crystal, which was determined to be a 2 : 2 complex of 2-chloropyrimidine and EGCg by X-ray crystallog. anal. The 2 : 2 complex was formed by the cooperative effect of three intermol. interactions, π-π and CH-π interactions, and intermol. hydrogen bonds. Upon formation of the 2 : 2 complex, a 2-chloropyrimidine mol. was captured by a hydrophobic space formed by the three aromatic rings of A, B, and B’ rings of two EGCg mols. The mol. capture abilities of various heterocyclic compounds using EGCg were evaluated by ratio of the heterocyclic compounds included in the precipitates of complex of EGCg to the heterocyclic compounds used. The amount of the heterocyclic compounds was measured by an integrated value of corresponding proton signals in the quant. 1H-NMR spectrum. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Elucidating the promotional effect of a covalent triazine framework in aerobic oxidation》 was published in Applied Catalysis, B: Environmental in 2020. These research results belong to Abednatanzi, Sara; Gohari Derakhshandeh, Parviz; Tack, Pieter; Muniz-Miranda, Francesco; Liu, Ying-Ya; Everaert, Jonas; Meledina, Maria; Vanden Bussche, Flore; Vincze, Laszlo; Stevens, Christian V.; Van Speybroeck, Veronique; Vrielinck, Henk; Callens, Freddy; Leus, Karen; Van Der Voort, Pascal. Application In Synthesis of 3-Pyridinemethanol The article mentions the following:

Synergistic catalysis holds great promise to enhance the catalytic performance of heterogeneous catalysts suffering from sluggish reaction kinetics. Much effort has been dedicated to the development of bimetallic systems in which the two promoter elements display synergistic benefits compared to monometallic counterparts. However, the use of bimetallic catalysts inescapably raises the cost of preparation and environmental issues. This study discovers a synergistic effect when using a bipyridine covalent triazine framework (bipy-CTF) as support for an IrIII complex in the aerobic oxidation reaction. The detailed mechanistic study provides insights into the function of the bipy-CTF in this synergistic catalysis. The EPR and in-situ XANES analyses confirm the applicability of bipy-CTF to activate oxygen and alc., resulting in an enhancement of the performance of the IrIII complex to exceed the activity of the homogeneous counterpart. This is an unprecedented report on promoting the activity of a heterogeneous catalyst through its solid support. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iron(0)-Catalyzed Transfer Hydrogenative Condensation of Nitroarenes with Alcohols: A Straightforward Approach to Benzoxazoles, Benzothiazoles, and Benzimidazoles》 was written by Putta, Ramachandra Reddy; Chun, Simin; Choi, Seung Hyun; Lee, Seok Beom; Oh, Dong-Chan; Hong, Suckchang. Recommanded Product: 100-55-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

The iron-catalyzed hydrogen transfer strategy has been applied to the redox condensation of o-hydroxynitrobenzene with alc., leading to the formation of benzoxazole derivatives A wide range of 2-substituted benzoxazoles were synthesized in good to excellent yields without the addition of an external redox agent. A series of control experiments provided a plausible mechanism. Furthermore, the reaction system was successfully extended to the synthesis of benzothiazoles and benzimidazoles. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Badhani, Gaurav; Joshi, Abhisek; Adimurthy, Subbarayappa published an article in 2021. The article was titled 《Ionic-Liquid-Catalyzed Synthesis of Imines, Benzimidazoles, Benzothiazoles, Quinoxalines and Quinolines through C-N, C-S, and C-C Bond Formation》, and you may find the article in European Journal of Organic Chemistry.Name: 3-Pyridinemethanol The information in the text is summarized as follows:

The tetra-Me ammonium hydroxide catalyzed oxidative coupling of amines RNH2 (R = Ph, cyclohexyl, pentyl, etc.) and alcs. R1CH2OH (R1 = Ph, 4-pyridyl, 2-naphthyl, etc.) for the synthesis of imines RN=CHR1 under metal-free conditions by utilizing oxygen from air as the terminal oxidant has been described. Under the same conditions, with ortho-phenylene diamines 1,2-(NH2)2C6H3R2 (R2 = 3-Me, 4,5-(Me)2, 4-F, etc.) and 2-aminobenzenethiols like 2-aminobenzenethiol and 2-amino-4-chlorobenzenethiol the corresponding benzimidazoles I (R3 = 6-Me, 5,6-Me2, 5-Cl, etc.; X = NH) and benzothiazoles I (R3 = H, 5-Cl; X = S) were obtained. Quinoxalines II (R4 = H, 6-Me, 6,7-Me2, 6-Cl, 6-F; Y = N) were obtained from ortho-phenylene diamines and 1-phenylethane-1,2-diol, and the conditions were then extended to the synthesis of quinoline building blocks II (R4 = 4-ClC6H4, 4-BrC6H4, 4-MeOC6H4, 2-naphthyl; Y = CH) by reaction of 2-amino benzyl alcs. like 2-aminobenzenemethanol either with 1-phenylethan-1-ol or acetophenone derivatives R4COMe. The formation of C-N, C-S and C-C bonds was achieved under metal-free conditions. A broad range of amines (aromatic, aliphatic, cyclic and heteroaromatic) as well as benzylic alcs. including heteroaryl alcs. reacted smoothly and provided the desired products. The mild reaction conditions, com. available catalyst, metal-free, good functional-group tolerance, broad range of products (imines, benzimidazoles, benzothiazoles, quinoxalines and quinolines) and applicability at gram scale reactions are the advantages of the present strategy. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 3-PyridinemethanolIn 2020 ,《Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols》 appeared in Asian Journal of Organic Chemistry. The author of the article were Chakraborty, Gargi; Sikari, Rina; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D.. The article conveys some information:

Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Safety of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C6H7NOIn 2020 ,《Quantitative perspective on online flow reaction profiling using a miniature mass spectrometer》 appeared in Organic Process Research & Development. The author of the article were Sheng, Huaming; Corcoran, Emily B.; Dance, Zachary E. X.; Smith, Joseph P.; Lin, Zhihao; Ordsmith, Victoria; Hamilton, Simon; Zhuang, Ping. The article conveys some information:

Online mass spectrometry has proven to be a useful tool for characterizing many aspects of chem. reactions. However, to the best of the authors’ knowledge, no reference standard (RS) quantitation approach has been applied in online MS profiling work to date. In this study, we present a RS approach for online quantitation of an aerobic oxidation reaction in flow using a miniature mass spectrometer, with both internal RS and external RS quantitation approaches being evaluated. Quinoline, a structurally similar and chem. inert compound under these reaction conditions, was chosen as the RS to quantify the pyridine aldehyde product. To investigate the optimal RS concentration and instrument attenuation, calibration curves were established by plotting the product/RS peak intensity ratio against the theor. product yield at different attenuation (dilution factor) values. The MS quantitation results for the actual flow reactions were validated with conventional offline 1H NMR anal. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0COA of Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Mittal, Rupali; Awasthi, Satish Kumar published an article in ACS Sustainable Chemistry & Engineering. The title of the article was 《Bimetallic Oxide Catalyst for the Dehydrogenative Oxidation Reaction of Alcohols: Practical Application in the Synthesis of Value-Added Chemicals》.Synthetic Route of C6H7NO The author mentioned the following in the article:

This work demonstrates the preparation of zinc cobalt oxide materials (ZCO-1, ZCO-2, and ZCO-3) via thermal annealing of novel zinc cobalt acetate hydroxide precursors prepared in three different Co/Zn molar ratios (2:1, 1:1, and 1:2). Among these, the ZCO-1 sample displayed superior catalytic activity for the dehydrogenative oxidation of alcs. to carboxylic acids, exhibiting wide substrate applicability and high yield output with concomitant evolution of hydrogen gas (latent fuel) under oxidant-free conditions. The high catalytic activity of ZCO-1 can be accredited to synergistic effects arising from a balanced molar ratio of Co/Zn (2:1), which led to the formation of pure spinel-structured zinc cobalt oxide and a sufficiently high surface area capable of furnishing copious active sites, resulting in faster reaction kinetics and higher productivity. Moreover, the practical utility of the current protocol was displayed via ZCO-1-catalyzed gram-scale synthesis of value-added chems. like nicotinic acid, terephthalic acid, and succinic acid. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0Synthetic Route of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts