Author: tianli

Torres, Maria J. published the artcileIntracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury, Product Details of C4H6O5, the main research area is ischemia reperfusion injury intracardiac ephrinA1 mitochondrial bioenergetics; Cardioprotection; Mitochondrial bioenergetics; Myocardial infarction; ephrinA1.

Herein, 10 wk-old B6129SF2/J male mice were exposed to acute ischemia/reperfusion injury immediately followed by intracardiac injection of either EphrinA1-Fc or IgG-Fc. After 24 h of reperfusion, sections of the infarct margin in the left ventricle were imaged via transmission electron microscopy, and mitochondrial function was assessed in both permeabilized fibers and isolated mitochondria, to examine mitochondrial structure, function, and energetics in the early stages of repair. At a structural level, EphrinA1-Fc administration prevented the I/R-induced loss of sarcomere alignment and mitochondrial organization along the Z disks, as well as disorganization of the cristae and loss of inter-mitochondrial junctions. Preservation of cardiac bioenergetics was not due to changes in mitochondrial JH2O2 emitting potential, membrane potential, ADP affinity, efficiency of ATP production, or activity of the main dehydrogenase enzymes, suggesting that EphrinA1-Fc indirectly maintains respiratory function via preservation of the mitochondrial network. Moreover, these protective effects were lost in isolated mitochondria, further emphasizing the importance of the intact cardiomyocyte ultrastructure in mitochondrial energetics. Collectively, these data suggest that intracardiac injection of EphrinA1-Fc protects cardiac function by preserving cardiomyocyte structure and mitochondrial bioenergetics, thus emerging as a potential therapeutic strategy in I/R injury.

Life Sciences published new progress about Apoptosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hou, Jingang published the artcileD-galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence, HPLC of Formula: 59-23-4, the main research area is glioblastoma astrocytoma astrocyte aging progression D galactose anticancer resistance.

In the present study, we aimed to investigate the involvement of astrocytes in D-galactose-induced brain aging in vitro. We found that D-galactose treatment significantly suppressed cell viability and induced cellular senescence. in addition, as of the accumulation of senescent cells, we proposed that the senescence-associated secretory phenotype (SaSP) can stimulate age-related pathologies and chemoresistance in brain. consistently, senescent astrocytic CRT cells induced by D-galactose exhibited increases in the levels of IL-6 and IL-8 via NF-kB activation, which are major SaSP components and inflammatory cytokines. conditioned medium prepared from senescent astrocytic CRT cells significantly promoted the viability of brain tumor cells (u373-MG and n2a). importantly, conditioned medium greatly suppressed the cytotoxicity of u373-MG cells induced by temozolomide, and reduced the protein expression levels of neuron marker neuron-specific class III beta-tubulin, but markedly increased the levels of c-Myc in N2a cells. Thus, our findings demonstrated that D-galactose treatment might mimic brain aging, and that D-galactose could contribute to brain inflammation and tumor progression through inducing the accumulation of senescent-secretory astrocytes.

Molecular Medicine Reports published new progress about Apoptosis. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Juan published the artcileApoptosis of human gastric carcinoma MGC-803 cells induced by a novel Astragalus membranaceus polysaccharide via intrinsic mitochondrial pathways, SDS of cas: 59-23-4, the main research area is Astragalus gastric carcinoma cell apoptosis polysaccharide intrinsic mitochondrial pathway; Cold-water soluble Astragalus membranaceus polysaccharide; Human gastric cancer; Mitochondrial apoptosis pathway.

In our previous study, a novel cold-water-soluble polysaccharide (APS4) was isolated from Astragalus membranaceus. This study aimed to evaluate the proliferation inhibition and apoptosis-induced effects of APS4 on human gastric carcinoma MGC-803 cells and to investigate its potential mol. mechanism. It was found that APS4 could significantly suppress the proliferation of MGC-803 cells in a concentration- and time-dependent manner. Morphol. observations and Annexin V-FITC/PI staining showed that APS4-treated MGC-803 cells exhibited typical morphol. characteristics of apoptosis. Cell cycle detection revealed that APS4 could arrest MGC-803 cells in S phase of the cell cycle. Addnl., APS4 treatment could induce the mitochondria-dependent apoptosis, which was closely related to the accumulation of intracellular ROS, the collapse of mitochondrial membrane potential, the increase of the pro-apoptotic/anti-apoptotic (Bax/Bcl-2) ratios, the release of cytochrome c, further activating the expression of caspase-9/-3 and the cleavage of poly-ADP-ribose polymerase (PARP) in MGC-803 cells. Taken together, our results suggested that APS4 had observable apoptosis-induced effects on MGC-803 cells via arresting the cell cycle in S phase and inducing the intrinsic mitochondrial apoptosis pathway.

International Journal of Biological Macromolecules published new progress about Apoptosis. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Chaozhi published the artcileThe characteristics of patulin detoxification by Lactobacillus plantarum 13M5, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is lactobacillus plantarum patulin characteristic detoxification; Degradation; Lactic acid bacteria; Lactobacillus plantarum; Patulin; Toxicity.

Patulin (PAT) is a widespread mycotoxin that harms the health of both humans and animals. In this study, among the 17 tested Lactobacillus plantarum strains, L. plantarum 13M5, isolated from traditional Chinese fermented foods, showed the highest PAT degradation rate of up to 43.8% (PAT 5 mg/L). Evaluation of the living and dead 13M5 cells revealed that only the living cells had the ability to remove PAT and degrade it into E-ascladiol. A cell-based assay revealed that L. plantarum 13M5 administration alleviated PAT-induced injuries in Caco-2 cells, including cytotoxicity, oxidative stress, and tight junction disruption. Our results suggest that L. plantarum 13M5 has the potential to reduce PAT toxicity and can thus be used as a probiotic supplement to reduce or eliminate the toxicity of PAT ingested from diet.

Food and Chemical Toxicology published new progress about Apoptosis. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khalil, Samah R. published the artcileRestoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: Targeting cell apoptosis-mediated pathways, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is Moringa leaf extract Tilmicosin heart injury apoptosis antioxidant; Apaf-1; Apoptosis; Bcl-2; Caspase-3; Moringa oleifera; Tilmicosin.

Tilmicosin (Til), an effective macrolide antibiotic, is widely used against respiratory diseases in livestock; however, its treatment is associated with cardiac tissue impairments. In this study, the ethanolic extract of Moringa oleifera (MO) leaves was investigated at two doses (400 and 800 mg/kg body weight [bw], orally) to determine its role in counteracting the effects of Til treatment (75 mg/kg bw) on the cardiac tissue in rats, exploring the oxidative stress-mediated damage and apoptosis. A high dose of MO ethanolic extract elicits considerable changes in the body weight, reduces the mortality rate, neutralizes the impaired cardiac injury markers, improves antioxidant endpoints (total antioxidant capacity, superoxide dismutase, catalase activity, and reduced glutathione level). Also it attenuates the oxidative stress indexes (total reactive oxygen species, 8-hydroxy-2-deoxyguanosine, lipid peroxides [malondialdehyde], and protein carbonyl levels) that are associated with Til injection. The co-administration of MO ethanolic extract with Til considerably modulates the expression of apoptosis pathway-encoding genes (Bcl-2, caspase-3, Bax, p53, apoptosis-inducing factor, and Apaf-1), particularly in the high-dose group. Our results support that the concurrent administration of MO ethanolic extract with Til at a dose of 800 mg/kg bw increases the protective activity of the antioxidant system and delays or slows the pathol. development of cardiotoxicity mediated by Til injection.

Gene published new progress about Apoptosis. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Nagender published the artcileNovel Chitosan-Gelatin microcapsules containing rosemary essential oil for the preparation of bioactive and protective linen, HPLC of Formula: 124-76-5, the main research area is chitosan gelatin linen fabric microcapsule rosemary essential oil.

Biomols. present in natural materials have always remained a prime choice for the development of safe, protective, and wellness-related textile products. In this study, functional microcapsules were prepared using the chitosan-gelatin complex as a shell material and rosemary essential oil as a core material. The prepared microcapsules were utilized for the development of multifunctional linen fabric. The oil release mechanism of microcapsules was studied using the Korsmeyer-Peppas model. The obtained microcapsules and finished linen fabrics were characterized using SEM-EDX anal. and ATR-FTIR anal. The durability of functionalities against repeated launderings was also studied. The microcapsules with an encapsulation efficiency of more than 70% were used to impart durable mosquito-repellency (more than 90%) against Anopheles mosquitoes, antibacterial properties against E. coli (> 93%) and S. aureus (> 95%) bacteria, significant (> 91%) antioxidant activity and a pleasant aroma. The chem. constituents of rosemary oil were also found to be responsible for imparting multifunctional properties. The novel combination of biopolymers and essential oil was explored for the development of multifunctional textiles.

Industrial Crops and Products published new progress about Anopheles. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Jeh-Chang published the artcileOn the nature of shape-fixing in semicrystalline shape-memory networks, Formula: C17H28O8S4, the main research area is phenolthiazine reinforced polymer composite shape memory network mech property.

Crystallization of polymer strands within elastically strained cross-linked networks can lower tension, leading to stabilization of mech. deformed states. This process, referred to as shape-fixing, is sensitive to thermomech. path because both mech. strain and thermal undercooling affect crystallization kinetics. In the present study, shape-fixing of a well-defined poly(caprolactone) network is examined at fixed strains ranging from 25 to 100%. Isothermal crystallization kinetics were studied using wide angle X-ray scattering while simultaneously monitoring tension loss. Plots of tensile stress vs. degree of crystallization show that significant stress reduction occurs at only a few percent crystallinity (<0.05). The development of young's modulus under identical conditions was evaluated, and results are combined to estimate the shape-fixity at different crystallization conditions and times. This study contributes to understanding the interrelationship between crystallization, stress reduction, and material stiffening to support further development of semicrystalline shape-memory networks. Polymer Crystallization published new progress about Annealing. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Hyun-Jung published the artcilePerformance improvement of slot-die-deposition based perovskite solar cells using diglycolic acid additives, COA of Formula: C4H6O5, the main research area is diglycolic acid slot die deposition perovskite solar cell.

In slot-die-coating process, novel approaches for better perovskite film formation were continuously required. Here, we studied additive processes for better slot-die-processed perovskite fabrication. As a novel additive, we introduced diglycolic acid (DA) material having a carboxyl group, well known as an effective functional group. With adding optimal amount of DA in the perovskite precursor solution, device efficiency and stability were all improved; DA-based perovskite device showed the best PCE of 14.63%. Moreover, the DA-based devices showed superior long-term stability guaranteeing 80% of initial efficiency during 95 days.

Materials Letters published new progress about Annealing. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ibanez, J. published the artcileDirect amination of 1-octanol with NH3 over Ag-Co/Al2O3: Promoting effect of the H2 pressure on the reaction rate, Product Details of C8H18O, the main research area is silver cobalt alumina ammonia octanol direct amination reaction rate.

The kinetics of the direct gas-phase amination reaction of 1-octanol with ammonia was studied over a Ag-Co/Al2O3 catalyst. An exhaustive exptl. dataset was acquired on a Flowrence unit using a full factorial exptl. design, covering the effect and interactions of the 1-octanol, ammonia and hydrogen partial pressures in the range 160-180 °C. An apparent zero order was obtained for both reactants (i.e. 1-octanol and NH3), addressing alc. dehydrogenation as the rate-determining step of the overall catalytic process. Most interestingly, a non-trivial pos. effect of the exogeneous H2 pressure was observed on the 1-octanol conversion, also favoring the formation of the secondary amine. To unveil the promoting role of H2 on the reaction rate, a comprehensive kinetic modeling study was carried out. Based on the observed exptl. trends, various kinetic models were proposed relying on an in situ catalytic deactivation-regeneration mechanism of the catalyst surface. Upon statistical discrimination, a robust kinetic model could be obtained, pointing out the adsorbed octylimine intermediate as the most plausible source of deactivation. The kinetic model afford an excellent description of the observed exptl. trends at both low and high 1-octanol conversion and provides a sound mechanistic explanation accounting for the unexpected role of H2 on alc. amination reactions.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Amination. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Feng published the artcileA multifaceted role of a mobile bismuth promoter in alcohol amination over cobalt catalysts, Application of n-Octanol, the main research area is alumina supported bismuth promoted cobalt catalyst alc amination.

Promotion with small amounts of different elements is an efficient strategy for the enhancement of the performance of many heterogeneous catalysts. Supported cobalt catalysts exhibit significant activity in the synthesis of primary amines via alc. amination with ammonia, which is an economically efficient and environmentally friendly process. Insufficient selectivity to primary amines, low activity and fast cobalt catalyst deactivation remain serious issues restricting the application of alc. amination in the industry. In this work, we have discovered the multifaceted role of the bismuth promoter, which is highly mobile under reaction conditions, in 1-octanol amination over supported cobalt catalysts. First, the overall reaction rate was enhanced more than twice on promotion with bismuth. Second, the selectivity to primary amines increased 6 times in the presence of Bi at high alc. conversion. Finally, the bismuth promotion resulted in extremely high stability of the cobalt catalyst. Characterization by XRD, temperature programmed reduction, STEM, CO chemisorption, BET, TGA and FTIR has showed that the enhancement of the catalytic performance on promotion with bismuth is due to better cobalt reducibility, easy removal of strongly adsorbed intermediates and products by the mobile promoter and suppression of amine coupling reactions resulting in secondary and tertiary amines.

Green Chemistry published new progress about Amination. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts