Author: tianli

Carpio, Humberto published the artcileSynthesis of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and homologous pyridine and azepine analogs thereof, Synthetic Route of 50966-69-3, the main research area is pyrrolopyrrolecarboxylic acid; pyrrolopyridinecarboxylic acid; pyrroloazepinecarboxylic acid; pyrroleacetate; pyridinecarboxylic acid pyrrolo; azepinecarboxylic acid pyrrolo.

Several syntheses of the previously unknown 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (I) and various 5- and 6-substituted derivatives were devised. Some of these processes were extended to the heretofore unreported 5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylic acid (II) and 5,6,7,8-tetrahydro-9H-pyrrolo[1,2-a]azepine-9-carboxylic acid derivatives (e.g., III). Two new processes were developed for the conversion of pyrroles into the corresponding pyrrole-2-acetic acid esters. Both processes were based on the use of the readily available ethoxalylpyrrole derivatives as the starting material. One sequence involved saponification of the α-keto ester, followed by Wolff-Kishner reduction of the crude α-keto acid salt and subsequent esterification of the acetic acid derivative thus produced. The 2nd synthesis commenced with reduction of the 2-ethoxalpyrrole with NaBH4 to the α-hydroxy ester, which was further reduced to the acetic acid ester with an equimolar mixture of PPh3 and PPh3I2.

Canadian Journal of Chemistry published new progress about pyrrolopyrrolecarboxylic acid; pyrrolopyridinecarboxylic acid; pyrroloazepinecarboxylic acid; pyrroleacetate; pyridinecarboxylic acid pyrrolo; azepinecarboxylic acid pyrrolo. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, Synthetic Route of 50966-69-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abramovitch, Rudolph A. published the artcileSolution and flash vacuum pyrolyses of β-(3,5-disubstituted-phenyl)ethanesulfonyl azides. Sultam, pyrindine, and azepine formation, SDS of cas: 93427-13-5, the main research area is pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine.

The solution and flash-vacuum pyrolyzes of azides I (R = Me, Cl, MeO, CF3) are reported. When R = Me, FVP results suggest that the substituents stabilize the intermediate leading to the sultam (II, R = R1 = Me). A new product, pyridine III, is observed, and a modification is proposed in the mechanism proposed earlier to account for the FVP of β-arylethanesulfonyl azides. No dihydropyrindine, which would have required a Me migration, is observed When R = Cl, migration of Cl does occur and a mixture of 5H- and 7H-1-pyrindines is obtained, together with other products. When R = MeO, some MeO migration occurs on FVP to give 6,7-dihydro-3,5-dimethoxy-5H-1-pyrindine. Monodemethoxylation to give II (R = MeO, R1 = H) also takes place, and a possible mechanism is proposed. When R = CF3 the main product on FVP at 300° is the fused azepine IV in respectable yield. This is the first example of the isolation of an N-sulfonylazepine from the intramol. reaction of a sulfonylnitrene and from a FVP.

Journal of Organic Chemistry published new progress about pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, SDS of cas: 93427-13-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farag, Michael M published the artcileHyaluronic Acid Conjugated Metformin-Phospholipid Sonocomplex: A Biphasic Complexation Approach to Correct Hypoxic Tumour Microenvironment., Category: alcohols-buliding-blocks, the main research area is MiaPaCa-2; hyaluronic acid; hypoxia-inducible factor; metformin; pancreatic ductal adenocarcinoma.

PURPOSE: Development of hyaluronic acid conjugated metformin-phospholipid sonocomplexes (HA-MPS), a biphasic complexation product compiled for enhancing both the lipophilicity and targeting potential of Metformin (MET) to CD44 receptors on pancreatic cancer. METHODS: MET was chemically conjugated to hyaluronic acid (HA) via amide coupling reaction. Then, the HA conjugated MET was physically conjugated to Lipoid™S100 via ultrasound irradiation. A combined D-optimal design was implemented to statistically optimize formulation variables. The HA-MPS were characterized through solubility studies, partition coefficient, drug content uniformity, particle size and zeta potential. The optimized HA-MPS was tested via proton nuclear magnetic resonance, infrared spectroscopy to elucidate the nature of physicochemical interactions in the complex which was further scrutinized on molecular level via molecular docking and dynamic simulation. RESULTS: The solubility and partition studies showed a lipophilicity enhancement up to 67 folds as they adopted inverted micelles configuration based on the packing parameter hypothesis. The optimized HA-MPS showed 11.5 folds lower IC50, extra 25% reduction in oxygen consumption rate, better reduction in hypoxia-inducible factor and reactive oxygen species in MiaPaCa-2 cells. CONCLUSION: These results proved better internalization of MET which was reflected by abolishing hypoxic tumour microenvironment, a mainstay toward a normoxic and less resistant pancreatic cancer.

International journal of nanomedicine published new progress about MiaPaCa-2; hyaluronic acid; hypoxia-inducible factor; metformin; pancreatic ductal adenocarcinoma. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiris, Baris published the artcileSeparation of Mandelic Acid by a Reactive Extraction Method Using Tertiary Amine in Different Organic Diluents, Safety of n-Octanol, the main research area is mandelic acid; reactive extraction; separation; tri-n-octylamine.

Mandelic acid is a valuable chem. that is commonly used in the synthesis of various drugs, in antibacterial products, and as a skin care agent in cosmetics. As it is an important chem., various methods are used to synthesize and extract this compound However, the yields of the used processes is not significant. A dilute aqueous solution is obtained when using several production methods, such as a fermentation, etc. In this study, the reactive extraction of mandelic acid from aqueous solutions using tri-n-octylamine extractant at 298.15 K was investigated. Di-Me phthalate (DMP), Me iso-Bu ketone (MIBK), 2-octanone, 1-octanol, n-pentane, octyl acetate, and toluene were used as diluents. The batch extraction results of the mandelic acid experiments were obtained for the development of a process design. Calculations of the loading factor (Z), distribution coefficient (D), and extraction efficiency (E%) were based on the exptl. data. The highest separation yield was obtained as 98.13% for 0.458 mol.L-1 of tri-n-octylamine concentration in DMP. The overall extraction constants were analyzed for the complex of acid-amine by the Bizek approach, including K11, K12, and K23.

Molecules published new progress about mandelic acid; reactive extraction; separation; tri-n-octylamine. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ali, Abbas published the artcileToxicity and Repellency of Magnolia grandiflora Seed Essential Oil and Selected Pure Compounds Against the Workers of Hybrid Imported Fire Ants (Hymenoptera: Formicidae)., HPLC of Formula: 111-87-5, the main research area is Magnolia seed essential oil; fire ant worker; repellency; toxicity.

We tested Magnolia grandiflora L. (Magnoliales: Magnoliaceae) seed essential oil and its pure compounds for their repellency and toxicity against workers of hybrid imported fire ants. Series of dosages were tested starting from 156 µg/g to the dose where the treatment failed. Workers removed significantly less sand from the vials with M. grandiflora seed essential oil and 1-octanol treated sand at serial dosages of 156-4.9 µg/g than the solvent control whereas the amount removed at 2.4-0.6 µg/g was similar to the solvent control. In 1-decanol treatments, workers removed significantly less sand at serial dosages of 156-0.15 µg/g than the solvent control whereas the removal of sand at the dose of 0.08 µg/g was similar to the solvent control. In DEET (N, N-diethyl-meta-toluamide) treatments, workers removed significantly less sand at serial dosages of 156-78 µg/g than the solvent control whereas the quantity of removed sand at 39 µg/g was similar to the solvent control. Based on the mean amount of sand removed, M. grandiflora essential oil, 1-decanol, and 1-octanol showed significantly higher repellency than DEET. 1-Decanol and 1-octanol, present in seed essential oil showed toxicity against fire ant workers. 1-Decanol with LC50 of 140.6 µg/g was the most toxic natural compound followed by 1-octanol (LC50 = 486.8 µg/g). Bifenthrin with LC50 value of 0.018 µg/g showed much higher toxicity than these natural compounds. High repellency and toxicity of 1-decanol makes it a natural compound of interest for further studies under field conditions.

Journal of economic entomology published new progress about Magnolia seed essential oil; fire ant worker; repellency; toxicity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oshizaka, Takeshi published the artcileEffects of Physicochemical Properties of Constituent Ions of Ionic Liquid on Its Permeation through a Silicone Membrane., Product Details of C8H18O, the main research area is ionic liquid; n-octanol/water partition coefficient; permeability coefficient; silicone membrane.

Ionic liquids (ILs), defined as liquid salts composed of anions and cations, have the advantage of allowing constituent ions to be stably absorbed through biological membranes, such as skin. However, limited information is currently available on the effects of the physicochemical properties of constituent ions on the membrane permeation of ILs. Therefore, we herein investigated the effects of the polarity of constituent cations on the membrane permeation of each constituent ion from IL. Various ILs were prepared by selecting lidocaine (LID) as a cation and a series of p-alkylbenzoic acids with different n-octanol/water partition coefficients (Ko/w) as anions. These ILs were applied to a skin model, a silicone membrane, and membrane permeability was investigated. The membrane permeabilities of p-alkylbenzoic acids from their single aqueous suspensions were also measured for comparison. The membrane permeability of p-alkylbenzoic acid from the aqueous suspension increased at higher Ko/w. However, the membrane permeability of ILs was similar regardless of the Ko/w of the constituent p-alkylbenzoic acid. Furthermore, the membrane permeability of the counterion LID remained unchanged regardless of the constituent p-alkylbenzoic acid. These results suggest that even when the Ko/w of IL constituents markedly differs, the resulting IL does not affect membrane permeability.

Chemical & pharmaceutical bulletin published new progress about ionic liquid; n-octanol/water partition coefficient; permeability coefficient; silicone membrane. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Argentini, M. published the artcileComparison of several methods for the synthesis of ω-iodine-123-heptadecanoic acid, Recommanded Product: 17-Hydroxyheptadecanoic acid, the main research area is iodoheptadecanoic acid iodine labeled; exchange iodine heptadecanoic acid.

Four different methods for the synthesis of ω-123I-heptadecanoic acid were presented: labeling of 17-bromoheptadecanoic acid with Na123I in solution or melt, reaction of Na123I with the tosylate of 17-hydroxyheptadecanoic acid, and phase-transfer catalyzed exchange of 17-iodoheptadecanoic acid with Na123I or H123I. The tosylate and phase transfer catalyst methods were superior to the former 2 methods.

Journal of Radioanalytical Chemistry published new progress about iodoheptadecanoic acid iodine labeled; exchange iodine heptadecanoic acid. 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, Recommanded Product: 17-Hydroxyheptadecanoic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ciura, Krzesimir published the artcileAffinity of antifungal isoxazolo[3,4-b]pyridine-3(1H)-ones to phospholipids in immobilized artificial membrane (IAM) chromatography, Quality Control of 111-87-5, the main research area is IAM-HPLC; immobilized artificial membrane; isoxazolo[3,4-b]pyridin-3(1H)-one; isoxazolone.

Currently, rapid evaluation of the physicochem. parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the lipophilicity of drug candidates is determined using the shake flash method (n-octanol/water system) or reversed phase liquid chromatog. (RP-LC), more biosimilar alternatives to classical lipophilicity measurement are currently available. One of the alternatives is immobilized artificial membrane (IAM) chromatog. The present study is a continuation of our research focused on physiochem. characterization of biol. active derivatives of isoxazolo[3,4-b]pyridine-3(1H)-ones. The main goal of this study was to assess the affinity of isoxazolones to phospholipids using IAM chromatog. and compare it with the lipophilicity parameters established by reversed phase chromatog. Quant. structure-retention relationship (QSRR) modeling of IAM retention using differential evolution coupled with partial least squares (DE-PLS) regression was performed. The results indicate that in the studied group of structurally related isoxazolone derivatives, discrepancies occur between the retention under IAM and RP-LC conditions. Although some correlation between these two chromatog. methods can be found, lipophilicity does not fully explain the affinities of the investigated mols. to phospholipids. QSRR anal. also shows common factors that contribute to retention under IAM and RP-LC conditions. In this context, the significant influences of WHIM and GETAWAY descriptors in all the obtained models should be highlighted.

Molecules published new progress about IAM-HPLC; immobilized artificial membrane; isoxazolo[3,4-b]pyridin-3(1H)-one; isoxazolone. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Barber, Amelia Moreno published the artcileSolid-phase synthesis of novel inhibitors of farnesyl transferase, Safety of (4-Butoxyphenyl)methanol, the main research area is hydroxynitrotrifluorophenyl ether preparation farnesyl transferase inhibitor.

A novel diphosphate mimic, the 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy group, has been employed as the template in the solid-phase synthesis of novel farnesyl transferase inhibitors using the Mitsunobu reaction. The most potent inhibitor 1-farnesyloxy-5-hydroxy-2,3,6-trifluoro-4-nitrobenzene displayed an IC50 of 6.3 μM vs. farnesyl transferase.

Bioorganic & Medicinal Chemistry Letters published new progress about hydroxynitrotrifluorophenyl ether preparation farnesyl transferase inhibitor. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Safety of (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

James, Kenneth published the artcileThe synthesis of per-O-benzyl-α-D-galactosyl and -α-L-fucosyl bromides, Related Products of alcohols-buliding-blocks, the main research area is hexopyranosyl perbenzylated bromide; galactopyranosyl perbenzylated bromide; fucopyranosyl perbenzylated bromide; benzylated hexopyranosyl bromide.

The title galactosyl bromide was prepared by benzylation of allyl galactopyranoside, with PhCH2Br-NaH, isomerization of the allyl group with tert-BuOK-Me2SO to prop-1-enyl tetra-O-benzyl-β-D-galactopyranoside. Removal of the vinyl residue with HgO and reaction with p-O2NC6H4COCl gave the tetra-O-benzyl-1-O-p-nitrobenzoyl-D-galactopyranose (I). Treatment of I with HBr gave 80% of the α-bromide as an oil. The fucopyranosyl derivative was prepared similarly.

Australian Journal of Chemistry published new progress about hexopyranosyl perbenzylated bromide; galactopyranosyl perbenzylated bromide; fucopyranosyl perbenzylated bromide; benzylated hexopyranosyl bromide. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts