Author: tianli

Woelke, Christian published the artcileUnderstanding the Effectiveness of Phospholane Electrolyte Additives in Lithium-Ion Batteries under High-Voltage Conditions, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is ChemElectroChem (2021), 8(5), 972-982, database is CAplus.

Six phospholane functional electrolyte additives that enable the formation of an effective cathode electrolyte interphase (CEI) via a polymerization reaction on the electrode surface were designed, synthesized, and comparatively analyzed by means of complementary exptl. and computational methods in order to understand their mode of action in NMC111||graphite battery cells under high voltage conditions. Two reaction mechanisms, namely a phosphate-based and a phosphonate-based mechanism, were postulated and, based on systematic anal., the phosphate mechanism was identified as the more likely. Direct correlation of the phospholane’s structural features and relevant properties impacting the direct correlation of the phospholane’s structural features and relevant properties impacting the overall cycling performance of NMC111||graphite cells, as depicted by capacity retention, stands for a vital example approach towards identifying promising electrolyte components for advanced, targeted applications.

ChemElectroChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C9H7NO4, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Manker, Lorenz P. published the artcileSustainable polyesters via direct functionalization of lignocellulosic sugars, Recommanded Product: Pentane-1,5-diol, the publication is Nature Chemistry, database is CAplus and MEDLINE.

The development of sustainable plastics from abundant renewable feedstocks was limited by the complexity and efficiency of their production, as well as their lack of competitive material properties. Here the authors demonstrate the direct transformation of the hemicellulosic fraction of nonedible biomass into a tricyclic diester plastic precursor at 83% yield (95% from com. xylose) during integrated plant fractionation with glyoxylic acid. Melt polycondensation of the resulting diester with a range of aliphatic diols led to amorphous polyesters (M_n = 30-60 kDa) with high glass transition temperatures (72-100°), tough mech. properties (ultimate tensile strengths of 63-77 MPa, tensile moduli of 2,000-2,500 MPa and elongations at break of 50-80%) and strong gas barriers (oxygen transmission rates (100 μm) of 11-24 cc m^-2 day^-1 bar^-1 and H₂O vapor transmission rates (100 μm) of 25-36 g m^-2 day^-1) that could be processed by injection molding, thermoforming, twin-screw extrusion and 3-dimensional printing. Although standardized biodegradation studies still need to be performed, the inherently degradable nature of facilitated their chem. recycling via methanolysis at 64°, and eventual depolymerization in room-temperature H₂O. [graphic not available: see fulltext].

Nature Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Recommanded Product: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Waugh, Stephen M. published the artcileIsolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding, Category: alcohols-buliding-blocks, the publication is Biochemistry (1989), 28(8), 3448-55, database is CAplus and MEDLINE.

Radiolabeled insulin was affinity crosslinked to purified insulin receptor with 6 sep. bifunctional N-hydroxysuccinimde esters of different lengths. Results were qual. identical for each crosslinker in that insulin was predominantly crosslinked through its B chain to the receptor’s α subunit. The maximum efficiencies of crosslinking were 10-15% for the most effective reagents, and this value was dependent upon the concentration and length of the crosslinker. In an effort to locate the crosslinking site, monoiodoinsulin was crosslinked to affinity-purified insulin receptor with disuccinimidyl suberate. Limited proteolysis of the hormone/receptor adduct with Staphylococcus aureus V8 protease, chymotrypsin, or thermolysin in an SDS-containing buffer rapidly generated a 55-kDa, insulin-labeled fragment as shown by SDS-PAGE. It was reported earlier that the 55-kDa chymotryptic fragment contained multiple internal SS bonds as evidenced by its shifting mobility on an SDS gel after dithiothreitol treatment. The 55-kDa fragment is also formed by proteolysis of the receptor in the absence of prior insulin crosslinking. This fragment was prepared in amounts sufficient for sequence anal. and was purified by passage successively over gel-permeation and reverse-phase HPLC columns. The sequence of the fragment’s N terminus corresponds to that of the N terminus of the receptor’s α subunit. This fragment also reacts with an antibody raised against a synthetic peptide corresponding to residues 242-253 of the receptor’s α subunit. On the basis of the fragment’s size, N-terminal sequence, and immunoreactivity, the results indicate that the fragment extends from the α subunit’s N terminus through the SS-rich region of this subunit, i.e., residues 155-312. These results are consistent with this region containing the insulin-binding site.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C19H21N3O3S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Na published the artcileToward Alkylphenols Production: Lignin Depolymerization Coupling with Methoxy Removal over Supported MoS₂ Catalyst, Recommanded Product: 4-Propylphenol, the publication is Industrial & Engineering Chemistry Research (2020), 59(39), 17287-17299, database is CAplus.

Alkylphenols are indispensable chems. that are currently derived from fossil resources. Conversion of lignin into alkylphenols in a selective manner is highly desirable, while it represents one of the biggest challenges in biorefinery. Herein, lignin depolymerization coupling with methoxy removal over supported MoS₂ catalyst for the direct production of alkylphenols has been studied. The catalysts were prepared by incipient wetness impregnation and characterized by N₂ physisorption, XRD, NH₃-TPD, CO chemisorption, ICP, TEM, and XPS. The catalytic performance and the reaction mechanism were initially assessed by the hydrodeoxygenation (HDO) of eugenol. Among the catalysts with MoS₂ supported on different supports (HZSM-5, SAPO-34, SiO₂, Al₂O₃, and activated carbon (AC)), the acid-rich MoS₂/AC with high sp. surface areas and more exposed MoS₂ edge sites owed a complete conversion of eugenol and 64.8% yield of 4-propylphenol under 3 MPa H₂ at 300°C for 3 h. In the conversion of lignin-oil, MoS₂/AC catalyst also exhibited excellent activity in the removal of all the methoxy groups in various aromatic monomers, achieving alkylphenols with selectivity up to 76.2%. Notably, this catalytic system also showed potential in simultaneous hydrocracking coupling with methoxy removal of realistic lignin to afford alkylphenols, thus providing a direct strategy for the selective valorization of lignin.

Industrial & Engineering Chemistry Research published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Takatsuka, Tsutomu published the artcileEffects of Isomalt on enamel de- and remineralization, a combined in vitro pH-cycling model and in situ study., Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is .

Isomalt is a non-cariogenic sweetener, which is widely used in sugar-free candy and chewing gum. Little is known about the effects of Isomalt on de- and remineralization. Binding between calcium and Isomalt has been reported, which could affect the mineral balance. The objective of this study was to examine the effects of Isomalt on de- and remineralization of bovine enamel lesions, both in vitro and in situ. In in vitro study, subsurface enamel lesions were subjected to 3-weeks pH-cycling. Treatments were 5-min rinses with 10% Isomalt solutions daily and 10% Isomalt additions to re- or demineralizing solutions. Standard pH-cycling conditions were used with a 0.2 ppm fluoride background during the remineralization phase. In in situ study, subsurface lesions were exposed 2 months in vivo and brushed three times daily with 10% Isomalt containing toothpaste. Treatment effects were assessed by chemical analysis of the solutions (in vitro) and transversal microradiography (in vitro and in situ). In in vitro study, while 5-min rinses with 10% Isomalt gave slightly increased remineralization, continuous presence of 10% Isomalt (in re- or demineralizing solutions) inhibited both de- and/or remineralization. This lead to significantly smaller overall mineral loss when Isomalt was added during demineralization. In in situ study, remineralization enhancement during short Isomalt treatments was confirmed. Isomalt had a positive effect on the de/remineralization balance when given under conditions relevant to practical use.

Clinical oral investigations published new progress in MEDLINE about 64519-82-0, 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Taghizadeh, Mohsen published the artcileEffects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial., Formula: C12H24O11, the main research area is .

OBJECTIVE: The aim of this study was to determine the effects of synbiotic food consumption on glycemic status and serum high sensitivity C-reactive protein (hs-CRP) levels of Iranian pregnant women. DESIGN: This randomized placebo-controlled clinical trial was performed among 52 pregnant women, primigravida, aged 18-35 year old, in their third trimester. After a 2-wk run-in period, subjects were randomly assigned to consume either a synbiotic (n=26) or control food (n=26) for 9 weeks. The synbiotic food consisted of a probiotic Lactobacillus sporogenes (1×107 CFU), 0.04 g inulin as prebiotic with 0.38 g isomalt, 0.36 g sorbitol and 0.05 g stevia as sweetener per 1 g. Control food (the same substance without probiotic bacteria and inulin) was packed in identical 9-gram packages. Patients were asked to consume the synbiotic and control foods two times a day. Fasting blood samples were taken at baseline and after a 9-wk intervention for quantification of related factors. RESULTS: Consumption of a synbiotic food did not show any significant change regarding the impact of insulin actions in the synbiotic group; nonetheless, compared to the control food, it resulted in a significant decrease in serum insulin levels (-0.26 vs. 6.34 µIU/mL, P=0.014) and HOMA-IR (-0.13 vs. 1.13, P=0.033), a significant difference in HOMA-B (5.30 vs. 34.22, P=0.040) and a significant rise in QUICKI score (0.002 vs. -0.02, P=0.022). CONCLUSIONS: Consumption of a synbiotic food for 9 weeks by pregnant women had beneficial effects on insulin actions compared to the control food, but did not affect FPG and serum hs-CRP concentrations.

Hormones (Athens, Greece) published new progress in MEDLINE about 64519-82-0, 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kempraj, Vivek published the artcile1-Octanol emitted by Oecophylla smaragdina weaver ants repels and deters oviposition in Queensland fruit fly, Product Details of C8H18O, the main research area is .

Abstract: Humans have used weaver ants, Oecophylla smaragdina, as biol. control agents to control insect pests in orchards for many centuries. Over recent decades, the effectiveness of weaver ants as biol. control agents has been attributed in part to deterrent and oviposition inhibiting effects of kairomones produced by the ants, but the chem. identity of these kairomones has remained unknown. We have identified the kairomone responsible for deterrence and oviposition inhibition by O. smaragdina, providing a significant advance in understanding the chem. basis of their predator/prey interactions. Olfactometer assays with extracts from weaver ants demonstrated headspace volatiles to be highly repellent to Queensland fruit fly, Bactrocera tryoni. Using electrophysiol. and bioassays, we demonstrate that this repellence is induced by a single compound, 1-octanol. Of 16 compounds identified in O. smaragdina headspace, only 1-octanol evoked an electrophysiol. response from B. tryoni antennae. Flies had greatly reduced oviposition and spent significantly less time in an olfactometer arm in the presence of 1-octanol or a synthetic blend of headspace volatiles containing 1-octanol than in the presence of a synthetic blend of headspace volatiles without 1-octanol, or clean air. Taken together, our results demonstrate that 1-octanol is the functional kairomone component of O. smaragdina headspace that explains repellence and oviposition deterrence, and is hence an important contributor to the effectiveness of these ants as biol. control agents.

Scientific Reports published new progress in CAplus and MEDLINE about 111-87-5, 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weiglein, Alice published the artcileOne-trial learning in larval Drosophila, Formula: C8H18O, the main research area is .

Animals of many species are capable of “”small data”” learning, i.e., of learning without repetition. Here we introduce larval Drosophila melanogaster as a relatively simple study case for such one-trial learning. Using odor-food associative conditioning, we first show that a sugar that is both sweet and nutritious (fructose) and sugars that are only sweet (arabinose) or only nutritious (sorbitol) all support appetitive one-trial learning. The same is the case for the optogenetic activation of a subset of dopaminergic neurons innervating the mushroom body, the memory center of the insects. In contrast, no onetrial learning is observed for an amino acid reward (aspartic acid). As regards the aversive domain, one-trial learning is demonstrated for high-concentration sodium chloride, but is not observed for a bitter tastant (quinine). Second, we provide follow-up, parametric analyses of odor-fructose learning. Specifically, we ascertain its dependency on the number and duration of training trials, the requirements for the behavioral expression of one-trial odor-fructose memory, its temporal stability, and the feasibility of one-trial differential conditioning. Our results set the stage for a neurogenetic anal. of one-trial learning and define the requirements for modeling mnemonic processes in the larva.

Learning & Memory published new progress in CAplus and MEDLINE about 111-87-5, 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khan, Hina published the artcileA prospective randomized trial to compare the effectiveness of zero calorie carbonated drink and water as a solvent in sodium phosphate for colonoscopy., HPLC of Formula: 124-76-5, the main research area is Zero calorie coke, Sodium phosphate..

Objectives: To compare the effectiveness of zero-calorie soft drink and plain water as a solvent for sodium phosphate in terms of good palatability and better patient tolerance. METHODS: The randomised controlled trial was conducted from May to December 2019 at the Dowites Operation Theatre Endoscopy Suite, Surgical Unit 3, Civil Hospital Karachi, and comprised patients aged >18 years of either gender undergoing colonoscopy for screening and non-emergency/non-urgent colorectal diseases. The patients were randomised into group A, which was assigned to take sodium phosphate in water, and group B, which was assigned to take sodium phosphate in zero-calorie soft drink. Bowel preparation was assessed by the consultant during endoscopy. Outcome variables, such as bowel cleanliness, palatability, tolerance of solution, adverse effects, and willingness to repeat the preparation, were evaluated in both groups. Data was analysed using SPSS 21. RESULTS: Of the 162 patients, there were 81(50%) in each of the two groups. There were 124(76.5%) males and the overall mean age was 43±8.66 years. The palatability score was significant (p=0.01) for group B compared to group A. Due to better palatability and tolerance, 64(79%) patients in group B took the preparation in <6 hours. CONCLUSIONS: Use of zero-calorie soft drink was found to be a better option for colonoscopic preparation compared to plain water. RCT Registration: Clinical trial unit (www.clinicaltrials.gov), NCT04316858. JPMA. The Journal of the Pakistan Medical Association published new progress in MEDLINE. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hofmann, Natalie published the artcileSynthesis of tetrahydroquinolines via borrowing hydrogen methodology using a manganese PN3 pincer catalyst, Formula: C5H12O, the main research area is tetrahydroquinoline preparation.

A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcs. and simple secondary alcs. is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodol. promoted by a manganese (I) PN3 pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required.

Organic Letters published new progress about tetrahydroquinoline preparation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts