Author: tianli

Huang, Yongliang published the artcileConvenient and flexible syntheses of gem-dimethyl carboxylic triggers via mono-selective β-C(sp³)-H arylation of pivalic acid with ortho-substituted aryl iodides, Computed Properties of 20880-92-6, the publication is Organic Chemistry Frontiers (2022), 9(12), 3293-3300, database is CAplus.

This work presents a palladium(II)-catalyzed mono-selective C(sp³)-H arylation of pivalic acid for rapid construction of an important library of 3-aryl-2,2-dimethylpropanoic acids, especially ortho-substituted-aryl compounds The strategy greatly streamlines access to a series of trimethyl-lock-type triggers – arylated gem-di-Me carboxylic acids bearing ortho-activatable substituents, which was used as a self-immolative spacer for selective chem. release initiated under specific conditions. Flexible transformation and derivatization of these activatable carboxylic triggers were also showcased.

Organic Chemistry Frontiers published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Jie published the artcileOptimum target plasma concentration of propofol in preventing adverse effects of carboprost tromethamine in patients undergoing caesarean section, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhonghua Mazuixue Zazhi (2016), 36(3), 321-324, database is CAplus.

Objective To investigate the optimum target plasma concentration of propofol in preventing the adverse effects of carboprost tromethamine in the patients undergoing caesarean section. Methods One hundred and twenty-eight nulliparous parturients who were at full term with a singleton fetus, of American Society of Anesthesiologists phys. status I or II, aged 24-37 yr, weighing 54-78 kg, scheduled for elective caesarean section under combined spinal-epidural anesthesia, were randomly divided into 4 groups (n = 32 each) using a random number table: control group (group C) and different concentrations of propofol groups (P_1-3 groups). Carboprost tromethamine 250 μg was injected into the body of the uterus, and propofol with the target plasma concentrations of 0.8, 1.2 and 1.6 μg/mL was simultaneously given by target-controlled infusion in P₁, P₂ and P₃ groups, resp., and normal saline was infused at a rate of 0.5 mL·kg^-1·h^-1 in group C. The occurrence of cardiovascular events was recorded from the end of carboprost tromethamine administration until the end of surgery. The related adverse effects after carboprost tromethamine administration and Ramsay sedation score at 15 mm after carboprost tromethamine administration were recorded, and satisfactory sedation was defined as Ramsay sedation score of 2. The occurrence of complications associated with combined spinal-epidural anesthesia was recorded during the postoperative follow-up. Results Compared with group C, the incidence of carboprost tromethamine-related adverse effects was significantly decreased in P₂ and P₃ groups, the rate of satisfactory sedation was significantly increased in P₁ and P₂ groups, the incidence of hypotension and tachycardia was significantly decreased in group P₁ (P<0.05), and no significant change was found in the incidence of carboprost tromethamine-related adverse effects in group P₁ and in the rate of satisfactory sedation in group P₃ (P>0.05). Compared with group P₁, the incidence of carboprost tromethamine-related adverse effects was significantly decreased in P₂ and P₃ groups, the rate of satisfactory sedation was significantly increased in group P₂, and the rate of satisfactory sedation was significantly decreased in group P₃ (P<0.05). Compared with group P₂, the rate of satisfactory sedation was significantly decreased (P<0.05), and no significant change was found in the incidence of carboprost tromethamine-related adverse effects in group P₃ (P>0.05). No cardiovascular events were found in group P₂, and the incidence of hypotension was 9% in group P₃. Conclusion The optimum target plasma concentration of propofol in preventing the adverse effects of carboprost tromethamine is 1.2 μg/mL in the patients undergoing caesarean section.

Zhonghua Mazuixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Xiaofeng published the artcileChemical crosslinking approach to reveal spatial arrangement of subunits in PS II oxygen-evolving core complexes, Formula: C18H20N2O12, the publication is Zhiwu Shenglixue Tongxun (2002), 38(6), 599-602, database is CAplus.

The spatial arrangement of subunits of photosystem II O₂-evolving core complexes was analyzed by crosslinking the core complexes with bifunctional crosslinking agent [such as 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide, di-Me hexanedioate, N,N- dicyclohexylcarbodiimide, etc.] at room temperature for 10 min, terminating with 10% glycine solution, centrifuging, suspending in SMN buffer (composed of sucrose 0.4, NaCl 10, and Mes-NaOH 50 mM, its pH 6.0), and detecting via SDS-PAGE.

Zhiwu Shenglixue Tongxun published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C14H26O2, Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Jingwen published the artcileMetabolic engineering of microorganisms for vitamin C production, Computed Properties of 526-98-7, the publication is Subcellular Biochemistry (2012), 241-259, database is CAplus and MEDLINE.

A review. Vitamin C, an important organic acid, is widely used in the industries of pharmaceuticals, cosmetics, food, beverage and feed additives. Compared with the Reichstein method, biotechnol. production of vitamin C is an attractive approach due to the low cost and high product quality. In this chapter, biosynthesis of vitamin C, including one-step fermentation processes and two-step fermentation processes are discussed and compared. Furthermore, the prospects of the biotechnol. production of vitamin C are also presented.

Subcellular Biochemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C17H19N3O6, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tai, Benjamin C. U. published the artcileSynthetic Poly(Vinylalcohol)-Based Membranes for Cartilage Surgery and Repair, Quality Control of 6346-09-4, the publication is Biotechnology Journal (2017), 12(12), n/a, database is CAplus and MEDLINE.

Cell-based therapies for cartilage repair are continually being developed to treat osteoarthritis. The cells are either introduced directly by intra-articular injection or via a cell-seeded matrix scaffold. Here, poly(vinylalc.)-based membranes are developed to be used for mesenchymal stem cell implantation in cartilage repair procedures, having controllable physicochem. properties such as porosity, mech. strength, and permeability, and a unique self-sealing property. The membranes possess a bilayer structure with a less porous layer providing mech. strength and selective permeability, exhibit an elastic modulus of between 0.3 and 0.9 MPa, and are permeable to mols. <40 kDa, which is in the range of cartilage permeability. Three different peptide ligands with the sequences Ac-GCGYGRGDSPG, Ac-GCG(OPG)4REGOFG(OPG)4, and Ac-GCG(OPG)7, resp., are conjugated to the membranes and subject to in vitro cell adhesion and differentiation assays. Col I/Col II gene expression ratios indicated that the collagen-mimetic peptide, Ac-GCG(OPG)7, best supported mesenchymal stem cell differentiation into the chondrogenic lineage. Although low retention of the membrane is observed in vivo in a rabbit knee model, results suggest that the membrane was able to facilitate mesenchymal stem cell implantation and differentiation to chondrocytes. These PVA-based membranes provide a feasible, synthetic, off-the-shelf material for the delivery of stem cells, and can be modified for other surgical applications.

Biotechnology Journal published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C19H21N3O3S, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cortes-Arriagada, Diego published the artcileInsights into the luminescent properties of anionic cyclometalated iridium(III) complexes with ligands derived from natural products, Formula: C8H5F3O3, the publication is International Journal of Quantum Chemistry (2018), 118(17), n/a, database is CAplus.

In the search of remarkable anionic electroluminescent semiconductors to be applied in energy conversion devices such as Light Emitting Electrochem. Cells, we report the electronic, photophys., and charge injection/transfer properties of a series of cyclometalated iridium(III) complexes through a DFT/TD-DFT procedure. The proposed semiconductors involve bidentated ligands based on natural products (salicylic acid and boldine), and phenylpyridine and phenylpyrazole as the cyclometalating units. The proposed compounds emit in the range of 446 to 571 nm, where the boldine based compounds have red-shifted emissions compared to their analogs with salicylic acid. Blue phosphors were obtained by the use of phenylpyrazole units; however, the ligand field is weak in these cases compared to the ligand field exerted by the phenylpyridine ligands. The latter allows the accessibility to the radiationless states for emitters below 495 nm as a result of the increased stability of the metal centered excited states; consequently, the luminescent quantum yield could be decreased. Conversely, the semiconductors with phenylpyridine units show a restricted accessibility to radiationless processes, which could result in emitters with a high luminescent quantum yield and low non-radiative constants Finally, the proposed anionic semiconductors show a better balance between hole/electron transfer rate compared to related cationic Ir(III) complexes; while, the easier hole-electron injection is favored for semiconductors with salicylic acid and phenylpyridine units.

International Journal of Quantum Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Horakova, Eva published the artcileSynthesis and in vitro evaluation of novel N-cycloalkylcarbamates as potential cholinesterase inhibitors, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Monatshefte fuer Chemie (2017), 148(12), 2143-2153, database is CAplus.

Abstract: This present paper describes the preparation and characterization of a series of O-substituted N-cycloalkylcarbamate derivatives These compounds were tested as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All studied carbamates exhibited moderate inhibitory activity of both cholinesterases with values of IC₅₀ in the range of 36.1-78.6 μM for AChE and 9.8-215.4 μM for BChE, resp. These values are comparable with those values of inhibition obtained with the established drug rivastigmine. The cytotoxicity of all carbamates was evaluated using standard in vitro test with Jurkat cells. Many of the studied carbamates can be considered as promising compounds for potential medicinal applications with regard to their inhibitory activity as well as negligible cytotoxicity. Graphical abstract: [Figure not available: see fulltext.].

Monatshefte fuer Chemie published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dem’yanov, I. N. published the artcileVinyltrimethylene and its Derivatives, Category: alcohols-buliding-blocks, the publication is Zhurnal Russkago Fiziko-Khimicheskago Obshchestva (1913), 176-84, database is CAplus.

The alc. (a) obtained by shaking vinyltrimethylene (b) with H₂SO₄ (Gustavson, J. prakt. Chem., [2] 54, 104), not being oxidizable to an aldehyde or ketone, is doubtless tertiary; it b₇₅₅, 117.5-8.5° m. -5°, d₄²² 0.889, n₄²² 1.4315. Of the 2 formulas of (a), and preference is given to the 2nd. By converting (a) into an iodide (b₂₂ 50°) and treating the latter with Zn + AcOH a mixture of a hydrocarbon C₅H₁₀ (c) and the acetate of (a) was obtained. (c) b₇₅₃ 34-5°, d₀⁰ 0.6973, d₄⁰ 0.6805, n_D¹⁷ 1.3814; its formula is supposed to be. A hydrocarbon almost identical with (c) is more readily obtainable by reducing (b) with H + Pt black. The acetate of (c) b. 130-2.5°, d₄²⁰ 0.9351, n_D²⁰ 1.419.

Zhurnal Russkago Fiziko-Khimicheskago Obshchestva published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Mei published the artcileNovel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants, Application of 2-Morpholinoethanol, the publication is ACS Medicinal Chemistry Letters (2020), 11(6), 1196-1204, database is CAplus and MEDLINE.

Flexible heterocyclic moieties as the P2 ligands of HIV-1 protease inhibitors may be adapted to the minimally distorted active site of mutations easily and enhance activity against DRV-resistant HIV-1 variants. Herein, the design, synthesis, and biol. evaluation of a new series of inhibitors containing morpholine derivatives as the P2 ligands were described, among which, carbamate inhibitor I and carbamido inhibitor II exhibited almost 4- and 2-fold superior activity with enzyme Ki of 0.092 nM and 0.21 nM, as well as antiviral IC50 values of 0.41 nM and 0.95 nM, resp., compared to DRV. Besides, they exhibited excellent activity with inhibition of 94% and 91%, resp. Furthermore, they also showed appreciable antiviral activity against DRV-resistant HIV-1 variants.

ACS Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H6BrF3S, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cai, Kun published the artcileChanges in Phenolic Profiles and Inhibition Potential of Macrophage Foam Cell Formation during Noni (Morinda citrifolia Linn.) Fruit Juice Fermentation, COA of Formula: C8H8O3, the publication is Fermentation (2022), 8(5), 201, database is CAplus.

The dynamic changes in phenolic composition and antioxidant activity, and the potential effect on foam cell formation and cholesterol efflux during noni (Morinda citrifolia Linn.) fruit juice fermentation were investigated in this study. The composition of phenolic compounds was significantly different at various fermentation times. Rutin, quercetin, and isoquercitrin were the major phenolics in fermented noni fruit juice based on a quant. anal. of representative phenolics. The contents of caffeic acid, 2,4-dihydroxybenzoic acid, p-coumaric acid, rutin, and quercetin tended to increase, while those of isoquercitrin decreased during the fermentation process. Fermented noni juice extracts showed high antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), hydroxyl radical scavenging activity, and ferric reducing antioxidant power. Notably, the highest antioxidant activity was observed after 28 days of fermentation Furthermore, the treatment of fermented noni juice extracts was shown to reduce foam cell formation, intracellular cholesterol level, and the cholesterol esterification ratio. A correlation anal. indicated a strong pos. relationship between the phenolic composition, antioxidant activity, and the ratio of cholesterol ester and total cholesterol. This study may provide a theor. basis for the quality improvement and standardized production of fermented noni fruit juice, thus promoting the development of the noni food industry.

Fermentation published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts