Author: tianli

Dalton, David R. published the artcileBromohydrin formation in aqueous dimethyl sulphoxide; electronic and steric effects, Application In Synthesis of 2588-77-4, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1971), 85-9, database is CAplus.

The role of electronic and steric effects in the stereospecific trans-addition of HOBr to olefins, with moist Me2SO as solvent-reactant and N-bromosuccinimide as the source of Br, was examined In the absence of severe steric restrictions, the electronic effects were observed to direct the addition in a Markovnikov sense. Highly hindered olefins and those wherein the electron d. at the C:C double bond is severely depleted by electron-withdrawing substituents fail to react. Similar systems which have shown a susceptibility to carbonium ion rearrangements in analogous reactions fail to yield, for the most part, rearranged products. The intermediate is deemed best represented by a bromonium ion, symmetrical or nonsymmetrical, depending upon the structure of the starting olefin. If the addition of HOBr is retarded owing to electronic or steric effects, considerable amounts of dibromide accompany bromohydrin.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Application In Synthesis of 2588-77-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chams, Amani published the artcileDirect growth of polymer brushes from an electrodeposited conducting poly(dithienylpyrrole) layer functionalized with ATRP initiating moieties, Synthetic Route of 23351-09-9, the publication is Journal of Electroanalytical Chemistry (2013), 20-30, database is CAplus.

A new strategy for growing polymer brushes using surface-initiated atom transfer radical polymerization (SI-ATRP) from a thin functionalized conducting-polymer layer is reported. Three new heterocyclic monomers based on thiophene and/or pyrrole bearing an ATRP-initiator have been synthesized. Electrochem. behavior and electrodeposition of these monomers was carried out by both potentiodynamic (CV) and potentiostatic (CA) methods. Remarkably, the use of a tricyclic (2,5-dithienyl)pyrrole-based monomer allowed the formation of a conducting film at a relatively low oxidation potential (onset ∼0.65 V/SCE). Electroactivity characterization showed that conducting, stable and adherent thin polymer layer was formed. The charge-transfer agent was subsequently engaged in SI-ATRP to grow polymethacrylate brushes directly from the conducting functionalized surface. Both the functionalized conducting polymer layer and the resulting tethered polymer brushes were characterized using XPS and SEM (SEM). This study confirms that polymethacrylate brushes can efficiently grow directly from a functionalized conducting-polymer thin layer by using a conventional SI-ATRP procedure.

Journal of Electroanalytical Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Synthetic Route of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ilic, Milos published the artcileTowards dual antithrombotic compounds – Balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is European Journal of Medicinal Chemistry (2013), 329-340, database is CAplus and MEDLINE.

Enantiomers of 2,3-dihydro-1,4-benzodioxine derivatives possessing both thrombin and fibrinogen GPIIb/IIIa binding inhibitory activities were prepared from (R)- and (S)-glycidol as potential dual antithrombotic compounds The influence of chirality and substitution pattern on thrombin inhibition and on inhibition of fibrinogen binding to GPIIb/IIIa was analyzed. Docking studies were used in an attempt to rationalize the results. The (S)-isomers of both 2,3-dihydro-1,4-benzodioxine regioisomers at positions 6 and 7 were found to be better thrombin inhibitors than the corresponding (R)-enantiomers, whereas we observed that stereochem. does not display a consistent influence on fibrinogen GPIIb/IIIa binding inhibitory activity. Compound 11b, the (S)-isomer of the 6-substituted regioisomer, possessed the best balanced dual activity, with K_i(thrombin) = 1.67 ± 0.27 μM and IC_{50(GPIIb/IIIa)} = 0.665 ± 0.26 μM, raising the hope that merging anticoagulant and platelet antiaggregatory activities in the same mol. could lead to successful multitarget antithrombotic agents.

European Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ryczaj, Klaudia published the artcilePotentially harmful substances in moisturizers, COA of Formula: C11H24O3, the publication is Journal of Allergy and Clinical Immunology (2021), 148(2), 653-654, database is CAplus and MEDLINE.

A review. Despite the promising results of preliminary studies and hope for preventing atopic dermatitis (AD) and food allergy (FA) in high-risk infants by emollient application from their first days of life, further analyses failed to confirm the validity of such an approach. Haptens are low-mol.-weight chems. that may cause irritant or allergic contact dermatitis or subclin. skin barrier function changes. In 13 of the 17 emollients, at least 1 hapten was identified. The haptens found in the preparations were as follows: lanolin, iso-Pr myristate, phenoxyethanol, benzyl alc., sorbitan oleate, sorbitan sesquioleate, tocopheryl acetate, tocopherol, sorbic acid, propylene glycol, panthenol, ethylhexyl glycerin, cetearyl alc., cetyl alc., and stearyl alc. Thus, it is possible that chronic use of moisturizers containing haptens may lead to a vicious cycle of inflammation and skin barrier disruption that requires repeated applications of products

Journal of Allergy and Clinical Immunology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Yun-Xing published the artcileSynthesis and binding of 6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine and related ring-opened analogs at central nicotinic receptors, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is European Journal of Medicinal Chemistry (1999), 34(2), 177-190, database is CAplus.

6,7,8,9-Tetrahydro-5H-pyrido[3,4-d]azepine (I) and its N₇-Me derivative were synthesized and evaluated as potential nicotinic acetylcholinergic receptor (nAChR) ligands. On the basis that 6,7,8,9-tetrahydro-5H-pyrido[3,4-c]azepine, which binds to nAChR with low affinity (K_i = 1100 nM), possesses an inter-nitrogen distance (4.6 Å) that may be less than optimal, I was designed due to its similar shape but longer inter-nitrogen distance (5.5 Å). Compound I (K_i = 46 nM) was found to bind with enhanced affinity. However, unlike what is seen with nornicotine/nicotine, N-methylation of I reduced affinity (K_i = 268 nM) rather than enhancing it. The results suggest that the title compounds may interact at nicotine receptors in a manner that is somewhat different from that of nicotine. Ring-opening of the pyrido[3,4-d]azepine ring led to a series of 3-(2-aminoethyl)pyridines that retained the affinity of the cyclic compound Subsequent modification, including further chain lengthening (e.g. (aminopropyl)pyridine derivatives) and introduction of unsaturation, ultimately led to the development of a series of 3-(2-aminoethoxy)pyridine derivatives Simple N-substituted derivatives of 3-(2-aminoethoxy)pyridine were found to bind with K_i values of 20 to 35 nM. Because parallel structural changes in several series of related compounds did not result in parallel shifts in nAChR affinity, it is unlikely that all the investigated compounds bind in a similar fashion at these receptors. Nevertheless, some of these compounds represent novel classes of nAChR ligands.

European Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, KaKing published the artcileChiral Crystalline Sponges for the Absolute Structure Determination of Chiral Guests, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Journal of the American Chemical Society (2017), 139(33), 11341-11344, database is CAplus and MEDLINE.

Chiral crystalline sponges [(ZnI₂)₃(tpt)₂]_n·xG^* (1) where tpt = 2,4,6-tris(4-pyridyl)-1,3,5-triazine; G^* = (S,S) or (R,R)-4,5-dimethyl-2-(triphenylen-2-yl)-1,3-dioxolane, with preinstalled chiral references were synthesized. On the basis of the known configurations of the chiral references, the absolute structures of guest compounds absorbed in the pores of the crystalline sponges can be reliably determined without crystallization or chem. modification.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C21H37BO, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gu, Yu-Rui published the artcileIminyl Radical-Triggered Intermolecular Distal C(sp³)-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade, HPLC of Formula: 20117-47-9, the publication is Organic Letters (2019), 21(4), 917-920, database is CAplus and MEDLINE.

An efficient iron-catalyzed intermol. remote C(sp³)-H heteroarylation of alkyl ketones has been developed via an iminyl radical-triggered 1,5-hydrogen-atom transfer (HAT) cascade. This protocol was amenable to a wide variety of alkyl ketones and heteroaryls, thus providing a straightforward method for the late-stage functionalization of alkylketones and heteroaryls to obtain, e.g., I.

Organic Letters published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, HPLC of Formula: 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Pipeng published the artcileResonance energies and tautomerism of substituted aromatic heterocycles and their benzo derivatives, COA of Formula: C4H4OS, the publication is Youji Huaxue (1991), 11(6), 620-3, database is CAplus.

The recently developed quantified resonance theory (QRT) has been applied to substituted aromatic five- and six-membered heterocycles and their benzo derivatives The calculated resonance energy differences ΔRE between tautomeric forms agree with those estimated from tautomeric equilibrium data for the 2- and 4-pyridone, 2-quinolone and 1-isoquinolone series. For tautomerism of extensive heteroaromatic compounds in solution, the ΔRE and the differences in heats of atomization ΔΔH₃ calculated by QRT can be used to rationalize and predict the predominant tautomer and the shifting trend in the equilibrium for a series of similar compounds

Youji Huaxue published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C22H12F6O6S2, COA of Formula: C4H4OS.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kassie, Abebu A. published the artcileSynthesis and Reactivity of Zr MOFs Assembled from P^NN^NP-Ru Pincer Complexes, Recommanded Product: Triethylsilanol, the publication is Organometallics (2019), 38(18), 3419-3428, database is CAplus.

Three isostructural Zr metal-organic frameworks were synthesized from P^NN^NP-Ru pincer metallolinkers bearing different combinations of ancillary ligands (1, Zr₆O₄(OH)₄(OAc)₄{cis-(P^NN^NP)RuCl₂(CO)}₂; 2, Zr₆O₄(OH)₄(O₂CH)₄{(P^NN^NP)RuCl(CO)₂}₂Cl₂; 3, Zr₆O₄(OH)₄(OAc)₄{cis-/trans-(P^NN^NP)RuCl₂(CO)}₂; P^NN^NP = 2,6-(HNPAr₂)₂C₅H₃N; Ar = p-C₆H₄CO₂^–). The structure and composition of the P^NN^NP-Ru pincer MOFs were determined using synchrotron X-ray powder diffraction, solid- and solution-state NMR spectroscopy, IR spectroscopy, and elemental anal. Reaction of 2 with KO^tBu results in deprotonation of an NH group of the P^NN^NP-RuCl(CO)₂ linkers. Subsequent treatment with Me₃NO removes a Ru-coordinated CO ligand, generating 2–b (5), which proved to be a recyclable catalyst for the hydrosilylation of aryl aldehydes with Et₃SiH. A similar postsynthetic treatment of 1 and 3 does not generate active catalysts, highlighting the importance of precatalyst design and activation. A homogeneous analog of 2–b also showed inferior catalytic performance, demonstrating the benefit of catalyst immobilization.

Organometallics published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Bang-Jin published the artcileAn enantioselective potentiometric sensor for 2-amino-1-butanol based on chiral porous organic cage CC3-R, Related Products of alcohols-buliding-blocks, the publication is Molecules (2019), 24(3), 420/1-420/9, database is CAplus and MEDLINE.

Porous organic cages (POCs) have attracted extensive attention due to their unique structures and tremendous application potential in numerous areas. In this study, an enantioselective potentiometric sensor composed of a polyvinyl chloride (PVC) membrane electrode modified with CC3-R POC material was used for the recognition of enantiomers of 2-amino-1-butanol. After optimization, the developed sensor exhibited enantioselectivity toward S-2-amino-1-butanol (log KPotS,R = -0.98) with acceptable sensitivity, and a near-Nernstian response of 25.8 ± 0.3 mV/decade within a pH range of 6.0-9.0.

Molecules published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C9H22OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts