Author: tianli

Koester, Roland published the artcileBoron compounds. XXIX. Catalyzed diethylborylation of alcohols and phenols, Product Details of C4H7BrO, the publication is Justus Liebigs Annalen der Chemie (1975), 352-72, database is CAplus.

The elimination of 1 Et group as ethane from Et3B below 80° by ROH or dihydroxy organic compounds with Me3CCO2BEt2 as catalyst gave Et2BOR (R = Me, Et, Bu, allyl, propargyl, naphthyl, etc.) and (Et2BO)2X (X = CH2CH2, (CH2)5, CH2CCCH2, 1,2-, 1,3-, 1,4-cyclohexanediyl, etc.). Other trialkylboranes react more slowly than Et3B, the rates decreasing: BEt3 > BPr3 > B(CHMe2)3 > B(CH2CHMe2)3. Borylations with BMe3 are very slow and do not proceed uniformly. Alkyl pivalates, pivalonitrile, and other derivatives of pivalic acid and derivatives of other carboxylic acids are less active as catalysts; the catalyzed diethylborylations of hydroxy compounds containing C:C or CC bonds, halogens, carboxylate and aromatic nitro groups all proceed without side reactions. The catalytic diethylborylation is effective for the quant. determination of hydroxy groups in alcs.

Justus Liebigs Annalen der Chemie published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Product Details of C4H7BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Mol, Eva published the artcileEPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor, COA of Formula: C3H6O2, the publication is ACS Chemical Biology (2016), 11(9), 2499-2505, database is CAplus and MEDLINE.

Castration-resistant prostate cancer is the lethal condition suffered by prostate cancer patients that become refractory to androgen deprivation therapy. EPI-001 is a recently identified compound active against this condition that modulates the activity of the androgen receptor, a nuclear receptor that is essential for disease progression. The mechanism by which this compound exerts its inhibitory activity is however not yet fully understood. Here we show, by using high resolution solution NMR spectroscopy, that EPI-001 selectively interacts with a partially folded region of the transactivation domain of the androgen receptor, known as transactivation unit 5, that is key for the ability of prostate cells to proliferate in the absence of androgens, a distinctive feature of castration-resistant prostate cancer. Our results can contribute to the development of more potent and less toxic novel androgen receptor antagonists for treating this disease.

ACS Chemical Biology published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, COA of Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Qinghua published the artcile¹⁹F magnetic resonance imaging enabled real-time, non-invasive and precise localization and quantification of the degradation rate of hydrogel scaffolds in vivo, Name: 3,3,3-Trifluoropropan-1-ol, the publication is Biomaterials Science (2020), 8(12), 3301-3309, database is CAplus and MEDLINE.

The degradation behavior of hydrogel scaffolds is closely related to the controlled release of bioactive agents and matching with the proliferative demands of newly generated tissues. Here, for the first time, we presented the use of ¹⁹F magnetic resonance imaging (¹⁹F MRI) to precisely monitor the localization and quantify the degradation rate of implantable or injectable hydrogels in a real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth. The total voxel and content in the region of interest (ROI) were linearly correlated to the injection amount, providing exact 3D stereoscopic and 2D anatomical information in the meantime. Moreover, a computational algorithm was established to present the real-time degradation rate in vivo as a function of time, which was implemented directly from the ¹⁹F MRI dataset. In addition, labeling with a zwitterionic ¹⁹F contrast agent demonstrated a facile and general applicability for multiple types of materials with no influence on their original gelation properties as well as ¹⁹F NMR properties in the hydrogel matrix. Therefore, this ¹⁹F MRI method offers a new approach to non-invasively track the degradation rate of hydrogel scaffolds in vivo in a precise localization and accurate quantification way, which will suffice the need for the evaluation of implants at deep depths in large animals or human objects.

Biomaterials Science published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Name: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Haibin published the artcileColloidal self-assembly based all-metal metasurface absorbers to achieve broadband, polarization-independent light absorption at UV-Vis frequencies, HPLC of Formula: 111-29-5, the publication is Applied Surface Science (2022), 152624, database is CAplus.

Here, we demonstrate a straightforward colloidal self-assembly strategy to fabricate metasurface absorbers (MAs) with efficient broadband light absorption from UV to visible (Vis) spectral range. In this study, high-index faceted colloidal Au nanocrystals (NCs), i.e., Au icosidodecahedron with active surface plasmonic modes, are innovatively designed as the meta-atoms, while a facile electrostatic self-assembly progress is implemented to arrange these meta-atoms onto a gold reflecting film, resulting in MAs with all-metal structures. Optical characterizations show that the well-designed MAs with a 28-32% surface coverage of Au meta-atoms exhibit an average light absorption above 94% within the wavelengths ranging from 200 to 600 nm. Moreover, the particular absorption behaviors of the designed MAs are inherently polarization-independent for a broad range of incident angles (0-45°) owing to the ultrathin structure and topol. symmetry of the devices. It has been inferred that the pos. localized surface plasmon and gap plasmon resonances excited from the adjacent Au meta-atoms and gold film are critical for self-assembled MAs with excellent absorbing performances. Overall, this work provide an alternative and simple pathway for the construction of scalable and practical UV-Vis MAs, which may facilitate the high-frequency optical applications of thermophotovoltaics, photoelec. devices and photochem. systems.

Applied Surface Science published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C20H32B2O4, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Jintao published the artcileCopper-catalyzed aerobic oxidation of silanes to silanols, Computed Properties of 597-52-4, the publication is Changzhou Daxue Xuebao, Ziran Kexueban (2016), 28(1), 43-47, database is CAplus.

The Cu(OAc)₂-catalyzed selective hydrolytic oxidation of silanes toward the silanols using water as the oxidant was achieved. All the products were characterized by ¹H NMR, ¹³C NMR and GCMS. Compared with other methods, this silane hydrolysis protocol is featured with the solvent-free mild reaction conditions using H₂O as clean oxidant with good substrate compatibility. This work provides a new approach toward the synthesis of silanols.

Changzhou Daxue Xuebao, Ziran Kexueban published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C15H12O6, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhuang, Haining published the artcileIsolation, identification, and application of yeast strains from the local ecosystem of Summer Black vineyard, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of Food Processing and Preservation (2022), 46(3), e16341, database is CAplus.

Several indigenous yeast strains originating from the local ecosystems of Summer Black vineyard in Jingjiang, Jiangsu, China, were isolated and identified using Wallenstein Laboratory (WL) medium combined with 26S rDNA D1/D2 region sequence anal. The 18 isolated colonies were classified into four different culture types. Two yeast strains were selected for vinification of Summer Black wines, and the volatile compounds were analyzed by headspace solid-phase microextraction-gas chromatog.-mass spectrometry (HS-SPME/GC-MS). 2,3-butanediol, Et octanoate, Et hexanoate, and Et decanoate were the key odor-active compounds The wines vinificated using the two selected yeast strains had higher quantities of identified compounds than that vinificated by com. yeast. The two yeast strains isolated from the local ecosystem of Summer Black vineyard were more effective in producing aroma in Summer Black wines than com. yeast was. This study will give some guidance or fundamental data toward wine making and yeast selection and fermentation Novelty impact statement : Saccharomyces cerevisiae and Brettanomyces bruxellensis were two main strains isolated from local “Summer Black” grape yard located in Jingjiang, Jiangsu Province, China. 2,3-butanediol, Et octanoate, Et hexanoate, and Et decanoate were major contributors to the flavor of the grape wine. The two yeast strains were much more effective in producing aroma in wine than com. yeast strain BV818.

Journal of Food Processing and Preservation published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C18H26ClN3O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Shihuan published the artcileHollow fiber membrane-protected amino/hydroxyl bifunctional microporous organic network fiber for solid-phase microextraction of bisphenols A, F, S, and triclosan in breast milk and infant formula, Safety of 4,4′-Sulfonyldiphenol, the publication is Food Chemistry (2022), 133217, database is CAplus and MEDLINE.

Bisphenols and triclosan have been used in various products, and exposure to these chems. may affect human health. The present study proposes a sensitive method for the determination of bisphenols A, F, S, and triclosan. The fiber was coated by amino/hydroxyl bifunctional microporous organic network and protected by polyvinylidene fluoride hollow fiber membrane for direct immersion solid phase microextraction The limit of detection was 0.005μg/L (μg/kg), and the recoveries were in the range of 76.7% to 107.5% (87.4% to 107.6%) for breast milk (infant formula), with intra-day and inter-day precisions <10.5% (7.3%) and 13.6% (8.4%), resp. Fiber-to-fiber reproducibility of < 9.5% and a lifespan of >100 cycles were obtained. The 95th percentile estimated daily intake of total bisphenols was close to temporary tolerable daily intake for infants fed by human milk, which highlighted the needs for further attention on human exposure to BPA and its substitutes.

Food Chemistry published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Safety of 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Qiuxu published the artcileSimultaneous determination of seven bisphenol analogues in surface water by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry, Quality Control of 80-09-1, the publication is Microchemical Journal (2022), 107098, database is CAplus.

For the simultaneous determination of seven types of bisphenol analogs (BPs) in surface water, a method combining solid-phase extraction (SPE) with ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) was developed. The extraction efficiency was improved by optimizing the parameters that affect it, including the sorbent types of SPE cartridge, pH, enrichment factor, flow rate, rinsing and elution volume On the basis of the single factor experiments, an attempt to obtain the result of optimizing by response surface methodol. was made, and the optimal parameters were as follows: at a flow rate of 8 mL/min, 1000 mL of water sample was run through the hydrophilic-lipophilic balance cartridge, rinsed with 10% methanol, eluted with 9 mL methanol, and concentrated with nitrogen using an automatic SPE system. The analytes were separated on an Acquity UPLC BEH C18 column using gradient elution with a mobile phase of acetonitrile and 0.05% (volume/volume) ammonia, and then analyzed using UPLC-MS/MS with multiple reaction monitoring in the neg.-ion mode, with an 8-min chromatog. run time. In the range of 1.0-500μg/L, seven BPs showed good linearity with the correlation coefficient greater than 0.998. The recovery ranged from 82.3 to 96.7%, and the range of matrix effect was 89.2 to 107%. These results indicated excellent recovery and minimal matrix effect. The limits of detection were 0.05-1.5 ng/L, the relative standard deviation ranged from 2.9 to 8.5%. Applying the developed method, seven BPs in Luoma Lake and its inflow rivers were analyzed. Only five BPs were detected in Luoma Lake and four BPs were detected in inflow rivers, and the concentrations of the detected BPs were determined BPA and BPF were the predominant BPs, and the concentration of BPA was the highest.

Microchemical Journal published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C8H6ClF3, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Baoguo published the artcileSelection of drying techniques for Pingyin rose on the basis of physicochemical properties and volatile compounds retention, COA of Formula: C10H18O, the publication is Food Chemistry (2022), 132539, database is CAplus and MEDLINE.

Awareness of edible rose being beneficial for health has attracted researchers in exploring different rose products. The study aimed to investigate effects of vacuum freeze drying (VFD), hot air drying (HAD), heat pump drying (HPD), relative humidity drying (RHD) and catalytic IR drying (CID) on the physicochem. properties, and volatile organic compounds (VOCs) of Pingyin roses. Results showed that the VFD roses had significantly (p < 0.05) bright color, complete tissue cells, low shrinkage, and good plasma membrane permeability. CID roses showed the highest total phenols content (164.09 ± 0.88 mg/g) and the strongest antioxidant activity. Besides, the odor is the most crucial indicator for dried roses. VFD can well prevent the odor from diminishing/destroying and preserve the natural smell of rose. Thermal drying including HAD, HPD, RHD, and CID, could cause significant losses of VOCs. Consequently, the findings can provide the scientific basis for future large-scale production of dried rose products.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C12H10FeO4, COA of Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Chen published the artcileManipulating the Assembly of Au Nanoclusters for Luminescence Enhancement and Circularly Polarized Luminescence, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Nanomaterials (2022), 12(9), 1453, database is CAplus and MEDLINE.

Au nanocluster (AuNCs)-based luminescent functional materials have attracted the interest of researchers owing to their small size, tractable surface modification, phosphorescence lifetime and biocompatibility. However, the poor luminescence quantum yield (QY) of AuNCs limits their practical applications. Herein, we synthesized a type of AuNCs modified by 4,6-diamino-2-mercaptopyrimidine hydrate (DPT-AuNCs). Furthermore, organic acids, i.e., citric acid (CA) and tartaric acid (TA), were chosen for co-assembly with DPT-AuNCs to produce AuNCs-based luminescent materials with enhanced emission. Firstly, it was found that CA could significantly enhance the emission of DPT-AuNCs with the formation of red emission nanofibers (QY = 17.31%), which showed a potential for usage in I- detection. The n···π/π···π interaction between the CA and the DPT ligand was proposed as crucial for the emission. Moreover, chiral TA could not only improve the emission of DPT-AuNCs, but could also transfer its chirality to DPT-AuNCs and induce the formation of circularly polarized luminescence (CPL)-active nanofibers. It was demonstrated that the CPL signal could increase 4.6-fold in a ternary CA/TA/DPT-AuNCs co-assembly system. This work provides a convenient way to build AuNCs-based luminescent materials as probes, and opens a new avenue for building CPL-active materials by achiral NCs through a co-assembly strategy.

Nanomaterials published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts