Author: tianli

Glover, Stephen A. published the artcileStable hydroperoxide synthesis, Synthetic Route of 596-38-3, the publication is South African Journal of Chemistry (1984), 37(4), 164-70, database is CAplus.

The photooxidation of 9-phenylxanthene to its 9-hydroperoxy derivative was shown to be ketone-sensitized and sensitive to the wavelength of the irradiation Highest yields are obtained from irradiation at wavelengths > 310 nm. Prolonged irradiation produces bis(9-phenylxanthen-9-yl) peroxide. 5-Phenyltribenzo[a,c,e]cycloheptene could not be converted into peroxidic products, and dioxolanes produced labile peroxides under irradiation

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Giri, Rajan published the artcileSynthesis and cancer cell cytotoxicity of substituted xanthenes, Category: alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2010), 18(4), 1456-1463, database is CAplus and MEDLINE.

A series of substituted xanthenes was synthesized and screened for activity using DU-145, MCF-7, and HeLa cancer cell growth inhibition assays. The most potent compound, 9g (I) ([N,N-diethyl]-9-hydroxy-9-(3-methoxyphenyl)-9H-xanthene-3-carboxamide), was found to inhibit cancer cell growth with IC₅₀ values ranging from 36 to 50 μM across all three cancer cell lines. Structure-activity relationship (SAR) data is presented that indicates addnl. gains in potency may be realized through further derivatization of the compounds (e.g., the incorporation of a 7-fluoro substituent to 9g). Results are also presented that suggest the compounds function through a unique mechanism of action as compared to that of related acridine and xanthone anticancer agents (which have been shown to intercalate into DNA and inhibit topoisomerase II activity). A structural comparison of these compounds suggests the differences in function may be due to the structure of the xanthene heterocycle which adopts a nonplanar conformation about the pyran ring.

Bioorganic & Medicinal Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Calderon, Davir published the artcileA Novel Chemoselective Cleavage of (tert-Butyl)(dimethyl)silyl (TBS) Ethers Catalyzed by Ce(SO₄)₂.4 H₂O, Recommanded Product: Triisopropylsilanol, the publication is Helvetica Chimica Acta (2014), 97(7), 965-972, database is CAplus.

(tert-Butyl)(dimethyl)silyl (tBuMe₂Si; TBS) phenyl/alkyl ethers were efficiently cleaved to the corresponding parent hydroxy compounds in good yields using catalytic amounts of Ce(SO₄)₂.4 H₂O by microwave-assisted or conventional heating in MeOH. Intramol. and competitive experiments demonstrated the chemoselective deprotection of TBS ethers in the presence of triisopropylsilyl (ⁱPr₃Si; TIPS) and (tert-butyl)(diphenyl)silyl (tBuPh₂Si; TBDPS) ethers.

Helvetica Chimica Acta published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hidalgo-Liberona, Nicole published the artcileIncreased intestinal permeability in older subjects impacts the beneficial effects of dietary polyphenols by modulating their bioavailability, Formula: C8H8O3, the publication is Journal of Agricultural and Food Chemistry (2020), 68(44), 12476-12484, database is CAplus and MEDLINE.

Polyphenols have great potential in regulating intestinal health and ameliorating pathol. conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochems. may significantly be influenced by interindividual variability factors affecting their bioavailability and consequent biol. activity. In the present study, urine samples collected from older subjects undergoing a crossover intervention trial with polyphenol-rich foods were subjected to metabolomics anal. for investigating the impact of increased IP on the bioavailability of polyphenols. Interestingly, urinary levels of phase II and microbiota-derived metabolites were significantly different between subjects with healthier intestinal barrier integrity and those with increased IP disruption. Our results support that this IP-dependent impaired bioavailability of polyphenols could be attributed to disturbances in the gut microbial metabolism and phase II methylation processes. Furthermore, we also observed that microbiota-derived metabolites could be largely responsible for the biol. activity elicited by dietary polyphenols against age-related disrupted IP.

Journal of Agricultural and Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Carbo, Jorge J. published the artcileConstruction of titanasiloxanes by incorporation of silanols to the metal oxide model [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ₃-CR)]: DFT elucidation of the reaction mechanism, Product Details of C9H22OSi, the publication is Chemistry – A European Journal (2008), 14(26), 7930-7938, database is CAplus and MEDLINE.

A family of novel titanasiloxanes containing the structural unit {[Ti(η⁵-C₅Me₅)O]₃} were synthesized by hydron-transfer processes involving reactions with equimol. amounts of μ₃-alkylidyne derivatives [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ₃-CR)] (R = H (1), Me (2)) and monosilanols, R₃‘Si(OH), silanediols, R₂‘Si(OH)₂, and the silanetriol tBuSi(OH)₃. Treatment of 1 and 2 with triorganosilanols (R’ = Ph, iPr) in hexane affords the new metallasiloxane derivatives [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ-CHR)(OSiR₃‘)] (R = H, R’ = Ph (3), iPr (4); R = Me, R’ = Ph (5), iPr (6)). Analogous reactions with silanediols, (R’ = Ph, iPr), give the cyclic titanasiloxanes [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ-O₂SiR’₂)(R)] (R = Me, R’ = Ph (7), iPr (8): R = Et, R’ = Ph (9), iPr (10)). Use of tBuSi(OH)₃ with 1 or 2 at room temperature produces the intermediate complexes [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ-O₂Si(OH)tBu)(R)] (R = Me (11), Et (12)). Further heating of solutions of 11 or 12 affords the same compound with an adamantanoid structure, [{Ti(η⁵-C₅Me₅)(μ-O)}₃(η-O₃SitBu)] (13) and methane or ethane elimination, resp. The x-ray crystal structures of 3, 4, 6, 8, 10, 12, and 13 were determined To gain an insight into the mechanism of these reactions, DFT calculations were performed on the incorporation of monosilanol to the model complex [{Ti(η⁵-C₅H₅)(μ-O)}₃(μ₃-CMe)] (2H). The propose mechanism consists of three steps: (1) hydron transfer from the silanol to one of the O atoms of the Ti₃O₃ ring, forming a titanasiloxane; (2) intramol. hydron migration to the alkylidyne moiety; and (3) a μ-alkylidene ligand rotation to give the final product.

Chemistry – A European Journal published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sharma, Hemant K. published the artcileSiloxymethylamines as aminomethylation reagents for amines leading to labile diaminomethanes that can be trapped as their [Mo(CO)₄] complexes, Computed Properties of 597-52-4, the publication is Chemistry – A European Journal (2016), 22(22), 7363-7366, database is CAplus and MEDLINE.

Compound Et₃SiOCH₂NMe₂ transfers the aminomethyl group, Me₂NCH₂ to R₂NH (R₂ = Et₂, PhMe, [Cr(η⁶-C₆H₅)(CO)₃]Me, PhH) giving previously unknown diaminomethanes, Me₂NCH₂NR₂ and, in the case of R₂ = PhH, the triamine Me₂NCH₂N(Ph)CH₂NMe₂. The diaminomethanes exhibit an unreported disproportionation to a mixture of (R₂N)₂CH₂, (Me₂N)₂CH₂, and Me₂NCH₂NR₂, which can be trapped as their [Mo(CO)₄(diamine)] complexes. Whereas PhMeNCH₂NMe₂ is a labile compound, the metal-substituted [(η⁶-C₆H₅)Cr(CO)₃]MeNCH₂NMe₂ is a stable material. The triamine Me₂NCH₂N(Ph)CH₂NMe₂ is unstable with respect to transformation to 1,3,5-triphenyltriazine, but is readily trapped as the bidentate-triamine Mo(CO)₄ complex. All metal complexes were characterized by single-crystal x-ray diffraction.

Chemistry – A European Journal published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C4H6O3, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Peng published the artcileSolvent-free, B(C₆F₅)₃-Catalyzed S-H Insertion of Thiophenols and Thiols with α-Diazoesters, Quality Control of 4410-99-5, the publication is Chemistry – An Asian Journal (2022), 17(16), e202200465, database is CAplus and MEDLINE.

A B(C₆F₅)₃-catalyzed S-H insertion reaction of thiophenols and thiols with α-diazoesters to access valuable α-thioesters was described. With the established protocol, an array of α-thioester products were generated in moderate to good yields with broad scope and functional group tolerance. In addition, this reaction maintained its high efficiency on gram scale and the product can be easily transformed into other useful motifs. This reaction proceeded under solvent-free conditions at room temperature, and generally finished in twenty minutes upon magnet stirring, which offers an expedient way for synthesis of thioether-containing compounds

Chemistry – An Asian Journal published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H11NO, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bao, Zhi-hui published the artcileClinical analysis of carboprost tromethamine and misoprostol in the prevention of postpartum hemorrhage of high-risk pregnant women after cesarean section, Related Products of alcohols-buliding-blocks, the publication is Shiyong Yaowu Yu Linchuang (2014), 17(2), 243-245, database is CAplus.

Objective: To compare the value of carboprost tromethamine and misoprostol in the prevention and treatment of postpartum hemorrhage in high-risk pregnant women after cesarean section. Methods: 102 cases of high-risk pregnant women were randomly divided into 2 groups, 52 cases in group A were treated with carboprost tromethamine, while 52 cases in group B were treated with misoprostol. The postpartum hemorrhage rate and the amount of bleeding were compared between the two groups. Results: There was no significant difference in the postpartum hemorrhage rate between the 2 groups (P > 0.05). The amount of bleeding at postpartum 2 h and 24 h in group A were less than those of group B (P < 0.05). No significant difference was found in the incidence of adverse reactions between the 2 groups (P > 0.05). Conclusion: Carboprost tromethamine can prevent postpartum hemorrhage, and the effect is superior to that of misoprostol, it can improve the rate of contraction of the uterus, and reduce the rate of postpartum hemorrhage.

Shiyong Yaowu Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Jiandong published the artcileNickel-catalyzed, regio- and enantioselective benzylic alkenylation of olefins with alkenyl bromide, SDS of cas: 20880-92-6, the publication is Angewandte Chemie, International Edition (2021), 60(8), 4060-4064, database is CAplus and MEDLINE.

A NiH-catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has been developed, affording benzylic alkenylation products with high yields and excellent chemoselectivity. The mild conditions of the reaction preclude olefinic products from undergoing further isomerization or subsequent alkenylation. Catalytic enantioselective hydroalkenylation of styrenes was achieved by using a chiral bisoxazoline ligand.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arzumanyan, Ashot V. published the artcileAerobic Co or Cu/NHPI-catalyzed oxidation of hydride siloxanes: synthesis of siloxanols, HPLC of Formula: 597-52-4, the publication is Green Chemistry (2018), 20(7), 1467-1471, database is CAplus.

A highly efficient preparative method for the synthesis of siloxanols based on aerobic Co(OAc)₂ or Cu(OAc)₂/NHPI-catalyzed oxidation of hydrosilanes and hydrosiloxanes using “green”, com. available, simple inexpensive reagents and mild reaction conditions has been proposed. This is a general reaction for the synthesis of mono-, oligo- and polymeric siloxanols with various structures (linear, branched and cyclic).

Green Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, HPLC of Formula: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts