Author: tianli

Wahlang, Banrida published the artcileAssociations between residential exposure to volatile organic compounds and liver injury markers, HPLC of Formula: 90-64-2, the publication is Toxicological Sciences (2022), 185(1), 50-63, database is CAplus and MEDLINE.

Occupational exposures to volatile organic compounds (VOCs) have been associated with numerous health complications including steatohepatitis and liver cancer. To address this knowledge gap, the objective of this cross-sectional study is to investigate associations between VOCs and liver injury biomarkers in community residents. Subjects were recruited from six Louisville neighborhoods, and informed consent was obtained. Exposure biomarkers included 16 creatinine-adjusted urinary metabolites corresponding to 12 parent VOCs. Serol. disease biomarkers measured included cytokertain-18 (K18 M65 and M30), liver enzymes, and direct bilirubin. The population comprised of approx. 60% females and 40% males; White persons accounted 78% of the population; with more nonsmokers (n = 413) than smokers (n = 250). In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene, and xylene were pos. associated with alk. phosphatase. These associations persisted in smokers, with the exception of crotonaldehyde, and addition of N,N-dimethylformamide and propylene oxide metabolites. Although no pos. associations were observed for K18 M30, the benzene metabolite was pos. associated with bilirubin, irresp. of smoking status. Taken together, the results demonstrated that selected VOCs were pos. associated with liver injury biomarkers. These findings will enable better risk assessment and identification of populations vulnerable to liver disease.

Toxicological Sciences published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C5H5BrN2, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Riva, Beatrice published the artcilePyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis, Formula: C6H13NO2, the publication is Journal of Medicinal Chemistry (2018), 61(21), 9756-9783, database is CAplus and MEDLINE.

In recent years, channels that mediate store-operated calcium entry (SOCE, i.e., the ability of cells to sense a decrease in endoplasmic reticulum luminal calcium and induce calcium entry across the plasma membrane) have been associated with a number of disorders, spanning from immune disorders to acute pancreatitis and have been suggested to be druggable targets. In the present contribution, we exploited the click chem. approach to synthesize a class of SOCE modulators where the arylamide substructure that characterizes most inhibitors so far described is substituted by a 1,4-disubstituted 1,2,3-triazole ring. Within this series, inhibitors of SOCE were identified and the best compound I proved effective in an animal model of acute pancreatitis, a disease characterized by a hyperactivation of SOCE. Strikingly, two enhancers of the process were discovered, affording invaluable research tools to further explore the (patho)physiol. role of capacitative calcium entry.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Formula: C6H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boontanonda, Pavares published the artcilePalladium(II)-catalyzed ring expansion of methylenecyclobutanes and related systems, Formula: C5H10O, the publication is Journal of the Chemical Society, Chemical Communications (1977), 583-4, database is CAplus.

Treatment of methylenecyclobutane (I; R = H) with PdCl₂-CuCl₂-O₂-H₂O in C₆H₆ at 0° gave 75% cyclopentanone (II; R = H). I (R = CH₂NHAc, CN) underwent analogous oxidative ring expansion at room temperature and 60° resp. on treatment with PdCl₂-CuCl₂-O₂-H₂O in EtOAc to give 65 and 82% II resp., whereas similar treatment of camphene (iso-PrOH, 65°), methylenecamphor (EtOAc, 45°) and methylenecyclopentane (EtOAc, 65°) gave only low yields of the corresponding ring expanded products. Methylenenorbornane (iso-PrOH, 45°), and β-pinene (Me₃COH, 45°) gave the corresponding bis-π-allyl palladium chloride dimers quant. on treatment with PdCl₂3-CuCl₂-O₂-H₂O whereas similar treatment of 4-RC₆H₄CPh:CH₂ (R = H, MeO) gave 28.5% Ph₂CO and 28.5% PhCH₂COPh, and 62.5% PhCOC₆H₄OMe-4, resp.

Journal of the Chemical Society, Chemical Communications published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Formula: C5H10O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yekai published the artcileMetabolic signature of the aging eye in mice, HPLC of Formula: 86-48-6, the publication is Neurobiology of Aging (2018), 223-233, database is CAplus and MEDLINE.

Aging is a major risk factor for age-related ocular diseases including age-related macular degeneration in the retina and retinal pigment epithelium (RPE), cataracts in the lens, glaucoma in the optic nerve, and dry eye syndrome in the cornea. We used targeted metabolomics to analyze metabolites from young (6 wk) and old (73 wk) eyes in C57 BL6/J mice. Old mice had diminished electroretinogram responses and decreased number of photoreceptors in their retinas. Among the 297 detected metabolites, 45-114 metabolites are significantly altered in aged eye tissues, mostly in the neuronal tissues (retina and optic nerve) and less in cornea, RPE/choroid, and lens. We noted that changes of metabolites in mitochondrial metabolism and glucose metabolism are common features in the aged retina, RPE/choroid, and optic nerve. The aging retina, cornea, and optic nerve also share similar changes in NAD (NAD), 1-methylnicotinamides, 3-methylhistidine, and other methylated metabolites. Metabolites in taurine metabolism are strikingly influenced by aging in the cornea and lens. In conclusion, the aging eye has both common and tissue-specific metabolic signatures. These changes may be attributed to dysregulated mitochondrial metabolism, reprogrammed glucose metabolism and impaired methylation in the aging eye. Our findings provide biochem. insights into the mechanisms of age-related ocular changes.

Neurobiology of Aging published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C12H14O2, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sircar, Ila published the artcileCalcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3-pyridinecarboxylate and analogs. Synthesis and structure-activity relationships, Formula: C10H15NO, the publication is Journal of Medicinal Chemistry (1991), 34(7), 2248-60, database is CAplus and MEDLINE.

A series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxylic acid esters and analogs, e.g., I, were prepared via a three component Hantzsch reaction using a substituted benzaldehyde, enamine, and the requisite β-keto ester. These compounds possess unique profile, namely calcium channel blocking and pos. inotropic activities in vitro. Compound I was selected as the best compound in the series and was studied in detail. The synthesis and biol. profiles of enantiomers of I are also reported. The data indicate that although the calcium channel blocking property of I is stereospecific the pos. inotropic activity is not. Examples of 3- and 6-cyano and other closely related 1,4-dihydropyridine derivatives are described and evaluated for comparison and were found to be devoid of dual activities mentioned above.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C8H6BrF3S, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Matviitsuk, Anastassia published the artcileUnanticipated Silyl Transfer in Enantioselective α,β-Unsaturated Acyl Ammonium Catalysis Using Silyl Nitronates, Application of Triisopropylsilanol, the publication is Organic Letters (2020), 22(1), 335-339, database is CAplus and MEDLINE.

The use of silyl nitronates is reported for the isothiourea-catalyzed synthesis of γ-nitro-substituted silyl esters containing up to two contiguous stereocenters in good yields with excellent enantioselectivities (up to 93% yield and 99:1 er). The serendipitously discovered formation of silyl ester products in this reaction demonstrates a novel platform for catalyst turnover in α,β-unsaturated acyl ammonium catalysis.

Organic Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghislieri, Diego published the artcileEngineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products, COA of Formula: C8H19NO2, the publication is Journal of the American Chemical Society (2013), 135(29), 10863-10869, database is CAplus and MEDLINE.

The development of cost-effective and sustainable catalytic methods for the production of enantiomerically pure chiral amines is a key challenge facing the pharmaceutical and fine chem. industries. This challenge is highlighted by the estimate that 40-45% of drug candidates contain a chiral amine, fueling a demand for broadly applicable synthetic methods that deliver target structures in high yield and enantiomeric excess. Herein we describe the development and application of a “toolbox” of monoamine oxidase variants from Aspergillus niger (MAO-N) which display remarkable substrate scope and tolerance for sterically demanding motifs, including a new variant, which exhibits high activity and enantioselectivity toward substrates containing the aminodiphenylmethane (benzhydrylamine) template. By combining rational structure-guided engineering with high-throughput screening, it has been possible to expand the substrate scope of MAO-N to accommodate amine substrates containing bulky aryl substituents. These engineered MAO-N biocatalysts have been applied in deracemization reactions for the efficient asym. synthesis of the generic active pharmaceutical ingredients Solifenacin and Levocetirizine as well as the natural products (R)-coniine, (R)-eleagnine, and (R)-leptaflorine. We also report a novel MAO-N mediated asym. oxidative Pictet-Spengler approach to the synthesis of (R)-harmicine.

Journal of the American Chemical Society published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Askey, Hannah E. published the artcilePhotocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines, Quality Control of 6346-09-4, the publication is Journal of the American Chemical Society (2021), 143(39), 15936-15945, database is CAplus and MEDLINE.

A solution to these problems using organophotoredox catalysis, enabling a direct, modular and sustainable preparation of α-(di)substituted γ-arylamines, including challenging electron-neutral and moderately electron-rich aryl groups was reported. A broad range of functionalities were tolerated, and the reactions was run on multigram scale in continuous flow. The method was applied to a concise, protecting-group-free synthesis of the blockbuster drug Fingolimod, as well as a phosphonate mimic of its in-vivo active form (by iterative α-C-H functionalization of ethanolamine). The reaction was sequenced with an intramol. N-arylation to provided a general and modular access to valuable (spirocyclic) 1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydronaphthyridines. Mechanistic and kinetic studies supportes an irreversible hydrogen atom transfer activation of the alkylamine by the azidyl radical and some contribution from a radical chain. The reaction was photon-limited and exhibits a zero-order dependence on amine, azide, and photocatalyst, with a first-order dependence on styrene.

Journal of the American Chemical Society published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Langford, Vaughan S. published the artcileSelected ion flow tube studies of several siloxanes, HPLC of Formula: 597-52-4, the publication is Rapid Communications in Mass Spectrometry (2013), 27(6), 700-706, database is CAplus and MEDLINE.

People are using increasing amounts of siloxanes which ultimately end up in landfills, then in landfill gas and biogas digesters. Their presence poses difficulties for industries to use the energy content of landfill gas and biogas because the combustion process oxidizes Si to SiO₂ which in turn damages engine parts. Rapid, efficient, accurate methods are needed to quantify the presence of siloxanes. Selected ion flow tube mass spectrometry (SIFTMS), an emerging real-time technique, is used to monitor trace volatile compounds in air. Samples containing the trace volatile compounds are drawn into the flow tube and convected in a He stream. Chem. ionization reactions from mass-selected reagent ions with the volatile compounds occur. To quantify volatile compounds in the sample, the ion chem. of the reagent ion with each volatile must be known. Rate coefficients and product ion branching ratios were determined for dodecamethylpentasiloxane, decamethylcyclopentasiloxane, decamethyltetrasiloxane, octamethylcyclotetrasiloxane, triethylsilanol, tetramethylsilane, and hexamethyldisilazane. The ion/mol. reactions of these 7 Si-containing compounds were fast, occurring at or near the collision rate, allowing for low concentration detection. The very simple reaction chem. of proton transfer, electron transfer, and Me loss enables easy siloxane quantitation in landfill gas and biogas by SIFTMS. Copyright © 2013 John Wiley & Sons, Ltd.

Rapid Communications in Mass Spectrometry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, HPLC of Formula: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Villemin, Elise published the artcilePolydiacetylene Nanotubes in Heterogeneous Catalysis: Application to the Gold-Mediated Oxidation of Silanes, Synthetic Route of 17877-23-5, the publication is Macromolecular Chemistry and Physics (2015), 216(24), 2398-2403, database is CAplus.

A layer-by-layer approach is used to anchor small gold nanoparticles onto organic nanotubes resulting from the self-assembly and polymerization of diacetylene-containing nitrilotriacetic amphiphiles. The obtained nanotube-gold hybrid is used as a catalyst for the aerobic oxidation of various silanes. With minimal gold loading (0.05 mol%), all substrates are converted into the corresponding silanols with hydrogen gas as the only byproduct. The catalyst operates under mild conditions and can be easily recycled, losing neither activity nor selectivity.

Macromolecular Chemistry and Physics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C6H8O3, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts