Author: tianli

Zhu, Cheng published the artcileKinetics of nitrogen-, oxygen- and sulfur-containing compounds hydrotreating during co-processing of bio-crude with petroleum stream, Recommanded Product: 4-Propylphenol, the publication is Applied Catalysis, B: Environmental (2022), 121197, database is CAplus.

The rational selection of catalysts and process parameters for co-processing biomass- and waste-derived bio-crudes with petroleum streams requires detailed reaction networks and kinetics of the conversion of heteroatom-containing compounds existed in both kinds of feedstocks. We provide the kinetics and reaction networks for the hydrotreating of N,N-diethyldodecanamide and N-methyldodecanamide, model compounds of major components in bio-crudes from hydrothermal liquefaction of wet waste. Their conversion undergoes via two pathways over sulfided NiMo/Al₂O₃ catalyst: deoxygenation followed by denitrogenation of the amine intermediate (DO pathway), and denitrogenation followed by deoxygenation of the alkanol intermediate (DN pathway)-with the DO pathway dominant over the DN pathway. H2S inhibits the deoxygenation step and promotes the denitrogenation step in the DO pathway. The amine intermediate inhibits the amide conversion, with weaker effects on the conversion of secondary amide than on the tertiary amide. The kinetics of hydrotreating of several model compounds representing the main species during co-processing indicate that the removal of nitrogenous species, which are in large quantities and of varying structures, remains the main challenge (compared with S- and O-removal) for co-processing.

Applied Catalysis, B: Environmental published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C14H31NO2, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reitti, Marcus published the artcileSynthesis of Phenols and Aryl Silyl Ethers via Arylation of Complementary Hydroxide Surrogates, Synthetic Route of 17877-23-5, the publication is Organic Letters (2018), 20(7), 1785-1788, database is CAplus and MEDLINE.

Two transition-metal-free methods to access substituted phenols via the arylation of silanols or hydrogen peroxide with diaryliodonium salts are presented. The complementary reactivity of the two nucleophiles allows synthesis of a broad range of phenols without competing aryne formation, as illustrated by the synthesis of the anesthetic Propofol. Furthermore, silyl-protected phenols can easily be obtained, which are suitable for further transformations.

Organic Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shivarkar, Anandkumar B. published the artcileTandem Synthesis of β-Amino Alcohols from Aniline, Dialkyl Carbonate, and Ethylene Glycol, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Industrial & Engineering Chemistry Research (2008), 47(8), 2484-2494, database is CAplus.

An efficient tandem route for selective synthesis of β-amino alcs. from anilines, dialkyl carbonate and ethylene glycol in the presence of recyclable Na-Y zeolite was demonstrated. Transesterification of dialkyl carbonate by ethylene glycol produce ethylene carbonate which further reacts with aniline to give β-amino alcs. in a single step. This reaction system was studied under high-pressure and pot reaction condition. Various process parametric effects were studied for the reaction of aniline, dialkyl carbonate, and ethylene glycol. A maximum 51% yield of mono-β-amino alc., i.e., N-phenylethanolamine (NPEA). Is obtained under pressure conditions. The yield of NPEA was improved drastically (>91%) by carrying out the reaction under pot conditions using di-Et carbonate as transesterification agent. Finally activity and selectivity of solid catalyst was explained on the basis of nature of active sites and pore structure of the catalyst.

Industrial & Engineering Chemistry Research published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C8H9BFNO3, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qiao, Chunhua published the artcile5′-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins, SDS of cas: 328-90-5, the publication is Journal of Medicinal Chemistry (2007), 50(24), 6080-6094, database is CAplus and MEDLINE.

A study of the structure-activity relationships of 5′-O-[N-(salicyl)sulfamoyl]adenosine (6), a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase (MbtA, encoded by the gene Rv2384) in Mycobacterium tuberculosis, is described, targeting the salicyl moiety. A systematic series of analogs was prepared exploring the importance of substitution at the C-2 position revealing that a hydroxy group is required for optimal activity. Examination of a series of substituted salicyl derivatives indicated that substitution at C-4 was tolerated. Consequently, a series of analogs at this position provided 4-fluoro derivative, which displayed an impressive MIC₉₉ of 0.098 μM against whole-cell M. tuberculosis under iron-limiting conditions. Examination of other heterocyclic, cycloalkyl, alkyl, and aminoacyl replacements of the salicyl moiety demonstrated that these nonconservative modifications were poorly tolerated, a result consistent with the fairly strict substrate specificities of related nonribosomal peptide synthetase adenylation enzymes.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maji, Ankur published the artcileWell-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2022), 87(13), 8351-8367, database is CAplus and MEDLINE.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gong, Xiao-li published the artcileEffects of Bacillus megaterium 2980’s spore formation on 2 KGA production of Gluconobacter oxydans, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Gongye Weishengwu (2013), 43(6), 49-53, database is CAplus.

In order to determine the relationship between the spore formation of Bacillus megaterium 2980 (B, m 2980, called companion bacterium) and Gluconobacter oxydans (G. o, called acid-producing strain) in vitamin C two-step fermentation, the effects of the culture supernatant, the cytosol and the mixed component solution of companion bacterium which cultured for 12 h (not forming spores) and 36 h (forming spores) on the growth of G. o and its synthesizing ability of 2-keto-L-gulonic acid (2-KGA) were studied through the anal. of B. m 2980 growth characteristics. The results showed that when the B. m 2980 spores did not form, the culture supernatant, the cytosol and mixed component solution had low effects on the growth of acid-producing strain and its 2-KGA production The cytosol of B. m 2980 promoted the growth and 2 KGA production of G. o greater than that of the culture supernatant. After the spore formation of B. m 2980, the culture supernatant and mixed component solution of B. m 2980 affected growth and 2-KGA production of G. o significantly.

Gongye Weishengwu published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lyu, Shuxia published the artcileEffect of rare earth elements on vitamin C fermentation by mixed cultures, Formula: C6H10O7, the publication is International Journal of Agriculture and Biology (2014), 16(6), 1135-1140, database is CAplus.

In recent years, the research on rare earth metals has expanded to the field of microbiol. In China, the production of Vitamin C is through mixed culture fermentation, which transforms L-sorbose to 2-keto-L-gulonic acid (2-KGA), the precursor of Vitamin C. In this study we compared the yields of 2-KGA by an acid-producing strain of Ketogulonigenium vulgare that was co-cultured with different companion bacterial strains in the presence of four light rare earth elements, lanthanum, cerium, neodymium, and samarium at selected concentrations We found that all of the tested rare earth elements had a promoting effect on 2-KGA production at concentration up to 5 mM. At or above 10 mM, the yield of 2-KGA was reduced. When cultured sep. with 5 mM of given rare earth elements, the growth of two companion bacterial strains (Bacillus megaterium 25-B and B. subtilis A9) were both significantly reduced, while that of the K. vulgare strain was enhanced.

International Journal of Agriculture and Biology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Jiaxin published the artcileFood Waste Management Employing UV-Induced Black Soldier Flies: Metabolomic Analysis of Bioactive Components, Antioxidant Properties, and Antibacterial Potential, Synthetic Route of 90-64-2, the publication is International Journal of Environmental Research and Public Health (2022), 19(11), 6614, database is CAplus and MEDLINE.

Food waste, as a major part of municipal solid waste, has been increasingly generated worldwide. Efficient and feasible utilization of this waste material for biomanufg. is crucial to improving economic and environmental sustainability. In the present study, black soldier flies (BSF) larvae were used as carriers to treat and upcycle food waste. Larvae of the BSF were incubated with UV light for 10, 20, and 30 min at a wavelength of 257.3 nm and an intensity of 8 W. The food waste utilization efficiency, antioxidant assays, antibacterial activity, and bioactive metabolites without and with UV treatment were determined and compared. This showed that the BSF larvae feed utilization rate was around 75.6%, 77.7%, and 71.2% after UV treatment for 10, 20, and 30 min resp., contrasting with the non-UV induced group (73.7%). In addition, it was perceived that the UV exposure enhanced antioxidant and antimicrobial properties of BSF extracts, and the maximum values were observed after 20 min UV induction time. Moreover, UV-induced BSF extracts showed an improved metabolic profile than the control group, with a change in the amino acids, peptides, organic acids, lipids, organic oxides, and other derivatives This change in metabolomics profile boosted environmental signaling, degradation of starch, amino acids, sugars, and peptide metabolism It was concluded that the bioconversion of food wastes using UV-induced BSF larvae can enhance the generation of a variety of functional proteins and bioactive compounds with potent antioxidant and antimicrobial activity. However, more studies are required to exploit the efficiency of UV treatment in improving BSF′s potential for upcycling of food wastes.

International Journal of Environmental Research and Public Health published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Pingsheng published the artcileFluorine Meets Amine: Reducing Microenvironment-Induced Amino-Activatable Nanoprobes for ¹⁹F-Magnetic Resonance Imaging of Biothiols, SDS of cas: 2240-88-2, the publication is ACS Applied Materials & Interfaces (2018), 10(22), 18532-18542, database is CAplus and MEDLINE.

¹⁹F-magnetic resonance imaging (MRI) is of great significance for noninvasive imaging and detection of various diseases. However, the main obstacle in the application of ¹⁹F-MRI agents stems from the unmet signal sensitivity due to the poor water solubility and restricted mobility of segments with high number of fluorine atoms. Herein, the authors report a kind of intracellular reducing microenvironment-induced amino-activatable ¹⁹F-MRI nanoprobe, which can be used for specific imaging of biothiols. In principle, the nanoprobe has an initial architecture of hydrophobic core, where the trifluoromethyl-containing segments are compactly packed and ¹⁹F NMR/MRI signals are quenched (“OFF” state). Upon encountering sulfydryl, the strong electron-withdrawing 2,4-dinitrobenzenesulfonyl groups are excised to recover secondary amino groups, whose pK_a is 7.21. As a consequence, the mol. weight loss of the hydrophobic segment and the protonation of amino groups induce significant disturbance of hydrophilic/hydrophobic balance, leading to the disassembly of the nanoprobes and regain of spin-spin relaxation and ¹⁹F NMR/MRI signals (“ON” state, T₂ up to 296 ± 5.3 ms). This nanoprobe shows high sensitivity and selectivity to biothiols, enabling intracellular and intratumoral imaging of glutathione. The authors’ study not only provides a new nanoprobe candidate for biothiols imaging in vivo but also a promising strategy for the mol. design of real water-soluble and highly sensitive ¹⁹F-MRI nanoprobes.

ACS Applied Materials & Interfaces published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Genyi published the artcileModular click chemistry libraries for functional screens using a diazotizing reagent, Application of 2-Aminobutan-1-ol, the publication is Nature (London, United Kingdom) (2019), 574(7776), 86-89, database is CAplus and MEDLINE.

Alkyl and aryl azides were prepared from the corresponding primary alkyl and aryl amines by reaction with fluorosulfonyl azide generated in situ from a fluorosulfonylimidazolium triflate and sodium azide, expanding access to azides and both to the 1,2,3-triazoles derived from them and to functional screens employing them. The method allowed the preparation of a library of >1000 azides from the corresponding amines; the azide library underwent copper-catalyzed azide-alkyne cycloaddition reactions to yield a library of >1000 1,2,3-triazoles.

Nature (London, United Kingdom) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts