Author: tianli

Mascharak, P. K. published the artcileStructural distortions of the [Fe₄S₄]²⁺ core of [Fe₄S₄(S-tert-C₄H₉)₄]^2- in different crystalline environments and detection and instability of oxidized ([Fe₄S₄]³⁺) clusters, Name: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Inorganica Chimica Acta (1983), 80(3), 157-70, database is CAplus.

The structural and redox chem. of the clusters [Fe₄S₄(SR)₄]^2- with R = tert-alkyl were investigated for the purpose of determining the structures of the same cluster in different environments and the stability of the oxidized species [Fe₄S₄(SR)₄]^1-. (Me₃NCH₂Ph)₂[Fe₄S₄(S-tert-Bu)₄] crystallizes in the monoclinic space group P2₁/c with no imposed symmetry. (Et₄N)₂[Fe₄S₄(S-tert-Bu)₄] crystallizes in the tetragonal space group I4̅2m with D_2d symmetry imposed on the cluster. The [Fe₄S₄]²⁺ cluster cores in both compounds exhibit compressed tetragonal structures with different extents of distortion from T_d symmetry. These structures are compared to those of other [Fe₄S₄]²⁺ clusters by means of core shape parameters. Clusters with R = tert-alkyl (tert-Bu, C(CH₃)₂CH₂OH, C(CH₃)₂CH₂NHPh) in DMF exhibit, in addition to the usual 2-/3- and 3-/4- redox reactions common to all [Fe₄S₄(SR)₄]^2- species, discrete 1-electron oxidations near -0.1 V vs. SCE. Cyclic voltammetry of [Fe₄S₄(S-tert-Bu)₄]^2- reveals an essentially reversible 1-/2- couple with E_1/2 = -0.12 V, supporting the authenticity of clusters containing an oxidized ([Fe₄S₄]³⁺) core. This couple cannot be electrochem. resolved from multi-electron oxidation in the case of clusters in DMF with other types of R substituents, a behavior apparently due to cathodic potential shifts by tert-alkyl groups. Stability of oxidized clusters is low, and [Fe₄S₄(S-tert-Bu)₄]^1- could not be generated in appreciable concentrations at longer times by coulometric or chem. oxidation The relative stabilities of analog and protein [Fe₄S₄]³⁺ clusters are discussed. Preparations of 4 new [Fe₄S₄(SR)₄]^2- cluster salts are described including water-soluble (Et₄N)₂[Fe₄S₄(SC(CH₃)₂CH₂OH)₄].

Inorganica Chimica Acta published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Name: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marzenell, Paul published the artcileAminoferrocene-Based Prodrugs and Their Effects on Human Normal and Cancer Cells as Well as Bacterial Cells, Product Details of C14H21BO3, the publication is Journal of Medicinal Chemistry (2013), 56(17), 6935-6944, database is CAplus and MEDLINE.

Aminoferrocene-based prodrugs are activated under cancer-specific conditions (high concentration of reactive oxygen species, ROS) with the formation of glutathione scavengers (p-quinone methide) and ROS-generating iron complexes. Herein, the authors explored three structural modifications of these prodrugs to improve their properties: (a) the attachment of a -COOH function to the ferrocene fragment leads to the improvement of water solubility and reactivity in vitro but also decreases cell-membrane permeability and biol. activity, (b) the alkylation of the N-benzyl residue does not show any significant affect, and (c) the attachment of the second arylboronic acid fragment improves the toxicity (IC₅₀) of the prodrugs toward human promyelocytic leukemia cells (HL-60) from 52 to 12 μM. Finally, the authors demonstrated that the prodrugs are active against primary chronic lymphocytic leukemia (CLL) cells, with the best compounds exhibiting an IC₅₀ value of 1.5 μM. The most active compounds were found to not affect mononuclear cells and representative bacterial cells.

Journal of Medicinal Chemistry published new progress about 1370732-71-0. 1370732-71-0 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester, name is (3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol, and the molecular formula is C14H21BO3, Product Details of C14H21BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al Farraj, Dunia A. published the artcileCharacterization of pyrene and chrysene degradation by halophilic Hortaea sp. B15, SDS of cas: 86-48-6, the publication is Bioprocess and Biosystems Engineering (2019), 42(6), 963-969, database is CAplus and MEDLINE.

Polycyclic aromatics hydrocarbons (PAHs) are ubiquitous and toxic pollutants that are dangerous to humans and living organism in aquatic environment. Normally, PAHs has lower mol. weight such as phenanthrene and naphthalene that are easy and efficient to degrade, but high-mol.-weight PAHs such as chrysene and pyrene are difficult to be biodegraded by common microorganism. This study investigated the isolation and characterization of a potential halophilic bacterium capable of utilizing two high-mol.-weight PAHs. At the end of the experiment (25-30 days of incubation), bacterial counts have reached a maximum level (over 40 × 10¹⁶ CFU/mL). The highest biodegradation rate of 77% of chrysene in 20 days and 92% of pyrene in 25 days was obtained at pH 7, temperature 25°C, agitation of 150 rpm and Tween 80 surfactant showing to be the most impressive parameters for HMWPAHs biodegradation in this research. The metabolism of initial compounds revealed that Hortaea sp. B15 utilized pyrene to form phthalic acid while chrysene was metabolized to form 1-hydroxy-2-naphthoic acid. The result showed that Hortaea sp. B15 can be promoted for the study of in situ biodegradation of high mol. weight PAH.

Bioprocess and Biosystems Engineering published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fejes, Zsolt published the artcileSynthesis of ether-linked [60]fullerene glycoconjugates by nucleophilic cyclopropanation, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Chemical Papers (2015), 69(6), 896-900, database is CAplus.

Et acetoacetate-sugar derivatives were prepared by standard alkylation of primary or secondary hydroxyls of diacetonide-protected sugars with Et 4-chloroacetoacetate. The obtained D-fructose, D-galactose, D-glucose and F-allose derivatives were conjugated to C₆₀ using the Bingel reaction to afford hydrolytically stable, ether-linked fullerene-carbohydrates. Conjugation of an ester-protected mannose derivative to the C₆₀ scaffold was carried out by the combination of the acetoacetate chem. with the azide-alkyne click reaction.

Chemical Papers published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shoshan-Barmatz, Varda published the artcileCrosslinking of the ryanodine receptor/Ca²⁺ release channel from skeletal muscle, Related Products of alcohols-buliding-blocks, the publication is Biochimica et Biophysica Acta, Biomembranes (1995), 1237(2), 151-61, database is CAplus and MEDLINE.

The relationship between the tetrameric organization of the ryanodine receptor (RyR) and its activity in binding of ryanodine was approached through crosslinking studies using several bifunctional reagents, differing in their linear dimensions and flexibility, as well as in the reactivity of the active groups. Crosslinking with: 1,5-difluoro-2,4-dinitrobenzene (DFDNB); di(fluoro-3-nitrophenyl)sulfone (DFNPS), 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC); di-Me suberimidate (DMS); ethylene glycol bis(succinimidyl succinate) (EGS); and glutaraldehyde resulted in the disappearance of the, 470 kDa, RyR monomer protein band with concomitant appearance of addnl. bands of mol. masses higher than the monomer. At the relatively low concentrations of the reagents and the conditions used, RyR is the only cross-linked protein of SR membranes. The ‘new’ protein bands cross-react with antibodies against the RyR and correspond to dimers and tetramers of the RyR subunits while trimers were not detectable. DFDNB and DFNPS produced also a 560 kDa protein band which probably represents an intramol. cross-linked monomer. The SDS-electrophoretic patterns of the cross-linked purified RyR resemble those of the membrane-bound receptor. Ryanodine binding to the high-affinity site was inhibited by modification of SR membranes with DFDNB and DFNPS, but not with DMS, EDC, EGS and glutaraldehyde, although RyR was completely cross-linked. The inhibition by DFDNB and DFNPS is due to modification of a specific lysyl residue which is also involved in the control of Ca²⁺ release. On the other hand, cross linking of the RyR with glutaraldehyde or EGS resulted in inhibition of ryanodine binding to the low-affinity, but not to the high-affinity binding sites. Thus, the crosslinking of two or more sites in each monomer (which lead to fixation of dimers or tetramers) did not prevent the conformational changes involved in the binding and occlusion of ryanodine at the high-affinity site, but inhibited its binding to the low-affinity sites.

Biochimica et Biophysica Acta, Biomembranes published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C8H10BNO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavez, Damien published the artcileMaize black Mexican sweet suspension cultured cells are a convenient tool for studying aquaporin activity and regulation, Synthetic Route of 85618-21-9, the publication is Plant Signaling & Behavior (2009), 4(9), 890-892, database is CAplus and MEDLINE.

Aquaporins (AQPs) are channel proteins that facilitate and regulate the permeation of water across biol. membranes. Black Mexican sweet suspension cultured cells are a convenient model for studying the regulation of maize AQP expression and activity. Among other advantages, a single cell system allows the contribution of plasma membrane AQPs (PIPs, plasma membrane intrinsic proteins) to the membrane water permeability coefficient (P_f) to be determined using biophys. measurement methods, such as the cell pressure probe or protoplast swelling assay. We generated a transgenic cell culture line expressing a tagged version of ZmPIP2;6 and used this material to demonstrate that the ZmPIP2;6 and ZmPIP2;1 isoforms phys. interact. This kind of interaction could be an addnl. mechanism for regulating membrane water permeability by acting on the activity and/or trafficking of PIP hetero-oligomers.

Plant Signaling & Behavior published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Semleit, Nina published the artcileControlling the Gold(I)-Catalyzed 1,5-Allenene Reaction: Construction of Fused Rings with Excellent Diastereoselectivity, Category: alcohols-buliding-blocks, the publication is Organic Letters (2021), 23(24), 9635-9639, database is CAplus and MEDLINE.

In the present study, the gold(I)-catalyzed reaction of 1,5-allenenes was controlled in such a way that instead of a [2+3] cycloaddition, a 5-exo-cyclization with the formation of a carbocation occurred. The latter could be trapped with both oxygen and carbon nucleophiles. In the investigated system, fused tricyclic frameworks I (R = Me; R¹ = Me, Cl, Br, etc.; Nu = OMe, OEt, 2-furyl, etc.) with three contiguous stereocenters with excellent chemo- and diastereoselectivity in up to 95% yield were obtained.

Organic Letters published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H19NO8, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Habek, Jasna Čerkez published the artcileREFRACTORY BRADYCARDIA–A RARE COMPLICATION OF CARBOPROST TROMETHAMINE FOR INDUCTION OF ABORTION, COA of Formula: C25H47NO8, the publication is Acta clinica Croatica (2016), 55(2), 323-5, database is MEDLINE.

We report a first case of refractory several-hour sinus bradycardia, a rare but already described side effect of intramuscular administration of carboprost tromethamine to induce abortion for medical indication in a patient without cardiovascular and other diseases. After administration of atropine sulfate 3×0.5 mg intravenously without effect, the patient‘s sinus rhythm spontaneously normalized as carboprost was eliminated from the body (it has a 3-hour half-life). It is reasonable to believe that the specific prostaglandin underlay the etiology of bradycardia.

Acta clinica Croatica published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gormemis, Ahmet E. published the artcileBenzofuroindole analogues as potent BK_Ca channel openers, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is ChemBioChem (2005), 6(10), 1745-1748, database is CAplus and MEDLINE.

New, potent, large-conductance, calcium-activated potassium-channel (BK_Ca) openers that show calcium-independent activation in electrophysiol. evaluations have been designed through optimizing the structure of the benzofuroindole skeleton by comparison with a known BK_Ca-channel opener (BMS-204352). A series of substituted benzofuroindoles I (R¹ = H, Br; R² = H, CF₃, OCH₃, Cl; R³ = H, COOH, COOCH₃, Cl, OCH₃, CF₃; R⁴ = H, Cl, F; R⁵ = H, Cl, CF₃; R⁶ = H, Cl, F, CF₃) were prepared via sequence of reactions including as a key step either classical Fischer indole or microwave assisted cyclization of phenylhydrazones of benzofuranones. The BK_Ca-channel-opening activities of synthesized benzofuroindoles were studied. In particular, compound I (R¹ = R⁴ = R⁵ = H; R² = CF₃; R³ = COOH, R⁶ = Cl) showed the most potent and effective activity in an intracellular calcium-independent manner. These new potassium channel openers might find therapeutic use to treat neuronal damage and be applied to therapeutic intervention in stroke, asthma, hypertension, convulsion, and traumatic brain injury.

ChemBioChem published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Feiqing published the artcileSquaryl group modified phosphoglycolipid analogs as potential modulators of GPR55, Safety of (R)-Oxiran-2-ylmethanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(61), 8470-8473, database is CAplus and MEDLINE.

Lysophosphatidyl glucoside (LPGlc) is a structurally unique glycolipid that acts as a guidance cue for extending axons during central nervous system development by activating the class A G protein coupled receptor (GPR) 55 of spinal cord sensory axons. GPR55 not only plays an important role during development, but is also implicated in many disease states, rendering mols. that target GPR55 of widespread interest. In this study, we developed synthetic access to a novel class of LPGlc analogs featuring a squaryl diamide group as surrogate for the phosphodiester. We report the facile synthesis of a series of LPGlc analogs, their GPR dependent biol. activity and a systematic anal. of the structure-activity relationship in regards to GPR55 modulation. The lead compound featuring identical configuration at all stereo-centers compared to natural LPGlc exhibits an activity to repel axons of dorsal root ganglion (DGR) nociceptive neurons.

Chemical Communications (Cambridge, United Kingdom) published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Safety of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts