Author: tianli

Pitcher, Noel P. published the artcileDevelopment of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract, Name: 3-Hydroxyphenylacetic acid, the publication is ACS Omega (2022), 7(8), 6737-6759, database is CAplus and MEDLINE.

Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization agents have been largely unsuccessful thus far. Herein, we report modification of the 1,2,4-oxadiazole class of antimicrobial compounds with poorly permeable functional groups in order to target bacterial pathogens within the GI tract. We have identified that the quaternary ammonium functionality of analog 26a (I) results in complete impermeability in Caco-2 cell monolayers while retaining activity against GI pathogens Clostridioides difficile and multidrug-resistant (MDR) Enterococcus faecium. Low compound recovery levels after oral administration in rats were observed, which suggests that the analogs may be susceptible to degradation or metabolism within the gut, highlighting a key area for optimization in future efforts. This study demonstrates that modified analogs of the 1,2,4-oxadiazole class may be potential leads for further development of colon-targeted antimicrobial agents.

ACS Omega published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Name: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Jian-ning published the artcileA new type of iridium (III) phenylpyrazole complexes: synthesis, photophysical characterization, Category: alcohols-buliding-blocks, the publication is Guangpuxue Yu Guangpu Fenxi (2010), 30(9), 2424-2427, database is CAplus and MEDLINE.

New heteroleptic iridium(III) complexes (ppz)₂Ir(LX), which consist of two cyclometalated ligands ppz(1-pheny-lpyrazole) together with an ancillary ligand LX (LX=2-(2′-hydroxylphenyl)benzothiazole (BTZ),2-(3′-methyl-2′-hydroxyl-phenyl) benzothiazole (3-MeBTZ), 2-(4′-methyl-2′-hydroxylphenyl)benzothiazole (4-MeBTZ) and 2-(4′-Trifluoromcthyl-2′-hydroxylphenyl)benzothiazole (4-tfmBTZ)), were synthesized and characterized. The mol. structures and photophys. properties were characterized and analyzed comparatively. The results show that the four complexes have basically similar UV-Vis absorption spectra, fluorescence excitation and emission spectra. Their maximum emission peaks are located at 583-615 nm, and accompanied by a lower intensity emission band around 400 nm. The weak emissions around 400 nm are ascribed to the radiation transition of single state excition from ancillary ligand BTZ perturbed by metallic ion, and light emission around long-wavelength to the radiation transition of ³MLCT of Ir(BTZ) fragment. While the triplet state ³MLCT of Ir(ppz)₂ fragment might be quenched at room temperature For all complexes, the excitations with maximum efficiency are located at 250-310 nm, which indicates that main contributor to light emitting is ligand-centered absorption(¹π-π^*) of ppz and BTZ rather than ³MLCT transitions, and thus provides a striking evidence that there is intersystem crossing from ¹π-π^* state to ³MLCT state in these complexes. Compared with Ir(ppz)₃, these complexes not only have stronger phosphorescence at room temperature but also their emission color can be tuned by modifying ancillary ligand.

Guangpuxue Yu Guangpu Fenxi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C10H2F12NiO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Xiao-xia published the artcileNew highly phosphorescent heteroleptic tris-cyclometalated iridium(III) complexes: Synthesis and photophysical characterization, Product Details of C8H5F3O3, the publication is Guangpuxue Yu Guangpu Fenxi (2010), 30(1), 170-173, database is CAplus and MEDLINE.

New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)₂Ir(LX) [ppy = 2-phenylpyridine, LX = Sal (salicylic acid), MSal (4-methylsalicylic acid), FSal (4-trifluoromethylsalicylic acid)] was synthesized and characterized. The mol. structure, photophys. properties and thermal stability were tested and analyzed. The results show that the absorption peaks were located around 270, 370, 450 and 484 nm resp. at room temperature The two former peaks at 270 and 370 nm should belong to ¹π^–π^* transition at ppy and transition from salicylic acid ligands to 2-phenylpyridine. The peaks around 450 and 484 nm can be assigned to the charge transfer transition from Ir to ligand (¹MLCT and ³MLCT) and ³π^–π^* transition resp. The PL emission peaks were located at 520, 522, and 510 nm, resp. The emission of (ppy)₂Ir(Sal) and (ppy)₂Ir(MSal) was mainly ascribed to the radiation transition of triple state ³MLCT, while the emission of (ppy)₂ Ir(FSal) was mainly from the radiation transition between Sal and ppy, partly from the radiation transition of single state ¹MLCT and triple state ³MLCT. The quantum efficiencies of these complexes were 0.37, 0.33 and 0.29 resp. The thermal decomposition temperature was from 306 to 328°C. (ppy)₂Ir(LX), being efficient phosphorescent materials with good thermal stability, can be used in organic electroluminescent devices.

Guangpuxue Yu Guangpu Fenxi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Product Details of C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Jing published the artcileMetabolic and microbial modulation of phenolic compounds from raspberry leaf extract under in vitro digestion and fermentation, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is International Journal of Food Science and Technology (2021), 56(10), 5168-5177, database is CAplus.

Raspberry leaves, byproducts in raspberry production, are also a rich source of bioactive phytochems. In this study, the changes of phenolic compounds in raspberries leaf extract (RLE) under in vitro digestion and colonic fermentation were further studied by HPLC-MS anal. and 16S rRNA. The results showed that the phenolic compounds in RLE were relatively stable during in vitro gastric digestion; however, in the subsequent intestinal digestion and colonic fermentation, their content decreased sharply. A large amount of hydroxyphenylpropionic acid, hydroxyphenylacetic acid and urolithins were produced under the action of gut microbiota. Moreover, compared with corresponding control, RLE significantly reduced the ratio of Firmicutes/Bacteroidetes in all volunteers, increased the relative abundances of some beneficial bacteria, Enterococcus, Prevotella, and decreased the relative abundances of potential pathogens, Clostridium and Faecalibacterium. These findings suggest that RLE during in vitro digestion and fermentation has pos. effects on gut microbiota and potential value of maintaining intestinal health.

International Journal of Food Science and Technology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C15H20O6, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ru, Xiangli published the artcileSynthesis and characterization of new coenzyme NADH model compound, Name: 9-Phenyl-9H-xanthen-9-ol, the publication is Henan Shifan Daxue Xuebao, Ziran Kexueban (2013), 41(3), 103-104, 129, database is CAplus.

BNAH and 9-Ph xanthene(9-PhXnH) are new nicotinamide coenzyme NADH model compounds, and they have been becoming more and more important in green synthesis of drugs. In this paper, the coenzyme NADH model compounds of BNAH and 9-Ph xanthene were synthesized with nicotinamide and 9-Ph xanthene ethanol as raw materials, and by 1H NMR, elemental anal., UV and other anal. methods, n BNAH and 9-Ph xanthene were characterized. This synthetic route had easily available raw materials, mild reaction conditions, simple operation, high yield, high product purity.

Henan Shifan Daxue Xuebao, Ziran Kexueban published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Name: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Bowen published the artcileFluorinated paclitaxel prodrugs for potentiated stability and chemotherapy, SDS of cas: 2240-88-2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(48), 9971-9979, database is CAplus and MEDLINE.

Robust colloidal stability is an essential prerequisite for effective drug delivery. Herein, a series of fluorinated paclitaxel prodrugs bridged with redox-responsive linkages were synthesized, and the effect of fluorination on the assembly behavior and physiol. stability was investigated. The 17-fluorinated ethanol-modified paclitaxel prodrug could self-assemble into stable nanoparticles without the addition of any surfactants. Fluorinated paclitaxel prodrug nanoparticles possessed potent cytotoxicity toward cancer cells and superior antitumor activity. This study offers a universal fluorination approach to improve drug delivery efficacy by enhancing the self-assembly capability and improving the colloidal stability of prodrugs for potentiating chemotherapy.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Qiuhong published the artcileEutectogels as Matrices to Manipulate Supramolecular Chirality and Circularly Polarized Luminescence, Product Details of C8H8O3, the publication is ACS Nano (2022), 16(4), 6825-6834, database is CAplus and MEDLINE.

The occurrence and manipulation of supramol. chirality in deep eutectic solvents (DESs) was explored. Transfer from inherent chiral DES to solutes in either aggregated or monomeric building units is blocked. The chiral assembly of π-conjugated amino acids was realized. Compared to aqueous media, self-assembly in DES hinders the spontaneous structural and chirality evolution that benefit from efficient solvation, where the π-conjugated amino acids were involved as H bonding donors. DES performs as a dye-friendly matrix to afford chiroptical eutectogels with tunable circularly polarized luminescence, whereby a large dissymmetry g-factor of ≤0.015 was realized. DES behaves as feasible and flexible solvents to fabricate and stabilize functional soft chiral self-assemblies with controllable chiroptical properties.

ACS Nano published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oppegard, Martin published the artcileDetermination of C₀-C₉ alkyl phenols in produced-water-exposed fish eggs using gas chromatography/tandem mass spectrometry, Recommanded Product: 4-Propylphenol, the publication is Rapid Communications in Mass Spectrometry (2020), 34(24), e8950, database is CAplus and MEDLINE.

Rationale: Produced water (PW) discharge from the oil and gas industry represents the largest intentional marine waste volume Alkyl phenols (APs) are one of the main toxic component groups found in PW, with concentration of APs in discharged PW from the Norwegian Sector of the North Sea up to >16 mg/L. Several species of fish spawn in direct proximity to offshore production platforms and may be at risk of AP exposure. Therefore, a sensitive method to determine the potential for bioaccumulation of APs in fish eggs is needed. Methods: Fish eggs were extracted using liquid-solid extraction followed by gel permeation chromatog. cleanup. Anal. was performed by gas chromatog. coupled to triple quadrupole mass spectrometry. Extraction and anal. conditions were optimized for anal. of phenol and 30 APs (C₁-C₉) with different degrees of branching in the alkyl chain. The method was verified and applied to analyze the body residue of APs in PW-exposed marine fish (Atlantic cod, Gadus morhua) eggs. Results: A comprehensive and sensitive method for the determination of C₀-C₉ APs was developed. Detection limits were in the range 0.03-8 ng. Apart from a few compounds with poor recovery, the method generally provided reliable results with good precision (<15%). Conclusions: We demonstrate the successful application of an optimized extraction method for APs in fish eggs and show first results of AP accumulation in cod embryos exposed to PW in the laboratory

Rapid Communications in Mass Spectrometry published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Szabo, Lajos Z. published the artcilePreparation of S-glycoside surfactants and cysteine thioglycosides using minimally competent Lewis acid catalysis, Category: alcohols-buliding-blocks, the publication is Carbohydrate Research (2016), 1-4, database is CAplus and MEDLINE.

Here we report a method for the preparation of anomerically pure β-S-glycopyranosides (1,2-trans-glycosides) from the corresponding peracetate donors. S-glycosylation was performed in CHCl₃ at reflux in the presence of a catalytic amount of InBr₃. Deacylation of the intermediate peracetates were achieved under Zemplén conditions. Five pyranose examples, monosaccharides D-glucose and D-galactose and disaccharides cellobiose, maltose, and lactose, were used as donors, and five thiols including an α/ω dithiol and Fmoc-L-cysteine were used as acceptors. M.ps., high res MS, [α]_D and NMR data (¹H and ¹³C, including COSY, HSQC and HMBC) are reported for compounds not previously described.

Carbohydrate Research published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H17BF3NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dreiling, Alena published the artcileEarly cleavage of ethylene glycol bis(succinimidylsuccinate) (EGS)-linker moieties during enzymatic digestion of cross-linked proteins, Quality Control of 70539-42-3, the publication is Rapid Communications in Mass Spectrometry (2014), 28(21), 2385-2388, database is CAplus and MEDLINE.

It has become popular to combine the crosslinking of proteins with mass spectrometry (MS) to study their tertiary structure or interactions. There are several difficulties with the method which make it a challenge. They include the limited availability of crosslinked peptides for MS anal. due to low yield of the crosslinking reaction and unwanted side chem. Recently, the authors have pointed out the uncontrolled quenching of azide linkers by buffer components rendering them almost useless for the intended task. Here, the authors describe a phenomenon involving cleavable crosslinkers. They have been designed to overcome the drawback that crosslinked peptides provide poor gas-phase fragmentation mass spectra because of their branched structure. Moreover, isotope coding on such linkers may assist in finding the low-abundance crosslinked peptides in mass spectra as described for ethylene glycol bis(succinimidylsuccinate) (EGS). In some of the authors’ experiments, this compound provided better crosslinking yields compared to other N-hydroxysuccinimide-derived reagents as detected by one-dimensional sodium dodecyl sulfate PAGE. For best results from crosslinking experiments using cleavable agents such as EGS, careful control of sample preparation protocols for early hydrolysis products is advisable.

Rapid Communications in Mass Spectrometry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Quality Control of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts