Author: tianli

Liu, Jia published the artcileAphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant, Name: (R)-Oxiran-2-ylmethanol, the publication is Journal of Organic Chemistry (2014), 79(2), 599-607, database is CAplus and MEDLINE.

Aphadilactones A-D isolated from Aphanamixis grandifolia (Meliaceae) are 4 diastereoisomers with an unprecedented carbon skeleton. Their challenging structures and absolute configurations were determined by a combination of spectroscopic data, chem. degradation, fragment synthesis, exptl. CD spectra, and ECD calculations The aphadilactones A-D and their oxidative products were tested for DGAT inhibitory activities in vitro. Aphadilactone C with the 5S,11S,5’S,11’S configuration had potent and selective inhibition against diacylglycerol O-acyltransferase-1 (DGAT-1; IC₅₀ = 0.46 μM; selectivity index >217). Thus, aphadilactone C is the strongest natural DGAT-1 inhibitor discovered to date. The aphadilactones A-D also had significant antimalarial activities against Plasmodium falciparum with in vitro IC₅₀ values of 190, 1350, 170, and 120 nM, resp.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Ling published the artcileAcceptorless Dehydrogenative Cross-Coupling of Primary Alcohols Catalyzed by an N-Heterocyclic Carbene-Nitrogen-Phosphine Chelated Ruthenium(II) Complex, Safety of Pentane-1,5-diol, the publication is Journal of Organic Chemistry (2022), 87(7), 4550-4559, database is CAplus and MEDLINE.

The acceptorless dehydrogenative cross-coupling of primary alcs. to form cross-esters with the liberation of H₂ gas was enabled using a [RuCl(η⁶-C₆H₆)(κ²-CNP)][PF₆]Cl complex as the catalyst. This sustainable protocol was applicable to a broad range of primary alcs., particularly for the sterically demanding ones, featuring good functional group tolerance and high selectivity. The good catalytic performance can be attributed to the nitrogen-phosphine-functionalized N-heterocyclic carbene (CNP) ligand, which adopted a facial coordination mode as well as the facile dissociation of coordinated benzene.

Journal of Organic Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C8H5F3N4, Safety of Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Feihua published the artcilePalladium-catalyzed ortho-C-H hydroxylation of benzoic acids, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Tetrahedron Letters (2021), 153434, database is CAplus.

A simple Pd(OAc)₂ catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant was explored. This protocol featured relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates was an effective complement to the previous ortho-hydroxylation reaction.

Tetrahedron Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yuming published the artcileTwo-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of alcs., Computed Properties of 4410-99-5, the publication is European Journal of Organic Chemistry (2021), 2021(7), 1179-1183, database is CAplus.

We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcs. to afford products containing a C-N, C-S, or C-O bond. In the first step the alc. undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-mol. drugs containing hydroxy-group.

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Konidala, Praveen published the artcileMolecular dynamics characterization of n-octyl-β-D-glucopyranoside micelle structure in aqueous solution, SDS of cas: 85618-21-9, the publication is Journal of Molecular Graphics & Modelling (2006), 25(1), 77-86, database is CAplus and MEDLINE.

N-Octyl-β-D-glucopyranoside (OG) is a non-ionic glycolipid, which is used widely in biotech. and biochem. applications. All-atom mol. dynamics simulations from two different initial coordinates and velocities in explicit solvent have been performed to characterize the structural behavior of an OG aggregate at equilibrium conditions. Geometric packing properties determined from the simulations and small angle neutron scattering experiment state that OG micelles are more likely to exist in a non-spherical shape, even at the concentration range near to the critical micelle concentration (0.025 M). Despite few large deviations in the principal moment of inertia ratios, the average micelle shape calculated from both simulations is a prolate ellipsoid. The deviations at these time scales are presumably the temporary shape change of a micelle. However, the size of the micelle and the accessible surface areas were constant during the simulations with the micelle surface being rough and partially elongated. Radial distribution functions computed for the hydroxyl oxygen atoms of an OG show sharper peaks at a min. van der Waals contact distance than the acetal oxygen, ring oxygen, and anomeric carbon atoms. This result indicates that these atoms are pointed outwards at the hydrophilic/hydrophobic interface, form hydrogen bonds with the water mols., and thus hydrate the micelle surface effectively.

Journal of Molecular Graphics & Modelling published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Xiao published the artcileEngineering of reversible luminescent probes for real-time intravital imaging of liver injury and repair, Related Products of alcohols-buliding-blocks, the publication is CCS Chemistry (2022), 4(1), 356-368, database is CAplus.

As the major organ for drug metabolism and detoxification, the liver is prone to damage and severely impaired functionality. The treatment of liver diseases is based on a clear understanding of the process underlying liver injury and repair. However, intravital real-time imaging of liver injury and repair is still limited due to the lack of in vivo reversible visualization methods. To this end, we proposed a rational design strategy for the development of a reversible upconversion luminescence nanoprobe that allows real-time and in vivo imaging of liver injury and repair processes. As a proof of concept, we first developed a small mol. probe NB3 which can reversibly respond to related analytes of early liver injury [peroxynitrite (ONOO^–)] and liver repair [glutathione (GSH)]. The small mol. probe was then integrated with a core-shell upconversion nanoparticle to form a sophisticated nanoprobe. Compared with traditional small mol. probes, this nanoprobe exhibited a higher selectivity to ONOO^–, longer retention time in liver, and wider dynamic response range to GSH after oxidation by ONOO^–. The novel nanoprobe facilitated the successful monitoring and discrimination among the different degrees of liver injury and repair in a mouse model.

CCS Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Jingjing published the artcilePhotoinduced Deaminative Borylation of Alkylamines, Application In Synthesis of 608534-44-7, the publication is Journal of the American Chemical Society (2018), 140(34), 10700-10704, database is CAplus and MEDLINE.

An operationally simple deaminative borylation reaction of primary alkylamines was developed. The formation of electron-donor-acceptor complexes between N-alkylpyridinium salts and bis(catecholato)diboron enables photoinduced single-electron transfer and fragmentation to C-centered radicals, which are subsequently borylated. The mild conditions allow a diverse range of readily available alkylamines to be efficiently converted into synthetically valuable alkylboronic esters under catalyst-free conditions.

Journal of the American Chemical Society published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H14, Application In Synthesis of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yi-Xuan published the artcilePhotochemical Organocatalytic Aerobic Cleavage of C=C Bonds Enabled by Charge-Transfer Complex Formation, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Organic Letters (2022), 24(22), 3920-3925, database is CAplus and MEDLINE.

A novel visible-light-driven organocatalytic protocol to access aerobic oxidative cleavage of olefins, e.g., 4-benzylidene-2,6-di-tert-butylcyclohexa-2,5-dien-1-one promoted by sodium benzene sulfinate, is described. An array of alkenes smoothly delivered the corresponding aldehydes RC(O)R¹ (R = naphth-2-yl, 2-chlorophenyl, 3,4-dimethoxyphenyl, etc.; R¹ = H) and ketones, e.g., 2, 6-di-tert-butylcyclohexa-2, 5-diene-1,4-dione under transition-metal-free conditions. Notably, α-halo-substituted styrenes, e.g., (1-bromovinyl)benzene proceeded with photoinduced oxidation to finally afford α-halo-acetophenones, e.g., 2-bromo-1-phenylethan-1-one with halogen migration. Crucial to this oxidation was the formation of charge-transfer complexes between sodium benzene sulfinate with mol. O₂ to ultimately deliver the carbonyl products.

Organic Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shao, Xuefei published the artcilePreparation of zinc-coordinated-DPA functionalized polyesters for gene condensation, SDS of cas: 111-29-5, the publication is Journal of Applied Polymer Science (2021), 138(34), 50843, database is CAplus.

Cationic polyesters have been widely utilized as efficient gene delivery carriers. Their ability in binding genes was majorly based on the electrostatic effect between the pos. charges of polymers and the negatives charges of genes. It has been well known that large numbers of pos. charges on the polymers would lead to undesired toxicity although strong gene binding capability. It was of great interest to developed a polymer with reduced pos. charges while enhanced gene condensation ability. In this work, a library of polyesters functionalized by zinc-coordinated-dimethylpyridinium amine (DPA-Zn) have been successfully prepared by the polycondensation method starting from di-Me 1,3-acetonedicarboxylate and 10 diols, followed by the post-modification using dimethylpyridinium amine and zinc nitrate. The post-modification efficiency was systemically evaluated and the optimized functionalization efficiency could reach around 50%. The gene condensation ability of the targeting polymers was also evaluated using gel retardation assay and dynamic light scatting. The results indicated that DPA-Zn functionalized polyesters could bind gene into nanocomplexes with the sizes around 200 nm.

Journal of Applied Polymer Science published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C15H10O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Guang-Ri published the artcileCleavage of arylalkylsilanes by sodium amide in liquid ammonia, Product Details of C9H22OSi, the publication is Synlett (2000), 619-622, database is CAplus.

The aryl carbon-silicon bonds in arylalkyl monosilanes have been cleaved by sodium amide in liquid ammonia. Sub-stoichiometric amounts of amide effect complete cleavage of the aryl anion. Reactions were complete in just a few minutes at room temperature except when bulky alkyl groups are present (eg. triisopropylphenylsilane). In dialkyldiarylsilanes both aryl functions were rapidly cleaved with little selectivity when the aryl groups had different substituents. The influence of metallic cations was important (NaNH₂, KNH₂ >> LiNH₂ > Ca(NH₂)₂). Solvent and temperature were also studied.

Synlett published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H8O4, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts