Author: tianli

Westphal, Matthias V. published the artcileWater-compatible cycloadditions of oligonucleotide-conjugated strained allenes for DNA-encoded library synthesis, COA of Formula: C10H9NO, the publication is Journal of the American Chemical Society (2020), 142(17), 7776-7782, database is CAplus and MEDLINE.

DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles, and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features, related to elements found to be powerful in phenotypic screening. DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features-related to elements found to be powerful in phenotypic screening.

Journal of the American Chemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C15H21BO2, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Kaili published the artcileElectrosynthesis of amino acids from biomass-derived α-hydroxyl acids, Related Products of alcohols-buliding-blocks, the publication is Green Chemistry (2022), 24(13), 5320-5325, database is CAplus.

Electrochem. conversion of biomass-derived intermediate compounds to high-value products has emerged as a promising approach in the field of biorefinery. Biomass upgrading allows for the production of chems. from non-fossil-based carbon sources and capitalization on electricity as a green energy input. Amino acids, as products of biomass upgrading, have received relatively little attention. Pharmaceutical and food industries will benefit from an alternative strategy for the production of amino acids that does not rely on inefficient fermentation processes. The use of renewable biomass resources as starting materials makes this proposed strategy more desirable. Herein, we report an electrochem. approach for the selective oxidation of biomass-derived α-hydroxyl acids to α-keto acids, followed by electrochem. reductive amination to yield amino acids as the final products. Such a strategy takes advantage of both reactions at the anode and cathode and produces amino acids under ambient conditions with high energy efficiency. A flow electrolyzer was also successfully employed for the conversion of α-hydroxyl acids to amino acids, highlighting its great potential for large-scale application.

Green Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Chongyang published the artcileAbsence of the nahG-like gene caused the syntrophic interaction between Marinobacter and other microbes in PAH-degrading process, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Hazardous Materials (2020), 121387, database is CAplus and MEDLINE.

In this study, Marinobacter sp. N4 isolated from the halophilic consortium CY-1 was found to degrade phenanthrene as a sole carbon source with the accumulation of 1-Hydroxy-2-naphthoic acid (1H2N). With the assistance of Halomonas sp. G29, phenanthrene could be completely mineralized. The hpah1 and hpah2 gene cluster was amplified from the genome of strain N4, that were responsible for upstream and downstream of PAH degradation Strain N4 was predicted for the transformation from phenanthrene to 1H2N, and strain G29 could transform the produced 1H2N into 1,2-dihydroxynaphthalene (1,2-DHN). The produced 1,2-DHN could be further transformed into salicylic acid (SALA) by strain N4. SALA could be catalyzed into catechol by strain G29 and further utilized by strains N4 and G29 via the catechol 2,3-dioxygenase pathway and catechol 1,2-dioxygenase pathway, resp. NahG, encoding salicylate hydroxylase, was absent from the hpah2 gene cluster and predicted to be the reason for 1H2N accumulation in the PAH-degrading process by pure culture of strain N4. The syntrophic interaction mode among Marinobacter and other microbes was also predicted. According to our knowledge, this is the first report of the PAH-degrading gene cluster in Marinobacter and the syntrophic interaction between Marinobacter and other microbes in the PAH-degrading process.

Journal of Hazardous Materials published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C9H9BrO2, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Xue published the artcileElectromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota, SDS of cas: 621-37-4, the publication is Ecotoxicology and Environmental Safety (2021), 112980, database is CAplus and MEDLINE.

Electromagnetic pollution cannot be ignored. Long-term low-dose electromagnetic field (EMF) exposure can cause central nervous system dysfunction without effective prevention. Male C57BL/6J mice (6-8 wk, 17-20 g) were used in this study. Depression-like and anxiety-like behaviors detected by behavioral experiments were compared among different treatments. 16S rRNA gene sequencing and non-targeted liquid chromatog.-mass spectrometry (LC-MS) metabolomics were used to explore the relationship between EMF exposure and heat acclimation (HA) effects on gut microbes and serum metabolites. Both EMF and HA regulated the proportions of p_Firmicutes and p_Bacteroidota. EMF exposure caused the proportions of 6 kinds of bacteria, such as g_Butyricicoccus and g_Anaerotruncus, to change significantly (p < 0.05). HA restored the balance of gut microbes that was affected by EMF exposure and the proportion of probiotics (g_Lactobacillus) increased significantly (p < 0.01). Serum metabolite anal. suggested that HA alleviated the disturbance of serum metabolites (such as cholesterol and -mannose) induced by EMF exposure. Both the metabolic KEGG pathways and PICRUSt functional anal. demonstrated that tryptophan metabolism, pyrimidine metabolism and amino acid biosynthesis were involved. EMF exposure not only led to depression-like neurobehavioral disorders, but also to gut microbiota imbalance. HA alleviated the depression features caused by EMF exposure. Based on the anal. of gut microbiota associated with serum metabolites, we speculated that gut microbiota might play a vital role in the cross-tolerance provided by HA.

Ecotoxicology and Environmental Safety published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Junming published the artcileSynergistic effect of polyphosphazene nanotubes and graphene on enhancing ablative resistance of ethylene propylene diene monomer insulation composites, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Journal of Applied Polymer Science (2022), 139(36), e52834, database is CAplus.

Many advanced fillers were used in ethylene propylene diene monomer (EPDM) insulation composites to enhance the ablative resistance by strengthening char layer. However, the structures of fillers and char layer were usually neglected. In this work, a new type of cross-linked network-like polyphosphazene nanotubes (PNTs) was added in EPDM composites in combination with graphene. The results showed that the ablation performance of EPDM composites was improved by 21.6% with the synergistic effect of PNTs and graphene. Moreover, the ablation mechanism was studied by analyzing ablated char layer using X-ray diffraction (XRD), SEM, energy disperse spectroscopy (EDS) and Raman spectroscopy. PNTs served as skeleton to build the cross-linked network char layer and graphene played a role in enhancing the properties of char layer. The findings of this work emphasize the synergistic effect of structures and properties of fillers when performing ablative modification, which provides a new idea to enhance the ablation properties of EPDM composites.

Journal of Applied Polymer Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chung, Shu-Ting published the artcileSynthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives, SDS of cas: 27292-49-5, the publication is Research on Chemical Intermediates (2016), 42(2), 1195-1215, database is CAplus.

Several derivatives of 4H-chromene and chromeno[2,3-b]pyridine were efficiently prepared under microwave irradiation in a one-pot reaction, and their anti-inflammatory activities were evaluated. Six synthetic products (1b, 1c, 1h, 2d, 2j, and 2l) exhibited more powerfully inhibited the production of tumor necrosis factor-α-induced nitric oxide (NO) than quercetin and exhibited comparable cell viability in both human and porcine chondrocytes. In particular, 2d at dosages of 10 and 20 mg/kg had a very potent anti-inflammatory effect by suppressing the formation of carrageenan-induced rat paw edema and prostaglandin E₂. The results herein suggest that these compounds may have potential as structural templates in the design and development of new anti-inflammatory drugs.

Research on Chemical Intermediates published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, SDS of cas: 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Liqin published the artcileFK506-Binding Protein Ligands: Structure-Based Design, Synthesis, and Neurotrophic/Neuroprotective Properties of Substituted 5,5-Dimethyl-2-(4-thiazolidine)carboxylates, Computed Properties of 101-98-4, the publication is Journal of Medicinal Chemistry (2006), 49(14), 4059-4071, database is CAplus and MEDLINE.

Structure-based design and discovery of novel neuroimmunophilin FK506-binding protein (FKBP) ligands were pursued in the present study. The binding mode of the known FKBP ligand, 3-(3-pyridyl)-1-propyl- (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate, in a complex with FKBP12 was investigated using LUDI simulation and upon which a novel scaffold structure predicted to possess improved binding affinity was designed. A virtual combinatorial library composed of diverse combinations of two substituted groups was constructed using Project Library, followed by an automated screening of the library against the ligand binding site on FKBP52 using DOCK. Forty-three candidate compounds I [R¹ = Me₃C, EtCMe₂, cyclopentyl, cyclohexyl, n-hexyl, n-octyl, Ph, 4-ClC₆H₄, 2,4,6-Me₃C₆H₂, PhCMe₂CH₂; R² = 3-(3-pyridyl)-1-Pr, Ph(CH₂)₃, H₂C:CH(CH₂)₈, etc.] that displayed favorable binding with the receptor were identified and synthesized. The neurotrophic activity of the candidate compounds was evaluated on chick dorsal root ganglion cultures in vitro. As a result, 15 compounds exhibited pos. effects on ganglion neurite outgrowth in the presence of 0.15 ng/mL NGF, among which 7 compounds at testing concentrations of 1 pM and 100 pM showed greater efficacy than 1 at 100 pM. I [R¹ = Me₃C; R² = 3-(3-pyridyl)-1-propyl; (II)] afforded the most potent effect in promoting the processes of neurite outgrowth and which was in a concentration-dependent manner from 1 pM to 100 pM. Half-maximal effect occurred at about 10 pM. Moreover, II at a dosage of 10 mg/kg was found to be significantly neuroprotective in a mouse peripheral sympathetic nerve injury model induced by 8 mg/kg 6-hydroxydopamine. This study further suggests the clin. potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson’s disease.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C9H11BO4, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xing-De published the artcileDesign, synthesis and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis, Name: Pentane-1,5-diol, the publication is European Journal of Medicinal Chemistry (2022), 114171, database is CAplus and MEDLINE.

Persistent activation of hepatic gluconeogenesis is a main cause of fasting hyperglycemia in patients with type 2 diabetes (T2D), and the salt-induced kinase 1 (SIK1) acts as a key modulator in regulating hepatic gluconeogenesis. Recently, we first reported phanginin A (PA, 1), a natural cassane diterpenoid isolated from the seeds of Caesalpinia sappan, exhibited potent anti-diabetic effect through activation of SIK1 and increasing PDE4 activity to inhibit hepatic gluconeogenesis pathway by suppressing the cAMP/PKA/CREB pathway in the liver. In present study, we designed and prepared 25 PA derivatives and their structure-activity relationship (SAR) for gluconeogenesis inhibitory activity were established. Among them, compound I exhibited remarkable inhibitory activity on hepatic gluconeogenesis by enhancing the SIK1 phosphorylation and ameliorated the hyperglycemia of type 2 diabetic mice. Our results supported that compound I could be served as a potential candidate for the treatment of T2D.

European Journal of Medicinal Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C16H24BF4Ir, Name: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajendran, Ranjith kumar published the artcileBiodegradation of the endocrine disrupter 4-tert-octylphenol by the yeast strain Candida rugopelliculosa RRKY5 via phenolic ring hydroxylation and alkyl chain oxidation pathways, Related Products of alcohols-buliding-blocks, the publication is Bioresource Technology (2017), 55-64, database is CAplus and MEDLINE.

4-(1,1,3,3-Tetramethylbutane)-phenol (4-tert-OP) is one of the most prevalent endocrine disrupting pollutants. Information about bioremediation of 4-tert-OP remains limited, and no study has been reported on the mechanism of 4-tert-OP degradation by yeasts. The yeast Candida rugopelliculosa RRKY5 was proved to be able to utilize 4-methylphenol, bisphenol A, 4-ethylphenol, 4-tert-butylphenol, 4-tert-OP, 4-tert-nonylphenol, isooctane, and phenol under aerobic conditions. The optimum conditions for 4-tert-OP degradation were 30°C, pH 5.0, and an initial 4-tert-OP concentration of 30 mg L^-1; the maximum biodegradation rate constant was 0.107 d^-1, equivalent to a min. half-life of 9.6 d. SEM revealed formation of arthroconidia when cells were grown in the presence of 4-tert-OP, whereas the cells remained in the budding form without 4-tert-OP. Identification of the 4-tert-OP degradation metabolites using liquid chromatog.-hybrid mass spectrometry revealed three different mechanisms via both branched alkyl side chain and aromatic ring cleavage pathways.

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gong, Jun published the artcileIodization-enhanced fluorescence and circularly polarized luminescence for dual-readout probe design, Recommanded Product: 2-Phenylethanethiol, the publication is Sensors and Actuators, B: Chemical (2021), 130610, database is CAplus.

Circularly polarized luminescence (CPL) is a preferential emission from chiral systems. Introducing CPL to traditional small fluorescence probes will greatly enhance selectivity and sensitivity due to avoiding the background fluorescence. Small-mol. probes are practically useful for bioimaging and sensing but always suffer from weak CPL properties. To optimize chiral perturbation, the study of structure-CPL correlation is an urgent necessity. Here, we investigated the influence of 3, 3′-substituent of BINOL on optical properties and found that iodization could significantly enhance the fluorescence quantum yield (Φ_F) and dissymmetry factor (|g_lum|). Based on this finding, we presented a strategy to design dual-readout probes emiting both robust total fluorescence and CPL upon activation. As an application example, we first designed a pair of thiols probes, R/S-P1, with the fluorescence readout showing good linear response to cysteine, and CPL signal displaying significant enhancement with |g_lum| from undetectable value to 0.7 x 10^-3.

Sensors and Actuators, B: Chemical published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts