Author: tianli

Satoh, Yasushi published the artcileHighly selective synthesis of hydrosiloxanes by Au-catalyzed dehydrogenative cross-coupling reaction of silanols with hydrosilanes, Computed Properties of 17877-23-5, the publication is ACS Catalysis (2017), 7(3), 1836-1840, database is CAplus.

We report a highly selective synthesis of siloxane building blocks containing SiH₂or SiH functionalities. The system AuCl(PPh₃)/PPh₃ or AuCl(PPh₃)/PBu₃ catalyzed the reaction of trihydrosilanes with silanols giving SiH₂-containing siloxanes exclusively. On the other hand, a highly selective reaction of dihydrosilanes with silanols to afford SiH-containing siloxanes was achieved by simply changing the phosphine ligand to a bidentate one, xantphos. Usefulness of SiH₂-containing siloxanes was demonstrated by the synthesis of a trisiloxane, Et₃SiOSi(Ph)(H)OSi^tBuMe₂, and a pentasiloxane, Ph₂Si(OSiHPhOSiEt₃)₂, bearing SiH functionalities.

ACS Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Watanabe, Bunta published the artcileSynthesis and inhibitory activity of substrate-analog fructosyl peptide oxidase inhibitors, SDS of cas: 20880-92-6, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(18), 3910-3913, database is CAplus and MEDLINE.

Fructosyl peptide oxidases (FPOXs) play a crucial role in the diagnosis of diabetes. Their main function is to cleave fructosyl amino acids or fructosyl peptides into glucosone and the corresponding amino acids/dipeptides. In this study, the substrate-analog FPOX inhibitors were successfully designed and synthesized. These glycosyl-amino acid inhibitors mimic N^α-fructosyl-L-valine (Fru-Val), [N^α-fructosyl-L-valyl]-L-histidine (Fru-ValHis), and N^ε-fructosyl-L-lysine (εFru-Lys), resp. The secondary nitrogen atom in the natural substrates, linking fructose and amino acid or dipeptide moieties, was substituted in glycosyl-amino acids with a sulfur atom to avoid enzymic cleavage. Kinetic studies revealed that prepared glycosyl-amino acids act as competitive inhibitors against an FPOX obtained from Coniochaeta sp., and K_i values of 11.1, 66.8, and 782 μM were obtained.

Bioorganic & Medicinal Chemistry Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H15BF2O2, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Samarajeewa, Sandani published the artcileDegradable Cationic Shell Cross-Linked Knedel-like Nanoparticles: Synthesis, Degradation, Nucleic Acid Binding, and in Vitro Evaluation, Product Details of C18H20N2O12, the publication is Biomacromolecules (2013), 14(4), 1018-1027, database is CAplus and MEDLINE.

In this work, degradable cationic shell crosslinked knedel-like (deg-cSCK) nanoparticles were developed as an alternative platform to replace similar nondegradable cSCK nanoparticles that have been utilized for nucleic acids delivery. An amphiphilic diblock copolymer poly(acrylamidoethylamine)₉₀-block-poly(DL-lactide)₄₀ (PAEA₉₀-b-PDLLA₄₀) was synthesized, self-assembled in aqueous solution, and shell crosslinked using a hydrolyzable crosslinker to afford deg-cSCKs with an average core diameter of 45 ± 7 nm. These nanoparticles were fluorescently labeled for in vitro tracking. The enzymic- and hydrolytic-degradability, siRNA binding affinity, cell uptake and cytotoxicity of the deg-cSCKs were evaluated. Esterase-catalyzed hydrolysis of the nanoparticles resulted in the degradation of ca. 24% of the PDLLA core into lactic acid within 5 d, as opposed to only ca. 9% degradation from aqueous solutions of the deg-cSCK nanoparticles in the absence of enzyme. Cellular uptake of deg-cSCKs was efficient, while exhibiting low cytotoxicity with LD50 values of ca. 90 and 30 μg/mL in RAW 264.7 mouse macrophages and MLE 12 cell lines, resp., ca. 5- to 6-fold lower than the cytotoxicity observed for nondegradable cSCK analogs. Addnl., deg-cSCKs were able to complex siRNA at an N/P ratio as low as 2, and were efficiently able to facilitate cellular uptake of the complexed nucleic acids.

Biomacromolecules published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Product Details of C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Black, Kvar C. L. published the artcileIn vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biomaterials (2016), 53-63, database is CAplus and MEDLINE.

Nanoparticles (NPs) play expanding roles in biomedical applications including imaging and therapy, however, their long-term fate and clearance profiles have yet to be fully characterized in vivo. NP delivery via the airway is particularly challenging, as the clearance may be inefficient and lung immune responses complex. Thus, specific material design is required for cargo delivery and quant., noninvasive methods are needed to characterize NP pharmacokinetics. Here, biocompatible poly(acrylamidoethylamine)-b-poly(DL-lactide) block copolymer-based degradable, cationic, shell-cross-linked knedel-like NPs (Dg-cSCKs) were employed to transfect plasmid DNA. Radioactive and optical beacons were attached to monitor biodistribution and imaging. The preferential release of cargo in acidic conditions provided enhanced transfection efficiency compared to non-degradable counterparts. In vivo gene transfer to the lung was correlated with NP pharmacokinetics by radiolabeling Dg-cSCKs and performing quant. biodistribution with parallel positron emission tomog. and Cerenkov imaging. Quantitation of imaging over 14 days corresponded with the pharmacokinetics of NP movement from the lung to gastrointestinal and renal routes, consistent with predicted degradation and excretion. This ability to noninvasively and accurately track NP fate highlights the advantage of incorporating multifunctionality into particle design.

Biomaterials published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elbehery, Huda H. published the artcileCinnamon essential oil loaded β-cyclodextrin/gum Arabic nanoparticles affecting life table parameters of potato tuber moth, Phthorimaea operculella (Zeller), Quality Control of 106-25-2, the publication is Biocatalysis and Agricultural Biotechnology (2022), 102349, database is CAplus.

Plant essential oils are considered potential natural alternatives to chem. insecticides. However, increased degradation and evaporation of essential oils on exposure to environmental conditions may affect the bioavailability of their phytocompounds and reduce their activity as bio-insecticides. Therefore, this study aimed to formulate nanocapsules of cinnamon essential oil (CEO) by lyophilization technique using mixtures of β-cyclodextrin and gum Arabic (βCD + GA) inclusion as coating materials. By measuring life table parameters, the dry nano-formulations of CEO-βCD/GA were tested for insecticidal activity against the potato tuber moth Phthorimaea operculella (Zeller). Gas Chromatog.-Mass Spectrometry anal. of CEO identified cinnamaldehyde as the major volatile, followed by benzyl alc. with eugenol and nerol detected as minor constituents. CEO-βCD/GA particle sizes were 164.43 ± 1.27 nm and 151.36 ± 1.24 nm, with PDI values of 0.11 ± 0.00 and 0.25 ± 0.00 for 5.0 and 2.5% concentration, resp. High percentage of encapsulation efficiency was obtained, reaching 81.53 ± 0.39 and 87.39 ± 0.31 for CEO-βCD/GA at concentrations of 2.5 and 5.0%, resp. Higher mortality rates occurred in larvae treated with 2.5 and 5.0% CEO-βCD/GA (80, 85%, resp.) compared with 45% and 65% mortality rates recorded for 2.5 and 5.0% pure CEO, resp. When compared to pure CEO, CEO-βCD/GA had a significant neg. impact on tested population parameters of life table. Our findings revealed that nanoencapsulation of CEO by loading with βCD + GA inclusion increased its insecticidal efficacy. CEO-βCD/GA nanocapsules could be effective in P. operculella integrated pest management program.

Biocatalysis and Agricultural Biotechnology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Quality Control of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Schoch, Silvia published the artcileTethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes, Computed Properties of 20880-92-6, the publication is Organometallics (2022), 41(5), 514-526, database is CAplus and MEDLINE.

Four propargyl O-glycosides derivatized with mannose, glucose, and fructose moieties were synthesized and then incorporated within a diiron structure as part of a vinyliminium ligand. Hence, six glycoconjugated diiron complexes, [2–5]CF₃SO₃ (see Scheme 1) and the nonglycosylated analogs [6a–b]CF₃SO₃, were obtained in high yields and unambiguously characterized by elemental anal., mass spectrometry, and IR and multinuclear NMR spectroscopies. All compounds exhibited a significant stability in DMSO-d₆/D₂O solution, with 63-89% of the complexes unaltered after 72 h at 37° and also in the cell culture medium. The cytotoxicity of [2–6]CF₃SO₃, as well as that of previously reported 7 and 8, was assessed on CT26 (mouse colon carcinoma), U87 (human glioblastoma), MCF-7 (human breast adenocarcinoma), and RPE-1 (human normal retina pigmented epithelium) cell lines. In general, the IC₅₀ values correlate with the hydrophobicity of the compounds (measured as octanol-H₂O partition coefficients) and do not show an appreciable level of selectivity against cancer cells with respect to the nontumor ones.

Organometallics published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reddy, A. B. published the artcileTriazino-caffeine Derivatives by Intramolecular Cyclization: Synthesis, Characterization and Antimicrobial Studies, Category: alcohols-buliding-blocks, the publication is Letters in Organic Chemistry (2018), 15(6), 540-545, database is CAplus.

In the present study, a new class of triazino-caffeine derivatives with good antimicrobial activities is reported. Eight new triazino-caffeine derivatives were synthesized via Mitsunobu reaction, followed by intramol. cyclization. Their chem. structures were established on the basis of elemental anal., IR, 1H NMR, mass spectral data as well as through an alternate synthetic route. The compounds were also screened for their antimicrobial activities, among them, compounds I (R = Me, H) showed good inhibitory potentials, indicating the importance of the morpholine moiety in enhancing antimicrobial activity. Therefore, it is concluded that the triazino-caffeine derivatives developed, show encouraging potentials in their medicinal applications.

Letters in Organic Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oh, Soo-Jin published the artcileMONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1, HPLC of Formula: 328-90-5, the publication is Molecular Pharmacology (2013), 84(5), 726-735, database is CAplus and MEDLINE.

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiol. functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiol. functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established. We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biol. activity and the nature and position of substituents in these derived compounds A structure-activity relationship revealed novel chem. classes of xANO1 blockers. The derivatives contain a -NO₂ group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC₅₀ < 10 μM. The most potent blocker, N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid (MONNA), had an IC₅₀ of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10∼30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacol. dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

Molecular Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Waterland, R. L. published the artcileGas phase UV and IR absorption spectra of CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3, 4), Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Fluorine Chemistry (2005), 126(9-10), 1288-1296, database is CAplus.

The UV and IR spectra of CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3, 4) were studied using computational and exptl. techniques. Computational methods were used to show that CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3) have UV absorption at λ = 140-175 nm. Photolysis is therefore not a significant environmental loss mechanism for fluorinated alcs. Exptl. methods were used to record IR spectra for CF₃CH₂CH₂OH and F(CF₂CF₂)_xCH₂CH₂OH (χ = 2, 3, 4) at spectral resolutions of 0.004-0.5 cm^-1 with, and without, 700 torr of air diluent. There was no discernable effect of total pressure or spectral resolution over the range studied. Calculated IR spectra agreed with those measured exptl., and were used to assign the IR spectra.

Journal of Fluorine Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H25Br, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Free, Paul published the artcileMannose-pepstatin conjugates as targeted inhibitors of antigen processing, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Organic & Biomolecular Chemistry (2006), 4(9), 1817-1830, database is CAplus and MEDLINE.

The mol. details of antigen processing, including the identity of the enzymes involved, their intracellular location and their substrate specificity, are still incompletely understood. Selective inhibition of proteolytic antigen processing enzymes such as cathepsins D and E, using small mol. inhibitors such as pepstatin, has proven to be a valuable tool in investigating these pathways. However, pepstatin is poorly soluble in water and has limited access to the antigen processing compartment in antigen presenting cells. We have synthesized mannose-pepstatin conjugates, and neomannosylated BSA-pepstatin conjugates, as tools for the in vivo study of the antigen processing pathway. Conjugation to mannose and to neomannosylated BSA substantially improved the solubility of the conjugates relative to pepstatin. The mannose-pepstatin conjugates showed no reduction in inhibition of cathepsin E, whereas the neomannosylated BSA-pepstatin conjugates showed some loss of inhibition, probably due to steric factors. However, a neomannosylated BSA-pepstatin conjugate incorporating a cleavable disulfide linkage between the pepstatin and the BSA showed the best uptake to dendritic cells and the best inhibition of antigen processing.

Organic & Biomolecular Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts