Author: tianli

Santhakumari, Sivasubramanian published the artcileIn vitro and in vivo effect of 2,6-Di-tert-butyl-4-methylphenol as an antibiofilm agent against quorum sensing mediated biofilm formation of Vibrio spp., Formula: C6H13NO2, the publication is International Journal of Food Microbiology (2018), 60-71, database is CAplus and MEDLINE.

This study unveils the in vitro and in vivo antibiofilm potential of 2,6-Di-tert-butyl-4-methylphenol (DTBMP) from Chroococcus turgidus against Vibrio spp. In the preliminary study, cell free culture supernatant (CFCS) of C. turgidus inhibited the violacein production in biomarker strain Chromobacterium violaceum and its mutant strain CV026 in a dose dependent manner. The effective biofilm inhibitory concentration (BIC) of pure compound DTBMP from C. turgidus was identified as 250μg/mL concentration in tested Vibrio species. Furthermore, DTBMP proved to effectively inhibit the bioluminescence production in V. harveyi and other biofilm related virulence traits such as exopolysaccharides (EPS) production, hydrophobicity index, swimming and swarming motility at its BIC concentration in three major pathogenic vibrios: V. harveyi, V. parahaemolyticus and V. vulnificus. The antibiofilm potential of DTBMP was validated through light, confocal laser scanning and scanning electron microscopic analyses. In addition, the non-bactericidal effect of DTBMP was determined through growth curve and 2,3-bis (2-methyloxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay. Real-time PCR studies revealed the down-regulation of master quorum sensing (QS) regulator genes of V. harveyi such as luxR, luxS, luxP, luxQ and luxO on treatment with DTBMP. In vivo results confirmed that DTBMP augmented the survival rate of Litopenaeus vannamei larvae up to 75, 88 and 66% upon infection with V. harveyi, V. parahaemolyticus and V. vulnificus, resp. The results of this study ascertain the promising effects of DTBMP as an antibiofilm agent, which could be pos. explored to treat biofilm-associated vibrios infections in aquaculture.

International Journal of Food Microbiology published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Formula: C6H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Oudat, Buthina A. published the artcileDesign, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents, HPLC of Formula: 86-48-6, the publication is Bioorganic & Medicinal Chemistry (2020), 28(16), 115608, database is CAplus and MEDLINE.

The enzyme glyoxalase-I (Glo-I) is an essential therapeutic target in cancer treatment. Significant efforts have been made to discover competitive inhibitors of Glo-I as potential anticancer agents. Herein, the synthesis of a series of diazenylbenzenesulfonamide derivatives 3-R-4-R¹-C₆H₃N=NR² (R = H, sulfamoyl, carboxy; R¹ = H, Me, carboxy, sulfo; R² = 4-amino-6-hydroxynaphthalen-1-yl, 8-hydroxyquinolin-5-yl, 4-hydroxyphenyl, etc.) and their in vitro evaluation against Glo-I and the resulting structure-activity relationships were reported. Among the compounds tested, compounds 3-R-4-R¹-C₆H₃N=NR² (R = sulfamoyl, R¹ = Me, R² = 8-hydroxyquinolin-5-yl) and (R = sulfamoyl, R¹ = Me, R² = 3-carboxy-4-hydroxynaphthalen-1-yl) exhibited the highest activity with IC₅₀ 1.28μM and 1.13μM, resp. Docking studies to explore the binding mode of the compounds identified the key moieties that may contribute to the observed activities. The active compounds will serve as suitable leads for further chem. optimization.

Bioorganic & Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Davies, Jacob published the artcileNi-Catalyzed carboxylation of aziridines en route to β-amino acids, Product Details of C4H11NO, the publication is Journal of the American Chemical Society (2021), 143(13), 4949-4954, database is CAplus and MEDLINE.

A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO₂ at atm. pressure is disclosed. The protocol is characterized by its mild conditions, exptl. ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.

Journal of the American Chemical Society published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Traeff, A. M. published the artcileC-F bond substitution via aziridinium ion intermediates, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(68), 13260-13263, database is CAplus and MEDLINE.

Aliphatic 1,2-aminofluorides undergo extremely fast substitution reactions under the influence of lanthanum tris(hexamethyldisilazide). The substitution proceeds via an in situ generated aziridinium ion intermediate, which subsequently undergoes ring opening by addition of a nucleophile, yielding various β-substituted amines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C13H19N5OS, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Sohyun published the artcileValidating the Mott Formula with Self-Assembled Monolayer (SAM)-Based Large-Area Junctions: Effect of Length, Backbone, Spacer, Substituent, and Electrode on the Thermopower of SAMs, Formula: C8H10S, the publication is Journal of Physical Chemistry C (2021), 125(36), 20035-20047, database is CAplus.

Understanding how the Seebeck effect of organic thermoelec. devices is associated with the chem. structure of active mols. within the devices is a key goal in organic and mol. thermoelecs. This paper describes a series of phys.-organic studies that investigate structure-thermopower relationships in self-assembled monolayers (SAMs) through measurements of the Seebeck coefficient (S, μV/K) using the eutectic gallium-indium (EGaIn)-based junction technique. Several hypotheses were derived from a transmission function-based simple toy model, the Lorentzian transmission function-based Mott formula. These hypotheses were tested by comparing values of S for simple alkyl and aryl mols. with different structures in terms of backbone, length, spacer, anchor, and substituent, and for different electrodes (Au vs Ag), and by monitoring responses of S to the structural modifications. Exptl. obtained S values were further reconciled with values simulated by the Mott formula and with interfacial electronic structure and mol.-electrode coupling strength, independently measured by UPS and transition voltage spectroscopy.

Journal of Physical Chemistry C published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Formula: C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bhunia, Susmita published the artcileCatalytic olefin epoxidation over cobalt(II)-containing mesoporous silica by molecular oxygen in dimethylformamide medium, Application In Synthesis of 57044-25-4, the publication is Catalysis Science & Technology (2014), 4(6), 1820-1828, database is CAplus.

A cobalt(II) Schiff base complex has been immobilized onto the surface of Si-MCM-41 to prepare a new catalyst. The amine group-containing organic moiety 3-aminopropyl-triethoxysilane had first been anchored on the surface of Si-MCM-41 via a silicon alkoxide route. Upon condensation with salicylaldehyde, the amine group affords a bidentate Schiff-base moiety in the mesoporous matrix, which is subsequently used for anchoring of cobalt(II) centers. The prepared catalyst has been characterized by UV-vis, IR, EPR spectroscopic and small angle X-ray diffraction (XRD) analyses, and N₂ sorption studies. The catalytic activity was tested in epoxidation reactions of olefinic compounds, including styrene and allyl alc., with mol. oxygen at atm. pressure in DMF medium in the absence of addnl. sacrificial reductant. The reactions seemed to proceed through a radical formation mechanism. The immobilized catalyst showed good activity and epoxide selectivity in the alkene epoxidation Notably, the catalyst can be recovered and reused without any loss of activity.

Catalysis Science & Technology published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

White, James D. published the artcileStudies of the Synthesis of Providencin: Construction and Assembly of Two Major Subunits, Application of (R)-Oxiran-2-ylmethanol, the publication is Journal of Organic Chemistry (2014), 79(2), 700-710, database is CAplus and MEDLINE.

The “northern” sector of the cembranoid diterpene providencin (I) containing a tetrasubstituted cyclobutane was synthesized from the bis(acetonide) of D-glucose using dicyclopentadienylzirconium(0)-mediated oxygen abstraction from a furanose. Oxidative scission of the vinyl substituent of this cyclobutane gave an aldehyde, which was reacted with an alkynylstannane to provide an allenol (II). Cyclization of the derived allenone with silver nitrate led to a cyclobutylfuran (III) comprising the northern subunit of providencin. The “southern” sector of the cembranoid skeleton containing a trisubstituted iodoalkene attached to an α-phenylselenyl-γ-lactone was synthesized from (R)-glycidol. Negishi carbometalation-iodination established the (E)-iodoalkene, and addition of the lithio dianion of phenylselenoacetic acid to a tosylate generated the substituted lactone (IV). The two sectors were joined via stannylation of the furan of the northern component followed by Stille cross-coupling of the furylstannane with the iodoalkene of the southern subunit. Linkage of the two segments was also made at C12-C13 of providencin using intermol. aldol condensation of the enolate from the selenyl lactone of the southern portion with an acetaldehyde appendage on the cyclobutane of the northern sector. Closure of the providencin macrocycle from these conjoined subunits was unsuccessful.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C15H15OP, Application of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Joufi, Fakhria A. published the artcileAnabasis articulata (Forssk.) Moq: A Good Source of Phytochemicals with Antibacterial, Antioxidant, and Antidiabetic Potential, SDS of cas: 90-64-2, the publication is Molecules (2022), 27(11), 3526, database is CAplus and MEDLINE.

Anabasis articulata is medicinally used to treat various diseases. In this study, A. articulata was initially subjected to extraction, and the resultant extracts were then evaluated for their antimicrobial, antioxidant, and antidiabetic potentials. After obtaining the methanolic extract, it was subjected to a silica gel column for separation, and fractions were collected at equal intervals. Out of the obtained fractions (most rich in bioactive compounds confirmed through HPLC), designated as A, B, C, and D as well hexane fraction, were subjected to GC-MS anal., and a number of valuable bioactive compounds were identified from the chromatograms. The preliminary phytochem. tests were pos. for the extracts where fraction A exhibited the highest total phenolic and flavonoid contents. The hexane fraction as antimicrobial agent was the most potent, followed by the crude extract, fraction A, and fraction D. DPPH and ABTS assays were used to estimate the free radical scavenging potential of the extracts Fraction C was found to contain potent inhibitors of both the tested radicals, followed by fraction D. The potential antidiabetic extracts were determined using α-glucosidase and amylase as probe enzymes. The former was inhibited by crude extract, hexane, and A, B, C and D fractions to the extent of 85.32 ± 0.20, 61.14 ± 0.49, 62.15 ± 0.84, 78.51 ± 0.45, 72.57 ± 0.92 and 70.61 ± 0.91%, resp., at the highest tested concentration of 1000 μg/mL with their IC50 values 32, 180, 200, 60, 120 and 140 μg/mL correspondingly, whereas α-amylase was inhibited to the extent of 83.98 ± 0.21, 58.14 ± 0.75, 59.34 ± 0.89, 81.32 ± 0.09, 74.52 ± 0.13 and 72.51 ± 0.02% (IC50 values; 34, 220, 240, 58, 180, and 200 μg/mL, resp.). The observed biol. potentials might be due to high phenolic and flavonoid content as detected in the extracts The A. articulata might thus be considered an efficient therapeutic candidate and could further be investigated for other biol. potentials along with the isolation of pure responsible ingredients.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Shaikh, Aminah Jeza published the artcileBioaugmentation of halophilic consortia for the degradation of petroleum hydrocarbons and petroleum wastewater treatment, Related Products of alcohols-buliding-blocks, the publication is International Journal of Advanced Research in Biological Sciences (2020), 7(9), 97-112, database is CAplus.

The present study, details about a halophilic bacterial consortium enriched from water and sediment samples from Red sea, Jeddah, Saudi Arabia analyzed for PAHs degradation potential under saline condition (40 g/L NaCl concentration). The bacterial consortium was able to growth in halophilic mineral salt medium with PAHs (Polycyclic Aromatic Hydrocarbons) as sole carbon source. Different types of selected LMW (Low Mol. Weight) PAHs such as phenathrene (PHN) and fluorine (FLU) at different concentrations (25, 50, 100, 200, 500 ppm) and pyrene (PY) from HMW(High Mol. Weight) PAH at 50 and 100 ppm concentrations was used in the study under saline condition. The results recorded 90% degradation of phenanthrene and fluoreneupto 500 ppm. HMW pyrene revealed 79% and 69% degradation at 50 ppm and 100 ppm concentration under saline condition by the halophilic consortium. Addition of FLU (100 ppm) along with the PY (50 ppm) recorded 85% of PY degradation in 8 days and 98% degradation in 12 days. Addition of yeast extract during PY degradation recorded complete degradation of PY (50 ppm) in 12 days. Lab Scale reactor study with CSTR (continuous stirred tank reactor) used to investigate the PAHs degradation and petroleum refinery wastewater treatment efficiency of in thehalophilic bacterial consortium. The results recorded 95% COD removal in 32 days with complete degradation of LMW PAHs in 12 days under saline condition. Bacterial strains in the consortium were identified by using mol. techniques such as DNA isolation and next generation sequencing.

International Journal of Advanced Research in Biological Sciences published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jorvekar, Sachin B. published the artcileDetermination of bisphenols and parabens in cow urine distillate from India: implication of human exposure and risk assessment, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Environmental Science and Pollution Research (2022), 29(35), 52507-52519, database is CAplus and MEDLINE.

The exposures of a wide range of endocrine-disrupting chems. to cows have been linked to diseases and are a major concern. In Indian scripts, cow urine is believed to be a treatment for many diseases. Nonetheless, exposure of bisphenols and parabens to cow urine distillates is unknown. Hence, in this study, we determined the concentration of bisphenols and parabens in com. available cow urine distillate collected from India. The mean concentration of total bisphenols and parabens ranges from the limit of quantification (LOQ) to 149.3 ng/mL and 1479.88 ng/mL, resp. Predominant bisphenol-F and bisphenol-A were accounted for 88.6% and 6% of total bisphenol concentration, resp., in marketed cow urine distillate, whereas Me and Pr parabens were dominant and accounted for 33% and 65%, resp. The estimated mean daily intake (EDI) of bisphenol for males and females were 45.94 ng/kg-bw/day and 54.29 ng/kg-bw/day, resp., while for parabens EDI was 455.35ng/kg-bw/day and 538.14 ng/kg-bw/day for males and females, resp. Hazard quotient, to evaluate the potential risk of exposure, showed no risk in the studied samples. Even though the EDI results from the Monte-Carlo risk assessment anal. did not exceed the acceptable daily intake, their estrogenic actions cannot be ignored in general populations. The estrogenic activities contributed by parabens and bisphenol A measured by estradiol equivalency quotient (EEQ) ranged from 0.00033-42 pg/mL and 2.3 pg/mL, resp. Our results revealed higher concentrations of bisphenols and parabens in cow urine distillates; hence, special attention should be given to the quality and safety of cow urine distillates. Moreover, strict guidelines should be enforced for the quality of cow urine distillates.

Environmental Science and Pollution Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts