Author: tianli

Zhang, Datong published the artcileSynthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings, Category: alcohols-buliding-blocks, the publication is Archives of Pharmacal Research (2010), 33(6), 831-842, database is CAplus and MEDLINE.

Two series of novel 2-Bu succinate-based Hydroxamate derivatives containing isoxazole rings, e.g. I [R = H, i-Bu], were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcusaureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

Archives of Pharmacal Research published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C8H14O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xi-Zhao published the artcileConcise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins, Computed Properties of 438565-33-4, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2007), 54(3), 643-652, database is CAplus.

The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C₆H₄-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO₂, -4-NO₂, -3-CF₃, -4-CF₃, C₆H₃-2,4-Cl₂, -3,4-Cl₂, C₆H₂-2,4,5-Cl₃, -3,4,5-Cl₃, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH₂OH using CuSO₄.5H₂O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H7BrO2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Yang published the artcilePorous organic cage for enantiomeric fluorescence recognition of amino acid and hydroxy acid, COA of Formula: C8H8O3, the publication is Luminescence (2021), 36(8), 2022-2027, database is CAplus and MEDLINE.

A new method based on the enantioselective recognition of porous organic cages CC3-R was established for the first time. Porous organic cages are widely used for separation, adsorption and host-guest interaction sensing, but are rarely used for fluorescence sensing. Based on the inherent chiral environment of CC3-R and the inherent fluorescence properties of the organic ligands constituting the cage, when different chiral monomers diffuse into the cage, different effects occur to produce changes in fluorescence. We found for the first time that the fluorescence of CC3-R can be enhanced and quenched by tyrosine and mandelic acid, resp., and that different chiral monomers are enhanced or quenched differently at the same concentration Unlike the chiral recognition of other composite luminescent materials, the chiral porous organic cage not only utilizes its own host-guest effect for chiral recognition, but also utilizes the organic ligands constituting the cage for luminescence recognition. This work provides an alternative method to accomplish chiral recognition other than chromatog., that is using porous organic cages (POC), but it can show the advantages of simplicity, low cost and high sensitivity. We believe this work could provide valuable thoughts in the exploration of POC in chiral recognition as new FL probes for the future.

Luminescence published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, L. published the artcileDesign, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2011), 50B(5), 695-703, database is CAplus.

N-formylhydroxylamines RC(NH₂):COCH₂NHCOCHBuCH₂N(OH)CHO (R = substituted Ph) were synthesized through a multi-step protocol starting from H₂C(CO₂Et)₂. The newly synthesized compounds were screened for antibacterial activity. All the compounds exhibited potent in-vitro inhibitory activity against S. aureus and weak activity against K. pneumoniae.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bachovchin, Daniel A. published the artcileSuperfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening, Quality Control of 23351-09-9, the publication is Proceedings of the National Academy of Sciences of the United States of America (2010), 107(49), 20941-20946, S20941/1-S20941/172, database is CAplus and MEDLINE.

Serine hydrolases (SHs) are-one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biol. understanding for most of the 110+ predicted mammalian metabolic SHs, in large part because of a dearth of assays to assess their biochem. activities and a lack of selective inhibitors to probe their function in living systems. We show here that the vast majority (>80%) of mammalian metabolic SHs can be labeled in proteomes by a single, active site-directed fluorophosphonate probe. We exploit this universal activity-based assay in a library-vs.-library format to screen 70+ SHs against 140+ structurally diverse carbamates. Lead inhibitors were discovered for ∼40% of the screened enzymes, including many poorly characterized SHs: Global profiles identified carbamate inhibitors that discriminate among highly sequence-related SHs and, conversely, enzymes that share inhibitor sensitivity profiles despite lacking sequence homol. These findings indicate that sequence relatedness is not a strong predictor of shared pharmaol. within the SH superfamily. Finally, we show that lead carbamate inhibitors can be optimized into pharmacol. probes that inactivate individual SHs with high specificity in vivo.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diao, Xinyong published the artcileFabricating high temperature stable Mo-Co₉S₈/Al₂O₃ catalyst for selective hydrodeoxygenation of lignin to arenes, COA of Formula: C9H12O, the publication is Applied Catalysis, B: Environmental (2022), 121067, database is CAplus.

Achieving high-temperature stability/duration without compromising the activity remains an arduous task in catalyst design, particularly for MoS₂ materials. Herein, a robust catalyst with Mo doped Co₉S₈ nanoparticles anchored on Al₂O₃ matrix is fabricated, which could selectively convert lignin to arenes with high hydrodeoxygenation activity, selectivity and particularly excellent stability. In the hydrodeoxygenation of di-Ph ether, this catalyst afforded 99.8% conversion and 91.0% yield of benzene at 265°C for at least 10 reaction runs. The resultant Mo-Co₉S₈ structure with chem. connection by covalent bonds of Mo-S-Co type on the Co₉S₈ surface demonstrates strong ability in the adsorption and activation of oxygen-containing substrates, which enables the effective C-O cleavage while avoids undesirable hydrogenation of benzene ring. The superior stability and water-resistance at elevated temperature was attributed to the anchoring effect of Al₂O₃ matrix and “protection” of surface-rich Co₉S₈ species to the active Mo-Co₉S₈ center. This strategy provides new sights for the rational design of efficient and stable sulfide catalysts toward the applications in demanding high-temperature reactions.

Applied Catalysis, B: Environmental published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diao, Xinyong published the artcileRational design of oligomeric MoO₃ in SnO₂ lattices for selective hydrodeoxygenation of lignin derivatives into monophenols, Name: 4-Propylphenol, the publication is Journal of Catalysis (2021), 234-251, database is CAplus.

Novel Mo-Sn bimetallic oxide catalysts with highly dispersed oligomeric MoO₃ in SnO₂ lattices, which were synthesized by the co-precipitation method and pretreated by anhydrous ethanol, were first employed in the hydrodeoxygenation of various lignin derivatives to produce monophenols with high activity and selectivity. In comparison with the pure α-MoO₃ and the previous reported catalysts, the α-2Mo1Sn exhibited superior activity in the hydrodeoxygenation of guaiacol, with full conversion and 92.5% phenol yield at 300°C under 4 MPa initial H₂ pressure in n-hexane for 4 h. According to comprehensive characterizations and catalytic measurements, the excellent performance of α-2Mo1Sn was ascribed to the formation of abundant Sn-O-Mo-O_V interfacial sites, which possessed strong Mo-Sn interaction with enhanced surface area, electron-donating group binding ability, Lewis acidity, and redox ability. It was demonstrated that over the present α-2Mo1Sn catalyst system, the Sn-O-Mo-O_V interfacial sites could greatly facilitate the adsorption and activation of C_aromatic-OCH₃ and C_aromatic-CH₃ bonds, and thus significantly promote the demethoxylation and demethylation reaction to produce phenol. This work figures out the rational design of MoO₃-based catalyst and displays a clear potential for the selective hydrodeoxygenation of lignin derivatives into monophenols.

Journal of Catalysis published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Shi published the artcileExploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Archiv der Pharmazie (Weinheim, Germany) (2019), 352(11), 1900129, database is CAplus and MEDLINE.

To gain further knowledge of the structure-activity relationship and druggability of novel oxazolidinone-based UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitors as Gram-neg. antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and their antibacterial activities against standard and clin. isolated Gram-neg. strains were evaluated. We summarized their structure-activity relationships and found that oxazolidinone-based compounds exhibited a narrower antibacterial spectrum compared with threonine-based compounds Furthermore, we parallelly compared the metabolic stabilities of the compounds with the classic threonine scaffold and the novel oxazolidinone scaffold in liver microsomes. The results indicated that the druggability of the oxazolidinone scaffold may be inferior to the classic threonine scaffold in the design of LpxC inhibitors.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bhattacharya, Ushashi published the artcileSurface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization, Category: alcohols-buliding-blocks, the publication is Scientific Reports (2021), 11(1), 18583, database is CAplus and MEDLINE.

Synaptosomes are subcellular fractions prepared from brain tissues that are enriched in synaptic terminals, widely used for the study of neural transmission and synaptic dysfunction. Immunofluorescence imaging is increasingly applied to synaptosomes to investigate protein localization. However, conventional methods for imaging synaptosomes over glass coverslips suffer from formaldehyde-induced aggregation. Here, we developed a facile strategy to capture and image synaptosomes without aggregation artifacts. First, ethylene glycol bis(succinimidyl succinate) (EGS) is chosen as the chem. fixative to replace formaldehyde. EGS/glycine treatment makes the zeta potential of synaptosomes more neg. Second, we modified glass coverslips with 3-aminopropyltriethoxysilane (APTES) to impart pos. charges. EGS-fixed synaptosomes spontaneously attach to modified glasses via electrostatic attraction while maintaining good dispersion. Individual synaptic terminals are imaged by conventional fluorescence microscopy or by super-resolution techniques such as direct stochastic optical reconstruction microscopy (dSTORM). We examined tau protein by two-color and three-color dSTORM to understand its spatial distribution within mouse cortical synapses, observing tau colocalization with synaptic vesicles as well postsynaptic densities.

Scientific Reports published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kopriva, Ivica published the artcileNon-negative Least Squares Approach to Quantification of ¹H Nuclear Magnetic Resonance Spectra of Human Urine, Formula: C8H8O3, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(2), 745-751, database is CAplus and MEDLINE.

Because of its quant. character and capability for high-throughput screening, ¹H NMR (NMR) spectroscopy is used extensively in the profiling of biofluids such as urine and blood plasma. However, the narrow frequency bandwidth of ¹H NMR spectroscopy leads to a severe overlap of the spectra of components present in the complex mixtures such as biofluids. Therefore, ¹H NMR-based metabolomics anal. is focused on targeted studies related to concentrations of the small number of metabolites. Here, we propose a library-based approach to quantify proportions of overlapping metabolites from ¹H NMR mixture spectra. The method boils down to the linear non-neg. least squares (NNLS) problem, whereas proportions of the pure components contained in the library stand for the unknowns. The method is validated on an estimation of the proportions of (i) the 78 pure spectra, presumably related to type 2 diabetes mellitus (T2DM), from their synthetic linear mixture; (ii) metabolites present in 62 ¹H NMR spectra of urine of subjects with T2DM and 62 ¹H NMR spectra of urine of control subjects. In both cases, the inhouse library of 210 pure component ¹H NMR spectra represented the design matrix in the related NNLS problem. The proposed method pinpoints 63 metabolites that in a statistically significant way discriminate the T2DM group from the control group and 46 metabolites discriminating control from the T2DM group. For several T2DM-discriminative metabolites, we prove their presence by independent anal. determination or by pointing out the corresponding findings in the published literature.

Analytical Chemistry (Washington, DC, United States) published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts