Author: tianli

Hu, Yiping published the artcileDesign, Synthesis, Molecular Docking Studies of Deferasirox Derivatives of 1,2,4-Triazole as Potential Antimicrobial Agents, Formula: C8H5F3O3, the publication is ChemistrySelect (2021), 6(45), 12914-12920, database is CAplus.

A series of deferasirox derivatives of 1,2,4-triazole I (R¹ = H, CF₃; R² = R³ = H, CF₃, COOH, COOMe, COOEt) were designed and synthesized by the ring-opening rearrangement reaction of Ph hydrazine or its substituents and imines, some compounds are previously unknown. The antibacterial activities of all compounds against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans and Aspergillus niger were exptl. evaluated. Most of them exhibited potential antimicrobial activity and promising antifungal activity. Especially, I (R¹ = CF₃; R² = COOEt; R³ = H) and I (R¹ = CF₃; R² = H; R³ = COOEt) showed the best antimicrobial activity (MIC₉₀ = 0.125-2.0μg/mL) against Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli, while compounds I (R¹ = R² = H; R³ = COOMe), I (R¹ = CF₃; R² = COOMe; R³ = H) showed excellent antifungal activity (MIC₉₀ = 0.5-2.0μg/mL). The mol. docking anal. further revealed that all the synthesized derivatives have shown potential binding affinities.

ChemistrySelect published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Haolan published the artcilePreparation of highly dispersed Cu catalysts from hydrotalcite precursor for the dehydrogenation of 1,4-butanediol, Quality Control of 111-29-5, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 251-259, database is CAplus.

Copper-based catalysts are widely used in methanol synthesis, selective catalytic reduction of NOx, hydrogenation, dehydrogenation and hydrogenolysis reactions. In this work, a series of Cux/Zn₃–₀.₅xMg₃–₀.₅xAl₂O₉-x catalysts were prepared via the controlled calcination and reduction of hydrotalcite-like structured CuxZn₃–₀.₅xMg₃–₀.₅xAl₂(OH)₁₆CO₃ precursors. The formation process of Cu₂/Zn₂Mg₂Al₂O₇ from Cu₂Zn₂Mg₂Al₂(OH)₁₆CO₃ was characterized via several techniques. Characterizations results indicated that the dispersion of Cu in reduced Cu₂/Zn₂Mg₂Al₂O₇ reached 79.3%, and it exhibited excellent activity for the dehydrogenation of 1,4-butanediol (1,4-BDO) to γ-butyrolactone (GBL). The detected conversion of 1,4-BDO reached 99.2% with a 99.5% selectivity of GBL at 240°C, 0.1 MPa and LHSV-1 = 0.13 h, and the calculated productivity of GBL was 7.07 g-GBL/g-cat/h. And Cu₂/Zn₂Mg₂Al₂O₇ could maintain its activity within 50 h on stream.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Zhixiang published the artcileOxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2019), 141(8), 3541-3549, database is CAplus and MEDLINE.

A robust and practical protocol for preparing alkyl aryl ethers has been developed, which relies on using two types of ligands to promote Cu-catalyzed alkoxylation of (hetero)aryl halides. The reaction scope is very general for a variety of coupling partners, particularly for challenging secondary alcs. and (hetero)aryl chlorides. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to alkoxylation of aryl iodides complete at room temperature Addnl., a number of carbohydrate derivatives are applicable for this coupling reaction, affording the corresponding carbohydrate-aryl ethers in 29-98% yields.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ganda, Sylvia published the artcileBiodegradable Glycopolymeric Micelles Obtained by RAFT-controlled Radical Ring-Opening Polymerization, COA of Formula: C12H20O6, the publication is Macromolecules (Washington, DC, United States) (2016), 49(11), 4136-4146, database is CAplus.

The design and synthesis of an entirely degradable glycopolymer micelle was presented. This design relies on the utilization of RAFT-controlled radical ring-opening polymerization (rROP) technique to afford multiple insertions of cleavable ester linkages onto the backbone of the corona. RAFT polymerization using a macroRAFT agent based on poly(ε-caprolactone) PCL was employed to control the polymerization of well-defined statistical glycopolymers of 1-O-acryloyl-2,3:4,5-di-O-isopropylidene-β-D-fructopyranose (1-O-AiPrFru) and 5,6-benzo-2-methylene-1,3-dioxepane (BMDO) monomer. Three block copolymers were synthesized to generate poly(ε-caprolactone)-b-poly[(1-O-acryloyl-2,3:4,5-di-O-isopropylidene-β-D-fructopyranose)-co-(5,6-benzo-2-methylene-1,3-dioxepane)] (PCL-b-P[(1-O-AiPrFru)-co-(BMDO)]) with varying block lengths. Self-assembly of the deprotected block copolymers generated nonspherical egg shaped micelles, where the shorter chains PCL₁₀₆-b-P[(1-O-AFru)₆₉-co-(BMDO)₉] underwent self-assembly forming micelles with the hydrodynamic diameter (D_H) of 106 nm. The biodegradation of these micelles were investigated via enzymic degradation by Lipase Pseudomonas sp., indicating entirely degradable architectures, which are no longer visible via dynamic light scattering (DLS). SEC further confirmed the appearance of fragmented glycopolymeric units. In vitro cell proliferation assay of the micelles and their degradation products revealed no toxicity against healthy human fibroblast HS27 and breast cancer MDA-MB-231 cell lines. The polymer concentration range tested was up to 0.20 mg·mL^-1 with the cell viabilities of ≥95%.

Macromolecules (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Da-Liang published the artcileNickel-Catalyzed Etherification of Phenols and Aryl Halides through Visible-Light-Induced Energy Transfer, Product Details of C9H12O, the publication is Organic Letters (2021), 23(21), 8327-8332, database is CAplus and MEDLINE.

A visible-light-initiated, nickel-catalyzed O-arylation of phenols with arylhalides using t-BuNH(i-Pr) as the base and thioxanthen-9-one as the photosensitizer under visible light was reported. This photocoupling exhibited a broad substrate scope.

Organic Letters published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H8BNO3, Product Details of C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Da-Liang published the artcileVisible-light-driven C(sp²)-H arylation of phenols with arylbromides enabled by electron donor-acceptor excitation, Related Products of alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(22), 3637-3640, database is CAplus and MEDLINE.

A catalyst-free visible-light-driven C(sp²)-H arylation of unprotected phenols ROH (R = Ph, naphthalen-2-yl, 3,5-dibromophenyl, etc.) with arylbromides R¹Br (R¹ = 4-cyclopropanecarbonylbenzen-1-yl, 2-cyanobenzen-1-yl, 3-cyano-5-(trifluoromethyl)phenyl, etc.) to give 2-arylated phenols RR¹ have been developed. This reaction proceeds through the excitation of an electron donor-acceptor complex between a phenolate and arylbromide, electron transfer, and debrominative C(sp²)-C(sp²) coupling.

Chemical Communications (Cambridge, United Kingdom) published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C8H10BNO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jingwu published the artcileReaction-activated palladium catalyst for dehydrogenation of substituted cyclohexanones to phenols and H₂ without oxidants and hydrogen acceptors, Computed Properties of 27292-49-5, the publication is Chemical Science (2015), 6(8), 4674-4680, database is CAplus and MEDLINE.

It was widely believed that the dehydrogenation of organic compounds was a thermodynamically unfavorable process, and thus required stoichiometric oxidants such as dioxygen and metal oxides or sacrificial hydrogen acceptors to remove the hydrogen from the reaction mixture to drive the equilibrium towards the products. A previously unappreciated combination of common com. Pd/C and H₂ which dehydrogenated a wide range of substituted cyclohexanones and 2-cyclohexenones to their corresponding phenols with high isolated yields, with H₂ as the only byproduct was reported. The reaction requires no oxidants or hydrogen acceptors because instead of removing the generated hydrogen with oxidants or hydrogen acceptors, it was used as a cocatalyst to help power the reaction. The method for phenol synthesis manifested a high atom economy, and was inherently devoid of the complications normally associated with oxidative dehydrogenations.

Chemical Science published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C38H24F4O4P2, Computed Properties of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Xiaozhen published the artcileEffects of different combination therapy to reduce the adverse reactions of patients with cesarean section caused by carboprost tromethamine, Computed Properties of 58551-69-2, the publication is Linchuang Mazuixue Zazhi (2015), 31(6), 612-613, database is CAplus.

The effects of different combination therapy to reduce the adverse reactions of patients with cesarean section caused by carboprost tromethamine were studied. One hundred fifty cases of cesarean section were divided into A group (dexamethasone 5 mg, tropisetron 5 mg), B group (dexamethasone 10 mg, penehyclidine hydrochloride 1 mg), and C group (dexamethasone 10 mg, tropisetron 5 mg, penehyclidine hydrochloride 1 mg). The results showed that the combined application of dexamethasone, tropisetron and penehyclidine hydrochloride could reduce the adverse reactions of patients with cesarean section caused by carboprost tromethamine.

Linchuang Mazuixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C48H47FeP, Computed Properties of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Li published the artcileCarboprost tromethamine prevents caesarean section associated postpartum hemorrhage, Category: alcohols-buliding-blocks, the publication is Tropical Journal of Pharmaceutical Research (2020), 19(4), 899-904, database is CAplus.

To investigate the effect of carboprost tromethamine on post-partum hemorrhage associated with caesarean section. One hundred patients with postpartum hemorrhage induced by cesarean section who were admitted to Binzhou People’s Hospital from Oct. 2016 to August 2018 were selected. They were randomly assigned to two groups: control group and treatment group. Patients in the control group were administered oxytocin, while those in the treatment group received oxytocin in combination with carboprost tromethamine. The incidence of hemorrhage and adverse reactions were compared for the two groups. The two groups showed gradually increasing degrees of postpartum hemorrhage within 24 h, but the treatment group had significantly lower volume of postpartum hemorrhage than the control group at different time points (p < 0.05). At the 1st, 3rd and 5th days after delivery, the height of the uterine fundus decreased gradually in the two groups, but was smaller in the treatment group than in the oxytocin group at all time points (p < 0.05). Total response in the treatment group was 98%, which was significantly higher than 78% in the control group (p < 0.05). The incidence of adverse reactions in the treatment group (12%) was significantly lower than that in the control group (24%, p < 0.05). Carboprost tromethamine prevents postpartum hemorrhage after cesarean section. It effectively reduces bleeding and promotes uterine involution, without obvious adverse reactions.

Tropical Journal of Pharmaceutical Research published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10CoF6P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Jie published the artcileSimultaneous determination of the main components in carboprost tromethamine injection by HPLC-UV-CAD, Quality Control of 58551-69-2, the publication is Zhongguo Xinyao Zazhi (2015), 24(1), 22-26, 51, database is CAplus.

Objective: To establish an HPLC-UV-CAD method for the simultaneous determination of carboprost, tromethamine and benzyl alc. in carboprost tromethamine injection. Methods: Carboprost, tromethamine and benzyl alc. were separated on a CAPCELL PAK CR 1:4 column (150 mm×4.6 mm, 5 μm). The mobile phase was composed of ultrapure water, 0.1 mol·L^-1 ammonium acetate buffer (pH 6.2) and methanol with gradient elution mode at a flow about 1.0 mL·min^-1; the injection volume was 10 μL and column temperature was 40 °C. CAD was used to detect carboprost and tromethamine, in which nebulization temperature was 35 °C and collection frequency was 30 Hz. UV was used to detect benzyl alc., in which detection wavelength was set at 258 nm and collection frequency was 5 Hz. Results: The linear range of carboprost was 9.38-56.2 μg·mL^-1 (r = 0.997 1, n = 6); the lowest limit of detection was 0.3 μg·mL^-1; LOQ was 0.6 μg·mL^-1; average recovery was 104.7%. The linear range of tromethamine was 5.19-23.3 μg·mL^-1 (r = 0.999 2, n = 6); the lowest limit of detection was 1 μg·mL^-1; LOQ was 2.5 μg·mL^-1; average recovery was 95.5%. The linear range of benzyl alc. was 0.297-1.78 mg·mL^-1 (r = 1, n = 6), the lowest limit of detection was 5.0 μg·mL^-1; LOQ was 10.0 μg·mL^-1; average recovery was 100.1%. The actual measurement results of the sample were consistent with the standard method currently used. Conclusion: The HPLC method established does not require derivative operations, and is cheap, sensitive, simple, accurate, reproducible and accurate. This method can simultaneously detect carboprost, tromethamine and benzyl alc. in carboprost tromethamine injection.

Zhongguo Xinyao Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C5H6BNO2, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts