Author: tianli

Tan, Xuerong published the artcileDevelopment and Validation of a Modified QuEChERS Method for the Analysis of Bisphenols in Meats by UPLC-MS/MS, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Chromatographia (2022), 85(5), 433-445, database is CAplus.

Abstract: A reliable and affordable QuEChERS (quick, easy, cheap, effective, rugged, and safe) methodol. in combination with ultra-high performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) was successfully developed and validated for the determination of eight bisphenols (BPs) residues containing in meats (chicken, duck, beef, pork, fish, shrimp, and mutton). A novel QuEChERS method optimization was carried out in terms of process efficiency (PE), matrix effect (ME), and extraction recovery (RE). After a simple vortex extraction of the samples with acetonitrile, 1 g sodium acetate was used for salting out (NaAC), and 100 mg primary secondary amine (PSA) purifying reagents were used for purification The properties of the sorbents were assessed by the obtained parameters, such as matrix effect (ME), linearity, sensitivity, accuracy, and precision. Under the optimal conditions, BPs were well separated on an ACQUITY UPLC BEH C₁₈ column in 8 min by gradient elution, and exhibited a good linear relationship (R² > 0.9988) in the linear range. Moreover, the limits of detection (LODs) and the limits of quantification (LOQs) were located in the range of 0.01- 0.11μg/kg and 0.03 – 0.37μg/kg, resp. The developed method was satisfactory in terms of accuracy (relative recoveries: 76.1% – 113.7%) and precision (relative standard deviations below 10.3%). Finally, the developed method was successfully employed to identify and quantify BPs residues in 28 real meat samples. The proposed QuEChERS-UPLC-MS/MS method is simple, high efficiency, cost-effective, practical, and susceptible to being implemented in routine laboratories to quickly detect the BPs in meats (chicken, duck, beef, pork, fish, shrimp, and mutton). In this sense, the method is useful for obtaining BPs residue data to evaluate the contamination status of BPs in meat food and provide scientific support for scientific supervision.

Chromatographia published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C10H2F12NiO4, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jia, Yaya published the artcileZirconium dioxide@phosphazene for enhancing mechanical property, flame retardancy, and thermal property of polythiourethane composites, Application In Synthesis of 80-09-1, the publication is Journal of Applied Polymer Science (2022), 139(22), 52230, database is CAplus.

Introducing high strength inorganic nanoparticles has emerged as an effective strategy to optimize the comprehensive properties of polymers, but good dispersion must be maintained to avoid clustering of inorganic nanoparticles. We report a novel phosphazene-coated ZrO₂ nanoparticles (ZrO₂@PZS) prepared by a simple ultrasonic method to further enhance thermal, mech., optical properties and flame retardancy of polythiourethane (PTU). ZrO₂@PZS nanoparticles presented good dispersion in composites, with regular spherical core-shell structures exhibiting significant enhancement effects for overall performance of PTU composites, through strong interfacial interaction. Studies revealed that regular spherical ZrO₂@PZS strengthened thermal and tensile properties of PTU, which reached 62.8°C and 79.28 MPa resp. More importantly, PTU composites showed good flame retardancy through catalytic carbonization, condensed phase shielding and gas phase dilution effect of ZrO₂@PZS, where the limiting oxygen index was increased to 25.39% from 20.39%. Moreover, the peak heat release rate, total heat release and smoke production rate could be reduced by 23.5%, 27.7% and 40.0%, resp. In brief, PTU composites show excellent potential in high strength special fireproof lenses.

Journal of Applied Polymer Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Application In Synthesis of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jia, Yaya published the artcileEnhancing mechanical, thermal property and flame retardancy of optical polythiourethane with self-assembly phosphazene nanoparticles, Quality Control of 80-09-1, the publication is Polymer Composites (2022), 43(4), 2010-2021, database is CAplus.

Polythiourethane (PTU) has attracted considerable attention in engineering building materials. Here, based on phosphazene nanoparticles (PZS-1 and PZS-2) prepared by water-triggered and ultrasonic self-assembly method, phosphazene/polythiourethane (PZS/PTU) composites with excellent mech. strength, high flame retardancy and good transparency was obtained. Then, the comprehensive properties of both composites were evaluated, where PZS-2 endowed PTU with better overall performance. Due to the good dispersibility of PZS and its strengthed interfacial interaction with PTU matrix, both PZS significantly enhanced mech. and thermal property of PTU, where the tensile strength and glass transition temperature of PZS/PTU composites reached to 84.34 MPa and 59.94°C resp. More importantly, compared to pure PTU, the values of peak heat release rate (HRR), total heat release rate (THR), smoke production rate (SPR), and total smoke production (TSP) of composites were decreased by 10.5%, 13.3%, 30.6% and 18.0%, resp. The limiting oxygen index of composites was improved to 21.39% due to the catalytic carbonization of PZS, the expanded carbon layer and the incombustible gases released during combustion. Meanwhile, the PZS/PTU composite exhibited the high refractive index of 1.6580 and good transparency (not less than 85% at 500 nm). The PZS/PTU composite was promising candidates for optical flame retardant coatings and engineering building materials.

Polymer Composites published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Songwen published the artcileDiscovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis, Synthetic Route of 622-40-2, the publication is Journal of Medicinal Chemistry (2019), 62(19), 8873-8879, database is CAplus and MEDLINE.

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease, and its mol. pathogenesis remains poorly understood. Recently, emerging evidence demonstrates that the PI3K signaling transduction pathway is linked to the pathol. of IPF. In this work, we rationally designed a new series of 4-methylquinazoline derivatives as highly potent PI3K inhibitors that significantly suppress the phosphorylation of the main PI3K downstream effectors and displays marked antiproliferative activity in mouse MLg2908 lung fibroblasts. In a bleomycin-induced mouse pulmonary fibrosis model, 5d from the series improved mouse lung function and slowed the progression of pulmonary fibrosis. Overall, this work promises a therapeutic potential for PI3K inhibitors to treat IPF.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Weihua published the artcileDegradation of phenanthrene by consortium 5H under hypersaline conditions, Product Details of C11H8O3, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119730, database is CAplus and MEDLINE.

PAHs have been widely detected to accumulate in saline and hypersaline environments. Moderately halophilic microbes are considered the most suitable player for the elimination of PAHs in such environments. In this study, consortium 5H was enriched under 5% salinity and completely degraded phenanthrene in 5 days. By high-throughput sequencing, consortium 5H was identified as being mainly composed of Methylophaga, Marinobacter and Thalassospira. Combined with the investigation of intermediates and enzymic activities, the degradation pathway of consortium 5H on phenanthrene was proposed. Consortium 5H was identified as having the ability to tolerate a wide range of salinities (1%-10%) and initial PAH concentrations (50 mg/L to 400 mg/L). It was also able to function under neutral to weak alk. conditions (pH from 6 to 9) and the phytotoxicity of the produced intermediates showed no significant difference with distilled water. Furthermore, the metagenome of consortium 5H was measured and analyzed, which showed a great abundance of catabolic genes contained in consortium 5H. This study expanded the knowledge of PAH-degradation under hypersaline environments and consortium 5H was proposed to have good potential for the elimination of PAH pollution in saline/hypersaline environments.

Environmental Pollution (Oxford, United Kingdom) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martinez-Hernandez, Gabriela Belen published the artcileA mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice, Quality Control of 621-37-4, the publication is Journal of Ethnopharmacology (2021), 113619, database is CAplus and MEDLINE.

The present study aims to focus on the evaluation of the antidepressant effect of the mixture of two flavonoids (FMix), and its interaction with serotonergic drugs. One of the fractions contained FMix wich is constituted of the mixture of quercetin 4′-O-rhamnoside y isoquercitrin. The mice were divided into the several following groups: FMix; FMix (1.0 mg/kg) and agonist DOI (2.0 mg/kg); FMix (1.0 mg/kg) and antagonist ketanserin (KET, 0.03 mg/kg) of 5-HT2A receptors; FMix (1.0 mg/kg) and selective agonist 8-OH-DPAT (8-OH, 0.01 mg/kg); FMix (1.0 mg/kg) and antagonist WAY100635 (WAY, 0.5 mg/kg) of 5HT1 receptors; PHL; DOPAC; p-HPAA; and m-HPAA were tested in FST or OFT. FMix induced dependent-dose antidepressant activity and, at the highest dose administered, a sedative effect was also observed The 8-OH-DPAT, or the DOI, or the KET combination with FMix (1.0 mg/kg) induced a higher antidepressant effect than compounds alone; there was no effect exerted with WAY. The activity on OFT increased only with the FMix and KET combination. At the same time, the products of the aglycon metabolism of quercetin, i.e., DOPAC and p-HPAA, decreased the immobility time of the mice in FST at 1.0 mg/kg, and a dose-curve was formed for these. The antidepressant effect of FMix could depend, at least in part, on the degradation products of quercetin and with a possible action mode through interaction with the serotoninergic system.

Journal of Ethnopharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brunet, Ernesto published the artcileThe use of lanthanide luminescence as a reporter in the solid state: Desymmetrization of the prochiral layers of γ-zirconium phosphate/phosphonate and circularly polarized luminescence, Application In Synthesis of 57044-25-4, the publication is Microporous and Mesoporous Materials (2013), 222-234, database is CAplus and MEDLINE.

Solid-state CPL measurements were performed for the first time on hybrid, laminar materials based on γ-ZrP pillared with organic diphosphonates. Ad hoc optically pure diphosphonates (I) were synthesized and the luminescence properties of their complexation with Tb(III) were verified in solution CD and CPL measurements showed that the bistriazolylpyridine chromophores bonded to the metal provided an effective chiral environment that produced significant signals. In the case of the γ-ZrP-derived materials, exptl. evidence and simple mol. modeling hinted to the occurrence of supramol. chirality in the particles, induced by the intrinsic dissymmetry of the organic diphosphonates or by the intercalation of chiral species such as 1-phenethylamine. Chirality at the supramol. level was revealed in the solid state by the CPL signals measured from reporter Tb(III) ions intercalated in the hybrid matrix.

Microporous and Mesoporous Materials published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Antinolo, Maria published the artcileTemperature Effects on the Removal of Potential HFC Replacements, CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH, Initiated by OH Radicals, Category: alcohols-buliding-blocks, the publication is Environmental Science & Technology (2011), 45(10), 4323-4330, database is CAplus and MEDLINE.

Gas phase kinetic coefficients of OH^– with 2 primary fluorinated alcs., CF₃CH₂CH₂OH (k₁) and CF₃(CH₂)₂CH₂OH (k₂), potential hydrofluorocarbon (HFC) replacements, are reported as a function of temperature (263-358° K) for the first time. K₁ and k₂ (together referred to as k_i) were measured under pseudo-first-order conditions with respect to the initial OH^– concentration using the pulsed laser photolysis/laser-induced fluorescence technique. The observed k_i temperature dependence (in cm³/mol.-s) is described by the following Arrhenius expressions: k₁(T) = (2.82 ± 1.28) × 10^-12 exp{-(302 ± 139)/T} cm³/mol.-s and k₂(T) = (1.20 ± 0.73) × 10^-11 exp{-(425 ± 188)/T} cm³/mol.-s. Arrhenius parameter uncertainties are at a 95% confidence level (±2σ). K_i(T) uncertainties include statistical and systematic errors. Activation energies were (2.5 ± 1.2) kJ/mol and (3.6 ± 1.6) kJ/mol for the OH^–-reaction with CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH, resp. Global lifetime (τ) at 275° K for CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH due to the OH^–-reaction was estimated to be approx. 2 wk and 5 days, resp. Reported Arrhenius parameters can be used in 3-dimensional models which account for geog. region and season of emissions to estimate a matrix of instantaneous lifetimes. As a consequence of the substitution of the -CH₃ group by a -CH₂OH group in HFC, e.g., CF₃CH₂CH₃ and CF₃(CH₂)₂CH₃, the tropospheric lifetime with respect to the OH^– reaction is significantly shorter, and, since their radiative forcing is similar, global warming potentials for CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH are negligible. Thus, CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH seem to be suitable alternatives for HFC.

Environmental Science & Technology published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Antinolo, Maria published the artcileAtmospheric removal of a series of fluoroalcohols and fluoroaldehydes: photochemistry initiated by OH radicals and sunlight, Category: alcohols-buliding-blocks, the publication is Trends in Photochemistry & Photobiology (2013), 89-103, database is CAplus.

A review. Hydrofluorocarbons (HFCs) are one of the alternatives to ozone-depleting chlorofluorocarbons (CFCs) in refrigeration, air conditioning and foam blowing. But their high global warming potentials (GWPs) have given rise to the concern that increased use and direct emissions of HFCs could have a significant impact on climate change. Some other CFC alternatives such as fluorinated alcs. (FAs) have been proposed in many industrial applications. The tropospheric photooxidation of FAs yields fluorinated aldehydes as secondary pollutants. To evaluate the tropospheric persistence of these species it is necessary to determine the rate coefficients of the main removal pathways in the gas-phase, namely UV photolysis and reaction with hydroxyl (OH) (J and k_OH, resp.). The tropospheric lifetimes (*au) of a species can be calculated from J and k_OH. In this article, the gas-phase kinetics of OH radicals with CF₃CH₂CH₂OH, CF₃(CH₂)₂CH₂OH, CF₃CF₂CH₂OH, CHF₂CF₂CH₂OH, CF₃CH₂CHO, CF₃(CH₂)₂CHO and CF₃CF₂CHO recently reported by our research group, as a function of temperature (263-359 K) and pressure (40-215 Torr of He), is reviewed. The determination of k_OH as a function of temperature was performed by Pulsed Laser Photolysis – Laser Induced Fluorescence (PLP – LIF). Furthermore, a photochem. study of the fluorinated compounds at 308 nm (in the actinic region) is also reviewed here, including the determination of the UV absorption cross sections (σ_λ) between 200 and 370 nm and photodissociation quantum yields by PLP at 308 nm coupled to Fourier transform IR (FTIR) spectroscopy (Φ_λ = 308nm). The formation of the photodegradation products initiated by absorption of UV radiation at 308 nm in a simulated clean atm. is also reviewed. It can be concluded that hydrofluorinated alcs. (HFAs) are suitable for replacing HFCs, since they are short-lived compounds that do not contribute to the Earth’s global warming. The degradation of these fluorocompounds is not expected to significantly contribute to air pollution in free-NO_x atmospheres.

Trends in Photochemistry & Photobiology published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Antinolo, M. published the artcilePhotochemistry of CF₃(CH₂)₂CHO in air: UV absorption cross sections between 230 and 340 nm and photolysis quantum yields at 308 nm, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2012), 231(1), 33-40, database is CAplus.

This work constitutes the first study on the photochem. degradation process of CF₃(CH₂)₂CHO. First, the wavelength and temperature dependence of the UV absorption cross sections, σ_λ, was determined The n → π^* electronic transition band of C=O chromophore was characterized between 230 and 340 nm in the 269-323 K range. A hyperchromic effect was observed in the structured part of the band when the temperature decreases. The pulsed laser photolysis of a stationary mixture of CF₃(CH₂)₂CHO/cyclohexane (OH-scavenger)/air or N₂ was carried out at 308 nm. Online Fourier transform IR (FTIR) spectroscopy was employed to monitor the decay of CF₃(CH₂)₂CHO and to obtain the photolysis quantum yield as a function of total pressure (20.5-760 Torr). A slight curvature in the Stern-Volmer plot was observed at pressures lower than 75 Torr. At high pressures, the pressure dependence of can be described by a Stern-Volmer relationship. Photodissociation of CF₃(CH₂)₂CHO at 308 nm can produce HCO and CF₃(CH₂)₂ radicals , CF₃CH₂CH₃ and CO and CF₃(CH₂)₂CO radicals and H atoms. HCO radicals are rapidly converted into CO in the presence of O₂. Formation of CF₃CH₂CHO and CF₃CH₂CH₂OH evidences the importance of secondary chem. involving CF₃(CH₂)₂ radicals formed in channel . Further photodegradation of CF₃CH₂CHO yields mainly CF₃CHO. Small quantities of HC(O)OH were also detected. CF₃(CH₂)₂C(O)OH was only observed in the absence of OH-scavenger, implying that formation of CF₃(CH₂)₂CO radicals in channel is not an important photolysis pathway. Consequently, photodissociation of CF₃(CH₂)₂CHO in the actinic region is a source of shorter fluorinated oxygenated compounds, but it is not expected to be a source of fluorinated acids.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts