Author: tianli

Sakthivel, Naga Arjun published the artcileSize Exclusion Chromatography: An Indispensable Tool for the Isolation of Monodisperse Gold Nanomolecules, Recommanded Product: 2-Phenylethanethiol, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(8), 3987-3996, database is CAplus and MEDLINE.

Highly monodisperse and pure samples of atomically precise gold nanomols. (AuNMs) are essential to understand their properties and to develop applications using them. Unfortunately, the synthetic protocols that yield a single-sized nanomol. in a single-step reaction are unavailable. Instead, we observe a polydisperse product with a mixture of core sizes. This product requires post-synthetic reactions and separation techniques to isolate pure nanomols. Solvent fractionation based on the varying solubility of different sizes serves well to a certain extent in isolating pure compounds It becomes tedious and offers less control while separating AuNMs that are very similar in size. Here, we report the versatile and the indispensable nature of using size exclusion chromatog. (SEC) as a tool for separating nanomols. and nanoparticles. We have demonstrated the following: (1) the ease of separation offered by SEC over solvent fractionation; (2) the separation of a wider size range (~5-200 kDa or ~1-3 nm) and larger-scale separation (20-100 mg per load); (3) the separation of closely sized AuNMs, demonstrated by purifying Au₁₃₇(SR)₅₆ from a mixture of Au₃₂₉(SR)₈₄, Au₁₄₄(SR)₆₀, Au₁₃₇(SR)₅₆, and Au₁₃₀(SR)₅₀, which could not be achieved using solvent fractionation; (4) the separation of AuNMs protected by different thiolate ligands (aliphatic, aromatic, and bulky); and (5) the separation can be improved by increasing the column length. Mass spectrometry was used for analyzing the SEC fractions.

Analytical Chemistry (Washington, DC, United States) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Jung-Hun published the artcileComparative study on carbon dioxide-cofed catalytic pyrolysis of grass and woody biomass, Safety of 4-Propylphenol, the publication is Bioresource Technology (2021), 124633, database is CAplus and MEDLINE.

This study investigated the mechanistic functions of CO₂ on the pyrolysis of two different biomasses to elucidate the effect of CO₂ on syngas formations during pyrolysis. To this end, CO₂-assisted pyrolysis of cellulosic biomass (barnyard grass, Echinochloa) and lignin-rich woody biomass (retinispora, Chamaecyparis obtusa) were compared. The confirmed mechanistic effectiveness of CO₂ on pyrolysis of biomass was gas phase reactions between CO₂ and volatile matters from biomass pyrolysis. Lignin-rich biomass had more CO₂ susceptibility, resulting in more enhanced CO formation via the gas phase reactions. To expedite the slow reaction rate of the gas phase reactions during biomass pyrolysis, earth-abundant catalysts (Co/SiO₂ and Ni/SiO₂) were employed for pyrolysis of two biomass substrates. With Co and Ni catalysts, the syngas formations were 2 and 3 times higher comparing to the pyrolysis of without catalyst. The cumulative formations of syngas from lignin-rich biomass was nearly doubled than that from cellulosic biomass.

Bioresource Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Safety of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Minhan published the artcileModular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters, COA of Formula: C12H20O6, the publication is Journal of the American Chemical Society (2020), 142(28), 11999-12004, database is CAplus and MEDLINE.

Ir-catalyzed intermol. amino group transfer to β-keto esters (amides) to α-aminocarbonyl products with excellent chemoselectivity was reported. The key strategy was engineered electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ²-N,O chelating ligands, thus facilitated nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Gracia Lux, Caroline published the artcileBiocompatible Polymeric Nanoparticles Degrade and Release Cargo in Response to Biologically Relevant Levels of Hydrogen Peroxide, SDS of cas: 25240-59-9, the publication is Journal of the American Chemical Society (2012), 134(38), 15758-15764, database is CAplus and MEDLINE.

Oxidative stress is caused predominantly by accumulation of hydrogen peroxide and distinguishes inflamed tissue from healthy tissue. Hydrogen peroxide could potentially be useful as a stimulus for targeted drug delivery to diseased tissue. However, current polymeric systems are not sensitive to biol. relevant concentrations of H₂O₂ (50-100 μM). Here we report a new biocompatible polymeric capsule capable of undergoing backbone degradation and thus release upon exposure to such concentrations of hydrogen peroxide. Two polymeric structures were developed differing with respect to the linkage between the boronic ester group and the polymeric backbone: either direct (1) or via an ether linkage (2). Both polymers are stable in aqueous solution at normal pH, and exposure to peroxide induces the removal of the boronic ester protecting groups at physiol. pH and temperature, revealing phenols along the backbone, which undergo quinone methide rearrangement to lead to polymer degradation Considerably faster backbone degradation was observed for polymer 2 over polymer 1 by NMR and GPC. Nanoparticles were formulated from these novel materials to analyze their oxidation triggered release properties. While nanoparticles formulated from polymer 1 only released 50% of the reporter dye after exposure to 1 mM H₂O₂ for 26 h, nanoparticles formulated from polymer 2 did so within 10 h and were able to release their cargo selectively in biol. relevant concentrations of H₂O₂. Nanoparticles formulated from polymer 2 showed a 2-fold enhancement of release upon incubation with activated neutrophils, while controls showed a nonspecific response to ROS producing cells. These polymers represent a novel, biol. relevant, and biocompatible approach to biodegradable H₂O₂-triggered release systems that can degrade into small mols., release their cargo, and should be easily cleared by the body.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, SDS of cas: 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

More, Uttam A. published the artcileDiscovery of target based novel pyrrolyl phenoxy derivatives as antimycobacterial agents: An in silico approach, Category: alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2015), 317-339, database is CAplus and MEDLINE.

A new series of pyrrolyl phenoxy derivatives bearing alkoxy linker were synthesized and evaluated for anti-tubercular activity (anti-TB) against Mycobacterium tuberculosis. Mol. modeling, pharmacophore constructed using GALAHAD to produce an effective alignment of data set and evaluated by Pareto ranking. The pharmacophore features were filtered by Surflex-dock study using enoyl ACP reductase from M. tuberculosis, which is one of the key enzymes involved in type II fatty acid biosynthesis pathway of M. tuberculosis. Compound I showed the H-bond with NAD⁺, whereas compound II showed H-bonds with Tyr158, Thr196, Met199 and NAD⁺ that fitted well into the binding pocket of target InhA. The alkoxy linker bridge and acceptor groups with benzene ring were advantageous for anti-TB activity, which merit further investigation.

European Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yadav, B. P. published the artcileSynthesis of some novel pyrimidine derivatives and compared to available antimicrobial (MTCC inhibitors) drugs, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is IOSR Journal of Pharmacy (2021), 11(9-1), 23-28, database is CAplus.

A new series of pyrimidine derivatives I (R¹ = trifluoromethyl, Cl; R² = Me, Et, i-Pr) have been synthesized by reacting substituted pyrimidine carboxylic acids II with 3-methoxyaniline, de-methylation using BBr₃ to form hydroxy derivatives, which were then alkylated with resp. alkyl halides R²I to synthesize substituted pyrimidine derivatives I. The synthesized compounds I were screened for their in vitro growth inhibiting activity against different strains.

IOSR Journal of Pharmacy published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C15H10O2, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barton, Benita published the artciletrans-N,N’-Bis(9-phenyl-9-xanthenyl)cyclohexane-1,2-diamine and its thioxanthenyl derivative as potential host compounds for the separation of anilines through host-guest chemistry principles, COA of Formula: C19H14O2, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2020), 97(3-4), 159-174, database is CAplus.

In this work, we investigate the potential of separating mixtures of the guest solvents aniline (ANI), N-methylaniline (NMA) and N,N-dimethylaniline (DMA) by means of host-guest chem. principles employing two novel host compounds, namely trans-N,N’-bis(9-phenyl-9-xanthenyl)cyclohexane-1,2-diamine (1,2-DAX) and trans-N,N’-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,2-diamine (1,2-DAT). These aniline solvents may exist in such mixtures since NMA and DMA are often prepared from ANI by alkylation methods, and reaction yields are seldom quant. Owing to their similar b.ps., ranging from 184 to 196°C, the more usual distillation techniques for their separation are challenging. After recrystallization experiments of the two host compounds from various combinations of these anilines, it was revealed that host-guest chem. certainly has the potential to serve as an alternative separation strategy for such mixtures Equimolar ANI/DMA solutions proved most successful, where both 1,2-DAX and 1,2-DAT showed near-quant. selectivity for DMA (90%). Both single crystal diffraction and thermal analyses were employed in order to understand the preferential behavior displayed by each host compound

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, COA of Formula: C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barton, Benita published the artcileSynthesis and assessment of compounds trans-N,N’-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine and trans-N,N’-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,4-diamine as hosts for potential xylene and ethylbenzene guests, Application of 9-Phenyl-9H-xanthen-9-ol, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2019), 93(3-4), 333-346, database is CAplus.

In this work, two novel compounds, trans-N,N’-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine 1 and trans-N,N’-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,4-diamine 2, were designed and successfully synthesized in our laboratories, and assessed for their host potential in the presence of potential xylene (Xy) isomer and ethylbenzene (EB) guests. Host 1 successfully formed complexes with all four of o-Xy, m-Xy, p-Xy and EB, while 2 only clathrated p-Xy and EB. Equimolar guest/guest competition experiments showed that hosts 1 and 2 possess very similar selectivities for these guests [p-Xy (73.9%) > EB (13.0%) > m-Xy (8.1%) > o-Xy (5.0%) and p-Xy (71.3%) > EB (20.2%) > m-Xy (6.0%) > o-Xy (2.5%) for 1 and 2, resp.]. Single crystal diffraction analyses revealed striking geometry changes for the sulfur host analog: while the tricyclic fused ring system of the oxygen host remained planar when guest was absent or present, this fused system of the sulfur analog experienced a dramatic geometry change from buckled (in the absence of guest) to planar (in guest presence). This observation explained the selectivity similarities of both hosts in the presence of these guests. Addnl., the relative thermal stabilities of the four complexes with host 1 were assessed by employing thermal analyses, and the results of these correlated exactly with the selectivity order, since the onset temperature of the guest release processes (Ton) was in the order p-Xy (88.0 °C) > EB (70.9 °C) > m-Xy (59.7 °C) > o-Xy (46.2 °C). Ton values also explained the significant preference of host 2 for p-Xy (115.5 °C) relative to EB (76.6 °C), resp.

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Application of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Agrawal, Aparna published the artcileFabrication and Characterization of Re-Entrant Honeycomb Polyurethane Aerogels, Name: Pentane-1,5-diol, the publication is ACS Applied Polymer Materials (2022), 4(5), 3791-3801, database is CAplus.

In this work, polyurethane aerogels are fabricated in re-entrant honeycomb forms to achieve auxeticity and much higher flexibility than corresponding aerogel monoliths. For this purpose, a set of re-entrant honeycomb-shaped hollow molds is first printed from high-impact polystyrene (HIPS) using a fused filament fabrication technique and subsequently filled with polyurethane sol synthesized from an aliphatic triisocyanate and a diol selected from among butanediol, pentanediol, hexanediol, or octanediol. A sol-gel transition process yields the gel in a re-entrant honeycomb shape, which is isolated by dissolving the HIPS mold and supercritically dried using carbon dioxide. The effects of diol chain length on the properties of aerogels, such as bulk d., pore size, and tensile properties are investigated. The auxetic aerogels show different deformation behavior and much higher elongation at break than dog bone-shaped aerogel monoliths. Such unique properties of auxetic structures can extend applications of aerogels as acoustic absorbers and smart bandages that require high porosity, tunable pore structures, and high flexibility.

ACS Applied Polymer Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Name: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Andringa, Ruben L. H. published the artcileSynthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate, Application In Synthesis of 57044-25-4, the publication is Organic & Biomolecular Chemistry (2022), 20(11), 2200-2204, database is CAplus and MEDLINE.

With a CoIII(salen)OTs catalyst, dibenzyl phosphate ring-opens a variety of terminal epoxides with excellent regio-selectively and yields up to 85%. The reaction is used in a highly efficient synthesis of enantiopure mixed-diacyl phosphatidic acids, including a photoswitchable phosphatidic acid mimic.

Organic & Biomolecular Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts