Author: tianli

Kemnitzer, William published the artcileDiscovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions, Recommanded Product: 3-Morpholinophenol, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(21), 4745-4751, database is CAplus and MEDLINE.

As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, the authors explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small hydrophobic group, such as NMe₂, NH₂, NHEt, and OMe, is preferred at the 7-position. Di-substitution at either the 5,7-positions or the 6,7-positions generally led to a large decrease in potency. Di-substitution at the 7,8-positions, in general, was found to result in potent compounds 7-NMe₂, 7-NHEt, 7-OMe, and 7,8-di-NH₂ analogs were found to have similar SAR for the 4-aryl group, and several 7-substituted and 7,8-di-substituted analogs were found to have similar potencies as the lead compound MX58151 (I) both as caspase activators and inhibitors of cell proliferation.

Bioorganic & Medicinal Chemistry Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Motokura, Ken published the artcileCopper-Catalyzed Formic Acid Synthesis from CO₂ with Hydrosilanes and H₂O, Computed Properties of 597-52-4, the publication is Organic Letters (2012), 14(10), 2642-2645, database is CAplus and MEDLINE.

A copper-catalyzed formic acid synthesis from CO₂ with hydrosilanes has been accomplished. The Cu(OAc)₂·H₂O-1,2-bis(diphenylphosphino)benzene system is highly effective for the formic acid synthesis under 1 atm of CO₂. The TON value approached 8100 in 6 h. The reaction pathway was revealed by in situ NMR anal. and isotopic experiments

Organic Letters published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kiraz, Asli Ozturk published the artcileTheoretical investigation of triazine based a star shape pyrrole monomer, Quality Control of 23351-09-9, the publication is Journal of Macromolecular Science, Part A: Pure and Applied Chemistry (2017), 54(1), 16-23, database is CAplus.

In this work, we report a comprehensive theor. investigation of electroactive star shaped pyrrole functionalized triazine monomer with two main goals. First goal of this work is to explore the phys. and chem. properties of the monomer, then to investigate correlation between the exptl. and the theor. properties of monomer. The scale factor which is calculated from B3LYP/cc-pVDZ was determined as 0.985 for FT-IR and it is an important and reliable contribution to the literature. It is determined that the most appropriate basis set for this mol. The other novel objective of this research is to investigate temperature effect on displacement of chlorine atoms in 2,4,6-trichloro-1,3,5-triazine. This method applied for the first time in the literature for triazines is especially crucial to the synthesis of unsym. triazines.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nikishin, G. I. published the artcileOxidative splitting of 1-methylcycloalkanols by the lead(IV) acetate-copper(II) acetate system, Related Products of alcohols-buliding-blocks, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1979), 1548-53, database is CAplus.

Oxidative cleavage of title alcs. I (n = 1-4) with Pb(OAc)₄-Cu(OAc)₂ gave 76-99% MeCO(CH₂)_nCH:CH₂ with 20-49% I conversion via the intermediate MeCO(CH₂)_n+2â€?radical. The reactivity of I decreased in the order of n 1 > 2 > 4 > 3.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lawan, Kunlayakorn published the artcileAntimicrobial efficacy of caprylyl glycol and ethylhexylglycerine in emulsion, Related Products of alcohols-buliding-blocks, the publication is Journal of Health Research (2009), 23(1), 1-3, database is CAplus.

Antimicrobial efficacies of caprylyl glycol and ethylhexylglycerin in an emulsion were evaluated by USP24-NF19. The min. concentration of caprylyl glycol and ethylhexylglycerin inhibited Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans within 1 day and Aspergillus niger within 28 days was 0.5% and 1.5%, resp. The 1:3 mixture ratio of the caprylyl glycol and ethylhexylglycerin was chosen for further steps on inhibitory effect towards those prohibited microbial in cosmetics by evaluation at the concentration of 0.5%, 1.0%, 1.5% and 2.0%, resp. It was found that the min. concentration inhibited S. aureus within 3 days, E. coli, P. aeruginosa and C. albicans within 1 day and A. niger within 28 days was 1.0%. This developed preservative system offers multifunctional cosmetic ingredients in addition to their emollient efficacies.

Journal of Health Research published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wan, Hui published the artcileEffect of high 2-KLG concentration on expression of pivotal genes involved in 2-KLG synthesis in Gluconobacter oxydans WSH-003, Application In Synthesis of 526-98-7, the publication is Weishengwu Xuebao (2016), 56(10), 1656-1663, database is CAplus and MEDLINE.

To analyze the effect of high 2-keto-L-gulonic acid (2-KLG) on important dehydrogenase, cofactor and transport proteins involved in 2-KLG synthesis. First, the growth of Gluconobacter oxydans under high 2-KLG was observed The real-time PCR was used to detect the expression of key sorbitol dehydrogenase gene sldAB, pyrroloquinoline quinone (PQQ) biosynthesis gene cluster pqqABCDE, and five genes encoding hypothetic PQQ transport proteins. According to results of the growth of G. oxydans under different 2-KLG concentration, 40, 80 and 120 g/L 2-KLG were decided to stimulate strains. Real-time PCR showed that PQQ synthesis genes pqqABCDE were not affected by high 2-KLG, but sorbitol dehydrogenase genes sldAB and part of genes encoding PQQ transport proteins were down-regulated under high 2-KLG stress. The expression of sorbitol dehydrogenase genes was restrained by high 2-KLG, PQQ transport was probably inhibited, but PQQ synthesis was not affected.

Weishengwu Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Choi, Ji-Ae published the artcileCycling performance of a lithium-ion polymer cell assembled by in-situ chemical cross-linking with fluorinated phosphorus-based cross-linking agent, Application of 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), the publication is Journal of Power Sources (2010), 195(18), 6177-6181, database is CAplus.

Li-ion polymer cells composed of a C anode and a LiCoO₂ cathode are assembled with a gel polymer electrolyte cured by in-situ chem. crosslinking with novel crosslinking agents. The strong interfacial adhesion between the electrodes and the porous polyethylene membrane by the chem. crosslinking results in the stable capacity retention of the cell. A reduction in the ionic mobility in both the electrolyte and the electrodes adversely affects the high rate performance of the cell. These results imply that proper control of the crosslinking d. in the cell is imperative for achieving good capacity retention and high rate performance of the cell.

Journal of Power Sources published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Application of 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol).

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Kai published the artcileCatalytic Amination of Phenols with Amines, COA of Formula: C9H12O, the publication is Journal of the American Chemical Society (2022), 144(3), 1144-1151, database is CAplus and MEDLINE.

Herein, a rhodium-catalyzed amination of phenols, which provided concise access to diverse anilines, with water as the sole byproduct was described. The arenophilic rhodium catalyst facilitated the inherently difficult keto-enol tautomerization of phenols by means of π-coordination, allowing for the subsequent dehydrative condensation with amines. The generality of this redox-neutral catalysis by carrying out reactions of a large array of phenols with various electronic properties and a wide variety of primary and secondary amines was demonstrated. Several examples of late-stage functionalization of structurally complex bioactive mols., including pharmaceuticals, further illustrated the potential broad utility of the method.

Journal of the American Chemical Society published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Kai published the artcileCatalytic Amination of Phenols with Amines, Name: 3-Morpholinophenol, the publication is Journal of the American Chemical Society (2022), 144(3), 1144-1151, database is CAplus and MEDLINE.

Herein, a rhodium-catalyzed amination of phenols, which provided concise access to diverse anilines, with water as the sole byproduct was described. The arenophilic rhodium catalyst facilitated the inherently difficult keto-enol tautomerization of phenols by means of π-coordination, allowing for the subsequent dehydrative condensation with amines. The generality of this redox-neutral catalysis by carrying out reactions of a large array of phenols with various electronic properties and a wide variety of primary and secondary amines was demonstrated. Several examples of late-stage functionalization of structurally complex bioactive mols., including pharmaceuticals, further illustrated the potential broad utility of the method.

Journal of the American Chemical Society published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Name: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Xiaotong published the artcileFormation pathway of disinfection by-products of lignin monomers in raw water during disinfection, Synthetic Route of 645-56-7, the publication is Science of the Total Environment (2022), 153706, database is CAplus and MEDLINE.

In this study, the dissolved organic matter (DOM) profiles of water samples from a water source in northeastern China were analyzed by high-resolution mass spectrometry (HRMS), and its changes after chlorination were investigated. The results showed that lignin substances accounted for a significant proportion in DOM and chlorinated products and were the main precursors of disinfection byproducts (DBPs). During disinfection, macromol. DOM was transformed into small mols., and lignin substances have the most obvious and complex changes in reaction. Two lignin monomers 4-propylphenol (4PP) and 4-propylguaiacol (4PG) were used as model compounds to study their reaction kinetics and degradation pathways during disinfection. The degradation of both lignin monomers conformed to pseudo-first-order reaction kinetics, and the reaction rate constant of 4PG was higher than that of 4PP. The effects of chlorine dosage, pH and temperature on the degradation reaction kinetics of two lignin monomers were investigated. The degradation rates of 4PP and 4PG increased with increasing chlorine dosage, pH and temperature The two monomers showed similar properties in the chlorination degradation process, and generated multiple intermediates, which were mainly transformed into small mols. by chlorine electrophilic substitution and nucleophilic substitution, and further generated DBPs.

Science of the Total Environment published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C11H15NO3, Synthetic Route of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts