Author: tianli

Fujii, Shinya published the artcileStructural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling, SDS of cas: 328-90-5, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(17), 127408, database is CAplus and MEDLINE.

We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 201 is a promising candidate for a new class of antihypertensive drugs.

Bioorganic & Medicinal Chemistry Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ifon, Binessi Edouard published the artcileEffects of bisphenols and perfluoroalkylated substances on fluorescence properties of humic and amino acids substances of dissolved organic matter: EEM-PARAFAC and ATR-FTIR analysis, Name: 4,4′-Sulfonyldiphenol, the publication is Journal of Environmental Chemical Engineering (2022), 10(4), 108186, database is CAplus.

Abiotic, biotic, and sparingly the xenobiotic factors are considered to influence the compositional variation of dissolved organic matter (DOM) in aquatic environments. Increasing discharge of xenobiotics into water bodies necessitates the need to investigate their effects on the key components of DOM. The effects of bisphenols (BP) and perfluoroalkylated substances (PFAS) on the fluorescence characteristics of pure humic substances (HS) and amino acids (AA) of DOM were examined by using excitation-emission matrix-parallel factor anal. (EEM-PARAFAC) and the attenuated total reflection Fourier-transform IR (ATR-FTIR) spectroscopy in this work. The results showed that interactions of fulvic acid (FA), humic acid (HA), and tryptophan (Trp) with the xenobiotic compounds could generate some fluorescence components like both HS and AA components, whereas the interactions with tyrosine (Tyr) could only generate AA fluorescence components. In addition, it was revealed that the fluorescence intensity of HS decreases by 50-70% and 18-25% in the treatments of HA and FA, resp., at low concentration (2.5 x 10^-3 mg/L) of BP, while this increases by 350-425% and 18-25% at the same concentration of PFAS. However, both BP and PFAS increase the fluorescence intensity of AA. The findings suggest that the xenobiotic compounds are important factors affecting the compositional variation of DOM, especially in the anthropogenically-impacted water bodies.

Journal of Environmental Chemical Engineering published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sripahco, Teerapong published the artcileChemical composition, antioxidant, and antimicrobial activity of Elsholtzia beddomei C. B. Clarke ex Hook. f. essential oil, HPLC of Formula: 106-25-2, the publication is Scientific Reports (2022), 12(1), 2225, database is CAplus and MEDLINE.

The essential oil of Elsholtzia beddomei C. B. Clarke ex Hook. f. was investigated for its chem. composition and tested for antioxidant and antimicrobial activities. The E. beddomei essential oil was extracted using hydrodistillation for 4 h (yield of 1.38% weight/weight). Forty-three volatile compounds were identified in the E. beddomei essential oil, including linalool (83.67%), perillaldehyde (4.68%), neral (3.68%), perillene (1.65%), E-caryophyllene (1.55%), and α-zingiberene (1.06%) as the major compounds The antioxidant activity of the E. beddomei essential oil was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation scavenging activity. The IC₅₀ values calculated using the DPPH and ABTS methods were 148.31 and 172.22μg/mL, resp. In addition, using disk diffusion and broth microdilution methods, the antimicrobial activities of the E. beddomei essential oil against Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Candida albicans were evaluated. The E. beddomei essential oil possessed an inhibitory effect with the min. inhibitory concentration in the range of 31.25-250.00μg/mL among these pathogens. The results indicated that E. beddomei essential oil is an alternative raw material of food, and medicinal products for use in pharmaceutical applications.

Scientific Reports published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C18H10F3NO3S2, HPLC of Formula: 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yilmaz, Can published the artcileIn vitro and in silico evaluation of inhibitory effects of bisphenol derivatives on acetylcholinesterase of electric eel (Electrophorus electricus L.), Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology (2022), 109416, database is CAplus and MEDLINE.

The inhibitory effects of bisphenol A (BPA) and bisphenol S (BPS), which are common pollutants, especially in marine and freshwater, on the elec. eel acetylcholinesterase (AChE) activity were studied in vitro and in silico. Both produced full non-competitive inhibition, but the Ki value of BPA was half that of BPS. Mol. docking analyses revealed that both interact with residues W286, F297, Y337, F338 in the PAS and ABS regions in the middle and entrance of the active site gorge, and that BPS also has hydrogen bond with S203 of the catalytic triad. The surge at IC50 values of both compounds with an inflection point at pH: 8.2 suggested that Y124 and/or Y337 in the narrow gorge are primary structural factors in binding. Less effective inhibition of BPS, especially at 25-30°C, the temperature at which enzyme activity peaks, was attributed to the conformation of the narrow gorge. Homol. analyses for AChE initially revealed a significant degree of identity, particularly in the alpha/beta hydrolase domain, which also comprises the active site, with sequences from seven distinct teleost species of various environments. Finally, it was discovered for the first time that BPS, like BPA, is a significant inhibitor of AChE, and this was confirmed by in vitro and in silico analyses done at various pH and temperature levels. It was concluded that this effect might also apply to AChE of most other bony fish.

Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is CBF6K, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lhotska, Ivona published the artcilePreparation of citrinin-selective molecularly imprinted polymer and its use for on-line solid-phase extraction coupled to liquid chromatography, Quality Control of 86-48-6, the publication is Analytical and Bioanalytical Chemistry (2019), 411(11), 2395-2404, database is CAplus and MEDLINE.

A new selective molecularly imprinted polymer has been prepared and used for extraction in online SPE-HPLC to achieve the selective determination of citrinin. Four different imprinted polymers varying in combinations of components were prepared by bulk polymerization and evaluated in terms of binding capacity and selectivity. Imprinted polymer prepared from a mixture comprising 1-hydoxy-2-naphtoic acid as the template mol., acrylamide as the structural monomer, ethylene dimethacrylate as the cross-linker (in a molar ratio of 1:4:16), and acetonitrile as the porogenic solvent exhibited the best properties. The selectivity of this sorbent was confirmed by comparison with the non-imprinted counterpart prepared using the same polymerization carried out in the absence of template. Imprinted polymer was packed in a 20 × 3 mm i.d. steel cartridge and coupled to the online SPE-HPLC system through a six-port switching valve. The method for determination of citrinin including the online extraction step was then developed and validated. The sample in the form of methanolic extract was loaded, cleaned, and preconcd. in the imprinted SPE cartridge. Subsequent separation of citrinin from residual interferences was achieved using the anal. column Kinetex Biphenyl 100 × 4.6 mm i.d., 5 μm particle size, and fluorescence detection (Ex 335, Em 500 nm). The total anal. time was only 9.50 min. Our fully validated method was also applied to anal. of food supplements based on red yeast rice extracts, the control of which is implemented in European legislation. Only minor yet acceptable contamination was found in tested samples.

Analytical and Bioanalytical Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vozhdaeva, Margarita Yu. published the artcileMonitoring and statistical analysis of formation of organochlorine and organobromine compounds in drinking water of different water intakes, Product Details of C5H11BrO, the publication is Molecules (2021), 26(7), 1852, database is CAplus and MEDLINE.

The main drawback of drinking water chlorination involves the formation of quite hazardous disinfection byproducts (DBPs), represented mainly by halogenated species. Based on the authors’ monitoring data since 2002, the prevalence of chlorine over bromine in the composition of volatile DBPs was shown for the drinking water in Ufa (Russia). However, the situation was completely reversed in the case of semi-volatile DBPs. The principal goal of the present study involved rationalization of the results of the long-term monitoring. Gas chromatog.-mass spectrometry (GC-MS) was used for the qual. and quant. anal. of volatile DBPs. Identification of semi-volatile compounds was carried out with GC-MS, while gas chromatog. with an at. emission detector (GC-AED) was used for their quantification. A significant contribution of oxygen to the composition of semi-volatile compounds proves the decisive role of the dissolved organic matter oxidative destructive processes. Statistical anal. revealed notable linear correlations for trihalomethane and haloacetic acid formation vs. chlorine dose. On the contrary, halogenated semi-volatile products do not demonstrate any correlations with the water quality parameters or chlorine dose. Principal component anal. (PCA) placed them into sep. groups. The results allow for proposing that formation of the organohalogenated species involved the fast penetration of bromine into the humic matter mols. and, further, their oxidative destruction by active chlorine.

Molecules published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C14H10O4S2, Product Details of C5H11BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gajare, Vikas S. published the artcileA concise stereoselective synthesis of (+)-1-deoxy-6-epi-castanospermine, SDS of cas: 57044-25-4, the publication is Tetrahedron Letters (2016), 57(13), 1486-1488, database is CAplus.

A concise stereoselective synthesis of (+)-1-deoxy-6-epi-castanospermine has been developed through stereoselective approach from the chiral precursor R-glycidol. The key steps in the synthesis involve Grignard reaction through Weinreb amide, followed by Sharpless dihydroxylation and stereoselective reduction of imine assigned the required stereochem. feature of indolizidine azasugar (+)-1-deoxy-6-epi-castanospermine.

Tetrahedron Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, SDS of cas: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gajare, Vikas S. published the artcileDiversity oriented concise asymmetric synthesis of azasugars: a facile access to L-2,3-trans-3,4-cis-dihydroxyproline and (3S,5S)-3,4,5-trihydroxypiperidine, Name: (R)-Oxiran-2-ylmethanol, the publication is Tetrahedron Letters (2015), 56(48), 6659-6663, database is CAplus.

Diversity oriented concise asym. syntheses of L-2,3-trans-3,4-cis-dihydroxyproline and (3S,5S)-3,4,5-trihydroxypiperidine have been developed from (R)-glycidol. The key step of the synthesis is Sharpless asym. dihydroxylation on enantiomerically pure TBDMS protected allylic alc. I which generates the triol intermediate II in excellent de. The (2R,3R,4S)-2,3-dihydroxypentanoate derivative II was subsequently converted to natural pyrrolidine azasugar L-2,3-trans-3,4-cis-dihydroxyproline and non-natural piperidine azasugar III under cascade reaction conditions in good yields.

Tetrahedron Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sheina, Elena E. published the artcileToward poly(3- and 3,4-alkoxythiophenes), Quality Control of 17236-59-8, the publication is Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2003), 44(1), 843-844, database is CAplus.

Regioregular head-to-tail 3-alkoxy-substituted polythiophenes (PTs) (with R=C₆H₁₃O- and CH₃OC₂H₄OC₂H₄O-) and poly(2,5-(3-functionalized-3,4-ethylenedioxy)bithiophene) with dodecyl and diethyleneglycol Me Et as hydrophobic and hydrophilic substituents, resp., were polymerized via a Grignard Methathesis Method (GRIM). Mol. weights were characterized by gel permeation chromatog. (GPC) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectroscopy, where the latter was used to obtain the end group composition UV-vis NIR spectroscopic studies showed that due to the presence of the electron donating oxygen atom, directly attached to the ring, the 3-alkoxy-substituted PTs possess a lower band gap than their alkyl analogs. The polymers self-oxidized in air and conductivity measurements revealed that further doping with I2 increases conductivity and prolongs the stability of the doped state. Poly(3-alkoxythiophenes) remain in the doped state for as long as three weeks.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C8H15ClN2, Quality Control of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Almir S. published the artcileFacile synthesis of 2-(2-arylpyrrolidin-1-yl)pyrimidines via acid-catalyzed reaction of N-(4,4-diethoxybutyl)pyrimidin-2-amine with phenols, Category: alcohols-buliding-blocks, the publication is Monatshefte fuer Chemie (2015), 146(11), 1845-1849, database is CAplus.

N-(4,4-diethoxybutyl)pyrimidin-2-amine undergoes acid-catalyzed intramol. cyclization in the presence of phenols leading to the formation of 2-(2-arylpyrrolidin-1-yl)pyrimidine derivatives Target compounds were obtained with moderate to good yields by operationally simple one-step procedure.

Monatshefte fuer Chemie published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts