Author: tianli

Ha, Eun Kyo published the artcilePersonal exposure to total VOC is associated with symptoms of atopic dermatitis in schoolchildren, Formula: C8H8O3, the publication is Journal of Korean Medical Science (2022), 37(8), e63, database is CAplus and MEDLINE.

The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with pos. SCORAD index values (defined as SCORAD �5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and pos. SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and pos. SCORAD results. Conclusion: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value.

Journal of Korean Medical Science published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van Houten, Kelly A. published the artcileA New Strategy for the Design of Monoamine Oxidase Inactivators. Exploratory Studies with Tertiary Allylic and Propargylic Amino Alcohols, SDS of cas: 101-98-4, the publication is Journal of the American Chemical Society (1998), 120(24), 5864-5872, database is CAplus.

A new strategy for the design of monoamine oxidase (MAO) inhibitors is proposed. The strategy is based on the premise that tertiary amine-containing MAO inactivators which operate by alkylation of active site nucleophiles are activated in situ by single electron transfer (SET) to the MAO-flavin cofactor to form aminium cation radicals which undergo secondary fragmentation reactions to produce reactive electrophiles. The purpose of the current work was to assess the feasibility and applicability of this proposal for the design of new families of MAO inactivators. Based on the documented retro-aldol type fragmentation reactivity of β-amino alc. cation radicals, tertiary β-allylic and propargylic β-amino alcs. were expected to serve as precursors of conjugated ketones in SET-promoted processes. Evidence supporting this hypothesis was gained from studies of model SET-photoreactions of members of this amino alc. family with 3-methyllumiflavin. The efficient production of 4a- and 4a,5-flavin adducts in these excited-state reactions demonstrates that aminium radicals, arising by SET-oxidation of tertiary β-allylic and -propargylic β-amino alcs., fragment to generate α,β-unsaturated ketones which react rapidly with the simultaneously formed 3MLF-hydroflavin anion. The second feature of the MAO-inactivator design strategy pathway was tested by examining reactions of the MAOs with substances which contain electrophilic, conjugated enone and ynone moieties tethered to amine functions to ensure delivery to the enzyme active sites. The covalent modification of active site cysteine thiol residues by the unsaturated ketone groups in these substances was confirmed by demonstrating that they serve as active site-directed, time-dependent, nonredox based, inactivators of MAO-A and MAO-B. In the key test of the feasibility of the new MAO-inactivator design strategy, it was shown that selected tertiary β-allylic and -propargylic β-amino alcs. undergo redox reactions in the MAO-A active site which result in inactivation of the enzyme via covalent modification of a single cysteine residue. The exptl. results which support the conclusions stated above are presented and discussed in this paper.

Journal of the American Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H10O2, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Han Ung published the artcileDirect conversion of lignin to high-quality biofuels by carbon dioxide-assisted hydrolysis combined with transfer hydrogenolysis over supported ruthenium catalysts, Formula: C9H12O, the publication is Energy Conversion and Management (2022), 115607, database is CAplus.

The central challenge in the biomass-to-fuel conversion process lies in the development of a catalytic strategy for the full utilization of each biomass component, to realize maximum carbon efficiency. In particular, the effective conversion of lignin into biomass is a major bottleneck because of its recalcitrant structure, necessitating the development of new catalytic reaction systems. Here, for the first time, a new hybrid reaction approach involving carbon dioxide-assisted hydrolysis and transfer hydrogenolysis using alcs. as hydrogen donors in a single reactor was investigated for the effective depolymerization of lignin. Specifically, the supercritical carbon dioxide-induced carbonic acid resulted in considerable acidity in the water/alc. reaction media, enhancing the hydrolytic depolymerization of solid lignin to soluble oligomers. The addition of supported metal catalysts (e.g., Ru/C) further depolymerized the oligomers to monomeric phenols through hydrogenolysis using the hydrogen produced in situ from alc. solvents. Systematic parameter studies on the carbon dioxide pressure, water/alc. mixing ratio, type of alc., catalyst addition, and temperature were performed to elucidate the synergistic role of carbon dioxide catalysis and transfer hydrogenolysis in lignin depolymerization Overall, for organosolv lignin, high biocrude oil and monomer yields of �75 and �21.4 wt%, resp., were successfully obtained at 300°C and 40 bar-carbon dioxide after 4 h using a water/ethanol cosolvent at a 25:75 ratio and Ru/C as a catalyst. The effectiveness of the combined carbon dioxide catalysis and transfer hydrogenolysis approach was further demonstrated in the direct depolymerization of lignin in raw biomass.

Energy Conversion and Management published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Song, Soo-Yeol published the artcile2-hydroxy-4-methylbenzoic anhydride inhibits neuroinflammation in cellular and experimental animal models of Parkinson’s disease, Synthetic Route of 328-90-5, the publication is International Journal of Molecular Sciences (2020), 21(21), 8195, database is CAplus and MEDLINE.

Microglia-mediated neuroinflammation is one of the key mechanisms involved in acute brain injury and chronic neurodegeneration. This study investigated the inhibitory effects of 2-hydroxy-4-methylbenzoic anhydride (HMA), a novel synthetic derivative of HTB (3-hydroxy-4-trifluoromethylbenzoic acid) on neuroinflammation and underlying mechanisms in activated microglia in vitro and an in vivo mouse model of Parkinson’s disease (PD). In vitro studies revealed that HMA significantly inhibited lipopolysaccharide (LPS)-stimulated excessive release of nitric oxide (NO) in a concentration dependent manner. In addition, HMA significantly suppressed both inducible NO synthase and cyclooxygenase-2 (COX-2) at the mRNA and protein levels in LPS-stimulated BV-2 microglia cells. Moreover, HMA significantly inhibited the proinflammatory cytokines such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in LPS-stimulated BV-2 microglial cells. Furthermore, mechanistic studies ensured that the potent anti-neuroinflammatory effects of HMA (0.1, 1.0, and 10μM) were mediated by phosphorylation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα) in LPS-stimulated BV-2 cells. In vivo evaluations revealed that i.p. administration of potent neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg, four times a 1 day) in mice resulted in activation of microglia in the brain in association with severe behavioral deficits as assessed using a pole test. However, prevention of microglial activation and attenuation of Parkinson’s disease (PD)-like behavioral changes was obtained by oral administration of HMA (30 mg/kg) for 14 days. Considering the overall results, our study showed that HMA exhibited strong anti-neuroinflammatory effects at lower concentrations than its parent compound Further work is warranted in other animal and genetic models of PD for evaluating the efficacy of HMA to develop a potential therapeutic agent in the treatment of microglia-mediated neuroinflammatory disorders, including PD.

International Journal of Molecular Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H7NO4, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, In Young published the artcileMannosylated polyethylenimine coupled mesoporous silica nanoparticles for receptor-mediated gene delivery, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is International Journal of Pharmaceutics (2008), 359(1-2), 280-287, database is CAplus and MEDLINE.

Organic-inorganic nanohybrids have been studied for their use as nonviral transfection agents. The purpose of this study was to examine the ability of mesoporous silica nanoparticles (MSN) coupled with mannosylated polyethylenimine (MP) to transfect plasmid DNA in vitro. Although MSN is biocompatible and has low cytotoxicity, it is not easily transfected into a variety of cell types. To overcome this barrier, MP was coupled to MSN (abbreviated as MPS) to target macrophage cells with mannose receptors and enhance transfection efficiency. The DNA conveyance ability of MPS was examined by evaluating properties such as particle size, zeta potential, complex formation, protection of plasmid DNA against DNase-I, and the release of DNA upon cell entry. Particle sizes of the MPS/DNA complexes decreased with increasing weight ratio of MPS to DNA, while the zeta potential increased. Complete MPS/DNA complexes were formed at a weight ratio of five, and their resistance to DNase-I was evaluated. Cytotoxicity studies showed that MPS/DNA complexes resulted in a high percentage of cell viability, compared with PEI 25K as a vector. The transfection efficiency of MPS/DNA complexes was evaluated on Raw 264.7 and HeLa cell lines. It was found that MPS/DNA complexes showed enhanced transfection efficiency through receptor-mediated endocytosis via mannose receptors. These results indicate that MPS can be employed in the future as a potential gene carrier to antigen presenting cells.

International Journal of Pharmaceutics published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kwon, Yongseok published the artcilePlatinum-Catalyzed Synthesis of Substituted Phenanthrenes from Biphenyl Propargyl Alcohols via a Carbene Intermediate, COA of Formula: C8H19NO2, the publication is Organic Letters (2014), 16(18), 4936-4939, database is CAplus and MEDLINE.

An efficient synthesis for phenanthrenes via a Pt-carbene intermediate is described. Using Pt as a catalyst, the readily accessible biphenyl propargyl alc. substrate can be transformed to the vinylphenanthrene system through a cascade involving electrophilic cyclization, dehydration, and 1,2-H migration. The synthetic utility and efficiency of this protocol were demonstrated via the concise total synthesis of antofine.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Isaacs, W. B. published the artcileAssociation of titin and myosin heavy chain in developing skeletal muscle, Category: alcohols-buliding-blocks, the publication is Proceedings of the National Academy of Sciences of the United States of America (1992), 89(16), 7496-500, database is CAplus and MEDLINE.

To understand mol. interactions that organize developing myofibrils, the biosynthesis and interaction of titin and myosin heavy chain in cultures of developing chicken leg myoblasts were examined Use of pulse-labeling, immunoprecipitation, and a reversible crosslinking procedure demonstrates that within minutes of synthesis, titin and myosin heavy chain can be chem. crosslinked into very large, detergent-resistant complexes retaining many features of intact myotubes. These complexes, predominantly of titin and myosin, occur very early in myofibrillogenesis as well as later. Apparently, synthesis and assembly of titin and myosin are temporally and spatially coordinated in nascent myofibrils, and titin mols. may help to organize sarcomere formation.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Son, Young Ju published the artcileMultifunctional Nanorods Serving as Nanobridges To Modulate T Cell-Mediated Immunity, Application In Synthesis of 96345-79-8, the publication is ACS Nano (2013), 7(11), 9771-9779, database is CAplus and MEDLINE.

Electrodeposited nanorods serving as multivalent bridges were fabricated and surface-decorated with ligands for immune cells. Gold and nickel solutions were sequentially electrodeposited on nanoporous anodized disk templates and the template was dissolved to retrieve bisegmented nanorods with different lengths. Gold and nickel segmented nanorods were surface-immobilized with mannose and RGD peptides to prepare immune-cell recruiting nanorods. Surface-functionalization of nanorods were confirmed by fluorescence-labeling of each ligands and confocal microscopy. Dendritic cells and T cells were co-incubated with the surface-functionalized nanorods, and the proximity between the nanorods and the immune cells was visualized by variable pressure SEM and confocal microscopy. The long nanorods were associated with the immune cells, whereas the shorter nanorods were rather endocytosed by cells, suggesting a feasibility of the longer nanorods as bridging for the cells. Cytokine releases from the immune cells were monitored by cultivating lipopolysaccharide-activated dendritic cells with T cells. Interleukin-2 and interferon-γ release profiles showed a strong correlation with the length of the nanorod, where the 4 μm nanorods induced the highest levels of cytokine release compared to 1 or 2 μm nanorods. Thus, the authors concluded that the proximity of the immune cells increased by bridging the immune cells with the nanobridging system, which subsequently increased cytokine release by facilitating the antigen presentation process.

ACS Nano published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H22OSi, Application In Synthesis of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hong, Ki Bum published the artcileCF₃-substituted mollugin 2-(4-morpholinyl)-ethyl ester as a potential anti-inflammatory agent with improved aqueous solubility and metabolic stability, Safety of 2-Morpholinoethanol, the publication is Molecules (2018), 23(8), 2030/1-2030/17, database is CAplus and MEDLINE.

Although mollugin, the main ingredient of the oriental medicinal herb Rubia cordifolia, has considerable anti-inflammatory effects, it has poor aqueous solubility as well as poor metabolic and plasma stability. To overcome these shortfalls, various mollugin derivatives have been synthesized and evaluated for their ability to inhibit U937 monocyte cell adhesion to HT-29 colonic epithelial cells in TNF-α or IL-6-induced models of colon inflammation. The 2-(4-morpholinyl)-Et ester of CF3-substituted mollugin (compound 15c) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-α and IL-6-induced colonic epithelial cell adhesion assays, suggesting that 15c is a potential anti-inflammatory agent.

Molecules published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Safety of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kang, Seok Hee published the artcilePLGA Microsphere Addition to 1-Hydroxy-2-naphthoic Acid Enhances the Sustained Release of Escitalopram, Related Products of alcohols-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2019), 40(8), 791-795, database is CAplus.

Escitalopram (ET), a selective serotonin reuptake inhibitor, has been utilized for the treatment of depression and anxiety.However, ET has serious side effects such as nausea, leading to an increased therapeutic dose, needing multiple administrations.Therefore, to overcome these issues, we developed ET encapsulated poly (d,l-lactic-co-glycolic acid) (PLGA) microspheres (PLGA-MS) as a sustained release carrier to maintain therapeutic efficacy.The mean particle size of the PLGA-MSs was measured by microscopy.Loading efficiency was measured by high performance liquid chromatog. (HPLC). Morphologies were determined by microscopy and SEM (SEM).Differential scanning calorimetry (DSC) was used for thermal anal. and glass transition temperature determinationMean particle size of the ET-loaded PLGA-MSs was 129 ± 14μm, loading efficiency was 36.8 ± 9.1%, and encapsulation efficiency was up to 70.6 ± 6.8%.Loading efficiency and encapsulation efficiency were increased by the addition of 1-hydroxy-2-naphthoic acid (HNA).ET was released from PLGA-MS for 4 wk, which was longer than ET release from PLGA-MS without the addition of HNA.Taken together, we demonstrate the optimum condition for sustained release of ET from PLGA-MS with the addition of HNA, and that this approach may be useful for depression therapy.

Bulletin of the Korean Chemical Society published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts