Author: tianli

Bacher, Emily P. published the artcileA Phosphine-Mediated Dearomative Skeletal Rearrangement of Dianiline Squaraine Dyes, Synthetic Route of 27292-49-5, the publication is Organic Letters (2021), 23(8), 2853-2857, database is CAplus and MEDLINE.

A phosphorus(III)-mediated dearomatization of ortho-substituted dianiline squaraine dyes results in an unusual skeletal rearrangement to provide exotic, highly conjugated benzofuranone and oxindole scaffolds bearing a C3 side chain comprised of a linear conflagration of an enol, a phosphorus ylide, and 2,4-disubstituted aniline. Employing exptl. and computational anal., a mechanistic evaluation revealed a striking dependence on the acidity of the aniline ortho substituent. Notably, the rearrangement adducts underwent rapid and complete reversion to the parent squaraine in the presence of a Bronsted acid.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Synthetic Route of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zyakun, A. M. published the artcileApplication of High-Performance Liquid Chromatography/High Resolution Mass Spectrometry to the Investigation of the Biodegradation and Transformation of Phenanthrene by a Plasmid Bearing Rhizosphere Bacteria Pseudomonas aureofaciens, SDS of cas: 86-48-6, the publication is Journal of Analytical Chemistry (2019), 74(13), 1355-1361, database is CAplus.

Mass spectrometry identified metabolites and estimated the efficiency of phenanthrene biodegradation and transformation by the rhizospheric bacteria, Pseudomonas aureofaciens BS1393. P. aureofaciens strains BS1393(pOV17) and BS1393(NPL-41) with various naphthalene biodegradation plasmids were used. Strain BS1393(pOV17) contained the pOV17 wild-type naphthalene biodegradation plasmid which determined naphthalene oxidation Krebs cycle metabolites. Strain BS1393(NPL-41) contained the mutant plasmid, NPL-41, governing the initial stages of naphthalene oxidation to salicylic acid. Phenanthrene biodegradation limiting stages in bacteria with various plasmids was identified according to intermediates accumulation. When bacteria were grown on phenanthrene, main metabolites were: 2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid/trans-4-(1-hydroxynaph-2-yl)-2-oxobut-3-enoic acid; 1-hydroxy-2-naphthoic acid; and salicylic acid. For strain BS1393(pOV17), 2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid/trans-4-(1-hydroxynaph-2-yl)-2-oxobut-3-enoic acid was observed during 1-14 days of cultivation. For strain BS1393(NPL-41), an insignificant amount of this metabolite was observed after only 14 days. Availability of 1-hydroxy-2-naphthoic acid in the growth of both strains showed the limited rate of its further decarboxylation. Salicylic acid as final biodegradation product was obsd for BS1393(NPL-41) growth. For strain BS1393(pOV17), this metabolite was not observed, indicating phenanthrene complete oxidation

Journal of Analytical Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C6H8O6, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Borkowski, Olivier published the artcileLarge scale active-learning-guided exploration for in vitro protein production optimization, Computed Properties of 122-20-3, the publication is Nature Communications (2020), 11(1), 1872, database is CAplus and MEDLINE.

Abstract: Lysate-based cell-free systems have become a major platform to study gene expression but batch-to-batch variation makes protein production difficult to predict. Here we describe an active learning approach to explore a combinatorial space of ~4,000,000 cell-free buffer compositions, maximizing protein production and identifying critical parameters involved in cell-free productivity. We also provide a one-step-method to achieve high quality predictions for protein production using minimal exptl. effort regardless of the lysate quality.

Nature Communications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Computed Properties of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boivin, Patrick published the artcileImmobilization of perfluoroalkylated enzymes in a biologically active state onto Perflex support, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biotechnology and Applied Biochemistry (1991), 14(2), 155-69, database is CAplus and MEDLINE.

Perflex was introduced as a new fluorocarbon-based technol. for protein immobilization. Due to the hydrophobic character of the support, however, significant loss of enzymic activity may occur upon immobilization of certain enzymes, which appears to be due to a large conformational change of the protein (inversion). Pretreatment of the Perflex support with a neutral fluorosurfactant lessened the surface hydrophobicity, thus decreasing the hydrophobic interaction between the support and the protein. Modification of enzymes with a high number of fluorocarbon residues, which forms a hydrophobic envelope around the protein, also appeared to prevent enzyme inactivation upon immobilization on Perflex support. Moreover, preactivation of the support with either perfluorooctylpropylisocyanate or reactive poly(fluoroalkyl)sugar reagents greatly improved the enzyme particle activity by increasing the amount of immobilized enzyme. Fluorosurfactant treatment of the support activated with perfluorooctylpropylisocyanate improved the retention of activity for sensitive enzymes such as chymotrypsin and increased the wet ability and ease of handling of the Perflex particles.

Biotechnology and Applied Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fuchise, Keita published the artcileOrganocatalytic ring-opening polymerization of cyclotrisiloxanes using silanols as initiators for the precise synthesis of asymmetric linear polysiloxanes, Synthetic Route of 597-52-4, the publication is Polymer Chemistry (2020), 11(48), 7625-7636, database is CAplus.

The organo-catalytic controlled/living ring-opening polymerization (ROP) of cyclotrisiloxanes such as hexamethylcyclotrisiloxane (D3) and 1,3,5-trimethyl-1,3,5-trivinylcyclotrisiloxane (V3) using silanol initiators and guanidine catalysts produced various asym. linear poly(dimethylsiloxane) (PDMS) and poly[methyl(vinyl)siloxane] (PMVS) compounds with controlled number-average molar mass (Mn), narrow molar-mass dispersity, and well-defined terminal structures. An extensive range of solvents and catalysts were tested in order to optimize the conditions for the ROP of D3 and V3 as well as to minimize undesired side-reactions, particularly the condensation of two Si-OH groups. 1,3-Trimethylene-2-n-propylguanidine (TMnPG) and 1,3-trimethylene-2-ethylguanidine (TMEG) were identified as the most appropriate catalysts for the ROP of D3 and V3. Asym. linear polysiloxanes that contain either a functional group on one terminus, i.e., hemi-telechelic polysiloxanes, or two different functional groups on each terminus, i.e., heterotelechelic polysiloxanes, were conveniently obtained from choosing a suitable combination of a functionalized silanol initiator and a functionalized chlorosilane end-capping agent. The controlled synthesis of a PDMS/PMVS diblock copolymer was also achieved by consecutive copolymerizations of D3 and V3. These polymerizations are considered to proceed via the initiator/chain-end activation mechanism, and intensive removal of water from the starting materials is necessary to control the polymerizations

Polymer Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Synthetic Route of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ido, Yohei published the artcileA Reactor System Using Electrospray in the Liquid Phase and Its Application in Selective Cyclosiloxane Synthesis, Quality Control of 597-52-4, the publication is Industrial & Engineering Chemistry Research (2017), 56(16), 4878-4882, database is CAplus.

Electrospraying is an electrochem. technique in which fine droplets are generated in the balance of electrostatic repulsion and surface tension. In this paper, we applied electrospray in the liquid phase in a new reactor system in which pos. and neg. charged fine droplets collided with each other between two electrospray nozzles submerged in a solvent. When the hydrolysis of alkylchlorosilanes was carried out using this reactor, not only did the reaction rates increase, but also, the product distribution changed: the kinetically favored cyclotrimer was predominantly formed over the thermodynamically favored cyclotetramer. The yield of cyclotrimer increased with an increase in the voltage between the needles. Since the droplet size decreases with an increase in the applied voltage, the result suggests that the formed cyclotrimer could diffuse into the solvent before it was converted to the thermodynamically favored cyclotetramer.

Industrial & Engineering Chemistry Research published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Quality Control of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Shih-Wei published the artcilePilot production of a sensitive ELISA kit and an immunochromatographic strip for rapid detecting citrinin in fermented rice, Category: alcohols-buliding-blocks, the publication is RSC Advances (2022), 12(31), 19981-19989, database is CAplus and MEDLINE.

Citrinin (CTN) is a mycotoxin primarily produced by Monascus species. Excess consumption of CTN may lead to nephrotoxicity and hepatotoxicity. A pilot study for com. production of competitive direct ELISA (cdELISA) kit and an immunochromatog. strip (immunostrip) for screening CTN in red yeast rice is established in this study. The coating antibody and the CTN-horse radish peroxidase (HRP) concentrations were optimized to increase the sensitivity and specificity of cdELISA kit. The conjugation methods/ratios of CTN to HRP as well as the long-term stability of kit components were also evaluated. The IC50 and detection limit of the ELISA kit were determined to be 4.1 and 0.2 ng mL-1, resp. Anal. of 20 red yeast rice samples using ELISA kits revealed the contamination levels of CTN from 64 to 29 404 ng g-1. The on-site rapid detection of CTN with the immunostrip showed that CTN levels in seven samples exceeded the regulatory limit of 5 ppm. Addnl., the coefficient correlation between the results of HPLC and ELISA kits of 20 samples was 0.96. Sensitive and convenient tools at com. levels for detection of CTN contamination in food are established herein to protect the health of the public.

RSC Advances published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C8H11BO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lang, Andreas published the artcileContribution to the chemistry of boron. Part 237. Bis(benzo-1,3,2-dioxaborolyl) oxide and 2-(2-hydroxyphenoxy)benzo-1,3,2-dioxaborole. Precursors for the synthesis of catecholborane (benzo-1,3,2-dioxaborole), Quality Control of 25240-59-9, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1997), 623(6), 901-907, database is CAplus.

The title compounds were prepared from B(OH)₃ with catechol with different stoichiometries and were characterized by NMR and x-ray structure anal. Bis(benzo-1,3,2-dioxaborolyl) oxide (I) has C₂ point group symmetry with a wide B-O-B bond angle (135.9°) in contrast to 2-(2-hydroxyphenoxy)benzo-1,3,2-dioxaborole which shows an almost planar mol. structure. These mols. form infinite chains in the solid state. 2-Hydroxy-1,3,2-dioxaborole crystallizes as a OH…O bridged dimer. Compound I proved to be a good starting material for the preparation of catecholborane.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Quality Control of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gajic, Mihajlo published the artcileRepurposing of 8-Hydroxyquinoline-Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors, Formula: C11H8O3, the publication is ChemMedChem (2022), 17(5), e202100694, database is CAplus and MEDLINE.

A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened in vitro for inhibition of DNase I (DNase I). Compounds 22, 8 and 7 are among the most potent synthetic non-peptide DNase I inhibitors reported to date. Three 8-hydroxyquinoline analogs inhibited both DNase I and BChE with IC50 values below 35 μM and 50 nM, resp., while two nitroxoline derivatives inhibited DNase I and Cat B endopeptidase activity with IC50 values below 60 and 20 μM. Selected derivatives were screened for various co-target binding affinities at dopamine D2 and D3, histamine H3 and H4 receptors and inhibition of 5-lipoxygenase. Compound 8 bound to the H3 receptor and is highlighted as the most promising multifunctional ligand with a favorable pharmacokinetic profile and one of the most potent non-peptide DNase I inhibitors. The present study demonstrates that 8-hydroxyquinoline is a structural fragment critical for DNase I inhibition in the presented series of compounds

ChemMedChem published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rosenkranz, Herbert S. published the artcileStructural basis of the genotoxicity of nitrosatable phenols and derivatives present in smoked food products, Application In Synthesis of 1139-46-4, the publication is Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis (1990), 230(1), 9-27, database is CAplus and MEDLINE.

The CASE (artificial intelligence-based structure-activity anal.) methodol. for studying structure-activity relationships was applied to investigating the basis of the genotoxicity of phenols and derivatives following exposure to nitrous acid. The structural features identified include availability of positions para or ortho to the hydroxyl groups, that one meta position must remain unoccupied and one ortho or para position must be unsubstituted as well. The analyses revealed that genotoxicity is dependent upon the ease of formation of the active phenyldiazonium intermediate and is influenced only secondarily by the nature of the genotoxicant or its ease of entry into the cell. With this data base, CASE predicts the genotoxicity, following nitrosation, of a number of agents, including serotonin, acetaminophen, and of some naturally-occurring pesticides present in edible plants.

Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Application In Synthesis of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts