Author: tianli

Xu, Hao published the artcileCharacterization of the Partition Rate of Ibuprofen Across the Water-Octanol Interface and the Influence of Common Pharmaceutical Excipients, Product Details of C8H18O, the main research area is ibuprofen bolus injection interfacial partition excipient dissolution; 2-phase dissolution; biomimetic; biorelevant; diffusion; dissolution test; interface; in vitro; partition; polymer; surfactant.

This work reports the measurement of the partition rate of a model drug, ibuprofen (IBU), from aqueous solutions into octanol in the absence and presence of common pharmaceutical excipients including glucose, lactose, maltoheptaose, hydroxypropyl methylcellulose, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate, hydroxypropyl methylcellulose AS, sodium dodecyl sulfate, Tween 80, and sodium taurocholate at varying concentrations This attempts to assess the kinetic aspect of IBU partitioning across the water-octanol interface by applying a mechanistic model and to characterize the interfacial resistance. A significant reduction in Pi across the water-octanol interface was observed with extremely low concentration of the selected excipients in the aqueous media. These results reveal the presence of a surface excess of adsorbed excipients at the water-octanol interface. The retardation of the Pi of IBU was found to be sensitive to (1) the mol. weight or the d.p. of these excipients, (2) the hydrodynamic condition of the exptl. method, and (3) the pH of the aqueous media. Retardation of the Pi of IBU in the presence of excipients observed in this study is proposed by a steric obstruction mechanism through the adsorbed surface excess layer of excipients located at the water-octanol interface.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Dissolution. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lenz, Elisabeth published the artcileImpact of fillers on dissolution kinetic of fenofibrate dry foams, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is fenofibrate tablet fast release drug delivery Maltrin Soluthin dissolution; Dissolution rate; dry foam granulation; eroding tablets; fast dissolving; starch derivatives; sugar alcohols.

Dry foam technol. reveals the opportunity to improve the dissolution behavior of poorly soluble drugs tending to agglomeration due to micronization. In this study, the impact of fillers on the manufacturability, the properties of dry foams and granules as well as the dissolution kinetics of dry foam tablets was investigated using fenofibrate as a model compound Different maltodextrins and dried glucose syrups, a maltodextrin-phosphatidylcholine complex, isomalt and a 1:1 mixture of mannitol/glucose syrup were used as filler. Within the group of maltodextrins and glucose syrups, the influences of dextrose equivalent (DE), particle morphol. and botanical source of starch were investigated. Comparable macroscopic foam structures were obtained with maltodextrins and glucose syrups whereas different foam morphologies were obtained for the other fillers tested. Regarding the maltodextrins and glucose syrups, different physicochem. and particle properties had a minor impact on granule characteristics and tablet dissolution Using the maltodextrin-phosphatidylcholine complex resulted in a low sp. surface area of the granules and a slow tablet dissolution caused by a slow disintegration. In contrast, a high sp. surface area and a fast release were obtained with isomalt and glucose syrup/mannitol mixture indicating that high soluble low mol. weight fillers enable the development of fast dissolving dry foam tablets.

Pharmaceutical Development and Technology published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Casian, Tibor published the artcileQbD for pediatric oral lyophilisates development: risk assessment followed by screening and optimization, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is oral lyophilisate tablet drug release delivery system; D-optimal design; Orodispersible tablets; failure mode effect analysis; freeze drying; pediatric formulation.

This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process, formulation and methodol. related parameters. Failure Mode Effect Anal. was applied to highlight critical formulation and process parameters with an increased probability of occurrence and with a high impact on the product performance. To investigate the effect of qual. and quant. formulation variables D-optimal designs were used for screening and optimization purposes. Process parameters related to suspension preparation and lyophilization were classified as significant factors, and were controlled by implementing risk mitigation strategies. Both quant. and qual. formulation variables introduced in the exptl. design influenced the product’s disintegration time, mech. resistance and dissolution properties selected as CQAs. The optimum formulation selected through Design Space presented ultra-fast disintegration time (5 s), a good dissolution rate (above 90%) combined with a high mech. resistance (above 600 g load). Combining FMEA and DoE allowed the science based development of a product with respect to the defined quality target profile by providing better insights on the relevant parameters throughout development process. The utility of risk management tools in pharmaceutical development was demonstrated.

Drug Development and Industrial Pharmacy published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nadernezhad, Ali published the artcileMelt Electrowriting of Isomalt for High-Resolution Templating of Embedded Microchannels, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is isomalt melt electrowriting high resolution templating microchannel.

Fabrication of microchannels using 3D printing of sugars as fugitive material is explored in different fields, including microfluidics. However, establishing reproducible methods for the controlled production of sugar structures with sub-100μm dimensions remains a challenge. This study pioneers the processing of sugars by melt electrowriting (MEW) enabling the fabrication of structures with so far unprecedented resolution from Isomalt. Based on a systematic variation of process parameters, fibers with diameters down to 20μm can be fabricated. The flexibility in the adjustment of fiber diameter by on-demand alteration of MEW parameters enables generating constructs with perfusable channels within polydimethylsiloxane molds. These channels have a diameter that can be adjusted from 30 to 200μm in a single design. Taken together, the experiments show that MEW strongly benefits from the thermal and phys. stability of Isomalt, providing a robust platform for the fabrication of small-diameter embedded microchannel systems.

Advanced Materials Technologies (Weinheim, Germany) published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anuja, Katariya-Jain published the artcileAn overview of HPDLC films and their applications, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is polymer dispersed liquid crystal film application.

The fusion of holog. to the LC-polymer composites give rise to holog. polymer dispersed liquid crystal (HPDLC) technol. The concentration of monomer unit in HPDLC films is quite high as compared to the other polymer-LC composite films. Difference in the rate of polymerization in different regions of composite film gives rise to alternate bright and dark fringes. In this review article along with the underlying principle of HPDLC films, we have discussed some electro-optical (EO) parameters like response time, diffraction efficiency (DE) and driving voltages necessary for the evaluation of a film. The classification and types of HPDLC gratings, which actually depend upon writing set up, grating period and thickness, has also found good space in this article. Recent advances to improve the efficiency of HPDLC films by varying material mixture and fabrication techniques is also discussed. Different types of evolved morphologies typically, LC droplet, Policryps and Polymer Scaffolding is described. Some trending applications of HPDLC films such as sensor, photonic crystals, mirrorless lasing etc are also highlighted.

Liquid Crystals published new progress about Diffraction. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

MacQueen, Blake published the artcileOptimum Reaction Conditions for 1,4-Anhydroerythritol and Xylitol Hydrodeoxygenation over a ReOx-Pd/CeO2 Catalyst via Design of Experiments, Related Products of alcohols-buliding-blocks, the main research area is anhydroerythritol xylitol hydrodeoxygenation ReO palladium Ceria catalyst.

In this study, we demonstrate that for the simultaneous hydrodeoxygenation (HDO) of 1,4-anhydroerythritol a comparable yield of THF is obtained at half the previously reported H2 pressure. The simultaneous hydrodeoxygenation was conducted using a heterogeneous ReOx-Pd/CeO2 catalyst. An L9 Taguchi design of experiment was enacted to elucidate the temperature, pressure, and catalyst loading effects on the yield of the HDO reaction by testing pressures ranging from 40 to 80 bar H2, temperatures of 100-180 °C, and Re loadings of 2-4 weight %. Our design showed that the yield of this reaction is significantly affected by the reaction temperature only. An L9 Taguchi design was conducted for xylitol simultaneous hydrodeoxygenation with pressures ranging from 5 to 10 bar H2, temperatures of 140-180 °C, and Re loadings of 2-4 weight %. The xylitol design elucidated the direct relation of pressure, and the inverse relation of temperature and catalyst loading, to yield with the optimal reaction condition being 140 °C and 10 bar H2.

Industrial & Engineering Chemistry Research published new progress about Deoxidation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Haiyang published the artcileCyclization of citronellal to p-menthane-3,8-diols in water and carbon dioxide, Category: alcohols-buliding-blocks, the main research area is citronellal cyclization menthanediol green chem.

A clean process has been developed for the synthesis of p-menthane-3,8-diols from cyclization of citronellal in CO2-H2O medium without any additives. With the addition of CO2, the reaction rate could be enhanced about 6 times for the cyclization of citronellal in H2O, because CO2 dissolved into water and formed carbonic acid inducing an increase of the acidity. Although, the reaction conversion in CO2-H2O is slightly lower compared to that obtained with sulfuric acid as catalyst, CO2-H2O could replace the sulfuric acid at a relative higher reaction temperature The reaction kinetics studies showed that the hydration of isopulegol to p-menthane-3,8-diols is a reversible reaction. The equilibrium constant and the maximum equilibrium yield obtained in CO2-H2O at a range of CO2 pressures are similar to that with sulfuric acid catalyst.

Green Chemistry published new progress about Cyclization. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xianheng published the artcilePreparation of Dolutegravir Intermediate Diastereomer, Safety of 2,2-Dimethoxyethanamine, the main research area is dolutegravir tricyclic intermediate diastereoselective preparation.

A convenient method was developed to prepare the diastereomer of dolutegravir tricyclic intermediate in the catalysis of EDCI/DMAP in up to 87% yield. Different solvents, temperature, and times were optimized. The synthesized diastereomer 6′ could be used as a standard for the industrial manufacture requirement of dolutegravir active pharmaceutical ingredient.

Journal of Heterocyclic Chemistry published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Safety of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hussain, Mulla Althafh published the artcileTotal synthesis of (±)-aspidostomide B, C, regioisomeric N-methyl aspidostomide D and their derivatives, HPLC of Formula: 22483-09-6, the main research area is aspidostomide B C D analog regioselective synthesis; cyclization total synthesis aspidostomide B C D; dehydration total synthesis aspidostomide B C D; regioselective ring opening total synthesis aspidostomide B C D.

A full account of the total synthesis of aspidostomide B, C, their analogs and our synthetic efforts towards the synthesis of aspidostomide D, which led to the synthesis of regioisomeric N-Me aspidostomide D, its analogs via epoxide opening strategy is presented. The synthesis of regioisomeric N-Me aspidostomide D involves an efficient, five-step sequence, with 36.3% overall yield, starting from 3,4,5-tribromo-1H-pyrrole-2-carboxylic acid. The key features of this protocol are intramol. cyclization, dehydration, oxidation, and a Lewis acid-mediated regioselective epoxide ring opening by C-3 position of 2,5-dibromo-1H-indole to furnish the title compounds

Tetrahedron Letters published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wong, Shaio Wen published the artcileCatalysis in competing isocyanate reactions, COA of Formula: C7H18N2O, the main research area is phenyl isocyanate butanol esterification kinetics; dipropylenetriamine catalyst isocyanate butanol esterification; organotin catalyst isocyanate butanol esterification; amine catalyst isocyanate butanol esterification.

The effects of various organotin and tertiary amine catalysts on the product distributions in the esterification of Ph isocyanate (I) [103-71-9] with n-BuOH (II) [71-36-3] as model reaction for the preparation of polyurethanes were determined The esterification in the presence of N,N,N’,N’,N”-pentamethyldipropylenetriamine (III) [66537-05-1] catalyst in MeCN at 50° was first order with respect to I and III concentrations and half order with respect to II concentration with an apparent activation energy of 22.9 kcal/mol. Tri-Ph isocyanurate (IV) [1785-02-0], Bu phenylcarbamate  [1538-74-5], and Bu α,γ-diphenylallophanate  [21367-12-4] were formed by the reaction with IV being the major reaction product. The presence of H2O delayed the reaction rate and inhibited the formation of IV.

Polimeri (Zagreb, Croatia) published new progress about Cyclization. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, COA of Formula: C7H18N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts