Author: tianli

Zolek, Teresa published the artcileDeposition of pentamidine analogues in the human body – spectroscopic and computational approaches, Application In Synthesis of 111-87-5, the main research area is pentamidine analog Pneumocystis jiroveci pneumonia prophylaxis therapy pharmacotherapy; Computational modelling; Drug-likeness; HSA and DNA interaction; Pentamidine analogues; Proton dissociation constants; Spectrofluorometry.

Bis-benzamidines are a diverse group of compounds with high potential in pharmacotherapy, and among them, pentamidine is a drug of great therapeutic significance in Pneumocystis jiroveci pneumonia (PJP) prophylaxis and therapy. Pharmacokinetic properties of these cationic species such as transport, acid/base equilibrium, and interactions with potential target mols. are still of interest, especially for recently designed compounds To broaden our knowledge drug-likeness, human serum albumin binding, and acidity constants (Ka) were exptl. and theor. examined for five pentamidine analogs 1 – 5 with -NH-CO-chain-CO-NH-bridges of increasing length and O, N, and S atoms in the chain. The studied analogs display very marked activity against Pneumocystis carinii without cytotoxicity that inspired us to perform an in silico anal. of their mode of action based on the hypothesis that the small DNA groove of rich in adenine-thymine pairs is their mol. target. These studies allowed us to classify them as very promising lead mols.

European Journal of Pharmaceutical Sciences published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application In Synthesis of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Suciu, Stefana published the artcileQbD approach in the development of oral lyophilisates with ibuprofen for paediatric use, SDS of cas: 64519-82-0, the main research area is oral lyophilisates mucosa ibuprofen methylcellulose drug safety xanthan gum.

Quality-by-Design (QbD) concept in drug formulation and development was introduced in order to achieve and ensure an adequate product quality through a good process understanding. By identifying the variability sources that influence the product features, the quality of the product can be built from the development phase. Applying the concept, in the current work it was intended to develop and characterize orodisperable lyophilisates (OLs) for paediatric use. The drug model used was ibuprofen and following risk assessment evaluation, twenty-five exptl. formulations were prepared With a D-optimal exptl. design with six factors and two levels, the influence of the formulation factors on the desired quality target product profile was assessed (QTPP, the quality characteristics of a product that is intended to be achieved considering the aspects related to the safety and efficacy of the product): disintegration time, wetting time, mean dissolution time, texture and bio-adhesive features of the OLs were studied. During this experiment, it was observed that the type of the matrix forming and bio-adhesive agent influenced the disintegration time. All formulation factors influenced the wetting time, while no significant influence was observed for the bio-adhesive properties of the OLs. The hardness and rigidity of the OLs was increased by gelatine, while the methylcellulose and xanthan gum conducted to opposite results. The fracturability of the OLs was influenced only by the quant. factors, resp. the percentage of the matrix forming agent and the bio-adhesive agent. The dissolution profile was slightly influenced by the type of bio-adhesive agent. The design space has been defined based on the obtained results. The QbD approach was successfully applicd within this study and OLs with ibuprofen for paediatric use with desired pharmaceutical characteristics may be successfully obtained by lyophilisation.

Farmacia (Bucharest, Romania) published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Strubbe-Rivera, Jasiel O. published the artcileThe mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is calcium overload mitochondrial permeability transition structure cryogenic electron microscopy.

Mitochondria have a remarkable ability to uptake and store massive amounts of calcium. However, the consequences of massive calcium accumulation remain enigmatic. In the present study, we analyzed a series of time-course experiments to identify the sequence of events that occur in a population of guinea pig cardiac mitochondria exposed to excessive calcium overload that cause mitochondrial permeability transition (MPT). By analyzing coincident structural and functional data, we determined that excessive calcium overload is associated with large calcium phosphate granules and inner membrane fragmentation, which explains the extent of mitochondrial dysfunction. This data also reveals a novel mechanism for cyclosporin A, an inhibitor of MPT, in which it preserves cristae despite the presence of massive calcium phosphate granules in the matrix. Overall, these findings establish a mechanism of calcium-induced mitochondrial dysfunction and the impact of calcium regulation on mitochondrial structure and function.

Scientific Reports published new progress about Absorption. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Craven, John published the artcileRhodopseudomonas palustris-based conversion of organic acids to hydrogen using plasmonic nanoparticles and near-infrared light, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is organic acid hydrogen Rhodopseudomonas palustris conversion plasmonic nanoparticle.

The simultaneous elimination of organic waste and the production of clean fuels will have an immense impact on both the society and the industrial manufacturing sector. The enhanced understanding of the interface between nanoparticles and photo-responsive bacteria will further advance the knowledge of their interactions with biol. systems. Although literature shows the production of gases by photobacteria, herein, we demonstrated the integration of photonics, biol., and nanostructured plasmonic materials for hydrogen production with a lower greenhouse CO2 gas content at quantified light energy intensity and wavelength. Phototrophic purple non-sulfur bacteria were able to generate hydrogen as a byproduct of nitrogen fixation using the energy absorbed from visible and near-IR (NIR) light. This type of biol. hydrogen production has suffered from low efficiency of converting light energy into hydrogen in part due to light sources that do not exploit the organisms’ capacity for NIR absorption. We used NIR light sources and optically resonant gold-silica core-shell nanoparticles to increase the light utilization of the bacteria to convert waste organic acids such as acetic and maleic acids to hydrogen. The batch growth studies for the small cultures (40 mL) of Rhodopseudomonas palustris demonstrated >2.5-fold increase in hydrogen production when grown under an NIR source (167 ± 18μmol H2) compared to that for a broad-band light source (60 ± 6μmol H2) at equal light intensity (130 W m-2). The addition of the mPEG-coated optically resonant gold-silica core-shell nanoparticles in the solution further improved the hydrogen production from 167 ± 18 to 398 ± 108μmol H2 at 130 W m-2. The average hydrogen production rate with the nanoparticles was 127 ± 35μmol L-1 h-1 at 130 W m-2.

RSC Advances published new progress about Absorption. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yun published the artcileGinger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is hepatocellular carcinoma cell cycle arrest apoptosis polysaccharide; Apoptosis; Cell cycle arrest; Ginger polysaccharide.

In this study, ginger polysaccharide (GP) was obtained from ginger by enzymic method, its chem. properties and antitumor activity were investigated. The results indicated that the composition and proportion of GP were L-rhamnose, D-arabinose, D-mannose, D-glucose and D-galactose in a molar ratio of 3.64:5.37:3.04:61.03:26.91, GP had the characteristic absorption peak of polysaccharide. Congo red experiment showed that GP had a triple helix structure, which could have anti-tumor effect. Furthermore, MTT assay, cell morphol. observation, nuclear morphol. observation and reactive oxygen species observation demonstrated that GP had significant antitumor effect. Flow cytometry suggested that GP could promote apoptosis and arrest cells in G0-G1 phase. Real-time fluorescence quantification and Western blot revealed that GP could up-regulate the expression of Bax, Fas, FasL, caspase-3, p21 and p53, and down-regulate the expression of Bcl-2. These studies suggested that GP would be used as an antitumor drug in foods to promote the development of functional foods.

International Journal of Biological Macromolecules published new progress about Absorption. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rozi, Parhat published the artcileIsolationscharacterizations and bioactivities of polysaccharides from the seeds of three species Glycyrrhiza, Product Details of C6H12O6, the main research area is Glycyrrhiza seed polysaccharide bioactivity; Antioxidant activity; Characterization; Glycyrrhiza; Polysaccharide.

In this paper, polysaccharides from the seeds of three species of genus Glycyrrhiza were extracted to investigate the physicochem. properties, structural characteristics and antioxidant activities. The polysaccharides were composed of xylose, mannose, galactose, and glucose with different molar ratio. Fourier transform IR spectroscopy showed the presence of key functional groups of polysaccharides whereas SEM anal. revealed the characteristic morphol. of different polysaccharides, and thermogravimetric anal. exhibited good thermal stability of all samples. The antioxidant activities of polysaccharides were evaluated in vitro. All the three polysaccharides demonstrated strong reducing power, as well as scavenging activity against DPPH, ABTS, and hydroxyl free radicals. Antioxidant assays indicated that all the polysaccharides have obvious antioxidant activities and possess a potential development and application value in food, cosmetics as well as pharmaceutical industries.

International Journal of Biological Macromolecules published new progress about Absorption. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gu, ShuangShuang published the artcileStructural characterization and inhibitions on α-glucosidase and α-amylase of alkali-extracted water-soluble polysaccharide from Annona squamosa residue, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Annona squamosa alpha glucosidase amylase polysaccharide structural characterization; Alkaline-extraction polysaccharide; Inhibitory on α-glucosidase and α-amylase; Structure analysis.

A novel acidic polysaccharide, named as AWPA, was extracted form Annona squamosa residue by 0.1 M NaOH alk. solution and purified by DEAE-cellulose and Sephadex G-150. HPLC anal. indicated that AWPA was a homogeneous polysaccharide with mol. weight of 3.08 x 103 kDa. The monosaccharide composition of AWPA, determined by ion chromatog., was consisted of L-arabinose, D-galactose, D-glucose, D-mannose, D-galacturonic acid in a percentage of 15.58:13.48:60.14:9.02:1.78, resp. The results of FT-IR, methylation and NMR showed that the sugar residue of AWPA were mainly composed ofα-L-Araf-(1â†? â†?)-α-D-Glcp-(1â†? â†?)-β-D-Galp-(1â†? â†?)-β-D-Glcp-(1â†? â†?,6)-β-D-Galp(1â†?â†?,6)-α-D-Manp-(1â†? resp). The Congo red experiment on AWPA showed that there was helix conformation. The microstructure of AWPA was detected by SEM, showing that the shape of AWPA was reticular and its structure was irregular. AWPA had effectively α-glucosidase inhibitory activity and α-amylase inhibitory activity with IC50 of 0.667 mg/mL and 1.360 mg/mL, resp. The inhibitory effects of AWPA on α-glucosidase and α-amylase were both reversible with mixed type and competitive type competition, resp. The significance of manuscript was not only to avoid the waste of Annona squamosa residue, but provided alternative in the developments of inhibitors of α-glucosidase and α-amylase.

International Journal of Biological Macromolecules published new progress about Absorption. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mourya, Satyanand published the artcileFormulation and evaluation of Rizatriptan fast dissolving tablets utilizing different super disintegrants with special emphasis on fenugreek, Related Products of alcohols-buliding-blocks, the main research area is Rizatriptan fast tablet disintegrant formulation.

FDTs (Fast Dissolving Tablets) are intended to dissolve quickly, allowing for excellent oral delivery without the need of water. Chewing these formulations also provides improved convenience and simplicity of administration, as well as a substantial potential effectiveness in improving patient compliance, particularly in populations that have difficulty swallowing traditional solid oral dose forms. Rizatriptan was used as API and different super disintegrants were used. Fenugreek was one of the super disintegrant. Pre formulation studies were performed on the raw materials. Different formulations were prepared using different technique and they were evaluated for various parameters. The purpose of this study was to find the best combination of super disintegrants for the creation of Rizatriptan benzoate orally disintegrating tablets. Ten formulations were prepared with different super disintegrants. Formulation F8 containing fenugreek as super disintegrant was found to be more efficacious as compared to other formulations. Croscarmellose sodium, sodium starch glycolate, and Cross-povidone were used as super disintegrants. A total of ten formulations were produced using the direct compression technique & assessed for friability, in-vitro dispersion time, hardness, wetting time, and water absorption ratio. The highest percentage drug release was determined to be 99.80 in formulation FD8.

World Journal of Pharmaceutical Research published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alshahrani, Saeed published the artcileEffect of thymoquinone on high fat diet and STZ-induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies, Synthetic Route of 111-87-5, the main research area is thymoquinone high fat diet streptozotocin diabetes mol docking; dipeptidyl peptidase IV; peroxisome proliferator-activated receptor-γ; streptozotocin; thymoquinone.

The aim was to investigate whether thymoquinone (TQ) attenuates hyperglycemia-induced insulin resistance in exptl. type 2 diabetes. Type 2 diabetes mellitus (T2DM) was induced by injection of streptozotocin (STZ, 40 mg/kg) in high fat diet (HFD) rats. The levels of glucose, insulin, area under curve (AUC) of glucose, lipid profile parameters, homeostasis model assessment of insulin resistance (HOMA-IR), peroxisome proliferator-activated receptor-γ (PPARγ), and dipeptidyl peptidase peptidase-IV (DPP-IV) were evaluated in HFD + STZ-induced type 2 diabetic rats. TQ treatment significantly reduced elevated levels of glucose, AUC of glucose, insulin, and DPP-IV in diabetic-treated groups. In addition, TQ treatment significantly reduced high levels of triglycerides (TG) and cholesterols (total, low-d. and very low-d. lipoprotein) accompanied by significant augmentation in high-d. lipoprotein (HDL) levels in diabetic-treated groups. However, TQ treatment significantly improved insulin sensitivity in diabetic-treated groups, which was confirmed by increased level of PPARγa; and decreased level of HOMA-IR. Mol. docking of TQ exhibited substantial binding affinity with PPARγ and DPP-IV target proteins, which is supported by in vivo results. These results demonstrate that TQ attenuates hyperglycemia-induced insulin resistance by counteracting hyperinsulinemia, improving lipid profile, insulin sensitivity, and inhibiting DPP-IV. T2DM results in relentless hyperglycemia which eventually progress to a state of insulin resistance. TQ is an active principle compound found in Nigella sative seed, having myriad of traditional medicinal values. Administration of TQ significantly prevented hyperglycemia, hyperinsulinemia, hyperlipidemia, insulin resistance, and inhibited DPP-IV in exptl. type 2 diabetes. The in vivo results are also supported by mol. docking study of PPARγ and DPP-IV target proteins. Thus, we hypothesize that TQ can be used as an alternative natural drug in the management of hyperglycemia-induced insulin resistance in T2DM.

Journal of Food Biochemistry published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Chun published the artcileClick chemistry assisted organic-inorganic hybrid photoresist for ultra-fast two-photon lithography, Formula: C17H28O8S4, the main research area is chem organic inorganic hybrid photoresist photon lithog.

Although the development of two-photon lithog. (TPL) for decades of years, fabrication of 2D micro architectures with high throughput is still challenging, due to the lack of suitable photoresists for ultra-fast TPL. In present work, curable zirconia nanoclusters (Zr-NCs) and click-chem. were incorporated together to form an organic-inorganic hybrid photoresist. Interestingly, Zr-NCs endowed photoresists higher photosensitivity by means of improving the adsorption capacity and reducing the absolute fluorescence quantum yield of used initiator. Moreover, oxygen inhibition had been eliminated by effective thiol-ene click reaction. As a result, the maximum lithog. speed of achieved photoresist was significantly enhanced to 2.0 m s-1, that was dozens of times higher than the reported TPL photoresists. Meanwhile, the photoresist also exhibited a distinguish min. feature size (59 nm), attributed to high sensitivity and inhibited diffusion of free radical in solid photoresist film. Finally, a high quality micro QR code had been successful prepared by our photoresist at 1.0 m s-1, which can be recognized to visit the affiliated website. Therefore, this work might provide an alternative strategy to pave the way of ultra-fast 2D TPL.

Additive Manufacturing published new progress about Absorption. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts