Author: tianli

Karami, Thomas K. published the artcileEyes on Lipinski′s Rule of Five: A New “”Rule of Thumb”” for Physicochemical Design Space of Ophthalmic Drugs, Formula: C8H18O, the main research area is ophthalmic drug delivery physicochem design space solubility; ocular permeability thermodn property; formulation; ocular permeability; ophthalmic drug delivery; physicochemical design space; solubility.

The study objective was to investigate mol. thermodn. properties of approved ophthalmic drugs and derive a framework outlining physicochem. design space for product development. Unlike the methodol. used to obtain mol. descriptors for assessment of drug-like properties by Lipinski′s Rule of 5 (Ro5), this work presents a retrospective approach based on in silico anal. of mol. thermodn. properties beyond Ro5 parameters (ie, free energy of distribution/partitioning in octanol/water, dynamic polar surface area, distribution coefficient, and solubility at physiol. pH) by using 145 marketed ophthalmic drugs. The study′s focus was to delineate inherent mol. parameters explicitly important for ocular permeability and absorption from topical eye drops. A comprehensive parameter distribution anal. on ophthalmic drugsâ€?mol. properties was performed. Frequencies in distribution analyses provided groundwork for physicochem. parameter limits of mol. thermodn. properties having impact on corneal permeability and topical ophthalmic drug delivery. These parameters included free energy of partitioning (ΔGo/w) calculated based on thermodn. free energy equation, distribution coefficient at physiol. pH (clog DpH7.4), topol. polar surface area (TPSA), and aqueous solubility (Sint, SpH7.4) with boundaries of clog DpH7.4 â‰?4.0, TPSA â‰?250 Å2, ΔGo/w â‰?20 kJ/mol (4.8 kcal/mol), and solubility (Sint and SpH7.4) â‰?1 μM, resp. The theor. free energy of partitioning model streamlined calculation of changes in the free energy of partitioning, Δ(ΔGo/w), as a measure of incremental improvements in corneal permeability for congeneric series. The above parameter limits are proposed as “”rules of thumb”” for topical ophthalmic drugs to assess risks in developability.

Journal of Ocular Pharmacology and Therapeutics published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Marques, Carolina S. published the artcileAmbipolar pentacyclic diamides with interesting electrochemical and optoelectronic properties, COA of Formula: C4H11NO2, the main research area is pentacyclic diamide organic thin film transistor electrochem optoelectronic property.

Developing organic semiconductors for organic thin film transistors (OTFT) and optoelectronic applications is a challenge. We developed highly crystalline pentacyclic diimides (3) and (4) which showed good OTFT and OLED potential and energy gaps of 2.60 eV and 2.54 eV. They exhibited interesting photo and eletroluminescence activity. Both compounds showed good quantum yields (0.56 for (3) and 0.60 for (4)).

Chemical Communications (Cambridge, United Kingdom) published new progress about Absorption. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, COA of Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matta, Eliana published the artcileIsomalt-Plasticized Methylcellulose-Based Films as Carriers of Ascorbic Acid, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is ascorbic acid methylcellulose film physicochem property.

In the present study, isomalt-plasticized methylcellulose-based films with and without ascorbic acid (AA) addition were developed. The aims of our research were to analyze the effect of the isomalt concentration and the drying temperature upon the physicochem. properties of films, also the stability of AA during film storage. Films prepared by 1.5% w/v methylcellulose (MC) using isomalt (0.25-1.5 w/v) showed improved properties when compared to those without isomalt. Unplasticized films exhibited higher elastic modulus and lower elongation at break than films with isomalt. The AA addition increased film elongation and decreased elastic modulus. FTIR spectra indicated that addition of AA produces structural changes in films and showed the presence of AA during storage. Two drying temperatures were tested, 37°C and 45°C. The change of drying temperature to a higher temperature significantly increased film water vapor permeability (WVP) and decreased the concentration of AA present in the films compared to those dried at a lower temperature Thus, based on the WVP and AA retention results, the selected drying temperature was 37°C. Films obtained by methylcellulose (1.5%) with 0.75% of isomalt, 0.4% of ascorbic acid, and dried at 37°C can result in a good carrier of ascorbic acid. These films can be consumed through foods such as fresh or dehydrated fruits coated.

Food and Bioprocess Technology published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qian, Jiasheng published the artcileOne-Step Nanoextraction and Ultrafast Microanalysis Based on Nanodroplet Formation in an Evaporating Ternary Liquid Microfilm, Name: n-Octanol, the main research area is ternary liquid microfilm nanodroplet formation nanoextn microanalysis.

Preconcentration is key for detection from an extremely low concentration solution, but requires separation steps from a large volume of samples using extracting solvents. Here, a simple approach is presented for ultrafast and sensitive microanal. from a tiny volume of aqueous solutions In this approach, liquid-liquid nanoextn. in an evaporating thin liquid film on a spinning substrate is coupled with quant. anal. in one step. The approach is exemplified using a liquid mixture comprising a target compound to be analyzed in water, mixed with extractant oil and co-solvent ethanol. With rapid evaporation of ethanol, nanodroplets of oil form spontaneously in the film. The compounds are highly concentrated by liquid evaporation and meanwhile extracted to nanodroplets. A detection limit of nanomolar to picomolar is demonstrated for fluorescent model compounds in only â‰?μL of solution with the entire process taking â‰?0 s. The combination of nanoextn. and IR microscopy also enables simultaneous chem. identification. The dynamics of thin film evaporation are revealed using fast imaging. The principle behind this approach is general, providing a powerful technique for fast and sensitive chem. anal. of a vast library of compounds for environment monitoring, national security, early diagnosis, and many other applications.

Advanced Materials Technologies (Weinheim, Germany) published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Lei published the artcileBoron contributes to excessive aluminum tolerance in trifoliate orange (Poncirus trifoliata (L.) Raf.) by inhibiting cell wall deposition and promoting vacuole compartmentation, HPLC of Formula: 97-67-6, the main research area is aluminum toxicity trifoliate orange vacuole compartmentation promotion; Alleviate; Aluminum toxicity; Boron; Malate; Subcellular; Vacuole.

Boron (B) is an indispensable micronutrient for plant growth that can also alleviate aluminum (Al) toxicity. However, limited data are available on the underlying mechanisms behind this phenomenon. Here, we found that a certain range of B application could alleviate the inhibitory effects of Al toxicity on citrus. Transcriptome anal. revealed that several Al stress-responsive genes and pathways were differentially affected and enriched, such as coding for the secretion of organic acid and the distribution of Al in subcellular components after B addition Specifically, B application enhanced rhizosphere pH and induced malate exudation by expressing PtALMT4 and PtALMT9 genes occurred in Al-treated root, which ultimately reduced the absorption of Al and coincided with down-regulated the expression of PtNrat1. Moreover, B supply suppressed the pectin methyl-esterase (PME) activity and displayed a lower level of PtPME2 expression, while enhanced the PtSTAR1 expression, which is responsible for reducing cell wall (CW) Al deposition. Boron addition enhanced the PtALS1 and PtALS3 expression, accompanied by a higher proportion of vacuolar Al compartmentation during Al exposure. Collectively, the protective effects of B on root injury induced by Al is mainly by subsiding the Al uptake in the root apoplast and compartmentalizing Al into vacuole.

Journal of Hazardous Materials published new progress about Absorption. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Jinyoung published the artcileSpatiotemporal vitrimerization of a thermosetting polymer using a photo-latent catalyst for transesterification, Product Details of C17H28O8S4, the main research area is thermosetting polymer transesterification photolatent catalyst.

Globally rising environmental concerns have increased the demand for recyclable polymers and efficient recycling practices. The lack of melt-processability of thermosets significantly limits their recycling because the simplest and most economical way to recycle polymers with a min. carbon footprint is repairing or re-melting them into new items. To this end, an approach to spatiotemporally converting a thermoset into a processable vitrimer is presented. This was achieved by incorporating a latent, heat-stable photo-active catalyst into an otherwise thermoset, activating network exchange reactions only after light exposure and subsequent heating. The thermoset film could be repaired and/or heat-processed by simply exposing the sample to light followed by annealing at elevated temperature and pressure, whereas the repairing/heat-processing failed in the absence of the light exposure step. This approach enables the polymer to initially behave as a thermoset at all temperatures until it requires repair or heat-processing.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Absorption. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Product Details of C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pourmohammadi, Kiana published the artcileEffects of sucrose, isomalt and maltodextrin on microstructural, thermal, pasting and textural properties of wheat and cassava starch gel, Quality Control of 64519-82-0, the main research area is wheat cassava starch gel sucrose isomalt maltodextrin microstructure; PCA; Polyol sugar; Starch; Thermal properties.

This study investigated the effect of different levels (4, 8 and 12%) of sucrose, isomalt and maltodextrin on the microstructural, water absorption, physico-chem., thermal and textural characteristics of wheat and cassava starch gels, by SEM (SEM), rapid visco anal. (RVA), differential scanning calorimetry (DSC) and texture profile anal. According to SEM anal., cassava granules were more impressed than wheat starch in the presence of isomalt > sucrose > maltodextrin. Results showed that water absorption decreased when the amount of sucrose, isomalt and maltodextrin increased. In contrast, onset (To), peak (Tp) and conclusion (Tc) temperature, and enthalpy (ΔH) of wheat and cassava starch gels, increased as the level of addition increased. With increasing the sugar concentration, To, Tp, Tc and ΔH gel enhanced significantly relative to the native starch. The polyols had more remarkable effects on the thermal properties of cassava starch than wheat starch. The texture of wheat and cassava starch gels incorporated with polyol sugars had solid-like properties. The gelatinization of starch was delayed more by isomalt than sucrose and maltodextrin. Moreover, the combination of principal component anal. and cluster anal. proved to be a suitable statistical approach to highlight the effect of adding varying levels of polyols to starch.

International Journal of Biological Macromolecules published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Quality Control of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Xinyuan published the artcilePreparation of a nanoscale dihydromyricetin-phospholipid complex to improve the bioavailability: in vitro and in vivo evaluations, Quality Control of 111-87-5, the main research area is diabetes mellitus dihydromyricetin phospholipid complex bioavailability pharmacokinetic; Bioavailability; Dihydromyricetin; Phospholipid complex; Type 2 diabetes mellitus.

Dihydromyricetin (DMY), a flavanonol compound found as the most abundant and bioactive constituent in Ampelopsis grossedentata (Hand-Mazz) W.T. Wang, possesses numerous pharmacol. activities, such as antioxidant, anti-inflammation, anticancer, anti-microbial, hypoglycemic and hypolipidemic effects, and so on. Recently, DMY shows a promising potential to develop as an agent for the prevention and treatment of Type 2 diabetes mellitus (T2DM). However, the low oral bioavailability of DMY was one of the special concerns to be resolved for its clin. applications. In this study, DMY phospholipid complex (DMY-HSPC COM) was prepared by the solvent evaporation technique and optimized with DMY combination ratio. SEM (SEM), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and Fourier transform IR spectrophotometry (FT-IR) were carried to characterize the formation of DMY-HSPC COM. The particle size, zeta potential, drug loading and solubility of DMY-HSPC COM were further investigated. The phospholipid complex technol. could significantly improve the solubility of DMY. Pharmacokinetic study results of DMY-HSPC COM in healthy SD rats and T2DM rats demonstrated that the oral bioavailability was significantly increased when compared with pure DMY as well, which could be attributed to the improvement of the aqueous solubility of the complex, absorption promotion and a probable decrease in intestinal and hepatic metabolism In addition, when compared with healthy SD rats, pharmacokinetic parameters of pure DMY and DMY-HSPC COM showed significant difference in T2DM rats. Thus, phospholipid complex technol. holds a promising potential for increasing the oral bioavailability of DMY.

European Journal of Pharmaceutical Sciences published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Galli, Paola published the artcileCyclic allylic sulfide based photopolymer for holographic recording showing high refractive index modulation, Application In Synthesis of 7575-23-7, the main research area is cyclic allylic sulfide photopolymer holog recording refractive index modulation.

The development and characterization of a new holog. photopolymer system showing high refractive index modulation (Δn) is presented. It exploits the ring-opening polymerization reaction of a cyclic allylic sulfide (CAS) monomer, which is dispersed in a cellulose acetate butyrate (CAB) polymer matrix together with a blue sensitive radical photoinitiator. Volume Phase Holog. Gratings (VPHGs) obtained using these films show a very good fidelity of the transferred pattern, without deviations from the theor. curves. A high Δn is obtained due to the addition to this system of a tetrafunctional thiol crosslinker, which maximizes the material potential (formula limit) of the formulation. It also allows for a thermal post process of the gratings, further enhancing the Δn. The photopolymer properties are evaluated as function of the monomer and thiol concentration to determine the optimal composition, at which a Δn greater than 0.03 is obtained. This is a considerably high value in the field of photopolymers for holog. and it enables the manufacturing of efficient holograms.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Absorption. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Yazhi published the artcileDirectly photopatterning of polycaprolactone-derived photocured resin by UV-initiated thiol-ene “”click”” reaction: Enhanced mechanical property and excellent biocompatibility, Synthetic Route of 7575-23-7, the main research area is biomedical polycaprolactone photocured resin UV photopatterning property biocompatibility.

This paper reports a novel routine for the fabrication of a polycaprolactone-derived (PCL-derived) photocured material crosslinked by pentaerythritol tetra (PETMP) with enhanced mech. property and excellent biocompatibility. The photocured material is crosslinked via UV irradiation through thiol-ene “”click”” chem. The main novelty of this technique is the facile fabrication of high-resolution patterns (âˆ?μm) using photolithog., and without adding photo-initiators. The photocured material is studied regarding to its thermal property, mech. property and cytocompatibility. DSC and DMA suggest that the flexibility and toughness of PCL-derived photocured material have improved. Accordingly, the PCL-derived photocured material achieves enhanced mech. property (with the increase of PCL segment content from 0 to 38.0%, the photocured samples monotonically increased their breaking strength from 0.62 to 3.10 MPa and Young’s modulus from 1.39 to 9.22 MPa). Due to the incorporation of the PCL-derived copolymer, the material shows excellent affinity to cells, which is demonstrated by the cell proliferation and release of LDH. The hemolysis ratio of PCL-derived photocured materials is all <5%, while the PEGDA photocured material is âˆ?7%. It can also be observed that PCL-derived photocured material will improve the biocompatibility and reduce biotoxicity compared with PEGDA. This facile route for synthesis of biocompatible photocured resin with micrometer-resolute patterns has a good impact in bioengineering and biomedical fields. Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Absorption. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Synthetic Route of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts