Author: tianli

Rucinque, Daniel Santiago published the artcileOcimum americanum and Lippia alba essential oils as anaesthetics for Nile tilapia: Induction, recovery of apparent unconsciousness and sensory analysis of fillets, Related Products of alcohols-buliding-blocks, the main research area is essential oil metabolite ethanol phenoxyethanol Ocimum Lippia anesthetic Oreochromis.

In Brazil, humane slaughter regulations do not include fish, and hypothermia or immersion in ice water is used in most fish slaughterhouses for pre-slaughter handling. Such a method is not considered humanitarian as it does not induce an immediate loss of consciousness and fish show aversive behavior when immersed in a water and ice mixture This study aimed to assess the times for induction and recovery using Ocimum americanum and Lippia alba essential oils as anesthetics in Nile tilapia, and their influence on the flavor and aroma of fillets. For the anesthetic evaluation, Nile tilapia (224.05 ± 67.56 g, 22.10 ± 2.41 cm) were divided into four groups (40 fish/group): ethanol (ET), 2-phenoxyethanol (PE), Ocimum americanum (OA) and Lippia alba (LA), all at 500μL/L. The times taken to reach total loss of equilibrium, anesthesia and consciousness recovery were recorded using a stopwatch. Blood was collected from the caudal vein after 0, 1, 4, 8 and 24 h of anesthesia for the anal. of glucose, lactate and cortisol. For the sensory anal., fillets from fish exposed to essentials oils and hypothermia at pre-slaughter were evaluated by 122 untrained assessors to determine differences in the aroma and flavor attributes. The induction of deep anesthesia (stage 4) was faster in the OA group (mean ± standard error of mean SEM) (126.8 ± 4.9 s), than the PE (152.3 ± 6.6 s) and LA groups (169.7 ± 10.9 s) (p < .01). A total of 91.7% (110/120) of the fish showed VOR (Vestibulo-Ocular Reflex) as the first behavioral response during consciousness recovery after anesthesia. The levels of glucose (mmol/L) were similar amongst the groups at each time. The lactate levels (mmol/L) were higher at 0 h of sampling in LA (2.0 ± 0.2) than in ET (1.4 ± 0.8) (p < .05) and the cortisol levels (ng/mL) at 0 h were higher in ET (150.3 ± 55.3) than in OA (33.9 ± 9.7). Fillets prepared from Nile tilapia anesthetized using OA essential oil received higher sensory scores (1.5 ± 0.1) than fillets from both the Lippia alba (1.0 ± 0.1) and control groups (0.7 ± 0.1). OA and LA essential oils at 500μL/L were effective in inducing deep anesthesia with unconsciousness duration of 126 s, allowing time for bleeding. Anesthesia with Ocimum americanum and Lippia alba essential oils may be indicated as an alternative to hypothermia for the pre-slaughter handling of fish in Brazil. Aquaculture published new progress about Anesthesia. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stefanucci, Azzurra published the artcileIn Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands, SDS of cas: 111-87-5, the main research area is KOR ligand design tripeptide compound identification; antinociceptive effect; binding; k-opioid receptor; molecular modelling; peptides.

The kappa opioid receptor (KOR) represents an attractive target for the development of drugs as potential antidepressants, anxiolytics and analgesics. A robust computational approach may guarantee a reduction in costs in the initial stages of drug discovery, novelty and accurate results. In this work, a virtual screening workflow of a library consisting of � million mols. was set up, with the aim to find potential lead compounds that could manifest activity on the KOR. This in silico study provides a significant contribution in the identification of compounds capable of interacting with a specific mol. target. The main computational techniques adopted in this exptl. work include: (i) virtual screening; (ii) drug design and leads optimization; (iii) mol. dynamics. The best hits are tripeptides prepared via solution phase peptide synthesis. These were tested in vivo, revealing a good antinociceptive effect after s.c. administration. However, further work is due to delineate their full pharmacol. profile, in order to verify the features predicted by the in silico outcomes.

Molecules published new progress about Analgesics. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Coste, Guilhem published the artcileNon-isocyanate polyurethane foams based on six-membered cyclic carbonates, Quality Control of 7575-23-7, the main research area is nonisocyanate polyurethane foam membered cyclic carbonate.

Polyurethane foams currently dominate the global foam market. Nevertheless, the main drawback of these foams remains the use of toxic isocyanate reagents. To overcome this issue, several ways have been explored. The most promising route appears to be the aminolysis of 5-membered cyclic carbonates leading to formation of polyhydroxyurethanes (PHUs). However, the lack of reactivity of systems using C5-cyclic carbonates currently limits the application range of PHUs. Hence, this study reports the first synthesis of PHUs foams using a new tetrafunctional 6-membered cyclic carbonate (TC6). The TC6 was reacted with different diamines under catalyst-free and mild temperature conditions in presence of a chem. blowing agent. Three different amines were employed, allowing access to various foams properties. Finally, promising flexible foams have been obtained, with interesting properties that could make them possible new candidates for applications as seating or insulation mattresses.

European Polymer Journal published new progress about Aminolysis. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vujic, Lovorka published the artcileImpact of dietetic tea biscuit formulation on starch digestibility and selected nutritional and sensory characteristics, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is tea biscuit formulation starch digestibility sensory property nutritional value.

In this research, the effects of replacement of 30% of wheat flour in a control biscuit formulation with different whole grain flours (barley, buckwheat, oat, amaranth or soy) or 15% of wheat flour with apple- or oat dietary fiber (DF) were investigated in terms of their impact on the nutritional quality, rates of starch digestibility and sensory characteristics of the final product. Modifications of control formulation resulted in improved macronutrient distribution ranges and increase of dietary fiber (DF) and protein content. Soy- and amaranth enriched samples contained significantly lower rapidly available glucose (RAG) and total starch (TS) content in comparison to control sample. The anal. of starch digestibility showed that the most significant increase of RAG content in the starch fraction was observed in oat- and apple dietary fiber enriched samples defining them as samples with the highest expected glycemic index (GI). All modifications of control sample resulted in formulations with acceptable sensory characteristics; addition of pure fiber can be considered as significantly less favorable in comparison to whole grain flours especially regarding the taste and texture of the final product.

LWT–Food Science and Technology published new progress about Amaranthus. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, X. published the artcileIsolation and characterization of endophytic bacteria for controlling root rot disease of Chinese jujube, Application In Synthesis of 584-02-1, the main research area is Ziziphus Fusarium endophytic bacteria root rot disease; Brevibacterium halotolerans ; Fusarium oxysporum ; Chinese jujube; biological control; endophytic bacteria; root rot disease.

Fusarium oxysporum is the primary pathogen causing root rot disease that severely affects cultivation of jujube fruit in the Xinjiang province of China. The aim of this study was to identify endophytic bacteria in healthy jujube organs that could effectively suppress F. oxysporum growth. Different plant organs (leaves, twigs and roots) were collected from healthy Chinese jujube cultivated in southern Xinjiang province of China. The endophytic bacterium Brevibacterium halotolerans JZ7 was selected for its strong antagonistic activity and growth-promoting characteristics. Gas-chromatog. mass-spectrometry anal. showed that acetoin, 2,3-butanediol and fenretinide were the three dominant volatile organic compounds produced by strain JZ7. Fenretinide strongly suppressed spore germination of F. oxysporum in vitro. Pot experiments showed that strain JZ7 colonized both the roots and rhizosphere soil of Chinese jujube and significantly reduced F. oxysporum level in jujube rhizosphere soil. We demonstrated that B. halotolerans JZ7 can be developed into a biol. control agent to combat root rot disease of Chinese jujube in the Xinjiang province of China. Significance and Impact of the Study : The suggested strategy for biol. control of jujube root rot disease is fully in accordance with the current principles of sustainability.

Journal of Applied Microbiology published new progress about Alternaria. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Application In Synthesis of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guzman, Dailyn published the artcileFully renewable thermosets based on bis-eugenol prepared by thiol-click chemistry, SDS of cas: 7575-23-7, the main research area is fully renewable thermoset bis eugenol thiol click chem.

Thiol-ene photocuring and thiol-epoxy thermal curing have been applied to prepare new thermosets from renewable substrates. As monomers, a tetrallyl and a tetraepoxy derivative of bis-eugenol were prepared by dimerization of eugenol, allylation and further epoxidation These compounds were reacted with a com. available tetrathiol, PETMP, and thiols synthesized from two natural resources as squalene (6SH-SQ) and eugenol (3SH-EU) in photoinitiated and thermal conditions. The reaction process was studied by calorimetry, and the materials obtained were characterized by thermogravimetry, thermomech. studies and mech. testing. Thiol-epoxy materials showed a better mech. performance than thiol-ene photocured thermosets. This new epoxy monomer of renewable origin allowed to prepare materials with final properties better than those obtained from the diglycidylether of bisphenol A, owing to the high functionality of bis-eugenol and its rigid and compact structure.

Reactive & Functional Polymers published new progress about Allylation. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, SDS of cas: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dambatta, Mubarak B. published the artcileTransition metal free α-C-alkylation of ketones using secondary alcohols, Application In Synthesis of 584-02-1, the main research area is aryl ketone preparation; ketone secondary alc alkylation.

A base-mediated α-C-alkylation of aryl Me ketones with secondary alcs. was developed for the synthesis of aryl ketones ArC(O)CH2CH(R1)(R2) [R1 = Me, Et; R2 = Me, Et, Ph, etc.; R1R2 = (CH2)4, (CH2)5, (CH2)6, etc.; Ar = 2,4,6-(Me)3C6H2, 2,3,5,6-(Me)4C6H, 2,3,4,5,6-pentamethylphenyl, etc.]. This transition metal free approach employed KOt-Bu as the base and exhibited a broad scope, allowing a range of commodity aliphatic secondary alcs. Aryl Me ketones underwent selective mono-α-C-alkylation in high isolated yields (23 examples, 65% average yield).

Tetrahedron published new progress about Alkylation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Application In Synthesis of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Howells, Rachel L. published the artcileSynthesis of Novel Pyrazine-Substituted-1H-Pyrrole-2-carboxamides and Related Tethered Heterocycles, Name: 2,2-Dimethoxyethanamine, the main research area is pyrazinyl pyrrole carboxamide preparation; fused bicyclic compound preparation.

The synthesis of a 4-(pyrazin-2-yl)-1H-pyrrole-2-carboxamide I and several fused bicyclic analogs, e.g., II all using standard procedures (SNAr, borylation, C-C cross couplings, hydrolysis, amide bond formation, cyclization, halogenation, and alkylation) from readily available starting materials is reported. The synthetic sequences range from 4-12 steps per final compound, with yields of isolated intermediates ranging from 20 to �00%.

Synthesis published new progress about Alkylation. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pandey, Bedraj published the artcileSelective Ketone Formations via Cobalt-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols, Product Details of C8H18O, the main research area is ketone preparation cobalt catalyst beta alkylation secondary primary alc.

A homogeneous cobalt-catalyzed β-alkylation of secondary alcs. with primary alcs. to selectively synthesize ketones via acceptorless dehydrogenative coupling is reported for the first time. Notably, this transformation is environmentally benign and atom economical with water and hydrogen gas as the only byproducts.

Organic Letters published new progress about Alkylation. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Zeye published the artcileHighly efficient NHC-iridium-catalyzed β-methylation of alcohols with methanol at low catalyst loadings, Formula: C5H12O, the main research area is alc methanol iridium catalyst alkylation regioselective; alkyl alc preparation.

A highly efficient β-methylation of primary and secondary alcs. with methanol was achieved by using bis-N-heterocyclic carbene iridium (bis-NHC-Ir) complexes. Broad substrate scope and up to quant. yields were achieved at low catalyst loadings with only hydrogen and water as byproducts. The protocol was readily extended to the β-alkylation of alcs. with several primary alcs. Control experiments, along with DFT calculations and crystallog. studies, revealed that the ligand effect was critical to their excellent catalytic performance, shedded light on more challenging Guerbet reactions with simple alcs.

Science China: Chemistry published new progress about Alkylation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts