Author: tianli

Ogden, Phillip B. published the artcileReversed phase HPLC with high temperature ethanol/water mobile phases as a green alternative method for estimation of octanol/water partition coefficients, Recommanded Product: n-Octanol, the main research area is high temperature liquid chromatog ethanol water mobile phase; octanol partition coefficient linear solvation energy relationship; Ethanol/water mobile phases; High temperature liquid chromatography; Linear solvation energy relationships; Octanol/water partition coefficient; Snyder-soczewinski equation.

High temperature ethanol/water was explored as a green eluent in the reversed-phase liquid chromatog. approximation of pure water retention (log kw) and subsequent estimation of the octanol/water partition coefficient (log P) via the Collander equation and the Leave-One-Out method. As part of this work, linear solvation energy relationships were employed to compare the log kw extrapolated systems based on high temperature ethanol/water, ambient acetonitrile/water, and ambient methanol/water mobile phases. Based on the comparisons of the three organic modifiers, high temperature ethanol/water mobile phases were observed to provide the best estimation of log P. This conclusion is based on a high log P correlation of 0.968 R2 and a near unity cos θ value of 0.997 between LSER coefficient vectors of ethanol/water estimated log P and octanol/water log P systems. The method employed in this work, further, provided high correlation for the hydrogen-bonding basicity term between the two systems.

Journal of Chromatography A published new progress about Partition. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kolobova, E. published the artcileSelective oxidation of n-octanol on unmodified and La-modified nanogold catalysts: Effect of metal content, Synthetic Route of 111-87-5, the main research area is gold titania lanthanum catalyst octanol oxidation.

We investigated the influence of metal loading in gold catalysts supported on titania, either unmodified or La-modified, on their catalytic performance and the formation of active sites for selective oxidation of n-octanol under mild conditions. Catalysts were characterized by BET, EDX, ICP, HRTEM, FTIR CO and XPS. Gold content had a significant effect on the catalytic properties of unmodified catalysts: activity of Au/TiO2 increased by increasing the metal load. However, in the case of a lanthanum-modified support samples, an increase of gold content from 0.5 to 4 weight% had no effect on its activity (ca. 40% conversion after 6 h for all catalysts). This catalytic behavior is due to a change in the surface concentration of Au+ ions. For the unmodified catalysts, the surface concentration of Au+ ions increased with increasing gold loading, and, as a consequence, a significant increase in activity was observed For La-modified catalysts, the surface concentration of Au+ ions is almost the same for all gold concentrations; as a result, no increase in activity was observed with the increase in gold content. It points to Au+ ions as the most probable active sites for the studied reaction.

Catalysis Today published new progress about Oxidation. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hirsjarvi, Pekka published the artcileFormation of camphene glycol carbonate in the oxidation of camphene with SeO2, Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is .

cf. CA 53, 16194g. Camphene glycol carbonate (I), m. 147-8° was separated by distillation or adsorption chromatog. from the oxidation products of camphene with SeO2 in boiling Ac2O. Alk. hydrolysis of I yielded camphene glycol (II), m. 196-8°. II formed a mono-p-tosylate, m. 84.5-7.0°, which formed camphene hydrate, m. 152-5° on reduction with LiAlH4. The formation of I by SeO2 is a stereospecific reaction.

Suomen Kemistilehti B published new progress about Oxidation. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lopez, Kenneth published the artcileMultiple linear regression models for predicting the n-octanol/water partition coefficients in the SAMPL7 blind challenge, HPLC of Formula: 111-87-5, the main research area is octanol water sulfonamide partition coefficient; Empirical methods; Multiple linear regression; N-sulfonamides; SAMPL7 blind challenge; n-Octanol/water partition coefficients.

A multiple linear regression model called MLR-3 is used for predicting the exptl. n-octanol/water partition coefficient (log PN) of 22 N-sulfonamides proposed by the organizers of the SAMPL7 blind challenge. The MLR-3 method was trained with 82 mols. including drug-like sulfonamides and small organic mols., which resembled the main functional groups present in the challenge dataset. Our model, submitted as “”TFE-MLR””, presented a root-mean-square error of 0.58 and mean absolute error of 0.41 in log P units, accomplishing the highest accuracy, among empirical methods and also in all submissions based on the ranked ones. Overall, the results support the appropriateness of multiple linear regression approach MLR-3 for computing the n-octanol/water partition coefficient in sulfonamide-bearing compounds In this context, the outstanding performance of empirical methodologies, where 75% of the ranked submissions achieved root-mean-square errors < 1 log P units, support the suitability of these strategies for obtaining accurate and fast predictions of physicochem. properties as partition coefficient of bioorganic compounds Journal of Computer-Aided Molecular Design published new progress about Molecules. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Burridge, Kevin M. published the artcileSimple derivatization of RAFT-synthesized styrene-maleic anhydride copolymers for lipid disk formulations, Category: alcohols-buliding-blocks, the main research area is RAFT styrene maleic anhydride copolymer nucleophile derivative lipid disk.

Styrene-maleic acid copolymers have received significant attention because of their ability to interact with lipid bilayers and form styrene-maleic acid copolymer lipid nanoparticles (SMALPs). However, these SMALPs are limited in their chem. diversity, with only Ph and carboxylic acid functional groups, resulting in limitations because of sensitivity to low pH and high concentrations of divalent metals. To address this limitation, various nucleophiles were reacted with the anhydride unit of well-defined styrene-maleic anhydride copolymers in order to assess the potential for a new lipid disk nanoparticle-forming species. These styrene-maleic anhydride copolymer derivatives (SMADs) can form styrene-maleic acid derivative lipid nanoparticles (SMADLPs) when they interact with lipid mols. Polymers were synthesized, purified, characterized by Fourier-transform IR spectroscopy, gel permeation chromatog., and NMR and then used to make disk-like SMADLPs, whose sizes were measured by dynamic light scattering (DLS). The SMADs form lipid nanoparticles, observable by DLS and transmission electron microscopy, and were used to reconstitute a spin-labeled transmembrane protein, KCNE1. The polymer method reported here is facile and scalable and results in functional and robust polymers capable of forming lipid nanodisks that are stable against a wide pH range and 100 mM magnesium.

Biomacromolecules published new progress about Liposomes. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Romero, Concepcion published the artcilePacking black ripe olives in acid conditions, Computed Properties of 111-87-5, the main research area is oxygen permeability lipid oxidation pentnal black ripe olive; Acid; Black ripe olive; Lipid oxidation; Oxygen; Packing.

The type of container (airtight and pouches with different O2 permeability) and packing conditions (cover brine, air or N2 atm) has been studied to preserve black ripe olives in acid medium for a year. Unlike the traditional sterilized product, these acidified olives only needed pasteurization to assure its microbial safety, the absence of acrylamide being an addnl. advantage. Surprisingly, an increase in the oxygen diffusion through the films (i) faded the black color of the olives, (ii) softened the fruit that lost around 33% of its initial firmness in only 6 mo, and (iii) produced the lipids oxidation forming volatile compounds that transmitted an abnormal flavor which tasters identified as rancid. Therefore, ripe olives in acid medium must be packed in airtight containers such as glass jars, cans o metallic pouches with cover brine or N2 atm. The addition of calcium is recommended to avoid olive softening.

Food Chemistry published new progress about Lethality. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Dongdong published the artcilePolymers with controlled assembly and rigidity made with click-functional peptide bundles, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is polymer rigidity peptide bundle.

The engineering of biol. mols. is a key concept in the design of highly functional, sophisticated soft materials. Biomols. exhibit a wide range of functions and structures, including chem. recognition (of enzyme substrates or adhesive ligands1, for instance), exquisite nanostructures (composed of peptides2, proteins3 or nucleic acids4), and unusual mech. properties (such as silk-like strength3, stiffness5, viscoelasticity6 and resiliency7). Here the authors combine the computational design of phys. (noncovalent) interactions with pathway-dependent, hierarchical ′clickâ€?covalent assembly to produce hybrid synthetic peptide-based polymers. The nanometer-scale monomeric units of these polymers are homotetrameric, α-helical bundles of low-mol.-weight peptides. These bundled monomers, or ′bundlemersâ€? can be designed to provide complete control of the stability, size and spatial display of chem. functionalities. The protein-like structure of the bundle allows precise positioning of covalent linkages between the ends of distinct bundlemers, resulting in polymers with interesting and controllable phys. characteristics, such as rigid rods, semiflexible or kinked chains, and thermally responsive hydrogel networks. Chain stiffness can be controlled by varying only the linkage. Furthermore, by controlling the amino acid sequence along the bundlemer periphery, the authors use specific amino acid side chains, including non-natural ′clickâ€?chem. functionalities, to conjugate moieties into a desired pattern, enabling the creation of a wide variety of hybrid nanomaterials.

Nature (London, United Kingdom) published new progress about Hydrogels. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Padra, Medea published the artcileHelicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins, SDS of cas: 59-23-4, the main research area is Helicobacter suis infection glycosylation gastric mucin.

Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the gastric mucosa of 60-95% of pigs at slaughter age, and is associated with chronic gastritis, decreased weight gain, and ulcers. Here, we show that exptl. H. suis infection changes the mucin composition and glycosylation, decreasing the amount of H. suis-binding glycan structures in the pig gastric mucus niche. Similarly, the H. suis-binding ability of mucins from H. pylori-infected humans is lower than that of noninfected individuals. Furthermore, the H. suis growth-inhibiting effect of mucins from both noninfected humans and pigs is replaced by a growth-enhancing effect by mucins from infected individuals/pigs. Thus, Helicobacter spp. infections impair the mucus barrier by decreasing the H. suis-binding ability of the mucins and by decreasing the antiprolific activity that mucins can have on H. suis. Inhibition of these mucus-based defenses creates a more stable and inhabitable niche for H. suis. This is likely of importance for long-term colonization and outcome of infection, and reversing these impairments may have therapeutic benefits.

Mucosal Immunology published new progress about Gastritis. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sarafian, Theodore A. published the artcileEnhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein, Application of (S)-2-hydroxysuccinic acid, the main research area is forebrain mitochondria oxygen consumption rate membrane potential alpha synuclein; RRID: AB_398107 ; RRID: AB_437779 ; RRID: SCR_003210 ; DOPAL; mitochondrial membrane potential; oxygen consumption rate; small molecule rescue; α-synuclein oligomers.

Oligomeric forms of α-synuclein are believed to cause mitochondrial injury, which may contribute to neurotoxicity in Parkinson’s disease (PD). Here oligomers of α-synuclein were prepared using the dopamine metabolite, DOPAL (3,4-dihydroxyphenylaldehyde), in the presence of guanidinium hydrochloride. Using isolated mouse brain mitochondria, DOPAL-oligomerized α-synuclein (DOS) significantly inhibited oxygen consumption rates compared with untreated, control-fibrillated, and dopamine-fibrillated synuclein, or with monomeric α-synuclein. Mitochondrial membrane potential studies using fluorescent probes, JC-1, and Safranin O, also detected enhanced inhibition by DOS compared with the other aggregated forms of α-synuclein. While diverse in chem. structure and mechanism, each compound has been reported to interact with mitochondrial complex I. The remaining set of chems. also did not disrupt oligomeric banding, attesting to the high structural stability of this α-synuclein proteoform. DOPAL and α-synuclein are both found in dopaminergic neurons, where their levels are elevated in PD and in animal models exposed to chem. toxicants, including agricultural pesticides. The current study provides further evidence of α-synuclein-induced mitochondrial injury and a likely role in PD neuropathol.

Journal of Neuroscience Research published new progress about Forebrain. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yantao published the artcileComparison and characterization of galactomannan at different developmental stages of Gleditsia sinensis Lam., HPLC of Formula: 59-23-4, the main research area is galactomannan Gleditsia growth; Galactomannan deposition; Gleditsia sinensis Lam.; Mannose to galactose ratio; Rheological properties; Solubility.

Pods from a Gleditsia sinensis Lam. tree were collected and the galactomannan content and other properties were determined at their different developmental stages. In green and immature seed, galactomannan was substituted to a great extent with a mannose to galactose (M/G) ratio of 2.4 from crude polysaccharides. During late galactomannan deposition, it was substituted to a lower extent and this ratio increased rapidly, reaching a M/G ratio of 3.1. Average mol. weight (Mw) of the extracted polysaccharides first increased, reached the maximum (1.19 × 106) at 17 wk after flowering (WAF), and then decreased. These changes might result from primary galactomannan biosynthesis and from galactose removal by α-galactosidase in the endosperm. The solubility of crude polysaccharides decreased with increased M/G ratio and maximum solubility was more than 89% that collected at 13 WAF. Rheol. properties showed that apparent viscosity was largely influenced by the mol. weight and M/G ratio of galactomannans.

Carbohydrate Polymers published new progress about Flowering. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts