Author: tianli

Mandal, Satadru Sekhar published the artcileNovel solutions for vaccines and diagnostics to combat brucellosis, Product Details of C13H19NO3, the main research area is vaccine Brucella A antigen polysaccharide tetanus toxoid brucellosis; diagnosis brucellosis Brucella synthetic M antigen polysaccharide.

Brucellosis is diagnosed by detection of antibodies in the blood of animals and humans that are specific for two carbohydrate antigens, termed A and M, which are present concurrently in a single cell wall O-polysaccharide. Animal brucellosis vaccines contain these antigenic determinants, and consequently infected and vaccinated animals cannot be differentiated as both groups produce A and M specific antibodies. We hypothesized that chem. synthesis of a pure A vaccine would offer unique identification of infected animals by a synthetic M diagnostic antigen that would not react with antibodies generated by this vaccine. Two forms of the A antigen, a hexasaccharide and a heptasaccharide conjugated to tetanus toxoid via reducing and nonreducing terminal sugars, were synthesized and used as lead vaccine candidates. Mouse antibody profiles to these immunogens showed that to avoid reaction with diagnostic M antigen it was essential to maximize the induction of anti-A antibodies that bind internal oligosaccharide sequences and minimize production of antibodies directed toward the terminal nonreducing monosaccharide. This objective was achieved by conjugation of Brucella O-polysaccharide to tetanus toxoid via its periodate oxidized terminal nonreducing monosaccharide, thereby destroying terminal epitopes and focusing the antibody response on internal A epitopes. This establishes the method to resolve the decades-long challenge of how to create effective brucellosis vaccines without compromising diagnosis of infected animals.

ACS Central Science published new progress about Animalia. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Xiaotong published the artcileEffects of deproteinization methods on primary structure and antioxidant activity of Ganoderma lucidum polysaccharides, Category: alcohols-buliding-blocks, the main research area is Ganoderma polysaccharide antioxidant activity primary structure deproteinization method; Antioxidant activities; Deproteinization; Ganoderma lucidum polysaccharides; Primary structure.

Ganoderma lucidum polysaccharides (GLP) as one of water-soluble polysaccharides has attracted much attention because of its bioactivities, especially antioxidant activity. Deproteinization is an essential step in the purification process of polysaccharides. In this study, three classic deproteinization methods, including neutral protease method, TCA precipitation and CaCl2 salting out, were evaluated for crude GLP processing. The methods had ability to remove proteins (71.50-87.36%), and meanwhile polysaccharide loss (8.35-11.39%) was observed Structure anal. indicated that these deproteinization methods had no significant effect (p > 0.05) on mol. weight of polysaccharides, but led to varying degrees of glycoside bond losses (1.14-64.05%). Moreover, the antioxidant activities of deproteinized polysaccharides were measured in vitro by hydroxyl radical, reducing power, 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) free radical and ferric-reducing antioxidant power tests. Purified GLP by enzymolysis maintained the strongest antioxidants activities with the retention rate of over 47.40%, and its deproteinization efficiency and polysaccharide loss ratio were 74.03% and 11.39% resp. In view of relatively high purity and antioxidant activity, enzymolysis was a suitable deproteinization method for GLP production

International Journal of Biological Macromolecules published new progress about Angelica. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stojanovic, Goran M. published the artcileRapid selective detection of ascorbic acid using graphene-based microfluidic platform, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is ascorbic acid graphene microfluidic platform selective detection.

In this paper, we present a compact microfluidic platform for selective detection of ascorbic acid. The microfluidic chip was fabricated by xurog. technique with microfluidic channel placed between the silver electrodes. To increase the conductivity of the platform and enhance electron transfer process, a graphene sheet was deposited in the gap between the electrodes. The suspension of tablets with ascorbic acid and a mixture of ascorbic acid and isomalt, a sugar substitute, were injected in the microfluidic channel. Measuring elec. parameters at the silver contacts, it was possible to successfully differentiate ascorbic acid from isomalt. The sensing mechanism of the developed microfluidic platform is based on the increase of the overall conductivity with the increase of the concentration of ascorbic acid, resulting in the decrease of the resistive parameters and increase of the capacitive parameters of the proposed equivalent elec. circuit. The addition of graphene was found to improve the response linearity by 5.28% and lower the limit of detection and quantification by 12%, compared to the reference structure without graphene.

IEEE Sensors Journal published new progress about Analysis. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Worawit, Chanatda published the artcileCombining graphite with hollow-fiber liquid-phase microextraction for extraction of polar organic compounds, Quality Control of 111-87-5, the main research area is graphite hollow fiber liquid phase microextraction extraction polar; organic compound water sample analysis; Carbon nanosorbent; Gas chromatography; Graphite; Hollow-fiber liquid-phase microextraction; Nanomaterial; Trihalomethane.

In this study, we have developed a simple and effective hybrid extraction method based on the incorporation of raw carbon nanosorbents and octanol in the pores of a hollow-fiber membrane for improving the extraction efficiency of relatively polar organic compounds Trihalomethanes (THMs) were used as model analytes. Three types of carbon nanosorbents (graphite, graphene, and multi-walled carbon nanotubes) were studied. The carbon sorbent incorporating membrane was used in a two-phase mode liquid-phase microextraction, with 1-octanol as the acceptor solution Using a graphite-reinforced hollow-fiber membrane and an extraction time of 10 min, enrichment factors of 40-71 were obtained for trichloromethane, bromodichloromethane, bromoform, and chlorodibromomethane. Linear working ranges of 0.2-100μg L-1 and limits of detection ranging from 0.01μg L-1 (for CHCl2Br and CHClBr2) to 0.1μg L-1 (for CHCl3) were achieved. The min. detectable concentrations were far below the maximum concentration levels (60-200μg L-1) set by the WHO for drinking water. The carbon-sorbent-reinforced hollow-fiber liquid-phase microextraction afforded higher extraction efficiency and shorter extraction time compared with conventional hollow-fiber liquid-phase microextraction Finally, the method was applied to the anal. of real water samples, such as drinking water, tap water, and swimming pool water samples.

Talanta published new progress about Analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Xue published the artcilePlasma galactose-deficient immunoglobulin A1 and loss of kidney function in patients with immunoglobulin A vasculitis nephritis, Computed Properties of 59-23-4, the main research area is human plasma galactose IgA vasculitis nephritis kidney function; IgA nephropathy; IgA vasculitis nephritis; galactose-deficient IgA1; kidney disease progression.

IgA (IgA) vasculitis nephritis (IgAV-N) is the most common secondary IgA nephropathy (IgAN). Many studies have demonstrated that galactose-deficient IgA1 (Gd-IgA1) in the IgA1 hinge region is associated with the development and also progression of primary IgAN. In this study, we aimed to evaluate the roles of Gd-IgA1 in kidney disease progression in a large Chinese cohort of IgAV-N patients. This cohort study enrolled 112 patients with IgAVN, 15 patients with IgA vasculitis (IgAV) without kidney involvement and 108 patients with IgAN. Plasma IgA1 and Gd- IgA1 levels at kidney biopsy were measured by ELISA. The primary endpoint was a 30% decline in estimated glomerular filtration rate or end-stage renal disease or death. The levels of Gd-IgA1 in IgAV-N and IgAN patients were higher than in healthy controls (mean±SD, 302.86±54.93 U/mL vs. 303.16±59.43 U/mL vs. 281.30±43.74 U/mL, resp.; P = 0.047), as well as compared with those with IgAV without kidney involvement (272.65±53.14 U/mL; P = 0.036). After adjusting clin. data, higher levels of Gd-IgA1 were found to be independently associated with a greater risk for kidney failure [hazard ratio (HR)=1.703 per 1 SD, 95% confidence interval (CI) 1.233-2.352; P = 0.001]. Compared with the first Gd-IgA1 quartile group (as reference), the fourth Gd-IgA1 quartile group retained a predictive value for poor renal outcome (HR = 3.740, 95% CI 1.204-11.619; P = 0.023). These data indicate that Gd-IgA1 levels were similarly elevated in adult patients with IgAN and those with IgAV-N. Moreover, increased Gd-IgA1 levels were associated with both the development and progression of IgAV-N, as observed in IgAN.

Nephrology, Dialysis, Transplantation published new progress about Analysis. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safaeian Laein, Sara published the artcileEvaluation of antibacterial and antioxidant activities of essential oil of lime (Citrus aurantifolia) pomace powder, Computed Properties of 124-76-5, the main research area is Citrus aurantifolia pomace essential oil antioxidant antibacterial activity.

This study aimed to determine the chem. compounds, antioxidant and antimicrobial activities of Essential Oil (EO) derived from lime pomace. Gas chromatog./mass spectrometry (GC-MS) was used to determine the major components of the obtained EO. The antioxidant activities of this EO were determined by radical scavenging activity (DPPH) and the Ferric Reducing Antioxidant Power (FRAP) test. For antimicrobial activity, the disk diffusion method was used and the Min. Inhibitory Concentrations (MIC) and the Min. Bactericidal Concentration (MBC) were studied against common foodborne pathogens including; Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa. The result showed that the Gram-pos. bacteria were more susceptible than gram-neg. bacteria. The result shows that lime pomace powder with IC50 83.061 mg/mL has a high antioxidant capacity and also, the chem. anal. of the EO showed that the EO contained a complex mixture of several components and the main constituents were D-limonene (28.86%), a- terpinene (15.65%) and D-terpinene (12.72%) resp.

Iranian Journal of Chemistry & Chemical Engineering published new progress about Analysis. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yeh, Ping-Yuan published the artcileChanges undergone by citronella-oil fractions on storage, Product Details of C10H20O2, the main research area is .

During 43-month storage in the dark at room temperature some of the distilled citronella oil fractions had completely changed. The changed citronellal fraction consisted of H2O 1, isopulegol 20, menthoglycol (?) 10, citronellic acid 12, and citronellylidenecitronellal and higher condensation products 57%. The terpene fractions and the terpene alc. fractions also changed to the oxidation, condensation, and polymerization products. A pure citronellal fraction stood for 5 years almost unchanged.

Taiwan Kexue published new progress about Alcohols. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Product Details of C10H20O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Zhirui published the artcileNetwork pharmacology-based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil, Formula: C10H18O, the main research area is network pharmacol dyspnoea zedoary turmeric oil; binding affinity; dyspnoea; haemoglobin; network pharmacology; zedoary turmeric oil.

Zedoary turmeric oil (ZTO) has been widely used in clinic. However, the unpleasant induced dyspnoea inevitably impedes its clin. application. Thus, it is urgent to elucidate the mechanism underlying the ZTO-induced dyspnoea. In this study, network pharmacol. was firstly performed to search the clue of ZTO-induced dyspnoea. The key target genes of ZTO-induced dyspnoea were analyzed using GO enrichment anal. and KEGG pathway anal. GO anal. suggested that haem binding could be a key mol. function involved in ZTO-induced dyspnoea. Hence, the Hb (Hb) was focused for its oxygen-carrying capacity with haem as its critical component binding to the oxygen. UV-visible absorption spectrum indicated that the ZTO injection (ZTOI) perturbed the Soret band of Hb, suggesting an interaction between ZTO and Hb. GC-MS anal. revealed that β-elemene, germacrone, curdione and furanodiene were main components of ZTOI. Mol. docking was used to illustrate the high affinity between representative sesquiterpenes and Hb, which was finally confirmed by surface plasmon resonance, suggesting their potential roles in dyspnoea by ZTO. Following a network pharmacol.-driven strategy, our study revealed an intervened Hb-based mechanism underlying the ZTO-induced dyspnoea, providing a reference for elucidating mechanism underlying adverse drug reactions of herbal medicines in clinic.

Basic & Clinical Pharmacology & Toxicology published new progress about Affinity. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Paruli, Ernesto III published the artcileMolecularly imprinted polymers by thiol-yne chemistry: making imprinting even easier, Quality Control of 7575-23-7, the main research area is thiol ene microsphere molecularly imprinted polymer preparation property.

Molecularly imprinted polymers (MIPs) are synthetic materials with recognition properties comparable to those of antibodies, but with superior physico-chem. stability. Synthesized in the presence of a template, MIPs contain binding sites with high specificity and selectivity for their target. In this work, we explored the radical-mediated thiol-yne chem. as a new approach to MIPs, using propranolol as a model template and acrylic acid as a functional monomer. Thiol-yne chem. proved to be advantageous due to its oxygen tolerance and reactivity with (meth)acrylates. Thus, polymerization was possible in air with no need for previous deoxygenation, which is important for MIPs shaped by micro or nanofabrication. Moreover, the incorporation of ester-based polythiols made the MIPs hydrolyzable in basic and acidic conditions, thus potentially reducing their persistence in the environment. This, together with the possibility of using the well-established library of template-functional monomer(s) pairs based on (meth)acrylates, is expected to rapidly spread the use of the thiol-yne chem. within the imprinting community.

Polymer Chemistry published new progress about Affinity. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Qinhong published the artcileA cross-comparison of biosurfactants as marine oil spill dispersants: Governing factors, synergetic effects and fates, Related Products of alcohols-buliding-blocks, the main research area is biosurfactant oil spill dispersant synergetic effect biodegradation wastewater treatment; Biosurfactant-based dispersants; Exmulsins; Oil spill dispersion; Surfactins; Trehalose lipids.

Biosurfactant-based dispersants (BBDs) may be more effective, cost-efficient and environmentally friendly than dispersants currently used for oil spill response. An improved understanding of BBD performance is needed to advance their development and com. use. In this study, the ability of four BBDs, i.e. sufactins, trehalose lipids, rhamnolipids and exmulsins, alone and as various combinations to disperse Arabian light crude oil and weathered Alaska North Slope crude oil was compared to a widely used com. oil dispersant (Corexit 9500A). Surfactin and trehalose lipids, which have balanced surface activity/emulsification ability, showed dispersion efficacy comparable to Corexit 9500A. Rhamnolipids (primarily a surface-active agent) and exmulsins (primarily an emulsifier) when used alone had significantly lower efficacy. However, blends of these surfactants had excellent dispersion performance because of synergistic effects. Balanced surface activity and emulsification ability may be key to formulate effective BBDs. Of the BBDs evaluated, surfactins with an effective dispersant-to-oil ratio as low as 1:62.3 and trehalose lipids with high oil affinity, biodegradation rate, and low toxicity characteristics show the most promise for com. development.

Journal of Hazardous Materials published new progress about Affinity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts