Author: tianli

Bolli, Martin H. published the artcileNovel S1P₁ receptor agonists – Part 5: From amino-to alkoxy-pyridines, Related Products of alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2016), 326-341, database is CAplus and MEDLINE.

In a previous communication we reported on the discovery of aminopyridine 1 as a potent, selective and orally active S1P₁ receptor agonist. More detailed studies revealed that this compound is phototoxic in vitro. As a result of efforts aiming at eliminating this undesired property, a series of alkoxy substituted pyridine derivatives was discovered. The photo irritancy factor (PIF) of these alkoxy pyridines was significantly lower than the one of aminopyridine 1 and most compounds were not phototoxic. Focused SAR studies showed, that 2-, 3-, and 4-pyridine derivatives delivered highly potent S1P₁ receptor agonists. While the 2-pyridines were clearly more selective against S1PR₃, the corresponding 3- or 4-pyridine analogs showed significantly longer oral half-lives and as a consequence longer pharmacol. duration of action after oral administration. One of the best compounds, cyclopentoxy-pyridine 45b lacked phototoxicity, showed EC₅₀ values of 0.7 and 140 nM on S1PR₁ and S1PR₃, resp., and maximally reduced the blood lymphocyte count for at least 24 h after oral administration of 10 mg/kg to Wistar rats.

European Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beilfuss, W. published the artcileA new concept to boost the preservative efficacy of phenoxyethanol, SDS of cas: 70445-33-9, the publication is SOFW Journal (2005), 131(11), 30,32-36, database is CAplus.

A new cosmetic preservative for leave-on products based on a combination of the active ingredient phenoxyethanol and the skin care additive and deodorant active ethylhexylglycerin is presented. Ethylhexylglycerin boosts the antimicrobial activity of phenoxyethanol. Properties, antimicrobial activity and a possible mechanism of action are discussed.

SOFW Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Meijere, Armin published the artcileDe novo synthesis of racemic spirocyclopropane-annelated 2-deoxyhexose derivatives, Quality Control of 50915-29-2, the publication is European Journal of Organic Chemistry (2003), 472-478, database is CAplus.

High-pressure-induced inverse-electron-demand hetero-Diels-Alder reactions of Et trans-4-ethoxy-2-oxo-3-butenoate and Me trans-4-benzyloxy-2-oxo-3-butenoate with benzyl (cyclopropylidenemethyl) ether each yielded mixtures of two separable diastereomeric esters (64% and 80%, resp.) which, in three subsequent steps, led to the 3-ethylated and 3-benzylated α- and β-anomeric benzyl spiro[2-deoxy-(D,L)-arabino-hexopyranoside-2,1′-cyclopropanes] α-10a,b and β-10a,b, resp. The relative configuration of β-10a was proved by an X-ray crystal structure anal. Deprotection of β-10b was achieved by Pd-catalyzed hydrogenation in dimethylacetamide leading to spiro[2-deoxy-α/β-2-(D,L)-arabino-hexopyranoside-2,1′ -cyclopropane].

European Journal of Organic Chemistry published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Quality Control of 50915-29-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leong, Shi Xuan published the artcileNoninvasive and Point-of-Care Surface-Enhanced Raman Scattering (SERS)-Based Breathalyzer for Mass Screening of Coronavirus Disease 2019 (COVID-19) under 5 min, Synthetic Route of 111-29-5, the publication is ACS Nano (2022), 16(2), 2629-2639, database is CAplus and MEDLINE.

Population-wide surveillance of COVID-19 requires tests to be quick and accurate to minimize community transmissions. The detection of breath volatile organic compounds presents a promising option for COVID-19 surveillance but is currently limited by bulky instrumentation and inflexible anal. protocol. Here, we design a hand-held surface-enhanced Raman scattering-based breathalyzer to identify COVID-19 infected individuals in under 5 min, achieving >95% sensitivity and specificity across 501 participants regardless of their displayed symptoms. Our SERS-based breathalyzer harnesses key variations in vibrational fingerprints arising from interactions between breath metabolites and multiple mol. receptors to establish a robust partial least-squares discriminant anal. model for high throughput classifications. Crucially, spectral regions influencing classification show strong corroboration with reported potential COVID-19 breath biomarkers, both through experiment and in silico. Our strategy strives to spur the development of next-generation, noninvasive human breath diagnostic toolkits tailored for mass screening purposes.

ACS Nano published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Harder, John W. published the artcileNew interlayer scavenger technology, Formula: C22H38O2, the publication is IS&T’s Annual Conference (1997), 206-209, database is CAplus.

Poor color reproduction can occur when oxidized color developer diffuses from the imaging layer in which it is formed into the color records. Typically, scavengers for oxidized color developers (also known as interlayer scavengers) reduce or eliminate by chem. reaction, the oxidized developer without forming any permanent dyes or other colored stains, nor releasing fragments that have photog. activity. One known class of scavengers are substituted hydroquinones. However, these materials are often prone to aerial oxidation leading to poor film keeping properties. It has been found that both 2-(N,N-disubstitutedcarbamoyl)-1,4-hydroquinones (Formula I) and 4-(N,N-disubstitutedcarbamoyl)-pyrocatechols (Formula II) are reactive scavengers with excellent aerial stability. Another known class of scavengers are acylhydrazides. Although stable to aerial oxidation, these materials are prone to poor activity and undesirable side reactions during processing. It has been found that acylhydrazides of Formula III, where X = an electron-withdrawing and water solubilizing group, are reactive scavengers that avoid undesirable side reactions.

IS&T’s Annual Conference published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Lina published the artcileGold nanoparticles supported on the periodic mesoporous organosilica SBA-15 as an efficient and reusable catalyst for selective oxidation of silanes to silanols, Formula: C6H16OSi, the publication is RSC Advances (2014), 4(13), 6807-6810, database is CAplus.

Gold nanoparticles are confined and stabilized within the channels of SBA-15 through the poly(ionic liquid) brushes that are anchored onto the pore walls of SBA-15. The supported gold catalyst exhibited remarkably high catalytic activities for selective oxidation of silanes into silanols using water as an oxidant without the use of organic solvents.

RSC Advances published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Lina published the artcileGold nanoparticles supported on the periodic mesoporous organosilica SBA-15 as an efficient and reusable catalyst for selective oxidation of silanes to silanols, Recommanded Product: Triisopropylsilanol, the publication is RSC Advances (2014), 4(13), 6807-6810, database is CAplus.

Gold nanoparticles are confined and stabilized within the channels of SBA-15 through the poly(ionic liquid) brushes that are anchored onto the pore walls of SBA-15. The supported gold catalyst exhibited remarkably high catalytic activities for selective oxidation of silanes into silanols using water as an oxidant without the use of organic solvents.

RSC Advances published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smith, Mark G. published the artcileNovel crystal forms of 4-aminoantipyrine and its derivatives: Co-crystallizing a reluctant molecule, Quality Control of 86-48-6, the publication is Journal of Molecular Structure (2019), 307-313, database is CAplus.

To the best of our knowledge, the first co-crystallization of the pharmaceutical ingredient 4-aminoantipyrine is reported with 2-aminobenzoic acid as the co-former, and the method used for its supramol. synthesis is discussed. Two mol. salts of 4-aminoantipyrine, as well as two co-crystals of a derivative of 4-aminoantipyrine were also synthesized. The complexes discussed show that careful application of synthon theory, choice of solvent and consideration of the pK_a difference between 4-aminoantipyrine and the co-former are required to successfully co-crystallize this reactive mol. In summary, the co-former must be chosen so that its functional group forms a robust heterosynthon with the reactive mol. The presence of polar solvents or large pK_a differences between 4-aminoantipyrine and its potential co-crystallizer favors salt formation, whereas a non-polar solvent and a small pK_a difference is required for the co-crystallization of 4-aminoantipyrine.

Journal of Molecular Structure published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C18H28N2O7, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Iwuoha, Emmanuel I. published the artcileReactivities of Organic-Phase Biosensors. 1. Enhancement of the Sensitivity and Stability of Amperometric Peroxidase Biosensors Using Chemically Modified Enzymes, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Analytical Chemistry (1997), 69(8), 1674-1681, database is CAplus.

Amperometric organic- and aqueous-phase peroxide biosensors were prepared with native and N-hydroxysuccinimide ester (NHS)-modified horseradish peroxidase (HRP). The ε-amino functions of the six free lysine residues of HRP were selectively modified with homobifunctional suberic acid bis(N-hydroxysuccinimide ester) (SA-NHS) or ethylene glycol bis(succinic acid N-hydroxysuccinimide ester) (EG-NHS). The biosensors were based on electrostatic complexation of the HRP variants with an osmium bis(bipyridyl)poly(4-vinylpyridine) polymer. The enzyme electrodes were operated in both aqueous (0.1 M phosphate buffer, pH 7.0) and organic (90% CH₃CN) phases, for the detection of hydrogen peroxide and Me isothiocyanate. Kinetic anal. of the steady-state amperometry data showed that chem. modification of HRP about up to a ∼5-fold enhancement of the biosensor sensitivity for H₂O₂ and an improvement in both sensor stability and organotolerance. Also, NHS modification of HRP results in a 3-fold extension of the range of linear response of the peroxide sensor in both aqueous and nonaqueous media. When used as a Me isothiocyanate sensor in the organic phase, the amperometric responses of the biosensors were doubled on changing from native HRP to NHS-HRP electrodes.

Analytical Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Denton, Elliott H. published the artcileCatalytic Carbochlorocarbonylation of Unsaturated Hydrocarbons via C-COCl Bond Cleavage, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Angewandte Chemie, International Edition (2021), 60(43), 23435-23443, database is CAplus and MEDLINE.

A palladium-catalyzed difunctionalisation of unsaturated C-C bonds with acid chlorides was reported. Formally, C-COCl bond of an acid chloride was cleaved and added, with complete atom economy, across either strained alkenes or a tethered alkyne to generate new acid chlorides I [Ar = Ph, 2-naphthyl, benzo[b]thiophen-2-yl, etc.]. The transformation does not require exogenous carbon monoxide, operated under mild conditions, showed a good functional group tolerance, and gave isolated products with excellent stereoselectivity. The intermol. reaction tolerated both aryl- and alkenyl-substituted acid chlorides and was successful when carboxylic acids were transformed to acid chloride in situ. The reaction also showed an example of temperature-dependent stereodivergence which, together with plausible mechanistic pathways, was investigated by DFT calculations Moreover, it was shown that benzofurans could be formed in an intramol. variant of reaction. Finally, derivatisation of products from intermol. reaction provided a highly stereoselective approach for synthesis of tetrasubstituted cyclopentanes.

Angewandte Chemie, International Edition published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts