Author: tianli

Yuan, Shiyu published the artcileMeasurement of non-hindered and hindered phenolic species in aviation fuels via tandem-SPE with comprehensive GC x GC-MS/FID, Application of 4-Propylphenol, the publication is Fuel (2021), 119561, database is CAplus.

Phenolic species have a great impact on the thermal oxidation stability of aviation fuels. However, it is difficult to measure phenolic complex composition and trace content. In this paper, a novel method based on tandem-solid phase extraction (SPE) with comprehensive two-dimensional gas chromatog. (GC x GC)-mass spectrometry (MS) and flame ionization detector (FID) was proposed for measurement of phenolic species in aviation fuels. The tandem of normal phase SPE and anion exchange SPE was employed to extract non-hindered and hindered phenolic species resp. from aviation fuels, and comprehensive GC x GC-MS/FID was used to identify and quantify individual phenolic species with few co-elution. Ninety-eight kinds of phenolic species were identified manually in aviation fuels according to the characteristic m/z and phenolic distribution regular in the 2D chromatogram. Quant. accuracy for phenolic species was verified as their recoveries were satisfactory, especially hindered phenols (BHT), which were totally deprotonated by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). Each phenolic species was individually quantified using calibration curve library. Moreover, this work analyzed the adsorption characteristics of phenolic isomers in tandem-SPE procedure and the variation of the contents of phenolic and other oxygenated species after thermal stress. This is an accurate and complete method for measurement of non-hindered and hindered phenolic species in aviation fuels, which is of great significance to establish and improve the kinetic model of thermal oxidation deposition.

Fuel published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C13H14N2O, Application of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Wenjing published the artcilePrevention effect of Guyuan Fujiu decoction combined with carboprost tromethamine on postpartum hemorrhage caused by uterine inertia in vaginal delivery, Application In Synthesis of 58551-69-2, the publication is Jianyan Yixue Yu Linchuang (2021), 18(16), 2335-2338, 2343, database is CAplus.

Objective To observe the preventive effect of Guyuan Fujiu decoction combined with carboprost tromethamine on postpartum hemorrhage caused by uterine inertia in vaginal delivery. Methods A total of 110 cases of postpartum hemorrhage due to uterine inertia in the hospital from Apr. 2018 to June 2020 were randomly divided into control group and observation group, 55 cases in each group. The control group was given carboprost tromethamine injection after the delivery of the fetus, and the observation group was given Guyuan Fujiu decoction on the basis of the control group. The incidence of postpartum hemorrhage, amount of postpartum hemorrhage, hemostatic time, use of other hemostatic measures, changes of Hb and hematocrit were compared between the two groups. Results The postpartum hemorrhage rate of the observation group (3.64%) was significantly lower than that of the control group (14.55%), the difference was statistically significant (χ²=3.960, P<0.05). Postpartum hemostasis time [(23.56±3.14) min] was significantly shorter than that in the control group [(40.05±5.74) min], the difference was statistically significant (t=18.691, P<0.05). Compared with the control group, the amount of bleeding in the observation group decreased significantly at 30 min, 2 h and 24 h postpartum (t=8.654, 13.495 and 15.496, P<0.05). The application rate of other hemostatic measures in the observation group (7.27%) was significantly lower than that in the control group (21.82%) (χ²=4.681, P<0.05). Compared with the control group, the decrease of maternal Hb and hematocrit in the observation group were significantly reduced (t=22.817, 28.939, P<0.05). Compared with the control group, the serum D-dimer level in the observation group was significantly lower at 2 h postpartum, and the FIB level was significantly higher (t=19.492, 17.256, P<0.05). The level of serum antithrombin-III in the observation group was significantly higher than that in the control group (t=6.090, 10.092, P<0.05). The adverse reaction rate of the observation group (7.27%) was lower than that of the control group (16.36%), but the difference was not statistically significant (χ²=2.181, P>0.05). Conclusion Guyuan Fuguo decoction combined with carboprost tromethamine can be used to prevent uterine hypostasis postpartum hemorrhage, reduce postpartum hemorrhage, improve coagulation function, promote uterine contraction and drug safety.

Jianyan Yixue Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Xinxia published the artcileObservation on carboprost tromethamine and oxytocin for reduction of hemorrhage in caesarean section, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhonghua Fuyou Linchuang Yixue Zazhi, Dianziban (2014), 10(5), 73-76, database is CAplus.

Objective: To observe the effect of carboprost tromethamine (hemabate) and oxytocin in cesarean section for preventing and reducing the intraoperative bleeding and compare their adverse reaction. Methods: From Nov. 2013 to March 2014, a total of 40 parturient women underwent cesarean section were included in the study. They were randomly divided into group I (20 cases using carboprost tromethamine injection) and group II (20 cases using oxytocin) according to different drugs for the injection into their uterine corpus immediately after fetal disengagement. There were no significant differences in maternal age, gestational age, body weight in general between two groups (P > 0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shanghai First Maternity and Infant Hospital. Informed consent was obtained from each participants. Results: The amount of blood loss during cesarean section in group I was obviously lower than that of group II (P < 0.05). There were significant differences in vital signs at 10 min after treatment between two groups (P < 0.05). The incidence rate of adverse reaction in group I was significantly higher than that of group II (P < 0.01). Conclusion: Carboprost tromethamine injection in caesarean operation can effectively decrease the intraoperative bleeding, but more attention should be paid on its adverse reaction.

Zhonghua Fuyou Linchuang Yixue Zazhi, Dianziban published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Yujiao published the artcileFlavor deterioration of Mandarin juice during storage by MDGC-MS/O and GC-MS/PFPD, Synthetic Route of 106-25-2, the publication is LWT–Food Science and Technology (2022), 113132, database is CAplus.

Com. mandarin juice often exhibits flavor deterioration during storage. The changes in volatile flavor profiles were investigated in mandarin juice stored under three different temperature conditions (4°C, 25°C, and 40°C). The application of multidimensional gas chromatog.-mass spectrometry/olfactometry (MDGC-MS/O) coupled with aroma extract dilution anal. (AEDA) identified 31 odorants in stored mandarin juice, including seven off-flavor contributing compounds: methanethiol (unpleasant, repulsive), di-Me sulfide (sulfur, cabbage), methional (cooked potato), p-cymene (solventy), 4-vinylguaiacol (medicine), terpinen-4-ol (wood), and α-terpineol (floral, mint). 4-Vinylguaiacol was also identified in mandarin juice for the first time. In addition, 64 volatile compounds determined by GC-MS/pulsed flame photometric detector (GC-MS/PFPD) were classified as alcs., terpenes, volatile sulfur compounds (VSCs), aldehydes, esters, ketones, and phenols. Volatile compound differences were observed in mandarin juice under different storage conditions by heat-map generation and principal component anal. (PCA). The results revealed that high-temperature storage led to a rapid increase in the concentration of total alcs. and VSCs. Furthermore, the flavor deterioration markers α-terpineol and di-Me sulfide were identified based on off-flavor contribution and variable importance in projection (VIP) (score >1) values in the PLS-DA model. These two compounds are valuable for marker-assisted flavor deterioration anal. in mandarin juice during storage.

LWT–Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Synthetic Route of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tang, Ri-Yuan published the artcileConformation-induced remote meta-C-H activation of amines, Product Details of C7H9NO, the publication is Nature (London, United Kingdom) (2014), 507(7491), 215-220, database is CAplus and MEDLINE.

Achieving site selectivity in carbon-hydrogen (C-H) functionalization reactions is a long-standing challenge in organic chem. The small differences in intrinsic reactivity of C-H bonds in any given organic mol. can lead to the activation of undesired C-H bonds by a non-selective catalyst. One solution to this problem is to distinguish C-H bonds on the basis of their location in the mol. relative to a specific functional group. In this context, the activation of C-H bonds five or six bonds away from a functional group by cyclometallation has been extensively studied. However, the directed activation of C-H bonds that are distal to (more than six bonds away) functional groups has remained challenging, especially when the target C-H bond is geometrically inaccessible to directed metalation owing to the ring strain encountered in cyclometallation. Here we report a recyclable template that directs the olefination and acetoxylation of distal meta-C-H bonds – as far as 11 bonds away – of anilines and benzylic amines. This template is able to direct the meta-selective C-H functionalization of bicyclic heterocycles via a highly strained, tricyclic-cyclophane-like palladated intermediate. X-ray and NMR studies reveal that the conformational biases induced by a single fluorine substitution in the template can be enhanced by using a ligand to switch from ortho- to meta-selectivity.

Nature (London, United Kingdom) published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C6H12Br2, Product Details of C7H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiao-Gen published the artcileHydrogenation of Esters by Manganese Catalysts, Formula: C5H12O2, the publication is Advanced Synthesis & Catalysis (2022), 364(4), 744-749, database is CAplus.

The hydrogenation of esters catalyzed by a manganese complex of phosphine-aminopyridine ligand was developed. Using this protocol, a variety of (hetero)aromatic and aliphatic carboxylates including biomass-derived esters and lactones were hydrogenated to primary alcs. R¹CH₂OH [R¹ = Me, Ph, 2-furyl, etc.] with 63-98% yields. The manganese catalyst was found to be active for the hydrogenation of Me benzoate, providing benzyl alc. with turnover numbers (TON) as high as 45,000. Investigation of catalyst intermediates indicated that the amido manganese complex was the active catalyst species for the reaction.

Advanced Synthesis & Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Shaoping published the artcileRecyclable aqueous two-phase system formed by two temperature-responsive polymers for the chiral resolution of mandelic acid enantiomers, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Molecular Liquids (2022), 118738, database is CAplus.

Aqueous two-phase systems (ATPSs) have been used in the chiral resolution of various enantiomers in recent years. However, it is difficult to recycle and reuse the phase-forming components and chiral selectors in these applications. Therefore, a completely recyclable ATPS that is based on two temperature-responsive polymers, viz., poly(MAH-β-CD-co-NIPAAm-DMAEMA-BMA) (PNDB-CD) and poly(NVCL-AM) (PVAm), was employed for the chiral separation of mandelic acid (MA) enantiomers. The two polymers can be recovered by simply adjusting the temperature; meanwhile, the polymer PNDB-CD can be used as a chiral selector. The factors that affect the chiral resolution process were also investigated. A maximum separation factor (α) of 1.49 was achieved via a one-step extraction under the following conditions: PVAm concentration of 14.0 wt%, PNDB-CD concentration of 9.0 wt%, MA concentration of 5.0 mg/g, and system p^H of 4.0. Moreover, the two polymers can be easily recycled after the chiral separation process. The recyclable ATPS used for enantioseparation in the current study can provide new ideas for other applications by using enantioselective liquid-liquid extraction (ELLE).

Journal of Molecular Liquids published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Masferrer-Rius, Eduard published the artcileExploration of highly electron-rich manganese complexes in enantioselective oxidation catalysis; a focus on enantioselective benzylic oxidation, Quality Control of 645-56-7, the publication is Catalysis Science & Technology (2021), 11(23), 7751-7763, database is CAplus.

The direct enantioselective hydroxylation of benzylic C-H bonds to form chiral benzylic alcs. represents a challenging transformation. Herein, the authors report on the exploration of new biol. inspired manganese and iron complexes bearing highly electron-rich aminopyridine ligands containing 4-pyrrolidinopyridine moieties ((S,S)-1, (R,R)-1, 2 and 5) in combination with chiral bis-pyrrolidine and N,N-cyclohexanediamine backbones in enantioselective oxidation catalysis with aqueous H₂O₂. The current manganese complexes outperform the analogous manganese complexes containing 4-dimethylaminopyridine moieties (3 and 4) in benzylic oxidation reactions in terms of alc. yield while keeping similar ee values (~60% ee), which is attributed to the higher basicity of the 4-pyrrolidinopyridine group. A detailed investigation of different carboxylic acid additives in enantioselective benzylic oxidation provides new insights into how to rationally enhance enantioselectivities by means of proper tuning of the environment around the catalytic active site, and has resulted in the selection of Boc-L-tert-leucine as the preferred additive. Using these optimized conditions, manganese complex 2 was shown to be effective in the enantioselective benzylic oxidation of a series of arylalkane substrates with up to 50% alc. yield and 62% product ee. A final set of experiments also highlights the use of the new 4-pyrrolidinopyridine-based complexes in the asym. epoxidation of olefins (up to 98% epoxide yield and >99% ee).

Catalysis Science & Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Di published the artcileAntimicrobial activity and mechanism of action of oregano essential oil against Morganella psychrotolerans and potential application in tuna, Category: alcohols-buliding-blocks, the publication is LWT–Food Science and Technology (2022), 113758, database is CAplus.

Morganella psychrotolerans is a psychrotolerant histamine producer capable of accumulating large amounts of histamine at low temperatures Oregano essential oil (OEO) is a natural antimicrobial agent used widely in the food industry, however, its antimicrobial effectiveness against M. psychrotolerans has not been studied. In this study, the inhibitory activity of OEO against M. psychrotolerans, causing damage to the membrane structure of the cell with 0.025% (volume/volume) min. inhibitory concentration (MIC) has been revealed. Metabolomics anal. revealed changes of 161 significant metabolites in ESI+ and ESI- modes, which involved in carbohydrates metabolism, amino acid metabolism, metabolism of cofactors and vitamins, nucleotides metabolism, lipids metabolism, and energy metabolism Furthermore, challenge tests revealed the OEO exhibited a significant inhibitory effect on M. psychrotolerans in tuna. These results provided new insights into the inhibition action of OEO on M. psychrotolerans and suggested that OEO had the potential to control M. psychrotolerans in the seafood industry.

LWT–Food Science and Technology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C4H6BrFO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Jie published the artcileStudy on ethylhexylglycerin and phenoxyethanol complex ligand, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Guangdong Huagong (2016), 43(2), 55-56, 58, database is CAplus.

The antimicrobial efficacy of Huake-CHLOR comprising ethylhexylglycerin and phenoxyethanol as cosmetic preservative was studied. The MIC of Huake-CHLOR with different ratio of ethylhexylglycerin and phenoxyethanol was measured. The best ratio between ethylhexylglycerin and phenoxyethanol was 1:9, so that the complex ligand at this ratio was named as Huake-CHLOR. The MIC of Huake-CHLOR on Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger was presented. The skin cream challenge test and deep moisturizing essence test showed that Huake-CHLOR had good long-acting antibacterial and antifungal efficacy. The toxicol. test showed that Huake-CHLOR under normal concentration had no irritation and allergy to skin and eye. The results showed that Huake-CHLOR has good long-acting antibacterial and antifungal efficacy, and has no irritation and allergy to skin and eye.

Guangdong Huagong published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C15H12O6, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts