Author: tianli

Nicolaou, K. C. published the artcileSynthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates, Name: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Journal of the American Chemical Society (2020), 142(29), 12890-12899, database is CAplus and MEDLINE.

Our previous studies with shishijimicin A resulted in the total synthesis of this scarce marine natural product and a number of its simpler analogs endowed with picomolar potencies against certain cancer cell lines. Herein, we describe the design, synthesis, and biol. evaluation of four linker-drugs, anticipating the construction of antibody-drug conjugates (ADCs) as the ultimate goal of this research program. Using a common payload, the assembly of these linker-drugs utilized different linkers and attachment points, providing opportunities to probe the optimal mol. design of the intended ADCs as targeted cancer therapies. In the course of ADC generation and in vitro evaluation, we identified two linker-drugs with a promising in vitro plasma stability profile and excellent targeted cytotoxicity and specificity. Conjugation of shishijimicin A enediyne payloads through their phenolic moiety represents a novel approach to enediyne ADC creation, while the pharmacol. profiles of at least two of the generated ADCs compare well with the profiles of the corresponding clin. approved ADC Kadcyla.

Journal of the American Chemical Society published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Name: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Shiyi published the artcileThe effect of solvents on the thermal degradation products of two Amadori derivatives, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is RSC Advances (2020), 10(16), 9309-9317, database is CAplus and MEDLINE.

To enrich the flavor additives of the Maillard reaction, two Amadori analogs, N-(1-deoxy-D-fructosyl-1-yl)-L-phenylalanine ester (Derivative 1) and di-O-isopropylidene-2,3:4,5-β-D-fructopyranosyl phenylalanine ester (Derivative 2), were chem. synthesized starting from D-fructose. The samples were reacted at 120 and 180°C for 2 h, and the effects of solvents (water and ethanol) on their degradation products were studied. The analyses of thermogravimetry (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), and gas chromatog.-mass spectrometry (GC/MS) were used to investigate the thermal behavior and degradation products of the samples. TG-DTG curves show that the T_p values of the samples corresponding to the largest mass-loss rates are 132 and 275°C, resp. The degradation products of Derivative 1 are mainly Ph acetaldehyde and phenylalanine Et ester in water and Et benzoate and benzaldehyde di-Et acetal in ethanol. For Derivative 2, the major degradation products both in water and ethanol are phenylalanine Et ester and diacetonefructose, but the products have different relative contents affected by solvent media. The products of the pyrolysis of the samples at 350°C were analyzed and compared with the degradation compounds obtained in solvent. These results show that organic solvents can greatly influence the degradation pathway and products. Finally, possible mechanisms of the degradation processes are proposed.

RSC Advances published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H10S, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Wenbin published the artcileEfficacy and safety of motherwort injection add-on therapy to carboprost tromethamine for prevention of post-partum blood loss: A meta-analysis of randomized controlled trials, Category: alcohols-buliding-blocks, the publication is Journal of Obstetrics and Gynaecology Research (2019), 45(1), 47-56, database is CAplus and MEDLINE.

Motherwort (YiMuCao), a traditional Chinese herb, has been shown beneficial effects for women’s diseases. This meta-anal. aimed to evaluate the efficacy and safety of motherwort injection add-on therapy to carboprost tromethamine for prevention of post-partum blood loss. A systematic literature search was conducted in PubMed, Embase, Cochrane Library, CNKI, VIP and Wanfang from their inception to Dec. 2017. Randomized controlled trials that determined the add-on effects of motherwort injection to carboprost for prevention of post-partum blood loss were eligible. Pooled risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI) were used to summarize the effect sizes. Eight trials including 1276 pregnant women fulfilled the inclusion criteria. Prophylactic use of motherwort injection add-on therapy significantly reduced the post-partum 2 h (MD -127.5 mL; 95% CI -149.13 to -105.88) and 24 h (MD -146.85 mL; 95% CI -179.77 to -113.94) blood loss and incidence of post-partum hemorrhage (RR 0.28; 95% CI 0.17-0.45) than carboprost. Moreover, adjunctive treatment with motherwort injection significantly decreased the length of the third stage of labor (MD -3.41 min; 95% CI -4.33 to -2.49) and duration of lochia (MD -7.13 days; 95% CI -8.49 to -5.76). There was no statistical significant difference in the incidence of adverse events (RR 0.76; 95% CI 0.50-1.16). VProphylactic use of motherwort injection add-on therapy to carboprost tromethamine could reduce post-partum blood loss. However, more well-designed trials are necessary to confirm the findings of this study due to the methodol. flaws of the included trials.

Journal of Obstetrics and Gynaecology Research published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shu, Riyang published the artcileEnhanced adsorption properties of bimetallic RuCo catalyst for the hydrodeoxygenation of phenolic compounds and raw lignin-oil, Safety of 4-Propylphenol, the publication is Chemical Engineering Science (2020), 115920, database is CAplus.

The synergistic effect of two metal species in bimetallic catalysts can promote the catalytic performances significantly, and the enhanced adsorption properties by the interaction between two metal species play an important role. In this study, we investigated the hydrodeoxygenation (HDO) performance of a bimetallic RuCo/SiO₂-ZrO₂ catalyst, paying close attention to its adsorption properties based on the exptl. and modeling study. RuCo catalyst presented a strong interaction between two metal species and electrons transfer from Ru to Co, which led to a higher spin-up d-band center value of surface atoms and thereby a different adsorption property from the monometallic catalysts. The good adsorption of hydrogen and substrate in RuCo catalyst played a crucial role on triggering the occurrence of HDO reaction for a better performance, which was also confirmed by the DFT calculation This catalyst performed well on the HDO of guaiacol, other phenolic compounds and raw lignin-oil.

Chemical Engineering Science published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C6H20Cl2N4, Safety of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Bowen published the artcileBoric Acid as a Novel Homogeneous Catalyst Coupled with Ru/C for Hydrodeoxygenation of Phenolic Compounds and Raw Lignin Oil, Formula: C9H12O, the publication is Industrial & Engineering Chemistry Research (2020), 59(39), 17192-17199, database is CAplus.

Simple and efficient catalytic routes have been explored to upgrade the raw lignin oil. Though homogeneous catalysis is easy to operate and possesses a high reaction rate, it also suffers from the difficulty of product separation In this work, we used H₃BO₃ as a novel homogeneous catalyst coupled with Ru/C to overcome the separation problem and carry out the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin oil. H₃BO₃ showed an outstanding performance over the liquid organic and mineral acids, with a good catalyst recyclability. Phenolic model compounds including monomers and dimers can be efficiently converted into cycloalkanes with yields close to 100%. Moreover, the raw lignin oil also had a good HDO result by using this bifunctional catalyst (H₃BO₃ and Ru/C). The content of hydrocarbons increased from 7.9% to 93.1% at 260°C, which promoted the upgraded lignin oil capable to be used as fuel directly.

Industrial & Engineering Chemistry Research published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Zujian published the artcileSuperhydrophilic fluorinated polymer and nanogel for high-performance ¹⁹F magnetic resonance imaging, Formula: C3H5F3O, the publication is Biomaterials (2020), 120184, database is CAplus and MEDLINE.

¹⁹F magnetic resonance imaging (¹⁹F MRI), a kind of non-invasive and non-radioactive diagnostic technique with no endogenous background signals, opens up new research avenues for accurate mol. imaging studies. However, ¹⁹F MRI is manily limited by the performance of contrast agents. Here, for the first time, we presented the zwitterionic fluorinated polymer and nanogel as new types of superhydrophilic, sensitive and ultra-stable ¹⁹F MRI contrast agents. The superhydrophilicity of carboxybetaine zwitterionic structure completely overcame the hydrophobic aggregation-induced signal attenuation associated with amphiphilic fluorinated polymer-based nanoprobes. In addition, the superhydrophilic contrast agent exhibited distinct advantages, including high ¹⁹F-content (19.1 wt%), superior resistance to protein adsorption, constant MR properties and ¹⁹F MRS-based quant. determination in complex biol. fluids, and intense ¹⁹F MRI signals in the whole-body images after i.v. injection. In combination with angiogenesis targeting ligand, the superhydrophilic contrast agent was applied for the unambiguous detection of tumor. Importantly, computational algorithm was established for the directly quant. determination of bioavailability and tumor-to-whole body ratio (TBR) from the in vivo¹⁹F MRI dataset, providing real-time information with non-invasive manner. Finally, crosslinked nanogels were developed with significantly prolonged systemic circulation, of which intense ¹⁹F MRI signals nonspecifically distributed in the aortaventralis and blood-rich organs, instead of being trapped steadily in liver as with the state-of-the-art superhydrophobic perfluocarbon nanoemulsions. Overall, this kind of superhydrophilic, zwitterionic fluorinated polymer and nanogel could be defined as a new generation of high-performance ¹⁹F MRI contrast agents, which hold great potential for image-based unambiguous disease detection and computational quantification.

Biomaterials published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Jian published the artcileA water-soluble BODIPY derivative as a highly selective “Turn-On” fluorescent sensor for H₂O₂ sensing in vivo, Product Details of C6H13BO3, the publication is Biosensors & Bioelectronics (2014), 58-63, database is CAplus and MEDLINE.

A type of BODIPY derivatives was designed and synthesized by the N-alkylation reaction of meso-(4-pyridinyl)-substituted BODIPY. The water-solubility of entire mol. was improved to a large extent as a result of the formation of cationic quaternary ammonium salt, while the strong fluorescence inherent to the BODIPY dye fragment is extinguished on alkylation of the pyridine N atom due to the photo-induced electron transfer (PET) process. The N-alkylated BODIPY derivative 4, as a novel water-soluble “Turn-On” fluorescent probe for the discrimination of H₂O₂, was constructed by incorporating 4-(Bromomethyl)benzeneboronic acid pinacol ester moiety, which showed highly selective fluorescent response to H₂O₂ against other interferences of ROS and RNS species under physiol. conditions, and the reaction mechanism of boronate oxidation was con by ¹H NMR, mass spectrum and optical spectroscopy anal. As a biocompatible probe in biol. systems, probe 4 was successfully applied for monitoring and imaging of H₂O₂ both in vitro and in vivo using HepG2/LO2 cells and angelfish.

Biosensors & Bioelectronics published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C24H29N5O3, Product Details of C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Yingtao published the artcileSynthesis of Axially Chiral Aldehydes by N-Heterocyclic-Carbene-Catalyzed Desymmetrization Followed by Kinetic Resolution, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Angewandte Chemie, International Edition (2022), 61(14), e202117340, database is CAplus and MEDLINE.

Herein an NHC-catalyzed atroposelective esterification of biaryl dialdehydes as a general and practical strategy for the construction of axially chiral aldehydes I [Ar = Ph, 1-naphthyl, 9-phenanthryl, etc.; R¹ = Et, CH₂CF₃, cyclopropyl, etc.] was described. Mechanistic studies indicated that coupling proceeds through a novel combination of NHC-catalyzed desymmetrization of the dialdehydes and kinetic resolution This protocol featured excellent enantioselectivity, mild conditions, good functional-group tolerance and applicability to late-stage functionalization and provided a modular platform for the synthesis of axially chiral aldehydes and their derivatives

Angewandte Chemie, International Edition published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H9ClN2O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiang published the artcileBlack Liquor Valorization by Using Marine Protist Thraustochytrium striatum and the Preliminary Metabolic Mechanism Study, Quality Control of 526-98-7, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(4), 1786-1796, database is CAplus.

Black liquor that contains various phenolic compounds from lignin solubilization has been the main byproduct of alk. pretreatment of lignocellulosic biomass in the biorefinery. In this study, black liquor from alk. pretreatment of corn stover was used as a sole carbon source for the cultivation of a marine protist, Thraustochytrium striatum. It was found that this strain can grow on black liquor and accumulate valuable products (e.g., fatty acids and carotenoids) simultaneously. Under optimal conditions (pH = 7 and NH₄Cl = 2 g/L), the cell mass concentration reached 5.2 g/L with total aromatics decreased from 8.18 to 3.09 g/L within 7 day incubation. Fed-batch cultivation was adopted to increase the contents of total fatty acids and carotenoids to 13% and 0.24 mg/g dry cell mass, resp. Although various compounds such as sugars and organic acids were detected in black liquor and consumed during microbial fermentation as carbon sources, lignin-derived compounds were identified as the major substrates for T. striatum fermentation Of total aromatics consumed, monomers including p-coumaric acid, ferulic acid, vanillin, and syringaldehyde were observed to be consumed and converted while polymeric fragments were also depolymerized and degraded. Under optimal conditions, around 50% of the total aromatics was consumed. The dynamic changes of compounds in black liquor indicated that diverse metabolic processes were involved in black liquor degradation and utilization by T. striatum. A strong adaptation of T. striatum to a wide range of pH (3-9) was also observed during black liquor fermentation A novel pathway for biotransformation of black liquor lignin into value-added bioproducts with marine protist, Thraustochytrium striatum.

ACS Sustainable Chemistry & Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Quality Control of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Agwunobi, Desmond O. published the artcileProteomic analysis suggests that monoterpenes in lemongrass disrupt Ca²⁺ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Proteomics (2022), 22(13-14), 2100156, database is CAplus and MEDLINE.

Complex mixtures of bioactive ingredients in plant essential oils present complex chemistries which involve different modes of action. An increasing body of scientific reports has recently focused on the acaricidal activities of plant essential oils attributed to their monoterpene components, but information about their underlying mol. mechanism of action is scarce. Here, after the chem. anal. of lemongrass oil, a proteomic anal. of the ovary, salivary gland, and midgut of Haemaphysalis longicornis exposed to Cymbopogon citratus (lemongrass) essential oil was performed via data-independent acquisition mass spectrometry (DIA-MS) technol. to further elucidate the mol. mechanisms involved. Pathway anal. reveals the activation of metabolic pathways mediated by oxidoreductases and transferases. Furthermore, the upregulation of various calcium-associated proteins and the upregulation of cytochrome c1, cytochrome c oxidase polypeptide IV, and programmed cell death protein 6-like isoform X1 suggest a cytotoxic mode of action via the formation of reactive oxygen species (ROS), mitochondrial Ca2+ overload, mitochondrial uncoupling, and depolarization, and ATP depletion leading to either apoptotic or necrotic death. Morphol. alterations observed after the RNAi of a major detoxification enzyme (glutathione S-transferase) merit further investigation. Hence, the cytotoxic mode of action exhibited by C. citratus oil could be vital for the development of eco-friendly acaricide.

Proteomics published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts