Author: tianli

Routti, Heli published the artcileEnvironmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro, Related Products of alcohols-buliding-blocks, the publication is Environmental Science & Technology (2016), 50(19), 10708-10720, database is CAplus and MEDLINE.

The authors studied interactions between polar bear peroxisome proliferator-activated receptor gamma (pbPPARG) and selected compounds using a luciferase reporter assay and predictions through mol. docking. Furthermore, the authors studied adipogenesis by liver and adipose tissue extracts from a polar bear and three synthetic mixtures of contaminants in murine 3T3-L1 preadipocytes and polar bear adipose tissue-derived stem cells (pbASCs). PCB153 and p,p’-DDE antagonized pbPPARG, although their predicted receptor-ligand affinity was weak. PBDEs, tetrabromobisphenol A, and PCB170 had a weak agonistic effect on pbPPARG, while hexabromocyclododecane, bisphenol A, oxychlordane, and endosulfan were weak antagonists. pbPPARG-mediated luciferase activity was suppressed by synthetic contaminant mixtures reflecting levels measured in polar bear adipose tissue, as were transcript levels of PPARG and the PPARG target gene fatty acid binding protein 4 (FABP4) in pbASCs. Contaminant extracts from polar bear tissues enhanced triglyceride accumulation in murine 3T3-L1 cells and pbASCs, whereas triglyceride accumulation was not affected by the synthetic mixtures Chem. characterization of extracts using non-target methods revealed presence of exogenous compounds that have previously been reported to induce adipogenesis. These compounds included phthalates, tonalide, and nonylphenol. In conclusion, major legacy contaminants in polar bear adipose tissue exert antagonistic effects on PPARG, but adipogenesis by a mixture containing emerging compounds may be enhanced through PPARG or other pathways.

Environmental Science & Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reading, Eamonn published the artcileThe Role of the Detergent Micelle in Preserving the Structure of Membrane Proteins in the Gas Phase, Computed Properties of 85618-21-9, the publication is Angewandte Chemie, International Edition (2015), 54(15), 4577-4581, database is CAplus and MEDLINE.

Despite the growing importance of the mass spectrometry of membrane proteins, it is not known how their transfer from solution into vacuum affects their stability and structure. To address this we have carried out a systematic investigation of ten membrane proteins solubilized in different detergents and used mass spectrometry to gain physicochem. insight into the mechanism of their ionization and desolvation. We show that the chem. properties of the detergents mediate the charge state, both during ionization and detergent removal. Using ion mobility mass spectrometry, we monitor the conformations of membrane proteins and show how the surface charge d. dictates the stability of folded states. We conclude that the gas-phase stability of membrane proteins is increased when a greater proportion of their surface is lipophilic and is consequently protected by the phys. presence of the micelle.

Angewandte Chemie, International Edition published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Computed Properties of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bajkacz, Sylwia published the artcileSeparation and Determination of Chemopreventive Phytochemicals of Flavonoids from Brassicaceae Plants, Quality Control of 621-37-4, the publication is Molecules (2021), 26(16), 4734, database is CAplus and MEDLINE.

The main aim of this study was to develop a method for the isolation and determination of polyphenols-in particular, flavonoids present in various morphol. parts of plants belonging to the cabbage family (Brassicaceae). Therefore, a procedure consisting of maceration, acid hydrolysis and measurement of the total antioxidant capacity of plant extracts (using DPPH assay) was conducted. Qual. anal. was performed employing thin-layer chromatog. (TLC), which was presented to be a suitable methodol. for the separation and determination of chemopreventive phytochems. from plants belonging to the cabbage family. The study involved the anal. of 25 vegetal samples, including radish, broccoli, Brussels sprouts, kale, canola, kohlrabi, cabbage, Chinese cabbage, red cabbage, pak choi and cauliflower. In addition, selected flavonoids content in free form and bonded to glycosides was determined by using an RP-UHPLC-ESI-MS/MS method.

Molecules published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Téteau, Ophélie published the artcileBisphenol S Alters the Steroidome in the Preovulatory Follicle, Oviduct Fluid and Plasma in Ewes With Contrasted Metabolic Status., Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Frontiers in endocrinology (2022), 892213, database is MEDLINE.

Bisphenol A (BPA), a plasticizer and endocrine disruptor, has been substituted by bisphenol S (BPS), a structural analogue that had already shown adverse effects on granulosa cell steroidogenesis. The objective of this study was to assess the effect of chronic exposure to BPS, a possible endocrine disruptor, on steroid hormones in the ovary, oviduct and plasma using the ewe as a model. Given the interaction between steroidogenesis and the metabolic status, the BPS effect was tested according to two diet groups. Eighty adult ewes were allotted to restricted (R) and well-fed (WF) groups, that were further subdivided into two subgroups. Ewes were exposed to 50 µg BPS/kg/day in their diet (R50 and WF50 groups) or were unexposed controls (R0 and WF0 groups). After at least 3 months of BPS exposure, preovulatory follicular fluid, oviduct fluid and plasma were collected and steroid hormones were analyzed by gas chromatography coupled with tandem mass spectrometry (GC-MS/MS). A deleterious effect of restricted diet on the volume of oviduct fluid and numbers of pre-ovulatory follicles was observed. Exposure to BPS impaired estradiol concentrations in both follicular and oviduct fluids of well-fed ewes and progesterone, estradiol and estrone concentrations in plasma of restricted ewes. In addition, a significant interaction between metabolic status and BPS exposure was observed for seven steroids, including estradiol. In conclusion, BPS acts in ewes as an endocrine disruptor with differential actions according to metabolic status.

Frontiers in endocrinology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C22H18Cl2N2, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chainet, Fabien published the artcileDevelopment of heart-cutting multidimensional gas chromatography coupled to time of flight mass spectrometry for silicon speciation at trace levels in gasoline samples, Application In Synthesis of 597-52-4, the publication is Journal of Chromatography A (2012), 80-86, database is CAplus and MEDLINE.

To improve the understanding of hydrotreatment (HDT) catalyst poisoning by silicon species, these mols. must be characterized in petroleum products using powerful anal. systems. Heart-cutting gas chromatog. coupled to time of flight mass spectrometry (GC-GC/TOFMS) method equipped with a Deans switch (DS) system was developed for the direct characterization of target silicon compounds at trace level (μg/kg) in gasoline samples. This method was performed to identify silicon compounds never characterized before. After the selection of the 2nd dimension column using GC-GC-FID, GC-GC/TOFMS was performed. The calibration curves obtained by the GC-GC/TOFMS method were linear up to 1000 μg kg^-1. Limits of detection (LOD) were ranging from 5 to 33 μg/kg in spiked gasoline. The method provided sufficient selectivity and sensitivity to characterize known silicon compounds thanks to their specific ions and their retention times. The anal. of a naphtha sample by GC-GC/TOFMS showed cyclic siloxanes (D_n) as major compounds of PDMS thermal degradation with the occurrence of linear siloxanes, especially hexamethyldisiloxane (L₂), which was never characterized in petroleum products but already known as severe poison for catalyst.

Journal of Chromatography A published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application In Synthesis of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bender, Christoph published the artcileStereoselective 1-arylation of isoquinolines via chiral N-acylisoquinolinium salts, Quality Control of 27292-49-5, the publication is ARKIVOC (Gainesville, FL, United States) (2008), 111-136, database is CAplus.

Reaction of isoquinolines with (R)-menthyl chlorocarbonate or (S)-α-Cbz-aminoacyl fluorides and arenes or heteroarenes gave access to the corresponding 2-R¹-1-R²-1,2-dihydroisoquinolines I [R¹ = H, Br, Ph, 4-ClC₆H₄; R² = menthyloxycarbonyl, N-benzyloxycarbonyl-2-amino-3-phenylpropionyl, N-benzyloxycarbonyl-2-amino-propionyl; R³ = 4-(1-dimethylaminonaphthyl), 4-Et₂NC₆H₄, 3-indolyl, etc.] in a Mannich-type reaction via intermediate N-acylisoquinolinium salts. As an alternative, aryl metal compounds could be used. Modest stereoselectivities were achieved. Further reduction and hydrolysis of the products gave access to 1,2,3,4-tetrahydroisoquinolines II (R² = H, Me; R³ = Ph, 4-Et₂NC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 3-indolyl).

ARKIVOC (Gainesville, FL, United States) published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Quality Control of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nikitin, Sergei published the artcileLignin-Inspired Polybenzylethersulfone Synthesis via S_NAr Reaction, Related Products of alcohols-buliding-blocks, the publication is Macromolecular Chemistry and Physics (2022), 223(13), 2100484, database is CAplus.

A new type of lignin-inspired polybenzylethersulfone (PBES) is synthesized by S_NAr reaction in 75% yield. Success of the polymerization is confirmed by ATR-IR, ¹H, ¹³C NMR spectroscopy and MALDI-TOF MS. The obtained polysulfone is solvent casted into a film which displays high thermal and chem. stability. Treatment with 33% HBr in acetic acid leads to degradation of the material. The isolated degradation products are identified and repolymd. back into PBES demonstrating the opportunity for chem. recycling of this new polymer.

Macromolecular Chemistry and Physics published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Nianhua published the artcileHighly Selective Hydroxylation and Alkoxylation of Silanes: One-Pot Silane Oxidation and Reduction of Aldehydes/Ketones, Synthetic Route of 597-52-4, the publication is Organometallics (2020), 39(1), 165-171, database is CAplus.

An efficient chemoselective iridium-catalyzed method for the hydroxylation and alkoxylation of organosilanes to generate hydrogen gas and silanols or silyl ethers was developed. A variety of sterically hindered silanes with alkyl, aryl, and ether groups were tolerated. Furthermore, this atom-economical catalytic protocol can be used for the synthesis of silanediols and silanetriols. A one-pot silane oxidation and chemoselective reduction of aldehydes/ketones was also realized.

Organometallics published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Synthetic Route of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Nianhua published the artcileHighly Selective Hydroxylation and Alkoxylation of Silanes: One-Pot Silane Oxidation and Reduction of Aldehydes/Ketones, Application In Synthesis of 17877-23-5, the publication is Organometallics (2020), 39(1), 165-171, database is CAplus.

An efficient chemoselective iridium-catalyzed method for the hydroxylation and alkoxylation of organosilanes to generate hydrogen gas and silanols or silyl ethers was developed. A variety of sterically hindered silanes with alkyl, aryl, and ether groups were tolerated. Furthermore, this atom-economical catalytic protocol can be used for the synthesis of silanediols and silanetriols. A one-pot silane oxidation and chemoselective reduction of aldehydes/ketones was also realized.

Organometallics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application In Synthesis of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Basch, Corey H. published the artcileHarnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation, Product Details of C8H19NO2, the publication is Journal of the American Chemical Society (2017), 139(15), 5313-5316, database is CAplus and MEDLINE.

We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with an unactivated alkyl group. This reaction enjoys broad scope and functional group tolerance. Primary and secondary alkyl groups can be installed. Preliminary studies suggest a Ni^I/Ni^III catalytic cycle.

Journal of the American Chemical Society published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts