Author: tianli

Zhang, Qian published the artcileSiderophores of Bacillus pumilus promote 2-keto-L-gulonic acid production in a vitamin C microbial fermentation system, Synthetic Route of 526-98-7, the publication is Journal of Basic Microbiology (2022), 62(7), 833-842, database is CAplus and MEDLINE.

The precursor of vitamin C, 2-keto-L-gulonic acid (2-KLG), is bio-converted from L-sorbose by a microbial consortium of Ketogulonicigenium vulgare and a helper strain (Bacillus spp.). Most helper strains produce siderophores. To understand the effects of siderophores on promoting 2-KLG yield, the siderophores of Bacillus pumilus SY-A9 were purified and added to a monoculture fermentation system of K. vulgare 25B-1. The results revealed that the titer of 2-KLG reached 7.18 g/L within 60 h and increased by 71.45% when the added concentration of siderophores was 500μg/L. Moreover, the increased production of 2-KLG was accompanied by the overexpressed iron uptake system-related genes, electron transfer chain-related genes, ATP synthesis enzyme-related genes, antioxidant enzyme-related genes, and 2-KLG producing enzyme-related genes, which reduced oxidative stress and ensured the normal energy metabolism of K. vulgare 25B-1. This study demonstrated that siderophores of the helper strain play a key role in the enhancement of 2-KLG biosynthesis.

Journal of Basic Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C8H4FNO3, Synthetic Route of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Hsuan-Ju published the artcileSolid- and vapour-phase antifungal activities of six essential oils and their applications in postharvest fungal control of peach (Prunus persica L. Batsch), Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is LWT–Food Science and Technology (2022), 113031, database is CAplus.

Plant-based essential oils (EOs) possess versatile antimicrobial effects, and these render EOs a potent, sustainable antimicrobial candidate for postharvest loss control. In this study, generally recognized as safe EOs of lavender, rosewood, dill weed and fennel were investigated with the benchmark thyme red EO, for their antifungal activity against six peach spoilage fungi. We further determined their chem. compositions, as well as monitored the effect of the EOs in the phys. parameters of peaches during the storage period. Most EOs exhibited antifungal activity in the solid phase against the peach spoilage fungi, while some EOs failed to do so in the vapor phase. Rosewood (RO), thyme red (TR) and fennel (FO) EOs could inhibit mycelia growth and spore germination in a dose-dependent manner. GC-MS anal. indicated that the dominant compounds for TR, RO and FO were thymol (53.03%), linalool (77.09%) and trans-anethole (82.35%), resp. The storage tests indicated that the peach treated with RO in the vapor phase exhibited a reduced decay and maintained weight loss and total soluble solids at the room and refrigerator temperatures Moreover, the Mucor nidicola-infected peaches treated with RO exhibited significantly smaller lesion diameters and lower disease incidence relative to that by the control peaches.

LWT–Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chung, Sheng-Hsuan published the artcileSynthesis of boron-containing primary amines, Recommanded Product: [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol, the publication is Molecules (2013), 18(10), 12346-12367, database is CAplus and MEDLINE.

B-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the 1st step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters, e.g., p-(pinB)C₆H₄CH₂NH₂ (Bpin = 4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl), in good to excellent yields. These compounds were further used to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation The prepared Ugi-4CR boronate esters were then successfully converted to the corresponding boronic acids. Finally, the peptoid structures were successfully modified by cross-coupling to aryl/heteroaryl chlorides via a Pd-mediated Suzuki coupling reaction to yield the corresponding derivatives in moderate to good yields.

Molecules published new progress about 1333264-06-4. 1333264-06-4 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol, and the molecular formula is C13H18BFO3, Recommanded Product: [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Zhiwen published the artcileNanoporous palladium-catalyzed silicon-based one-pot cross-coupling reaction of aryl iodides with organosilanes, SDS of cas: 597-52-4, the publication is Catalysis Science & Technology (2014), 4(6), 1734-1737, database is CAplus.

One-pot cross-coupling of aryl iodides with organosilanes was realized in excellent yield by utilizing dealloyed nanoporous palladium as a sustainable and heterogeneous catalyst. The reaction was completed under mild conditions and the catalyst was reused several times without evident loss of its catalytic activity.

Catalysis Science & Technology published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, SDS of cas: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Peng published the artcileZeolite-Encapsulated Cu Nanoparticles for the Selective Hydrogenation of Furfural to Furfuryl Alcohol, COA of Formula: C5H12O2, the publication is ACS Catalysis (2021), 11(16), 10246-10256, database is CAplus.

Catalytic hydrogenation of furfural (FFL) to furfuryl alc. (FAL) is one of the pivotal reactions for biomass valorization. Herein, well-defined Cu nanoparticles of ~1.8 nm encapsulated within titanium silicalite-1 (TS-1) have been successfully prepared by an in situ encapsulation approach, which possesses significant advantages in metal dispersion and uniformity compared to the traditional wet impregnation method. After a Na ion-exchange process for modulation of the zeolite microenvironment, the obtained Na-Cu@TS-1 catalyst affords an enhanced activity and selectivity in the selective hydrogenation of FFL into FAL, with a FFL conversion of 93.0% and a FAL selectivity of 98.1% at 110°C, 10 bar H₂, after a reaction time of 2 h. A turnover frequency value of 55.2 h^-1 has been achieved, reflecting some of the highest activity for Cu-based heterogeneous catalysts under similar conditions. Comprehensive characterization studies reveal that the confined environment of the zeolite could not only provide the spatial restriction for metal particles but also induce an electronic interaction between encapsulated Cu nanoparticles and Ti species in Na-Cu@TS-1, which both lead to effective suppression of the metal aggregation and leaching during catalysis. Na species, added by the ion exchange, not only mediate the acid/basic property of the zeolite for suppressing the side reactions but also modulate the encapsulated Cu species into an electronic-rich state, facilitating the FFL hydrogenation. Deactivation of Na-Cu@TS-1 is primarily caused by Na leaching into the liquid phase, but activity can be almost restored after a Na readdn. process.

ACS Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, COA of Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Da-Wei published the artcileEfficient synthesis of bis-isoxazole ethers via 1,3-dipolar cycloaddition catalysed by Zn/Zn²⁺ and their antifungal activities, Computed Properties of 438565-33-4, the publication is Chemical Papers (2015), 69(11), 1500-1511, database is CAplus.

A series of novel bis-isoxazole ether compounds I [R = 3-pyridyl, 3-O₂NC₆H₄, 4-O₂NC₆H₄, 4-(H₃C)₃CC₆H₄; R¹ = 4-C(CH₃)₃, 3-NO₂, (Z)-CH=CHC₆H₅, etc.] were synthesized starting from different substituted aldehydes RCHO and R¹CHO via 1,3-dipolar cycloaddition using Zn/Zn²⁺ as a catalyst. In addition, the antimicrobial properties of synthesized products were investigated. The synthesized compounds I exhibited significant antifungal activities in comparison with the standard drugs, fluconazole and itraconazole. It was found that Candida albicans was sensitive to 2-substituted Ph bis-isoxazole ethers bearing pyridyl I [R¹ = 2-OCH₃, 2-Cl].

Chemical Papers published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C12H17NS2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Studer, Peggy published the artcileSynthesis and Characterization of Poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) Block Copolymers Bearing a Mannose Group at the PEO Chain End, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Bioconjugate Chemistry (2005), 16(1), 223-229, database is CAplus and MEDLINE.

A poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) block copolymer (PEO-b-PMM 2.1.2) bearing a mannose moiety at the poly(ethylene oxide) chain end was synthesized by sequential anionic polymerization of ethylene oxide (EO) and methylidene malonate 2.1.2 (MM 2.1.2), followed by a coupling reaction between its poly(ethylene oxide) amino- or aldehyde-end group and a sugar derivative Different coupling procedures, either in organic media or in aqueous micellar solutions, were examined in order to optimize the poly(ethylene oxide) end-glycosylation yield. The micellar size of the functionalized block copolymers was determined by dynamic light scattering.

Bioconjugate Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C10H23N, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Johnny W. published the artcileRedox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C-H Di- and Trifluoromethoxylation, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Angewandte Chemie, International Edition (2020), 59(48), 21475-21480, database is CAplus and MEDLINE.

Applications of TEMPO· catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO·-catalyzed, redox-neutral C-H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike mols. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/visible studies, and DFT calculations support the proposed oxidative TEMPO·/TEMPO⁺ redox catalytic cycle. Mechanistic studies also suggest that Li₂CO₃ plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO· catalysis.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Hae Won published the artcileA Phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers, SDS of cas: 328-90-5, the publication is Expert Opinion on Drug Metabolism & Toxicology (2011), 7(12), 1471-1479, database is CAplus and MEDLINE.

Objectives: An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compare the pharmacokinetics, pharmacodynamics and safety of triflusal EC with triflusal in healthy Korean male subjects to determine bioequivalence and non-inferiority for the purposes of marketing approval. Methods: A randomized, open-label, two-period, crossover study was conducted in 38 subjects. Either triflusal EC or triflusal was administered orally as a single 900 mg loading dose (day 1) followed by eight 600 mg/day maintenance doses on days 2 – 9, with a 13-day washout period. The plasma concentrations of 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), the predominant active metabolite of triflusal, were assessed after administration of the loading dose, using HPLC/MS/MS. The platelet aggregation response to arachidonic acid was determined using turbidimetric aggregometry. Results: The 90% CIs, for the geometric mean ratios of the log-transformed AUC_τ and C_max of HTB were seen to be within the predetermined range of 0.8 – 1.25. Triflusal EC was also shown to be non-inferior in its anti-aggregatory effect. No serious AEs were reported during this study. Conclusions: The pharmacokinetic and pharmacodynamic profiles of the two triflusal formulations met the requirements for bioequivalence and non-inferiority, resp. Both formulations were well tolerated.

Expert Opinion on Drug Metabolism & Toxicology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mok, Sori published the artcileWithin- and between-person variability of urinary phthalate metabolites and bisphenol analogues over seven days: Considerations of biomonitoring study design, Related Products of alcohols-buliding-blocks, the publication is Environmental Research (2022), 112885, database is CAplus and MEDLINE.

Urine was used as a part of a human biomonitoring study based on the excretion kinetics of less-persistent contaminants, such as phthalates and bisphenol A (BPA). Despite the advantages of being non-invasive and easy to collect, urine can show a large variability of concentrations of phthalate metabolites and BPA within a person depending on sampling time. Therefore, it is essential to assess the variability of urinary concentrations for comprehensive sampling design in the context of exposure and risk assessments. In this study, 18 phthalate metabolites and eight BPs were measured in all spot urine (n = 401) collected from 12 participants for seven consecutive days to evaluate within- and between-person variabilities. The intraclass correlation coefficients (ICCs) for all spot urines were poor for monomethyl phthalate (ICC: 0.002) and BPA (0.121) but were moderate for monoethyl phthalate (0.514) and monobenzyl phthalate (0.462). Based on the results of di (2-ethylhexyl) phthalate (DEHP) metabolites, the half-life and differences in metabolic capability seem to affect the ICCs. Urinary mono (2-ethylhexyl) phthalate (MEHP), a primary metabolite of DEHP, was suggested as a short-term exposure marker of DEHP in our study. Creatinine- and sp. gr.-adjusted concentrations of phthalate metabolites and BPs resulted in increased ICCs, implying requirements for randomly collected spot urine. Most analytes in the first morning voids (FMVs) were correlated significantly with those in the daily composites, suggesting the feasibility of FMVs to estimate the daily exposure dose. This study facilitates a more comprehensive sampling design and data interpretation strategy for human biomonitoring studies.

Environmental Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts