Author: tianli

Gao, Lili published the artcileEfficient optimization of Gluconobacter oxydans based on protein scaffold-trimeric CutA to enhance the chemical structure stability of enzymes for the direct production of 2-keto-L-gulonic acid, Quality Control of 526-98-7, the publication is Journal of Chemistry (2020), 5429409, database is CAplus.

2-Keto-L-gulonic acid (2-KLG), the direct precursor of vitamin C, is produced by a two-step fermentation route from D-sorbitol in industry. However, this route is a complicated mix-culture system which involves three bacteria. Thus, replacement of the conventional two-step fermentation process with a one-step process could be revolutionary in vitamin C industry. The one-step fermentation of 2-keto-L-gulonic acid (2-KLG) has been achieved in our previous study; 32.4 g/L of 2-KLG production was obtained by the one-step strain G. oxydans/pGUC-tufB-sdh-GGGGS-sndh after 168 h. In this study, L-sorbose dehydrogenase (SDH) and L-sorbosone dehydrogenase (SNDH) were expressed in G. oxydans after the codon optimization. Furthermore, the trimeric protein CutA was used to improve the chem. structure stability of SDH and SNDH. The recombinant strain G. oxydans/pGUC-tufB-SH3-sdh-GGGGS-sndh-tufB-SH3lig-(GGGGS)2-cutA produced 40.3 g/L of 2-KLG after 168 h. In addition, the expression levels of the cofactor PQQ were enhanced to further improve 2-KLG production With the stepwise metabolic engineering of G. oxydans, the final 2-KLG production was improved to 42.6 g/L. The efficient one-step production of 2-KLG was achieved, and the final one-step industrial-scale production of 2-KLG is drawing near.

Journal of Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Quality Control of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yinling published the artcileRedox-neutral photocatalytic strategy for selective C-C bond cleavage of lignin and lignin models via PCET process, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol, the publication is Science Bulletin (2019), 64(22), 1658-1666, database is CAplus.

A redox-neutral photocatalytic strategy to accomplish this goal in both β-O-4 and β-1 lignin models at room temperature (RT) via proton-coupled electron transfer (PCET) process without any pretreatments of substrate, by adjusting the alkalinity of base to obtain a lignin models/base PCET pair with a bond dissociation free energy close to 102 kcal/mol was developed. Without breaking down C_β-C_γ bond and any C-O bonds, this PCET method is 100% atom economy and produces exclusive C_α-C_β bond cleavage products, such as benzaldehydes (up to 97%) and Ph ethers (up to 96%), in high to excellent yields and selectivities. Preliminary studies indicated that the PCET strategy was also effective for the depolymerization of native lignin at RT, thus providing significantly important foundation to the depolymerization of lignin.

Science Bulletin published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H22BBrO3, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ao, Junjie published the artcileBisphenol S exposure induces intestinal inflammation: An integrated metabolomic and transcriptomic study, SDS of cas: 80-09-1, the publication is Chemosphere (2022), 133510, database is CAplus and MEDLINE.

As a typical substitute for bisphenol A (BPA), bisphenol S (BPS) is raising concerns due to the potential adverse effects on human health. Limit evidence is available to understand the toxicity of BPS to the digestive system, especially for intestine. In this study, we aimed to investigate the potential effects and underlying mechanisms of BPS exposure on human colon mucosal epithelial cells (NCM460). Our results showed that BPS exposure significantly increased the production of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and interleukin-17A (IL-17A). The tight junctions of the cells has been destroyed by BPS exposure, which was characterized by a down-regulation of the tight junction proteins (Claudin1 and zonula occluden 1 (ZO1)). A multi-omics study explored the underlying mechanisms based on the metabolomic and transcriptomic responses. A variety of neurotransmitters increased significantly after exposure to BPS. The top enriched pathway was “glutamatergic synapse”;, which was activated by BPS exposure, resulting in the up-regulation of L-glutamine. Links were observed among the altered metabolites, genes and cytokines. Our results indicate that exposure to BPS may disturb the balance of gut-brain axis, leading to the production of inflammatory cytokines and the destruction of tight junction in NCM460 cells. It provides new clue for the development of intestinal inflammation in terms of the environmental pollutants.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Lungang published the artcileSelective Production of 2-Butanol from Hydrogenolysis of Levulinic Acid Catalyzed by the Non-precious NiMn Bimetallic Catalyst, Application In Synthesis of 111-29-5, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(46), 15603-15611, database is CAplus.

Selective production of 2-butanol from levulinic acid (LA) hydrogenolysis over a non-precious catalyst is long desirable. However, the process requires the precious metal Ru, and the yield of 2-butanol was less than 65%. Herein, we prepared Ni-based bimetallic catalysts, among which the NiMn catalyst exhibited the highest efficiency and reached an 84.5% yield of 2-butanol at 100% LA conversion under optimal conditions. The electronic states and surface properties were characterized by various techniques such as X-ray diffraction, XPS, temperature-programmed desorption, temperature-programmed reduction, and SEM/transmission electron microscopy. The high efficiency of the NiMn catalyst was due to the synergy between Ni⁰ and Mn²⁺ species, and the modified surface showed a high basicity and a high affinity to adsorb LA and LA-derived mols. with C=O or COOH. The high affinity of the NiMn catalyst was further confirmed by d. functional theory calculations

ACS Sustainable Chemistry & Engineering published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xie, Long-Yong published the artcileC(sp²)-H/O-H cross-dehydrogenative coupling of quinoxalin-2(1H)-ones with alcohols under visible-light photoredox catalysis, SDS of cas: 2240-88-2, the publication is Chinese Journal of Catalysis (2020), 41(8), 1168-1173, database is CAplus.

An efficient and practical route to various 3-alkoxylquinoxalin-2(1H)-ones through visible-light photocatalytic C(sp²)-H/O-H cross-dehydrogenation coupling of quinoxalin-2(1H)-ones and alcs. by employing ambient air as an oxidant at room temperature under metal-free conditions was developed.

Chinese Journal of Catalysis published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H9ClOS, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yongjie published the artcilePyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation, HPLC of Formula: 96-20-8, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127712, database is CAplus and MEDLINE.

Tropomyosin receptor kinases (Trks), a transmembrane receptor tyrosine kinases, have attracted more and more attention as antitumor drug targets. Here we reported the structure-based synthesis and biol. evaluation of novel pyrazolo[1,5-a]pyrimidine derivatives, i.e., I, as Trk inhibitors, which exhibited potent Trk inhibitory activities. Particularly, some of the compounds (8a, 8f, 9a, 9b and 9f) (IC₅₀ < 5 nM) showed significant inhibitory potency against Trk.

Bioorganic & Medicinal Chemistry Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C8H6ClF3, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Lian-fang published the artcileClinical study on prevention of postpartum hemorrhage of cesarean section using hemabatein high risk pregnant women, COA of Formula: C25H47NO8, the publication is Zhonghua Fuchanke Zazhi (2007), 42(9), 577-581, database is CAplus.

Objective: To observe the effect and safety of hemabat (H) on prevention of postpartum hemorrhage in cesarean section and after cesarean section in high risk pregnant women. Methods: Four hundred and sixty-nine pregnant women with high hemorrhagic risk factors including twin pregnancy, polyhydramnios, fetal macrosomia, placenta previa were planned cesarean section. A total of 457 pregnant women were divided into 3 groups by operation indications. There were 239 cases of fetal macrosomia, 145 cases of twin pregnancy and polyhydramnios, and 73 cases of placenta previa. Three kinds of hysterotonics were used randomly in each group. Group oxytocin (O): 20 U oxytocin injected into the uterine plus 20 U oxytocin intravascularly, 152 women; Group oxytocin + hemabate (O + H): 20 U oxytocin and 250 μg hemabat injected into the uterine, 192 women; group H: 250 μg hemabat, injected into the uterine, 125 women. The amount of bleeding during the operation and within 2-h after delivery were measured. The side effect of each group was observed Results: The amount of bleeding during cesarean section in group O was (445 ± 262) ml, in group 0 + H (332 ± 218) ml, and in group H (375 ± 265) ml. There was an extremely significant difference between group O and group O + H (P < 0.01). The amount of bleeding within 2 h after delivery in group O was (176 ± 193) ml, in group O + H was (110 ± 114) ml, and in group H was (124 ± 103) ml. There was a significant difference between groups O, O + H and H. Among the 469 women, 31 had total amount of bleeding more than 1000 mL during operation and within 2 h after delivery, 48% (15 women) were in group O, 23% in group O + H and 29% in group H. The total amount of bleeding in group O was much more than group O + H and group H in the group of fetal macrosomia (P < 0.01, P < 0.01). Similar results were found in the group of twin pregnancy and polyhydramnios (P < 0.01, P < 0.01). The total amount bleeding in group O + H was much less than group O in the group of placenta previa (P < 0.05). There were 5% (12) pregnant women whose total amount of bleeding was ≥ 1000 mL in the group of fetal macrosomia, 8% (11) in the group of twin pregnancy, 11% (8) in the group of placenta previa. No hysterectomy was done among the women. The incidence of side effects in the three groups was 2.6%, 11.5% and 7.0% resp. Vomiting was frequently seen in the latter two groups, but recovered soon without treatment. Conclusion: Hemabat can significantly reduce the amount of bleeding during the cesarean section in pregnant women with high hemorrhagic risk factors and can be used with oxytocin as firstline medicine to prevent hemorrhage during and after delivery.

Zhonghua Fuchanke Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C15H23BO2, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Yi-Xin published the artcileCd-Doped Polyoxotitanium Nanoclusters with a Modifiable Organic Shell for Photoelectrochemical Water Splitting, Synthetic Route of 328-90-5, the publication is Inorganic Chemistry (2021), 60(24), 19263-19269, database is CAplus and MEDLINE.

Incorporating heterometal and chromogenic groups into the titanium oxo cluster (TOC) nanomaterials is one of the effective strategies for the development of new high-performance photoelec. active materials. In this Article, the authors report the structures and photoelectrochem. (PEC) performances of a family of TOCs, including pure [Ti₁₂O₈(OEt)₁₆L₈] ({Me-Ti₁₂}) and six Cd-doped clusters formulated as [H₄Cd₂Ti₁₀O₈(OEt)₁₆(L)₈(H₂O)₂] ({Cd₂Ti₁₀}; L = salicylic acid and their derivatives). The six Cd-doped clusters are isostructural, containing the same {Cd₂Ti₁₀O₈} core, but are protected by salicylic ligands modified with different functional groups. The compositions, structures, and solution stability of these clusters were studied in detail by single-crystal x-ray diffraction and electrospray ionization mass spectrometry measurements. The embedding of heterometallic Cd(II) and chem. modification of organic protective shells can effectively regulate the PEC water oxidation activity of those clusters, with {F-Cd₂Ti₁₀} having the highest turnover number of 518.55 and the highest turnover frequency of 172.85 h^-1. The authors’ work highlights the potential of using TOCs that do not contain noble metals as water oxidation catalysts, and their catalytic activity can be regulated by structural modification.

Inorganic Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C3H6O2, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Shanshan published the artcileLow temperature catalytic hydrodeoxygenation of lignin-derived phenols to cyclohexanols over the Ru/SBA-15 catalyst, Product Details of C9H12O, the publication is RSC Advances (2022), 12(15), 9352-9362, database is CAplus and MEDLINE.

Cyclohexanol and its derivatives are widely used as chem. intermediates and fuel additives. Herein, Ru/SBA-15 catalysts were prepared via impregnation, and used for the production of cyclohexanols from lignin-derived phenols. The catalyst samples were characterized by XRD, XPS, TEM, etc., where the Ru⁰ species was speculated as the active phase. 5 wt% Ru/SBA-15 with small Ru particle size (4.99 nm) and high Ru dispersion (27.05%) exhibited an excellent hydrogenation activity. A high cyclohexanol yield of >99.9% was achieved at 20°C for 5 h in an aqueous phase, and the catalyst indicated stable activity and selectivity after five runs. Crucially, Ru/SBA-15 exhibited a zero-order reaction rate with an apparent activation energy (Ea) as low as 10.88 kJ mol^-1 and a TON of 172.84 at 80°C. Simultaneously, demethoxylation activity was also observed in the hydrodeoxygenation (HDO) of G- and S-type monophenols, and a high yield of 37.4% of cyclohexanol was obtained at 80°C and 4 h when using eugenol as substrate.

RSC Advances published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Product Details of C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Li published the artcileEvaluation of drug treatment for postpartum hemorrhage, Formula: C25H47NO8, the publication is Zhongguo Shiyong Fuke Yu Chanke Zazhi (2009), 25(2), 98-102, database is CAplus.

A review. Management options for postpartum hemorrhage (PPH) include pharmacol., surgical and radiol. interventions. In recent years, there are great progress in its pharmacol. treatment. Oxytocin and ergometrine remain first-line options, and there are many other new drugs such as carbetocin, hemabate, vasopressin and recombinant activated blood-coagulation factor VII a. This review summarizes the effectiveness, safety and the best drug combinations for the treatment of primary PPH, and highlights recent advances and developments.

Zhongguo Shiyong Fuke Yu Chanke Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C3H6BrNaO3S, Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts