Author: tianli

Inman, Chiraporn published the artcileAlternative application approach on black bean: hair coloring product, Computed Properties of 70445-33-9, the publication is Chemical and Biological Technologies in Agriculture (2020), 7(1), 2, database is CAplus.

Abstract: Background: Black bean is one of the important beans as the second most consumed bean globally after soybean. It has been reported as a sustainable source of anthocyanins, important natural colorants used in food and consumer products. However, industrial uses of black bean anthocyanins in pharmaceutics and cosmetics have rarely been explored. Thus, here, a black bean anthocyanin extract was prepared, quality controlled and developed into an efficient hair coloring product. Results: Black bean was macerated in hydrochloric ethanol to produce a dark-reddish 1.85 ± 0.04% dry extract with total anthocyanin content (TAC) of 1.24 ± 0.48 μg/mL cyanidin-3-glucoside. The extract was readily dissolved in propylene glycol (25%), giving a reddish to red-brownish solution at pH of 4.00-7.00. The addition of antioxidant significantly (p = 0.000) enhanced the stability of the extract in an accelerated stability test (90.34 ± 5.32 from 67.83 ± 3.45% TAC remaining). Three base hair gels containing different thickeners were developed to yield clear gels with a viscosity of 101,666.67-447,333.33 cps and a pH of 4.80-4.97. The gel base with the best hair application properties was chosen to mix with 8, 10 and 12% black bean extract to produce similar visually assessed red-brown gels (L* = 33.25-33.76, a* = 0.06-0.09, b* = – 0.45-0.38 and h* = 277.54-283.31) at 73,733.33-99,666.67 cps and a pH of 5.00-5.01. All of the black bean hair coloring gels were stable under the accelerated test. The 10% hair gel was tested for its hair staining efficacy. The black bean hair coloring gel was found to efficiently color hair, and the color was maintained through four washings. Conclusions: An alternative application approach of using black bean as a natural colorant is presented here, including its basic requirements for preparation and quality control from an industrial aspect. The efficient semi-permanent hair coloring product containing black bean is an innovative natural product and is considered as one progress towards a sustainable bio-based economy using a readily available industrial crop, black bean. [graphic not available: see fulltext]

Chemical and Biological Technologies in Agriculture published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Afonso, Carlos A. M. published the artcileSynthesis of 2,4,6-tri-substituted-1,3,5-triazines, Synthetic Route of 101-98-4, the publication is Molecules (2006), 11(1), 81-102, database is CAplus and MEDLINE.

Several specific synthetic protocols were developed for the preparation of a range of sym. and non-sym. di- and tri-substituted 1,3,5-triazines containing alkyl, aromatic, hindered, chiral and achiral hydroxyalkyl, ester and imidazole groups , e.g., I (R = H or Me) via sequential nucleophilic substitution of the C-Cl bond by C-O, C-N and C-S bonds, starting from cyanuric chloride.

Molecules published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kritikos, Nikolaos published the artcileQuantitative structure-chemiluminescence intensity relationships of 4-substituted phenols acting as luminol signal enhancers, Computed Properties of 23351-09-9, the publication is Chemometrics and Intelligent Laboratory Systems (2015), 478-484, database is CAplus.

The addition of a forth compound into this system has been thoroughly explored over the years, namely an enhancer promoting potency in the signal attained. Improvements in this regard serve to increase sensitivity and applicability of various biochem. methods. Studies exploring the ability of compounds to act as enhancers have proposed several chem. groups as possible candidates, amongst which 4-substituted phenols have been widely employed. Although some studies have explored the effect of the substituent on enhancer potency, no quant. structure – property relationships employing mol. descriptors for this group of compounds have been presented. Current study provides two such cross- and externally validated models, constructed by the projection to latent structures by means of partial least squares (PLS) multivariate linear regression method: i) a PLS-DA model contributing to the classification of such compounds into classes (relative to the signal), and ii) a PLS model for predicting the signal acquired. Validation was based on statistical metrics Q²ext(F3) for the test set and Roy’s metrics r²m(Av) & r²m(δ), assessing both predictive stability and internal validity. Applied in tandem, those models can assist in the recognition of available compounds as potential enhancers or inspire the synthesis of novel analogs. The significance of some characteristics governing the compounds’ behavior are also discussed based on the mol. descriptors chosen.

Chemometrics and Intelligent Laboratory Systems published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Computed Properties of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dotsikas, Yannis published the artcileEffect of the luminol signal enhancer selection on the curve parameters of an immunoassay and the chemiluminescence intensity and kinetics, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Talanta (2007), 71(2), 906-910, database is CAplus and MEDLINE.

In the present study, three luminol signal enhancers {4-methoxyphenol, 4-hydroxybiphenyl and 4-(1H-pyrrol-1-yl)phenol} were utilized in the chemiluminescence (CL) substrate solution of horseradish peroxidase (HRP). The latter was applied in a heterogeneous enzyme immunoassay that has been previously described. The employment of these mols. greatly affected important assay parameters, such as detection limit and the range of the calibration curve and the results were compared with those obtained from other two similar enhancers that have been described from the authors’ group. Practically, the use of a novel enhancer, even if this is a slightly changed 4-substituted phenol derivative, can affect assay properties so dramatically, one can assume that another substrate/enzyme system was applied. Furthermore, the use of different luminol signal enhancers in the luminol/HRP/H₂O₂ system affected not only the intensity of the obtained signal, which is well known, but also its kinetics. It was monitored that the stronger intensity was combined with a more rapid decrease of the CL signal.

Talanta published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Holmes, J. L. published the artcileHeats of formation of ionic and neutral enols of acetaldehyde and acetone, SDS of cas: 20117-47-9, the publication is Journal of the American Chemical Society (1982), 104(9), 2648-9, database is CAplus.

CH₂:C(OH)R (I, R = H, Me) are formed, together with C₂H₄, in the pyrolysis of II (R = H, Me) at 950°/10^-3 torr in a tubular quartz reactor leading to an ionization chamber; the pyrolysis of II (R = Me) at >950° gave CH₄ and CH₂:CO at the expense of enol. The ionization energies, accurately determined by the impact of a monoenergetic electron beam and the ionization efficiency curve threshold, were 9.15 ± 0.05 and 8.48 ± 0.05 eV. The low cross-section for ionization of I is due to the small Franck-Condon factors for the adiabatic transition which are related to the difference in the preferred conformation of the OH group in I and its radical cation. The formation heat of I and its radical cations are calculated; the enol radical cations are more stable than the keto or aldehyde radical cations in contrast to the neutral species. The formation heat increment for the -OCH: fragment was also estimated

Journal of the American Chemical Society published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, SDS of cas: 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mosallanejad, Arash published the artcileApplication of Tsunoda reagent to the convenient synthesis of drug-like pyrazoles, Quality Control of 622-40-2, the publication is Tetrahedron Letters (2018), 59(18), 1708-1710, database is CAplus.

The versatility of the under-utilized (cyanomethylene)tributylphosphorane (CMBP, Tsunoda reagent) was demonstrated on two occasions in a drug discovery context. Firstly, the high reactivity of the phosphorane allowed the alkylation of a weakly acidic pyrazole when standard Mitsunobu conditions were unsuccessful. Secondly, the clean reaction profile generally obtained using CMBP allowed the direct use of the crude mixture in a subsequent Suzuki cross coupling. This reagent was utilized when isolation of the Mitsunobu reaction product (e.g. containing a boronate) was not desirable.

Tetrahedron Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Veres, Peter published the artcileHybrid aerogel preparations as drug delivery matrices for low water-solubility drugs, COA of Formula: C8H5F3O3, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2015), 496(2), 360-370, database is CAplus and MEDLINE.

A comprehensive study of 14 hybrid aerogels of different composition with applications in drug delivery has been carried out. The overall objective was to modulate the release behavior of drug-impregnated aerogels, from an almost instantaneous release to a semi-retarded delivery prolonged during several hours, through internal surface functionalization. The designed hybrid aerogels were composed of silica and gelatin and functionalized with either Ph, long (16) hydrocarbon chain or Me moiety. As model systems, three class II active agents (pK_a < 5.5), ibuprofen, ketoprofen and triflusal, were chosen to impregnate the aerogels. The work relied on the use of supercritical fluid technol. for both the synthesis and functionalization of the hybrid aerogels, as well as for the impregnation with an active agent using supercritical CO₂ as a solvent. For the impregnated aerogels, in vitro release profiles were recorded under gastric and intestinal pH-conditions using HPLC techniques. The release behavior observed for the three studied drugs was explained considering the measured dissolution profiles of the crystalline drugs, the aerogel composition and its functionalization. Such features are considered of great interest to tailor the bioavailability of drugs with low water solubility

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C16H24BF4Ir, COA of Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Murillo-Cremaes, Nerea published the artcileNanostructured silica-based drug delivery vehicles for hydrophobic and moisture sensitive drugs, SDS of cas: 328-90-5, the publication is Journal of Supercritical Fluids (2013), 34-42, database is CAplus.

Facile and robust fabrication methodologies of complex materials with high added value for controlled drug delivery systems are highly sought-after in the pharmaceutical industry. Here, the authors have relied on the use of supercritical fluids for the matrix synthesis as well as for the drug impregnation process. As a model system of a hydrophobic and moisture sensitive active agent, triflusal was impregnated in different aerogel and polymeric matrixes using supercritical CO₂. In vitro release profiles of drug carriers consisting of SiO₂ aerogels as mesoporous monoliths and as microporous nanospheres loaded with triflusal are reported and compared to a more conventional polymeric system (PMMA). Silica-based matrixes are found to prevent the hydrolization of the active ingredient more efficiently than the polymeric matrix and displayed much faster release kinetics. Moreover, the triflusal is dispersed in a mol. form inside the silica-based materials. Such features are considered of great interest to enhance the bioavailability of low solubility drugs.

Journal of Supercritical Fluids published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Argemi, Anna published the artcileSpectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies, Application In Synthesis of 328-90-5, the publication is Journal of Pharmaceutical and Biomedical Analysis (2008), 46(3), 456-462, database is CAplus and MEDLINE.

This study describes the development and evaluation of an anal. method for the characterization of triflusal (2-acetoxy-4-(trifluoromethyl) benzoic acid) dispersed in sustained delivery systems prepared using supercritical fluid impregnation technol. Characterization assays comprised the determination of the percentage of triflusal and its degradation product impregnated in polymeric supports and further monitoring of the releases of the 2 drug components over time in physiol. conditions. Preliminary delivery profiles were monitored spectrophotometrically using a continuous-flow system. In this case, no selective wavelength for discriminating between triflusal and metabolite was found so that measurements at 225 nm provided overall profiles corresponding to the 2 compounds For a more accurate study, a chromatog. method was developed for monitoring the evolution of the concentration of the 2 components independently. Triflusal and metabolite were separated in a C₁₈ column and 25 mM acetic acid/acetate (pH 5.0) + methanol (40/60 volume/volume) mobile phase. Several triflusal-polymer samples were prepared under different exptl. conditions and release features were evaluated. Excellent delivery systems were obtained with poly(methyl)methacrylate beads treated at 40°C and 190 bar for 48 h using supercritical carbon dioxide as a solvent. These samples showed a constant sustained release of drug for several weeks.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application In Synthesis of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mondejar-Lopez, Maria published the artcileBiogenic Silver Nanoparticles from Iris tuberosa as Potential Preservative in Cosmetic Products, Related Products of alcohols-buliding-blocks, the publication is Molecules (2021), 26(15), 4696, database is CAplus and MEDLINE.

Biogenic-silver nanoparticles emerge as new nanosilver platforms that allow us to obtain silver nanoparticles via “green chem.”. In our study, biogenic-silver nanoparticles were obtained from Iris tuberosa leaf extract Nanoparticles were characterized by a UV-vis spectroscopy, dynamical light scattering technique. The transmission electron microscope revealed spheric and irregular nanoparticles with 5 to 50 nm in diameter Antimicrobial properties were evaluated against typical microbial contaminants found in cosmetic products, showing high antimicrobial properties. Furthermore, natural moisturizing cream was formulated with biogenic-silver nanoparticles to evaluate the preservative efficiency through a challenge test, indicating its promising use as preservative in cosmetics.

Molecules published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts