Author: tianli

Yu, Marcella published the artcileReversible pH Lability of Cross-linked Vault Nanocapsules, HPLC of Formula: 70539-42-3, the publication is Nano Letters (2008), 8(10), 3510-3515, database is CAplus and MEDLINE.

Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10 000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible crosslinking of recombinant vaults such that they may be closed and opened in a controllable manner.

Nano Letters published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C26H41N5O7S, HPLC of Formula: 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brimble, Margaret A. published the artcileSynthesis of a dimeric pyranonaphthoquinone via a novel double furofuran annulation strategy, Related Products of alcohols-buliding-blocks, the publication is Tetrahedron Letters (1998), 39(31), 5647-5650, database is CAplus.

The first synthesis of a dimeric pyranonaphthoquinone (I) which is related to the naturally occurring dimeric pyranonaphthoquinones, e.g. actinorhodin and crisamycin, is described. The key biaryl (II) is prepared by means of a Suzuki coupling reaction, utilizing the Miyaura reagent to generate the organoboron coupling partner. The first example of a double annulation of a bisquinone with 2-trimethylsilyloxyfuran to afford a bisfuronaphthofuran (III) and subsequent double oxidative rearrangement to a dimeric pyranonaphthoquinone is described.

Tetrahedron Letters published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Jayendra Z. published the artcileOptimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors, Product Details of C6H9N3O2S, the publication is ChemMedChem (2015), 10(2), 253-265, database is CAplus and MEDLINE.

At present, inhibitors of α/β-hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article describes the development of 1,2,5-thiadiazole carbamates as ABHD6 inhibitors. Altogether, 34 compounds were synthesized, and their inhibitory activity was tested using lysates of HEK293 cells transiently expressing human ABHD6 (hABHD6). Among the compound series, 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate I (JZP-430) potently and irreversibly inhibited hABHD6 (IC₅₀=44 nM) and showed ∼230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds Addnl., activity-based protein profiling indicated that I displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. I has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.

ChemMedChem published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Product Details of C6H9N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xiao-Feng published the artcileA General and Efficient Palladium-Catalyzed Alkoxycarbonylation of Phenols To Form Esters through In Situ Formed Aryl Nonaflates, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry – A European Journal (2012), 18(13), 3831-3834, S3831/1-S3831/27, database is CAplus and MEDLINE.

A novel process for the palladium catalyzed alkoxycarbonylation of phenols is presented. Activation of the phenols occurs via convenient in situ generation of aryl nonaflates. Electron-withdrawing or electron-donating substituents on the aryl or ester moiety are tolerated amongst the varied functional groups. Notably, not only homoesterification, but also cross-coupling of two different phenols (alcs.) are possible under these conditions.

Chemistry – A European Journal published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C22H18O2, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Xiao published the artcileAlkyl Aryl Ether Bond Formation with PhenoFluor, COA of Formula: C10H13NO2, the publication is Angewandte Chemie, International Edition (2015), 54(19), 5662-5665, database is CAplus and MEDLINE.

An alkyl aryl ether bond formation reaction between phenols and primary and secondary alcs. with PhenoFluor has been developed. The reaction features a broad substrate scope and tolerates many functional groups, and substrates that are challenging for more conventional ether bond forming processes may be coupled. A preliminary mechanistic study indicates reactivity distinct from conventional ether bond formation.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C8H10S, COA of Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Hwalkee published the artcileA novel morpholine-based rhodamine fluorescent chemosensor for the rapid detection of Hg²⁺ ions, Quality Control of 27292-49-5, the publication is Journal of Nanoscience and Nanotechnology (2019), 19(11), 6893-6898, database is CAplus and MEDLINE.

A novel rhodamine-based receptor bearing a morpholine (RDM) was developed as a fluorescent chemosensor with high selectivity toward Hg²⁺. After the addition of Hg²⁺ to RDM, the color of the solution changed from colorless to pink, and the new absorption band appears at 580 nm. The fluorescent of RDM appears to orange color in the presence of Hg²⁺. Upon the addition of Hg²⁺, ring-opening of the corresponding spirolactam gives rise to fluorescence, and a 1:1 metal-ligand complex formed.

Journal of Nanoscience and Nanotechnology published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Quality Control of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Potschka, Martin published the artcileThe two coiled coils in the isolated rod domain of the intermediate filament protein desmin are staggered. A hydrodynamic analysis of tetramers and dimers, Related Products of alcohols-buliding-blocks, the publication is European Journal of Biochemistry (1990), 190(3), 503-8, database is CAplus and MEDLINE.

Desmin protofilaments and the proteolytically derived α-helical rod domain have been characterized by high-resolution gel permeation chromatog. (GPC) using columns calibrated for the determination of viscosity radii. Addnl. characterization by chem. crosslinking and the determination of sedimentation values allowed the calculation of the mol. dimensions of the mol. species isolated. In dilute buffers GPC separated desmin rod preparations into 2 complexes: a dimer species (single coiled coil) with a length of 50 nm and a tetramer species (2 coiled coils) with a length of 65 nm. Thus the 2 coiled coils in the tetramer are staggered by ∼15 nm. The hydrodynamically derived lengths of the rod dimer and tetramer are supported by electron microscopy after metal shadowing. The hydrodynamic properties of desmin protofilaments follow that of the rod tetramer. The present results explain the inhomogeneity of mols. encountered in previous electron microscopical analyses.

European Journal of Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tomas-Navarro, Maria published the artcileNovel urinary biomarkers of orange juice consumption, interindividual variability, and differences with processing methods, Formula: C8H8O3, the publication is Journal of Agricultural and Food Chemistry (2021), 69(13), 4006-4017, database is CAplus and MEDLINE.

Untargeted metabolomics identified urinary biomarkers able to discriminate between the intake of fresh hand-squeezed and industrially processed orange juices. Processing led to an upregulation in the excretion of hydroxy-polymethoxyflavone sulfates, abscisic acid, and sinapic acid 4′-glucuronide. The demethylated polymethoxyflavone metabolites were produced with a significant interindividual variability suggesting that they could originate from gut microbiota metabolism No correlation between the excretion levels of flavanone and polymethoxyflavone metabolites was observed, showing that gut microbiota metabolism differences could be behind the interindividual variability. Subjects with a high excretion level of hesperetin conjugates could be low or high polymethoxyflavone excretors. Flavanone phase II metabolites were primarily glucuronides, while those of demethylated polymethoxyflavones were mainly sulfates. A comparative study with the available demethylated polymethoxyflavone standards suggested that the metabolites produced in humans could be tentatively 4′-hydroxy- and/or 3′-hydroxy-polymethoxyflavone sulfates. This study is the first to describe the bioavailability and metabolism of citrus juice polymethoxyflavones in humans.

Journal of Agricultural and Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C11H10N4, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Twum, Elvis A. published the artcileInitial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems, COA of Formula: C3H6O2, the publication is Bioorganic & Medicinal Chemistry (2015), 23(13), 3481-3489, database is CAplus and MEDLINE.

Cyclopropabenzaindoles (CBIs) are exquisitely potent cytotoxins which bind and alkylate in the minor groove of DNA. They are not selective for cancer cells, so prodrugs are required. CBIs can be formed at physiol. pH by Winstein cyclisation of 1-chloromethyl-3-substituted-5-hydroxy-2,3-dihydrobenzo[e]indoles (5-OH-seco-CBIs). Corresponding 5-NH₂-seco-CBIs should also undergo Winstein cyclisation similarly. A key triply orthogonally protected intermediate on the route to 5-NH₂-seco-CBIs has been synthesized, via selective monotrifluoroacetylation of naphthalene-1,3-diamine, Boc protection, electrophilic iodination, selective allylation at the trifluoroacetamide and 5-exo radical ring-closure with TEMPO. This intermediate has potential for introduction of peptide prodrug masking units (deactivating the Winstein cyclisation and cytotoxicity), addition of diverse indole-amide side-chains (enhancing non-covalent binding prior to alkylation) and use of different leaving groups (replacing the usual chlorine, allowing tuning of the rate of Winstein cyclisation). This key intermediate was elaborated into a simple model 5-NH₂-seco-CBI with a dimethylaminoethoxyindole side-chain. Conversion to a bio-reactive entity and the bioactivity of this system were confirmed through DNA-melting studies (ΔT_m = 13 °C) and cytotoxicity against LNCaP human prostate cancer cells (IC₅₀ = 18 nM).

Bioorganic & Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C6H20Cl2N4, COA of Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maman, Manju P. published the artcileReversible polymorphic structural transition of crown-like nickel nanoclusters and its effect on conductivity, Name: 2-Phenylethanethiol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(23), 2935-2938, database is CAplus and MEDLINE.

The reversible polymorphic phase transition of [Ni₆(PET)₁₂] (PET = phenylethanethiol) and its effect on the conductivity are reported. This cluster′s self-assembly leads to 2 polymorphic structures with distinct conductivity, caused by variation of the noncovalent S···S interactions. These results enlighten the effect of noncovalent interactions on conductivity

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts